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Chapter 13 - Trust and Oxytocin

Context-Dependent Exogenous and Endogenous Modulation of Trust

from Part IV - Neuromolecular Level of Trust

Published online by Cambridge University Press:  09 December 2021

By
Zhimin Yan  and
Peter Kirsch
Edited by
Frank Krueger
Frank Krueger
Affiliation:
George Mason University, Virginia
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Summary

The neuropeptide oxytocin (OXT) has been linked to interpersonal trust. While initial behavioral studies demonstrated a facilitating effect of OXT on trusting behavior, more recently these findings have been challenged. In this chapter we review the literature reporting two approaches that are used to evaluate OXT’s effects: exogenous OXT administration and the investigation of the endogenous OXT system. With respect to trust, we report results from studies investigating trusting behavior, mostly using economic games, and studies looking on the intention to trust other individuals. Overall, clear evidence for a direct trust-promoting effect of OXT as proposed by early studies cannot be found. Instead, there is evidence that the relationship between OXT and trust is modulated by manifold contextual factors that are closely interrelated, e.g., social affiliation, personality traits, gender, mental disorders, and genetic disposition. Furthermore, it could be argued that the effect of OXT on trust is not a specific one but only a subphenomenon of the more general prosocial effect of the neuropeptide.

Future research should aim to conceive models of the OXT–trust connection considering the interactions between genes, brain functioning, and the environment, advancing the knowledge of understanding interpersonal trust.

Keywords

oxytocinintranasal applicationendogenous oxytocingenetic variationtrusting behaviorintention to trustprosocial behavior
Type
Chapter
Information
The Neurobiology of Trust , pp. 315 - 337
Publisher: Cambridge University Press
Print publication year: 2021

