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Look Inside Alzheimer's Disease Drug Development
eBook forthcoming

Alzheimer's Disease Drug Development
Research and Development Ecosystem

$125.00 (M)

Jeffrey Cummings, Howard Fillit, Kurt Brunden, Goodwell Nzou, Carlo Ballatore, Andrew A. Pieper, J. Simon Mazza-Lunn, Diana R. Wetmore, Janet Sultana, Clive Ballard, Feixiong Cheng, Jefferson Kinney, Amanda M. Leisgang Osse, Bruce Lamb, Adrian Oblack, Alan D. Palkowitz, Frank J. Belas, Steven L. Wagner, Brenda Hug, Min Su Kang, Arturo Aliaga, Pedro Rosa-Neto, Julie Ottoy, Monica Shin, Marcel Seungsu Woo, Serge Gauthier, Eduardo R. Zimmer, Arnold Salazar, Manfred Windisch, Philip Scheltens, Willem de Haan, Roos J. Jutten, Everhard Vijverberg, Arno de Wilde, Niels Prins, Eric Siemers, Robert A. Dean, James E. Senetar, Janice M. Hitchcock, Russell L. Barton, Marwan Sabbagh, Jiong Shi, Paul Aisen, Rema Raman, Michael Rafii, Reisa Sperling, Ron Petersen, Craig W. Ritchie, Jason Bork, Cyndy Cordell, John Dwyer, Gabe Goldfeder, Debra R. Lappin, Richard Mohs, Julie Neild, Rona Schillinger, Jill Smith, Katy Smith, Leigh Zisko, George Vradenburg, Peter A. Ljubenkov, Adam Boxer, Suzanne Hendrix, Samuel P. Dickson, Jessie Nicodemus-Johnson, Newman T. Knowlton, Sean P. Hennessey, Samantha Erin John, Sara Walter, Jessica Langbaum, Rachel Nosheny, Emily D. Clark, Anton P. Porsteinsson, Huali Wang, Tao Wang, Shifu Xiao, Xin Yu, John Harrison, Rhoda Au, Honghuang Lin, Vijaya B. Kolachalama, Diana Kerwin, John J. Sramek, Henry Riordan, Michael F. Murphy, Neal R. Cutler, Cristina Sampaio, Swati Sathe, Joshua Grill, Soeren Mattke, Saif-Ur-Rahman Paracha, William Maurice Redden, George Grossberg, Kaj Blennow, Dawn Matthews, Mark E. Schmidt, Cally Xiao, Scott C. Neu, Arthur Toga, Ramon Cacabelos, Emily Largent, Daria Mochly-Rosen, Kevin V. Grimes, Amir Kalili, Gil Bashe, Charles Bernick, Jayna Cummings, Amanda Hu, Angela Su, Andrew Lo, Lauren G. Friedman, Meriel Owen, Alessio Travaglia, Maria C. Carrillo, Emily AS Meyers, Heather M. Snyder, Cara Altimus, Laurie Ryan, Suzana Petanceska, Lorenzo Refolo, Susan Catalano, Laurence Barker, Jonathan Behr, Christian Jung, Pragati Katiyar, Armineh Ghazarian, Zane Martin, Todd Haim
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  • Date Published: June 2022
  • availability: Available
  • format: Hardback
  • isbn: 9781108838665

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About the Authors
  • Alzheimer's Disease (AD) is a growing global public health challenge. The development of new therapies is urgently needed, and a complex ecosystem of organizations has grown to facilitate AD drug discovery and development. Masterfully collating information on the drug development ecosystem, this book emphasizes the contributions of each aspect in the pipeline with a uniform approach to chapters, enabling readers to access relevant information quickly. Topics covered include the use of non-clinical laboratory studies, biomarker development, artificial intelligence, design and management of clinical trials, and funding and financing models. Also discussed is the critical role of advocacy fundraising for drug development. With the approval of aducanumab, the function of the ecosystem has become apparent. This is a definitive overview of how the ecosystem works in transferring an AD drug from its discovery in the laboratory through clinical trial testing to regulatory review and eventual marketing.

    • Uniform outline and structure of chapters allows readers to select and digest the information most relevant to them quickly and efficiently.
    • Provides a definitive overview of the Alzheimer's disease drug development pipeline, with chapters devoted to the major aspects of drug discovery in sequence.
    • Tackles a hugely topical subject matter, with almost 6 million Alzheimer's patients in the US alone and new treatments needed urgently.
    • Aimed at the many individuals working in Alzheimer's disease drug development, the book helps readers understand their role and others' and how they intersect. This includes scientists involved in clinical trials, funding officials in private and public bodies, biotechnology and pharmaceutical companies, as well as students and clinicians working with Alzheimer's patients.
    • Provides insight into how a drug such as the recently approved aducanumab is discovered, developed, approved, and marketed.
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    Product details

    • Date Published: June 2022
    • format: Hardback
    • isbn: 9781108838665
    • length: 574 pages
    • dimensions: 259 x 183 x 30 mm
    • weight: 1.34kg
    • availability: Available
  • Table of Contents

    Part I. Advancing Alzheimer therapies in a collaborative science ecosystem
    Part II. Non-Clinical assessment of Alzheimer candidate drugs
    Part III. Alzheimer clinical trials
    Part IV. Imaging and biomarker development in Alzheimer drug discovery
    Part V. Academic drug development programs
    Part VI. Public-Private partnerships in Alzheimer drug development
    Part VII. Funding and financing Alzheimer drug development.

