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Section III - Care of the elderly by organ system

Published online by Cambridge University Press:  05 June 2016

Jan Busby-Whitehead
Affiliation:
University of North Carolina
Christine Arenson
Affiliation:
Thomas Jefferson University, Philadelphia
Samuel C. Durso
Affiliation:
The Johns Hopkins University School of Medicine
Daniel Swagerty
Affiliation:
University of Kansas
Laura Mosqueda
Affiliation:
University of Southern California
Maria Fiatarone Singh
Affiliation:
University of Sydney
William Reichel
Affiliation:
Georgetown University, Washington DC
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Reichel's Care of the Elderly
Clinical Aspects of Aging
, pp. 157 - 606
Publisher: Cambridge University Press
Print publication year: 2016

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References

References

Moran, AE, Forouzanfar, MH, Roth, GA, et al. Temporal trends in ischemic heart disease mortality in 21 world regions, 1980–2010: the Global Burden of Disease 2010 Study. Circulation 2014;129:14831492.CrossRefGoogle Scholar
Lozano, R, Naghavi, M, Foreman, K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:20952128.Google Scholar
Go, AS, Mozaffarian, D, Roger, VL, et al. Heart disease and stroke statistics – 2014 update: a report from the American Heart Association. Circulation 2014;129(3):399410.Google Scholar
Lakatta, EG. Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons. Heart Failure Reviews 2002;7:2949.Google Scholar
Rich, MW. Heart disease in the elderly. In: Rosendorff, C, ed. Essential Cardiology: Principles and Practice, Third Edition. New York: Springer, 2013:669686.Google Scholar
D’Agostino, RB, Vasan, RS, Pencina, MJ, et al. General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation 2008;117:743753.Google Scholar
Haffner, SM, Lehto, S, Ronnemaa, T, et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. New Engl J Med 1998;339:229234.CrossRefGoogle ScholarPubMed
Kuller, LH, Arnold, AM, Psaty, BM, et al. Ten-year follow-up of subclinical cardiovascular disease and risk of coronary heart disease in the Cardiovascular Health Study. Arch Int Med 2006;166:7178.Google Scholar
White, HD, Barbash, GI, Califf, RM, et al. Age and outcome with contemporary thrombolytic therapy: results from the GUSTO-I trial. Circulation 1996;94:18261833.CrossRefGoogle ScholarPubMed
Scirica, BM. Acute coronary syndrome: emerging tools for diagnosis and risk assessment. J Am Coll Cardiol 2010;55:14031415.Google Scholar
Eggers, KM, Venge, P, Lindahl, B, Lind, L. Cardiac troponin I levels measured with a high-sensitivity assay increase over time and are strong predictors of mortality in an elderly population. J Am Coll Cardiol 2013;61:19061913.Google Scholar
Thygesen, K, Alpert, JS, Jaffe, AS, et al. Third universal definition of myocardial infarction. J Am Coll Cardiol 2012;60:15811598.Google Scholar
O’Gara, PT, Kushner, FG, Ascheim, DD, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction. J Am Coll Cardiol 2013;61:e78140.CrossRefGoogle ScholarPubMed
Amsterdam, EA, Wenger, NK, Brindis, RG, et al. 2014 AHA/ACC Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes. J Am Coll Cardiol 2014;64(24):e139e228.CrossRefGoogle ScholarPubMed
ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988;332: 349360.Google Scholar
The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001;345: 494502.Google Scholar
Wiviott, SD, Braunwald, E, McCabe, CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007;357:20012015.Google Scholar
Wallentin, L, Becker, RC, Budaj, A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009;361:10451057.Google Scholar
Steen, H, James, S, Becker, RC, et al. Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the Prospective Randomized PLATelet Inhibition and Patient Outcomes (PLATO) trial. Circ Cardiovasc Qual Outcomes 2012;680688.Google Scholar
Mauri, L, Kereiakes, DJ, Yeh, RW, et al. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med 2014;371:21552166.Google Scholar
