Book contents
- Biological Implications of Circadian Disruption
- Biological Implications of Circadian Disruption
- Copyright page
- Contents
- Contributors
- Preface
- 1 Introduction to Circadian Rhythms
- 2 Central Clock Dynamics
- 3 Melatonin, Light, and the Circadian System
- 4 Disrupted Circadian Rhythms, Stress, and Allostatic Load
- 5 Disrupted Circadian Rhythms and Mental Health
- 6 Circadian Rhythms and Cognitive Functioning
- 7 Circadian Rhythm Disruption in Aging and Alzheimer’s Disease
- 8 Circadian Rhythms Regulate Neuroinflammation after Traumatic Brain Injury and Spinal Cord Injury
- 9 Disrupted Circadian Rhythms and Neuroendocrine Function in Fertility
- 10 Disrupted Circadian Rhythms and Metabolic Function
- 11 Disrupted Circadian Rhythms, Time Restricted Feeding, and Blood Pressure Regulation
- 12 Disrupted Circadian Rhythms and Immune Function
- 13 Circadian Rhythms and Cardiac Function
- 14 Disrupted Circadian Rhythms and Cancer
- 15 Light Effects across Species in Nature
- 16 Measurement and Analysis of Exposure to Light at Night in Epidemiology
- Index
- References
14 - Disrupted Circadian Rhythms and Cancer
Published online by Cambridge University Press: 07 October 2023
Book contents
- Biological Implications of Circadian Disruption
- Biological Implications of Circadian Disruption
- Copyright page
- Contents
- Contributors
- Preface
- 1 Introduction to Circadian Rhythms
- 2 Central Clock Dynamics
- 3 Melatonin, Light, and the Circadian System
- 4 Disrupted Circadian Rhythms, Stress, and Allostatic Load
- 5 Disrupted Circadian Rhythms and Mental Health
- 6 Circadian Rhythms and Cognitive Functioning
- 7 Circadian Rhythm Disruption in Aging and Alzheimer’s Disease
- 8 Circadian Rhythms Regulate Neuroinflammation after Traumatic Brain Injury and Spinal Cord Injury
- 9 Disrupted Circadian Rhythms and Neuroendocrine Function in Fertility
- 10 Disrupted Circadian Rhythms and Metabolic Function
- 11 Disrupted Circadian Rhythms, Time Restricted Feeding, and Blood Pressure Regulation
- 12 Disrupted Circadian Rhythms and Immune Function
- 13 Circadian Rhythms and Cardiac Function
- 14 Disrupted Circadian Rhythms and Cancer
- 15 Light Effects across Species in Nature
- 16 Measurement and Analysis of Exposure to Light at Night in Epidemiology
- Index
- References
Summary
A growing number of studies reveal that disruption of the endogenous, circadian (i.e., 24-hour) clock increases the risk for acquiring several diseases, including specific cancers. Significantly more work needs to be done to understand the molecular substrates involved in the mechanistic links between circadian clock disruption and cancer initiation and progression. Of particular complexity remains the contribution of the circadian clock in individual cells during the process of transformation (cancer initiation) versus its function in tumor-surrounding stroma and how this affects the process of tumor progression or metastasis. This chapter reviews some of the basic mechanisms understood to link circadian disruption and cancer at the level of gene expression and metabolism, while highlighting human studies supporting the association between circadian disruption and cancer incidence. In light of what is currently known, tremendous opportunites exist to use circadian approaches for future prevention and treatment strategies in the context of organ-specific cancer.
- Type
- Chapter
- Information
- Biological Implications of Circadian DisruptionA Modern Health Challenge, pp. 310 - 337Publisher: Cambridge University PressPrint publication year: 2023
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