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45022 Exploring Career Development Needs of Junior Investigators in Clinical Translational Science
- Jachael Gardner, Terry Nakazono, Jim Morrison, Kishore Athreya, Paige Hall, Pamela Davidson
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- Journal:
- Journal of Clinical and Translational Science / Volume 5 / Issue s1 / March 2021
- Published online by Cambridge University Press:
- 30 March 2021, pp. 61-62
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ABSTRACT IMPACT: By understanding Junior investigator characteristics and CTSA support services which strongly influence scientific productivity and impact, we will inform and improve research training and enhance the career development of future generations of clinical and translational science researchers. OBJECTIVES/GOALS: In the field of clinical and translational science, the career trajectory and definition of Junior Investigators (JIs) vary greatly. This study aims to investigate JI characteristics, training, and support that contribute to career development at the University of California Los Angeles (UCLA) Clinical and Translation Science Institute (CTSI). METHODS/STUDY POPULATION: Every 18 months, the UCLA CTSI administers the Longitudinal Scientific Achievement Survey, which collects information on the predictors of scientific productivity and impact. In 2018, a special supplement was added to survey JIs who received CTSA support between 2011 and 2017 (n=305), including questions on knowledge, use, and effectiveness of CTSA specific support, barriers and facilitators of research, scientific productivity, and perceived scientific impact. A literary analysis was conducted to explore previous categorizations of JIs. The JIs in our sample conducted bench to bedside, population and policy research at our four partner sites. Bivariate and logistic regression analysis were conducted to examine the significant predictors of a new grant award attributed to the CTSA support/services. RESULTS/ANTICIPATED RESULTS: The survey response rate was 82% (n=250). Respondents include core voucher co-investigators, enrollees in the Training Program in Translational Science, and K- and K-to-R workshop participants. Bivariate results showed new grant awardees significantly more likely to have the following characteristics: physician scientist with an MD and PhD (47%), pilot grant awardee (42%), core voucher awardee (49%), four or more types of CTSI support (48%), prior affiliation with an NIH institute/center other than NCATS (42%), and reported at least one impact in science, health, and/or the community (72%). Multivariate results showed that investigators with a prior core voucher award, a prior NIH affiliation, or reported one or more impacts were the strongest predictors of obtaining a new grant (each with OR>=4.0). DISCUSSION/SIGNIFICANCE OF FINDINGS: The most successful investigators consulted with NIH program officers and received feedback on their research plans and methods. Sufficient funding is crucially important to research progression. In our CTSA hub, vouchers and grants to initiate new studies or offset costs of existing research are consistent predictors of new extramural funding.
4145 Stepping Stones for Success in T3-T4 Translation: Building Collective Impact
- Kishore Athreya, Terry Nakazono, Jim Morrison, Pamela Davidson
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- Journal:
- Journal of Clinical and Translational Science / Volume 4 / Issue s1 / June 2020
- Published online by Cambridge University Press:
- 29 July 2020, p. 145
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OBJECTIVES/GOALS: We will investigate the influence of multisector partnerships in T3-T4 research associated with advances in delivery systems, patient/population outcomes and health policy and the translational processes linked to these improvements. METHODS/STUDY POPULATION: We are using both quantitative and qualitative data to measure and analyze partnership characteristics linked to successful translation into practice & policy. We aim to complete 100 surveys of investigators who have conducted CTSA-supported T3-T4 research to examine partnerships, conditions of collective impact, and quantifiable changes in delivery systems, health outcomes, and policy. Using rigorous criteria, we will select projects for more in-depth interviews to understand the practices of successful translation and roadblocks and barriers that challenge translation. RESULTS/ANTICIPATED RESULTS: The anticipated research products include: (i) an analytic report on partnership structure and processes and the statistical associations to stages of change outcomes, (ii) a series of vignettes to describe the impact stories and translational processes, (iii) cross-project analysis of the data and vignettes to produce generalizable information to improve T3-T4 translation, and (iv) peer-reviewed manuscript(s) for publication. DISCUSSION/SIGNIFICANCE OF IMPACT: The study will inform and improve researcher competencies and accelerate translation in CTSA hubs that emphasize T3-T4 research. We will develop novel definitions of the T3-T4 research impact. Ultimately, the results will inform research training to better address real-world priorities and needs.
3351 Research training and career development in junior investigators at a multi-institutional CTSA
- Jachael Gardner, Jim Morrison, Terry Nakazono, Pamela Davidson
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- Journal:
- Journal of Clinical and Translational Science / Volume 3 / Issue s1 / March 2019
- Published online by Cambridge University Press:
- 26 March 2019, pp. 73-74
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OBJECTIVES/SPECIFIC AIMS:. The study aims to understand the characteristics of junior investigators who are supported by the CTSI, their knowledge of CTSI services and resources, as well as the perceived effectiveness of CTSI research training and career development. The primary outcome is scientific productivity that enhances career development and promotion. The secondary outcome is to inform and improve CTSA research training and career development, not only for the UCLA CTSI hub but also for the CTSA Program nationally. METHODS/STUDY POPULATION:. The study sample includes post-doctoral and junior investigators who have received UCLA CTSI support between 2011 and 2017 (n=319). These junior investigators conduct research at our four partner sites (UCLA-Westwood, Cedars-Sinai Medical Center, The Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Charles R. Drew University of Medicine and Science). The CTSI administered the LSAS and the Career Development module in 2018 using Qualtrics, a subscription software for collecting and analyzing survey data. In order to reduce the burden on the survey respondents, the survey team pre-populated their previously reported publication in the Qualtrics survey system. Qualtrics sends customized email invitations containing a link to start the LSAS survey and subsequently automated sequences of reminder messages for non-responders and partial completers. The survey team initiated telephone call-backs and engaged partner site leaders to achieve a high response rate. RESULTS/ANTICIPATED RESULTS:. Preliminary results show a response rate of 83% (n=264). Respondents include K-to-R workshop participants (n=192), core voucher co-investigators (n=38), Training Program in Translational Science (TPTS) trainees (n=82), and junior investigators who participated in two or more of these activities (n=48). Trainee characteristics include degree, gender, and partner site location. The distribution of advanced degrees among the junior investigators include: PhD (29%), MD (55%), MD/PhD (13%), or other degree (3%). Forty-four percent (44%) respondents are male and 56% are female. Seventy-two percent (72%) have a primary appointment at UCLA-Westwood, while 28% have academic appointments at the partner institutions. Twenty-five percent (25%) received CTSI research training and 49% received CTSI career development support. Regarding scientific productivity, 58% reported having at least one peer-reviewed publication and 29% reported subsequent grant funding. DISCUSSION/SIGNIFICANCE OF IMPACT:. We are in the process of identifying the predictors of scientific productivity and the characteristics of the junior investigators most significantly correlated with productivity using multiple logistic regression analysis. We will analyze qualitative responses to examine the facilitators and barriers to conducting research at the CTSI and explore ways to improve administrative and clinical research processes. The significance of this research is to inform research training and career development programs within our CTSA hub and the CTSA Program nationally.