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References

Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010). Promoting social behavior with oxytocin in high-functioning autism spectrum disorders. Proceedings of the National Academy of Sciences, 107(9), 4389–4394. https://doi.org/10.1073/pnas.0910249107CrossRefGoogle ScholarPubMed
Apicella, C. L., Cesarini, D., Johannesson, M., et al. (2010). No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences. PLoS ONE, 5(6), Article e11153. https://doi.org/10.1371/journal.pone.0011153Google Scholar
Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2014). A sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans. Psychiatric Genetics, 24(2), 45–51. https://doi.org/10.1097/YPG.0b013e3283643684Google Scholar
Balliet, D., Wu, J., & De Dreu, C. K. (2014). Ingroup favoritism in cooperation: A meta-analysis. Psychological Bulletin, 140(6), 1556–1581. https://doi.org/10.1037/a0037737Google Scholar
Barraza, J. A., McCullough, M. E., Ahmadi, S., & Zak, P. J. (2011). Oxytocin infusion increases charitable donations regardless of monetary resources. Hormones and Behavior, 60(2), 148–151. https://doi.org/10.1016/j.yhbeh.2011.04.008Google Scholar
Bartz, J., Simeon, D., Hamilton, H., et al. (2011). Oxytocin can hinder trust and cooperation in borderline personality disorder. Social Cognitive and Affective Neuroscience, 6(5), 556–563. https://doi.org/10.1093/scan/nsq085Google Scholar
Bartz, J., Zaki, J., Bolger, N., & Ochsner, K. (2011). Social effects of oxytocin in humans: Context and person matter. Trends in Cognitive Sciences, 15(7), 301–309. https://doi.org/10.1016/j.tics.2011.05.002Google Scholar
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008). Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron, 58(4), 639–650. https://doi.org/10.1016/j.neuron.2008.04.009Google Scholar
Benjamin, D. J., Cesarini, D., Van Der Loos, M. J., et al. (2012). The genetic architecture of economic and political preferences. Proceedings of the National Academy of Sciences, 109(21), 8026–8031. https://doi.org/10.1073/pnas.1120666109Google Scholar
Berg, J., Dickhaut, J., & McCabe, K. (1995). Trust, reciprocity, and social history. Games and Economic Behavior, 10(1), 122–142. https://doi.org/10.1006/game.1995.1027Google Scholar
Bohnet, I., & Zeckhauser, R. (2004). Trust, risk and betrayal. Journal of Economic Behavior & Organization, 55(4), 467–484. https://doi.org/10.1016/j.jebo.2003.11.004Google Scholar
Boksem, M. A. S., Mehta, P. H., Van den Bergh, B., et al. (2013). Testosterone inhibits trust but promotes reciprocity. Psychological Science, 24(11), 2306–2314. https://doi.org/10.1177/0956797613495063Google Scholar
Bos, P. A., Hermans, E. J., Ramsey, N. F., & Van Honk, J. (2012). The neural mechanisms by which testosterone acts on interpersonal trust. NeuroImage, 61(3), 730–737. https://doi.org/10.1016/j.neuroimage.2012.04.002CrossRefGoogle ScholarPubMed
Bos, P. A., Terburg, D., & Van Honk, J. (2010). Testosterone decreases trust in socially naive humans. Proceedings of the National Academy of Sciences, 107(22), 9991–9995. https://doi.org/10.1073/pnas.0911700107Google Scholar
Buskens, V., Raub, W., Van Miltenburg, N., Montoya, E. R., & Van Honk, J. (2016). Testosterone administration moderates effect of social environment on trust in women depending on second-to-fourth digit ratio. Scientific Reports, 6(1), Article 27655. https://doi.org/10.1038/srep27655Google Scholar
Camerer, C., & Weigelt, K. (1988). Experimental tests of a sequential equilibrium reputation model. Econometrica, 56(1), 1–36. https://doi.org/10.2307/1911840Google Scholar
Campbell, A. (2010). Oxytocin and human social behavior. Personality and Social Psychology Review: An Official Journal of the Society for Personality and Social Psychology, Inc., 14(3), 281–295. https://doi.org/10.1177/1088868310363594Google Scholar
Cardoso, C., Ellenbogen, M. A., & Linnen, A.-M. (2012). Acute intranasal oxytocin improves positive self-perceptions of personality. Psychopharmacology, 220(4), 741–749. https://doi.org/10.1007/s00213-011-2527-6Google Scholar
Cardoso, C., Ellenbogen, M. A., Serravalle, L., & Linnen, A. M. (2013). Stress-induced negative mood moderates the relation between oxytocin administration and trust: Evidence for the tend-and-befriend response to stress? Psychoneuroendocrinology, 38(11), 2800–2804. https://doi.org/10.1016/j.psyneuen.2013.05.006CrossRefGoogle ScholarPubMed
