Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 2.1 The Chemical Synapse
- 2.2 Classification of Receptors: Metabotropic and Ionotropic Receptors
- 2.3 Neuronal Receptors and Drug Targets
- 2.4 Basic Pharmacology of Specific Neurotransmitter Pathways
- 2.5 Neuropeptides
- 2.6 Genetic Association Studies and Neurotransmitter Pathways
- 2.7 Opioids and Common Recreational Drugs
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 10 Neurodegeneration
- Index
- References
2.6 - Genetic Association Studies and Neurotransmitter Pathways
from 2 - Neurotransmitters and Receptors
Published online by Cambridge University Press: 08 November 2023
Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 2.1 The Chemical Synapse
- 2.2 Classification of Receptors: Metabotropic and Ionotropic Receptors
- 2.3 Neuronal Receptors and Drug Targets
- 2.4 Basic Pharmacology of Specific Neurotransmitter Pathways
- 2.5 Neuropeptides
- 2.6 Genetic Association Studies and Neurotransmitter Pathways
- 2.7 Opioids and Common Recreational Drugs
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 10 Neurodegeneration
- Index
- References
Summary
Over the past 50 years, genomic methodologies have paved the way to a greater understanding of the underlying pathology of mental health disorders. In that time the techniques have developed from candidate gene studies in relatively small samples of patients, to large-scale collaborative studies using array and DNA sequencing approaches. These methodological approaches are outlined in detail in Chapter 7. In particular, genome-wide association studies (GWAS), which examine the association between single-nucleotide polymorphisms (SNPs) and disease, have made great inroads into our understanding of genetic risk for mental health disorders. While SNPs can be used to investigate any part of the genome, here we focus on what they have taught us about the role of neurotransmitter systems in psychiatry.
- Type
- Chapter
- Information
- Cambridge Textbook of Neuroscience for Psychiatrists , pp. 41 - 44Publisher: Cambridge University PressPrint publication year: 2023
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