Morrow, DA, Braunwald, E, Bonaca, MP, et al. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 2012;366:14041413.CrossRefGoogle ScholarPubMed
The PURSUIT Trial Investigators. Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes. N Engl J Med 1998;339: 436443.Google Scholar
Antman, EM, Cohen, M, Radley, D, et al. Assessment of the treatment effect of enoxaparin for unstable angina/non-Q-wave myocardial infarction: TIMI 11B-ESSENCE meta-analysis. Circulation 1999;100:16021608.CrossRefGoogle ScholarPubMed
FRagmin and Fast Revascularization during InStability in Coronary artery disease (FRISC II) Investigators. Long-term low-molecular-mass heparin in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. Lancet 1999;354: 701707.Google Scholar
Dewilde, WJ, Oirbans, T, Verheugt, FW, et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomized, controlled trial. Lancet 2013;381:11071115.CrossRefGoogle ScholarPubMed
COMMIT Collaborative Group. Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 2005;366:16221632.CrossRefGoogle Scholar
ACE Inhibitor Myocardial Infarction Collaborative Group. Indications for ACE inhibitors in the early treatment of acute myocardial infarction: systematic overview of individual data from 100,000 patients in randomized trials. Circulation 1998;97:22022212.Google Scholar
Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico. GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Lancet 1994;343:11151122.Google Scholar
Ambrosioni, E, Borghi, C, Magnani, B, for the Survival of Myocardial Infarction Long-Term Evaluation (SMILE) Study Investigators. The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction. N Engl J Med 1995;332:8085.Google Scholar
The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators. Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 1993;342:821828.Google Scholar
Dickstein, K, Kjekshus, J. Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Lancet 2002;360:752760.CrossRefGoogle ScholarPubMed
Pitt, B, Remme, W, Zannad, F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003;348:13091321.CrossRefGoogle ScholarPubMed
Miettinen, TA, Pyorala, K, Olsson, AG, et al. Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris: findings from the Scandinavian Simvastatin Survival Study (4S). Circulation 1997;96:42114218.CrossRefGoogle ScholarPubMed
Lewis, SJ, Moye, LA, Sacks, FM, et al. Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range: results of the Cholesterol and Recurrent Events (CARE) trial. Ann Intern Med 1998;129:681689.Google Scholar
The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. N Engl J Med 1998;339:13491357.Google Scholar
Shepherd, J, Blauw, GJ, Murphy, MB, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 2002;360:16231630.Google Scholar
Stone, NJ, Intwala, S, Katz, D. Statins in very elderly adults. J Am Geriatr Soc 2014;62:943945.Google Scholar
Rich, MW. Aggressive lipid management in very elderly adults: less is more. J Am Geriatr Soc 2014;62:945947.Google Scholar
Sathasivam, S. Statin induced myopathy. BMJ 2008;337:a2286.Google Scholar
Lee, DS, Markwardt, S, Goeres, L, et al. Statins and physical activity in older men: the osteoporotic fractures in men study. JAMA Intern Med 2014;174:12631270.Google Scholar
Golomb, BA, Evans, MA, Dimsdale, JE, et al. Effects of statins on energy and fatigue with exertion: Results from a randomized controlled trial. Arch Intern Med 2012;172:11801182.Google Scholar
Evans, MA, Golomb, BA. Statin-associated adverse cognitive effects: survey results from 171 patients. Pharmacotherapy 2009;29:800811.Google Scholar
The Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy Investigators. A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. N Engl J Med 1997;336:16211628.CrossRefGoogle Scholar
De Boer, MJ, Ottervanger, JP, van’t Hof, AW, et al. Reperfusion therapy in elderly patients with acute myocardial infarction: a randomized comparison of primary angioplasty and thrombolytic therapy. J Am Coll Cardiol 2002;39:17231728.CrossRefGoogle ScholarPubMed