Carre, J. M., Baird-Rowe, C. D., & Hariri, A. R. (2014). Testosterone responses to competition predict decreased trust ratings of emotionally neutral faces. Psychoneuroendocrinology, 49, 79–83. https://doi.org/10.1016/j.psyneuen.2014.06.011Google Scholar
Christensen, J. C., Shiyanov, P. A., Estepp, J. R., & Schlager, J. J. (2014). Lack of association between human plasma oxytocin and interpersonal trust in a prisoner’s dilemma paradigm. PLoS ONE, 9(12), Article e116172. https://doi.org/10.1371/journal.pone.0119691Google Scholar
Dale, H. H. (1906). On some physiological actions of ergot. The Journal of Physiology, 34(3), 163–206. https://doi.org/10.1113/jphysiol.1906.sp001148Google Scholar
De Dreu, C. K., Greer, L. L., Handgraaf, M. J., et al. (2010). The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans. Science, 328(5984), 1408–1411. https://doi.org/10.1126/science.1189047CrossRefGoogle ScholarPubMed
de Visser, E. J., Monfort, S. S., Goodyear, K., et al. (2017). A little anthropomorphism goes a long way: Effects of oxytocin on trust, compliance, and team performance with automated agents. Human Factors, 59(1), 116–133. https://doi.org/10.1177/0018720816687205Google Scholar
Declerck, C. H., Boone, C., & Kiyonari, T. (2010). Oxytocin and cooperation under conditions of uncertainty: The modulating role of incentives and social information. Hormones and Behavior, 57(3), 368–374. https://doi.org/10.1016/j.yhbeh.2010.01.006Google Scholar
Declerck, C. H., Boone, C., Pauwels, L., Vogt, B., & Fehr, E. (2020). A registered replication study on oxytocin and trust. Nature Human Behaviour, 4, 646–655. https://doi.org/10.1038/s41562-020-0878-xGoogle Scholar
DeVries, A. C., Young, W. S. III, & Nelson, R. J. (1997). Reduced aggressive behaviour in mice with targeted disruption of the oxytocin gene. Journal of Neuroendocrinology, 9(5), 363–368. https://doi.org/10.1046/j.1365-2826.1997.t01-1-00589.xCrossRefGoogle ScholarPubMed
Donaldson, Z. R., & Young, L. J. (2008). Oxytocin, vasopressin, and the neurogenetics of sociality. Science, 322(5903), 900–904. https://doi.org/10.1126/science.1158668CrossRefGoogle ScholarPubMed
Ebert, A., Kolb, M., Heller, J., Edel, M.-A., Roser, P., & Brüne, M. (2013). Modulation of interpersonal trust in borderline personality disorder by intranasal oxytocin and childhood trauma. Social Neuroscience, 8(4), 305–313. https://doi.org/10.1080/17470919.2013.807301Google Scholar
Fang, Y., Li, Z., Wu, S., Wang, C., Dong, Y., & He, S. (2020). Oxytocin receptor gene polymorphisms moderate the relationship between job stress and general trust in Chinese Han university teachers. Journal of Affective Disorders, 260, 18–23. https://doi.org/10.1016/j.jad.2019.08.080Google Scholar
Feifel, D., Shilling, P. D., & MacDonald, K. (2016). A review of oxytocin’s effects on the positive, negative, and cognitive domains of schizophrenia. Biological Psychiatry, 79(3), 222–233. https://doi.org/10.1016/j.biopsych.2015.07.025Google Scholar
Gimpl, G., & Fahrenholz, F. (2001). The oxytocin receptor system: Structure, function, and regulation. Physiological Reviews, 81(2), 629–683. https://doi.org/10.1152/physrev.2001.81.2.629CrossRefGoogle ScholarPubMed
Grainger, S. A., Henry, J. D., Steinvik, H. R., & Vanman, E. J. (2019). Intranasal oxytocin does not alter initial perceptions of facial trustworthiness in younger or older adults. Journal of Psychopharmacology, 33(2), 250–254. https://doi.org/10.1177/0269881118806303Google Scholar
Green, L., Fein, D., Modahl, C., et al. (2001). Oxytocin and autistic disorder: Alterations in peptide forms. Biological Psychiatry, 50(8), 609–613. https://doi.org/10.1016/s0006-3223(01)01139-8CrossRefGoogle ScholarPubMed
Grinevich, V., Knobloch-Bollmann, H. S., Eliava, M., Busnelli, M., & Chini, B. (2016). Assembling the puzzle: Pathways of oxytocin signaling in the brain. Biological Psychiatry, 79(3), 155–164. https://doi.org/10.1016/j.biopsych.2015.04.013Google Scholar
Ide, J. S., Nedic, S., Wong, K. F., et al. (2018). Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males. NeuroImage, 174, 35–43. https://doi.org/10.1016/j.neuroimage.2018.02.035Google Scholar
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017). Overview of human oxytocin research. In Hurlemann, R. & Grinevich, V. (Eds.), Behavioral pharmacology of neuropeptides: Oxytocin (pp. 321–348). Springer. https://doi.org/10.1007/7854_2017_19CrossRefGoogle Scholar
Keverne, E. B., & Kendrick, K. M. (1992). Oxytocin facilitation of maternal behavior in sheep. Annals of the New York Academy of Sciences, 652(1), 83–101. https://doi.org/10.1111/j.1749-6632.1992.tb34348.xGoogle Scholar
