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Chapter 54 - Thrombocytopenia in Pregnancy

from Section 9 - Hematologic Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Amira El-Messidi ,
Marwa Salman  and
Anita Banerjee
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

During your obstetric call duty in a tertiary hospital center, you receive a telephone call from a colleague at an external center for an incidental isolated platelet count of 69 × 109/L in a 22-year-old primigravida with a singleton pregnancy at 24+3 weeks’ gestation by early dating sonography. The full/complete blood count (FBC/CBC) was performed to follow up on iron-deficiency anemia. Fetal activity is normal.

Keywords

Thrombocytopenia, pregnancyPhysiologyInvestigationsPhysical examinationDifferential diagnosisImmune thrombocytopenic purpuraTreatment, therapeuticsAnesthesiaPerinatal risks, complications, maternal-fetal morbidity, adverse outcomeAntepartum, intrapartum, postpartum managementContraception
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 690 - 702
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

ACOG Practice Bulletin No. 207: Thrombocytopenia in pregnancy. Obstet Gynecol. 2019;133(3):e181–e193.CrossRefGoogle Scholar
Baucom, AM, Kuller, JA, Dotters-Katz, S. Immune thrombocytopenic purpura in pregnancy. Obstet Gynecol Surv. 2019;74(8):490–496.CrossRefGoogle ScholarPubMed
Care, A, Pavord, S, Knight, M, et al. Severe primary autoimmune thrombocytopenia in pregnancy: a national cohort study. BJOG. 2018;125(5):604–612.CrossRefGoogle ScholarPubMed
Cines, DB, Levine, LD. Thrombocytopenia in pregnancy. Hematology Am Soc Hematol Educ Program. 2017;2017(1):144–151.Google Scholar
Fogerty, AE. Thrombocytopenia in pregnancy: approach to diagnosis and management. Semin Thromb Hemost. 2020;46(3):256–263.Google ScholarPubMed
Gernsheimer, T, James, AH, Stasi, R. How I treat thrombocytopenia. Blood 2013;121(1):38–47.CrossRefGoogle Scholar
Eslick, R, McLintock, C. Managing ITP and thrombocytopenia in pregnancy. Platelets. 2020;31(3):300–306.CrossRefGoogle ScholarPubMed
Goldman, BG, Hehir, MP, Yambasu, S, et al. The presentation and management of platelet disorders in pregnancy. Eur J Haematol. 2018;100(6):560–566.CrossRefGoogle ScholarPubMed
Pishko, AM, Levine, LD, Cines, DB. Thrombocytopenia in pregnancy: Diagnosis and approach to management. Blood Rev. 2020;40:100638.CrossRefGoogle ScholarPubMed
Provan, D, Arnold, DM, Bussel, JB, et al. Updated international consensus report on the investigation and management of primary immune thrombocytopenia. Blood Adv. 2019;3(22):3780–3817.CrossRefGoogle ScholarPubMed

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