  • Editors

    Jeffrey Cummings, University of Nevada, Las Vegas
    Jeffrey Cummings, MD, ScD, is Director of the Chambers-Grundy Center for Transformative Neuroscience at University of Nevada, Las Vegas. He is an expert clinical trialist and leading figure in drug development for Alzheimer's Disease including, disease-modifying agents, cognitive enhancing drugs, and treatments for neuropsychiatric symptoms. He has broad interests in therapeutic innovation, neuroscience, and the intersection of science, policy, and society. Dr. Cummings was Founding Director of the Mary S. Easton Center for Alzheimer's Disease Research at UCLA; Founder and Director of the Deane F. Johnson Center for Neurotherapeutics at UCLA; and Founding Director of the Cleveland Clinic Lou Ruvo Center for Brain Health.

    Jefferson Kinney, University of Nevada, Las Vegas
    Jefferson Kinney, PhD, is the Founder and Reg Grundy and Joy Chambers-Grundy Chair of the Department of Brain Health at the University of Nevada, Las Vegas. Research projects in Dr. Kinney's laboratory focus on the investigation of cellular and molecular mechanisms altered in pre-clinical models of Alzheimer's Disease, with particular emphasis on neuronal and glia interactions and the investigation of novel therapeutic targets.

    Howard Fillit, Alzheimer’s Drug Discovery Foundation
    Howard Fillit, MD, Founding Executive Director and Chief Science Officer of the Alzheimer's Drug Discovery Foundation, is an internationally recognized geriatrician, neuroscientist, expert in Alzheimer's Disease, and an innovative philanthropy executive. Dr. Fillit has had a distinguished academic medicine career and is currently a clinical professor of geriatric medicine and palliative care, medicine, and neurosciences at the Icahn School of Medicine at Mount Sinai in New York.

    Contributors

    Jeffrey Cummings, Howard Fillit, Kurt Brunden, Goodwell Nzou, Carlo Ballatore, Andrew A. Pieper, J. Simon Mazza-Lunn, Diana R. Wetmore, Janet Sultana, Clive Ballard, Feixiong Cheng, Jefferson Kinney, Amanda M. Leisgang Osse, Bruce Lamb, Adrian Oblack, Alan D. Palkowitz, Frank J. Belas, Steven L. Wagner, Brenda Hug, Min Su Kang, Arturo Aliaga, Pedro Rosa-Neto, Julie Ottoy, Monica Shin, Marcel Seungsu Woo, Serge Gauthier, Eduardo R. Zimmer, Arnold Salazar, Manfred Windisch, Philip Scheltens, Willem de Haan, Roos J. Jutten, Everhard Vijverberg, Arno de Wilde, Niels Prins, Eric Siemers, Robert A. Dean, James E. Senetar, Janice M. Hitchcock, Russell L. Barton, Marwan Sabbagh, Jiong Shi, Paul Aisen, Rema Raman, Michael Rafii, Reisa Sperling, Ron Petersen, Craig W. Ritchie, Jason Bork, Cyndy Cordell, John Dwyer, Gabe Goldfeder, Debra R. Lappin, Richard Mohs, Julie Neild, Rona Schillinger, Jill Smith, Katy Smith, Leigh Zisko, George Vradenburg, Peter A. Ljubenkov, Adam Boxer, Suzanne Hendrix, Samuel P. Dickson, Jessie Nicodemus-Johnson, Newman T. Knowlton, Sean P. Hennessey, Samantha Erin John, Sara Walter, Jessica Langbaum, Rachel Nosheny, Emily D. Clark, Anton P. Porsteinsson, Huali Wang, Tao Wang, Shifu Xiao, Xin Yu, John Harrison, Rhoda Au, Honghuang Lin, Vijaya B. Kolachalama, Diana Kerwin, John J. Sramek, Henry Riordan, Michael F. Murphy, Neal R. Cutler, Cristina Sampaio, Swati Sathe, Joshua Grill, Soeren Mattke, Saif-Ur-Rahman Paracha, William Maurice Redden, George Grossberg, Kaj Blennow, Dawn Matthews, Mark E. Schmidt, Cally Xiao, Scott C. Neu, Arthur Toga, Ramon Cacabelos, Emily Largent, Daria Mochly-Rosen, Kevin V. Grimes, Amir Kalili, Gil Bashe, Charles Bernick, Jayna Cummings, Amanda Hu, Angela Su, Andrew Lo, Lauren G. Friedman, Meriel Owen, Alessio Travaglia, Maria C. Carrillo, Emily AS Meyers, Heather M. Snyder, Cara Altimus, Laurie Ryan, Suzana Petanceska, Lorenzo Refolo, Susan Catalano, Laurence Barker, Jonathan Behr, Christian Jung, Pragati Katiyar, Armineh Ghazarian, Zane Martin, Todd Haim

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