Kirsch, P., Esslinger, C., Chen, Q., et al. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. Journal of Neuroscience, 25(49), 11489–11493. https://doi.org/10.1523/JNEUROSCI.3984-05.2005Google Scholar
Klackl, J., Pfundmair, M., Agroskin, D., & Jonas, E. (2013). Who is to blame? Oxytocin promotes nonpersonalistic attributions in response to a trust betrayal. Biological Psychology, 92(2), 387–394. https://doi.org/10.1016/j.biopsycho.2012.11.010Google Scholar
Knobloch, H. S., Charlet, A., Hoffmann, L. C., et al. (2012). Evoked axonal oxytocin release in the central amygdala attenuates fear response. Neuron, 73(3), 553–566. https://doi.org/10.1016/j.neuron.2011.11.030Google Scholar
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435(7042), 673–676. https://doi.org/10.1038/nature03701Google Scholar
Kovács, G. L. (1986). Oxytocin and behavior. In Ganten, D. & Pfaff, D. (Eds.), Neurobiology of oxytocin (pp. 91–128). Springer. https://doi.org/10.1007/978-3-642-70414-7_4Google Scholar
Kret, M. E., & De Dreu, C. K. (2017). Pupil-mimicry conditions trust in partners: Moderation by oxytocin and group membership. Proceedings of the Royal Society B: Biological Sciences, 284(1850), Article 20162554. https://doi.org/10.1098/rspb.2016.2554Google Scholar
Krueger, F., & Meyer-Lindenberg, A. (2019). Toward a model of interpersonal trust drawn from neuroscience, psychology, and economics. Trends in Neurosciences, 42(2), 92–101. https://doi.org/10.1016/j.tins.2018.10.004CrossRefGoogle Scholar
Krueger, F., Parasuraman, R., Iyengar, V., et al. (2012). Oxytocin receptor genetic variation promotes human trust behavior. Frontiers in Human Neuroscience, 6, Article 4. https://doi.org/10.3389/fnhum.2012.00004Google Scholar
Kumsta, R., & Heinrichs, M. (2013). Oxytocin, stress and social behavior: Neurogenetics of the human oxytocin system. Current Opinion in Neurobiology, 23(1), 11–16. https://doi.org/10.1016/j.conb.2012.09.004Google Scholar
Lambert, B., Declerck, C. H., & Boone, C. (2014). Oxytocin does not make a face appear more trustworthy but improves the accuracy of trustworthiness judgments. Psychoneuroendocrinology, 40, 60–68. https://doi.org/10.1016/j.psyneuen.2013.10.015Google Scholar
Lane, A., Mikolajczak, M., Treinen, E., et al. (2015). Failed replication of oxytocin effects on trust: The envelope task case. PLoS ONE, 10(9), Article e0137000. https://doi.org/10.1371/journal.pone.0137000CrossRefGoogle ScholarPubMed
Lazarus, S. A., Cheavens, J. S., Festa, F., & Rosenthal, M. Z. (2014). Interpersonal functioning in borderline personality disorder: A systematic review of behavioral and laboratory-based assessments. Clinical Psychology Review, 34(3), 193–205. https://doi.org/10.1016/j.cpr.2014.01.007Google Scholar
Lee, M. R., Scheidweiler, K. B., Diao, X. X., et al. (2018). Oxytocin by intranasal and intravenous routes reaches the cerebrospinal fluid in rhesus macaques: Determination using a novel oxytocin assay. Molecular Psychiatry, 23(1), 115–122. https://doi.org/10.1038/mp.2017.27CrossRefGoogle ScholarPubMed
Lee, M. R., Shnitko, T. A., Blue, S. W., et al. (2020). Labeled oxytocin administered via the intranasal route reaches the brain in rhesus macaques. Nature Communications, 11(1), Article 2783. https://doi.org/10.1038/s41467-020-15942-1Google ScholarPubMed
Lee, M. R., Wehring, H. J., McMahon, R. P., et al. (2019). The effect of intranasal oxytocin on measures of social cognition in schizophrenia: A negative report. Journal of Psychiatry and Brain Science, 4(1), Article e190001. https://doi.org/10.20900/jpbs.20190001Google Scholar
Long, P. A., & Freeman, H. (2019). Patients in pain: The effects of oxytocin on trust and decision making. Proceedings of the International Symposium on Human Factors and Ergonomics in Health Care, 8(1), 164–166. https://doi.org/10.1177/2327857919081040CrossRefGoogle Scholar
LoParo, D., & Waldman, I. (2015). The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: A meta-analysis. Molecular Psychiatry, 20(5), 640–646. https://doi.org/10.1038/mp.2014.77Google Scholar
Lord, C., Cook, E. H., Leventhal, B. L., & Amaral, D. G. (2000). Autism spectrum disorders. Neuron, 28(2), 355–363. https://doi.org/10.1016/s0896-6273(00)00115-xCrossRefGoogle ScholarPubMed
Luo, R., Xu, L., Zhao, W., et al. (2017). Oxytocin facilitation of acceptance of social advice is dependent upon the perceived trustworthiness of individual advisors. Psychoneuroendocrinology, 83, 1–8. https://doi.org/10.1016/j.psyneuen.2017.05.020CrossRefGoogle ScholarPubMed
MacDonald, E., Dadds, M. R., Brennan, J. L., Williams, K., Levy, F., & Cauchi, A. J. (2011). A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research. Psychoneuroendocrinology, 36(8), 1114–1126. https://doi.org/10.1016/j.psyneuen.2011.02.015Google Scholar
Manuck, S. B., & McCaffery, J. M. (2014). Gene-environment interaction. Annual Review of Psychology, 65, 41–70. https://doi.org/10.3389/fpsyg.2018.02036Google Scholar
McClelland, D. C. (1987). Human motivation. Cambridge University Press. https://doi.org/10.1017/CBO9781139878289Google Scholar
McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013). Problems with measuring peripheral oxytocin: Can the data on oxytocin and human behavior be trusted? Neuroscience & Biobehavioral Reviews, 37(8), 1485–1492. https://doi.org/10.1016/j.neubiorev.2013.04.018Google Scholar
Merolla, J. L., Burnett, G., Pyle, K. V., Ahmadi, S., & Zak, P. J. (2013). Oxytocin and the biological basis for interpersonal and political trust. Political Behavior, 35(4), 753–776. https://doi.org/10.1007/s11109-012-9219-8Google Scholar
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011). Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nature Reviews Neuroscience, 12(9), 524–538. https://doi.org/10.1038/nrn3044Google Scholar
Mikolajczak, M., Gross, J. J., Lane, A., Corneille, O., de Timary, P., & Luminet, O. (2010). Oxytocin makes people trusting, not gullible. Psychological Science, 21(8), 1072–1074. https://doi.org/10.1177/0956797610377343CrossRefGoogle Scholar
Mikolajczak, M., Pinon, N., Lane, A., de Timary, P., & Luminet, O. (2010). Oxytocin not only increases trust when money is at stake, but also when confidential information is in the balance. Biological Psychology, 85(1), 182–184. https://doi.org/10.1016/j.biopsycho.2010.05.010Google Scholar
Modahl, C., Green, L. A., Fein, D., et al. (1998). Plasma oxytocin levels in autistic children. Biological Psychiatry, 43(4), 270–277. https://doi.org/10.1016/s0006-3223(97)00439-3Google Scholar
Nave, G., Camerer, C., & McCullough, M. (2015). Does oxytocin increase trust in humans? A critical review of research. Perspectives on Psychological Science: A Journal of The Association for Psychological Science, 10(6), 772–789. https://doi.org/10.1177/1745691615600138Google Scholar
Nishina, K., Takagishi, H., Fermin, A., et al. (2018). Association of the oxytocin receptor gene with attitudinal trust: Role of amygdala volume. Social Cognitive and Affective Neuroscience, 13(10), 1091–1097. https://doi.org/10.1093/scan/nsy075Google Scholar
Nishina, K., Takagishi, H., Inoue-Murayama, M., Takahashi, H., & Yamagishi, T. (2015). Polymorphism of the oxytocin receptor gene modulates behavioral and attitudinal trust among men but not women. PLoS ONE, 10(10), Article e0137089. https://doi.org/10.1371/journal.pone.0137089CrossRefGoogle Scholar
O’Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004). Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science, 304(5669), 452–454. https://doi.org/10.1126/science.1094285Google Scholar
Ooi, Y. P., Weng, S.-J., Kossowsky, J., Gerger, H., & Sung, M. (2017). Oxytocin and autism spectrum disorders: A systematic review and meta-analysis of randomized controlled trials. Pharmacopsychiatry, 50(1), 5–13. https://doi.org/10.1055/s-0042-109400Google ScholarPubMed
Ott, I., & Scott, J. C. (1910). The action of infundibulin upon the mammary secretion. Proceedings of the Society for Experimental Biology and Medicine, 8(2), 48–49. https://doi.org/10.3181/00379727-8-27Google Scholar
Pedersen, C. A., Gibson, C. M., Rau, S. W., et al. (2011). Intranasal oxytocin reduces psychotic symptoms and improves theory of mind and social perception in schizophrenia. Schizophrenia Research, 132(1), 50–53. https://doi.org/10.1016/j.schres.2011.07.027Google Scholar
Pedersen, C. A., & Prange, A. J. (1979). Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin. Proceedings of the National Academy of Sciences, 76(12), 6661–6665. https://doi.org/10.1073/pnas.76.12.6661Google Scholar
Quintana, D. S., Rokicki, J., Van der Meer, D., et al. (2019). Oxytocin pathway gene networks in the human brain. Nature Communications, 10(1), 1–12. https://doi.org/10.1038/s41467-019-08503-8CrossRefGoogle ScholarPubMed
Quintana, D. S., Westlye, L. T., Rustan, Ø. G., et al. (2015). Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: A randomized four-way crossover trial with nasal cavity dimension assessment. Translational Psychiatry, 5(7), Article e602. https://doi.org/10.1038/tp.2015.93Google Scholar
Rimmele, U., Hediger, K., Heinrichs, M., & Klaver, P. (2009). Oxytocin makes a face in memory familiar. Journal of Neuroscience, 29(1), 38–42. https://doi.org/10.1523/JNEUROSCI.4260-08.2009Google Scholar
Salonia, A., Nappi, R. E., Pontillo, M., et al. (2005). Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women. Hormones and Behavior, 47(2), 164–169. https://doi.org/10.1016/j.yhbeh.2004.10.002CrossRefGoogle ScholarPubMed
Sauer, C., Montag, C., Reuter, M., & Kirsch, P. (2019). Oxytocinergic modulation of brain activation to cues related to reproduction and attachment: Differences and commonalities during the perception of erotic and fearful social scenes. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology, 136, 87–96. https://doi.org/10.1016/j.ijpsycho.2018.06.005Google Scholar
Spengler, F. B., Schultz, J., Scheele, D., et al. (2017). Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity. Biological Psychiatry, 82(12), 885–894. https://doi.org/10.1016/j.biopsych.2017.04.015Google Scholar
Tabak, B. A., McCullough, M. E., Carver, C. S., Pedersen, E. J., & Cuccaro, M. L. (2014). Variation in oxytocin receptor gene (OXTR) polymorphisms is associated with emotional and behavioral reactions to betrayal. Social Cognitive and Affective Neuroscience, 9(6), 810–816. https://doi.org/10.1093/scan/nst042Google Scholar
Tauber, M., Mantoulan, C., Copet, P., et al. (2011). Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: A randomised placebo-controlled trial in 24 patients. Orphanet Journal of Rare Diseases, 6(1), Article 47. https://doi.org/10.1186/1750-1172-6-47Google Scholar
Teed, A. R., Han, K., Rakic, J., Mark, D. B., & Krawczyk, D. C. (2019). The influence of oxytocin and vasopressin on men’s judgments of social dominance and trustworthiness: An fMRI study of neutral faces. Psychoneuroendocrinology, 106, 252–258. https://doi.org/10.1016/j.psyneuen.2019.04.014Google Scholar
Ten Velden, F. S., Daughters, K., & De Dreu, C. K. (2017). Oxytocin promotes intuitive rather than deliberated cooperation with the in-group. Hormones and Behavior, 92, 164–171. https://doi.org/10.1016/j.yhbeh.2016.06.005CrossRefGoogle ScholarPubMed
Theodoridou, A., Rowe, A. C., Penton-Voak, I. S., & Rogers, P. J. (2009). Oxytocin and social perception: Oxytocin increases perceived facial trustworthiness and attractiveness. Hormones and Behavior, 56(1), 128–132. https://doi.org/10.1016/j.yhbeh.2009.03.019CrossRefGoogle ScholarPubMed
Valstad, M., Alvares, G. A., Egknud, M., et al. (2017). The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews, 78, 117–124. https://doi.org/10.1016/j.neubiorev.2017.04.017Google Scholar
Van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2012). A sniff of trust: Meta-analysis of the effects of intranasal oxytocin administration on face recognition, trust to in-group, and trust to out-group. Psychoneuroendocrinology, 37(3), 438–443. https://doi.org/10.1016/j.psyneuen.2011.07.008CrossRefGoogle ScholarPubMed
Watson, M. L. (2005). Can there be just one trust? A cross-disciplinary identification of trust definitions and measurement. The Institute for Public Relations, 1–25.Google Scholar
Woolley, J., Chuang, B., Fussell, C., et al. (2017). Intranasal oxytocin increases facial expressivity, but not ratings of trustworthiness, in patients with schizophrenia and healthy controls. Psychological Medicine, 47(7), 1311–1322. https://doi.org/10.1017/S0033291716003433Google Scholar
Yao, S., Zhao, W., Cheng, R., Geng, Y., Luo, L., & Kendrick, K. M. (2014). Oxytocin makes females, but not males, less forgiving following betrayal of trust. The International Journal of Neuropsychopharmacology, 17(11), 1785–1792. https://doi.org/10.1017/s146114571400090xCrossRefGoogle Scholar
Zak, P. J., Kurzban, R., & Matzner, W. T. (2005). Oxytocin is associated with human trustworthiness. Hormones and Behavior, 48(5), 522–527. https://doi.org/10.1016/j.yhbeh.2005.07.009CrossRefGoogle ScholarPubMed
Zhang, H., Gross, J., De Dreu, C., & Ma, Y. (2019). Oxytocin promotes coordinated out-group attack during intergroup conflict in humans. eLife, 8, Article e40698. https://doi.org/10.7554/eLife.40698.001Google ScholarPubMed
Zhong, S., Monakhov, M., Mok, H. P., et al. (2012). U-shaped relation between plasma oxytocin levels and behavior in the trust game. PLoS ONE, 7(12), Article e51095. https://doi.org/10.1371/journal.pone.0051095Google Scholar

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