Antman, EM, Cohen, M, Bernink, PJLM, et al. The TIMI Risk Score for unstable angina/non-ST elevation MI: a method for prognostication and therapeutic decision making. JAMA 2000;284:835842.CrossRefGoogle Scholar
Granger, CB, Goldberg, RJ, Dabbous, O, et al. Predictors of hospital mortality in the Global Registry of Acute Coronary Events (GRACE). Arch Intern Med 2003;163:23452353.Google Scholar
FRagmin and Fast Revascularization during InStability in Coronary artery disease (FRISC II) Investigators. Invasive compared with non-invasive treatment in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. Lancet 1999;354: 708715.Google Scholar
Hochman, JS. Cardiogenic shock complicating acute myocardial infarction: expanding the paradigm. Circulation 2003;107:29983002.CrossRefGoogle ScholarPubMed
Hochman, JS, Sleeper, LA, White, HD, et al. for the SHOCK Investigators. One-year survival following early revascularization for cardiogenic shock. JAMA 2001;285:190192.Google Scholar
Dzavik, V, Sleeper, LA, Cocke, TP, et al. for the SHOCK Investigators. Early revascularization is associated with improved survival in elderly patients with acute myocardial infarction complicated by cardiogenic shock: a report from the SHOCK Trial Registry. Eur Heart J 2003;24:828837.Google Scholar
Bueno, H, Lopez-Palop, R, Perez-David, E, et al. Combined effect of age and right ventricular involvement on acute inferior myocardial infarction prognosis. Circulation 1998;98:17141720.Google Scholar
Hasdai, D, Topol, EJ, Califf, RM, et al. Cardiogenic shock complicating acute coronary syndromes. Lancet 2000;356:749756.Google Scholar
Fihn, SD, Gardin, JM, Abrams, J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease. J Am Coll Cardiol 2012;60:e44e164.Google Scholar
James, PA, Oparil, S, Carter, BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults. JAMA 2014;311:507520.Google Scholar
Stone, NJ, Robinson, JG, Lichtenstein, AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults. J Am Coll Cardiol 2014;63:28892934.Google Scholar
American Geriatrics Society Expert Panel on the Care of Older Adults with Diabetes Mellitus. Guidelines abstracted from the American Geriatrics Society guidelines for improving the care of older adults with diabetes mellitus: 2013 update. J Am Geriatrc Soc 2013;61:20202026.Google Scholar
Witt, BJ, Jacobsen, SJ, Weston, SA, et al. Cardiac rehabilitation after myocardial infarction in the community. J Am Coll Cardiol 2004;44:988996.Google Scholar
American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). ACC/AHA 2002 guidelines update for exercise testing. Circulation 2002;106:18831892.Google Scholar
The TIME Investigators. Trial of invasive versus medical therapy in elderly patients with chronic symptomatic coronary-artery disease (TIME): a randomised trial. Lancet 2001;358:951957.Google Scholar
Boden, WE, O’Rourke, RA, Teo, KK, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 2007;356:15031516.Google Scholar
Weintraub, WS, Veledar, E, Thompson, T, Burnette, J, Jurkovitz, C, Mahoney, E. Percutaneous coronary intervention outcomes in octogenarians during the stent era (National Cardiovascular Network). Am J Cardiol 2001;88:14071410.Google Scholar
Alexander, KP, Anstrom, KJ, Muhlbaier, LH, et al. Outcomes of cardiac surgery in patients ≥80 years: results from the National Cardiovascular Network. J Am Coll Cardiol 2000;35:731738.CrossRefGoogle ScholarPubMed
Newman, MF, Kirchner, JL, Phillips-Bute, B, et al. for the Neurological Outcome Research Groups and the Cardiothoracic Anesthesiology Research Endeavors Investigators. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med 2001;344:395402.CrossRefGoogle ScholarPubMed
Yancy, CW, Jessup, M, Bozkurt, B, et al. 2013 ACCF/AHA guideline for the management of heart failure. Circulation 2013;128:e240e327.Google ScholarPubMed
The ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker versus diuretic: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288:29812997.Google Scholar
Moser, M, Hebert, PR. Prevention of disease progression, left ventricular hypertrophy and congestive heart failure in hypertension treatment trials. J Am Coll Cardiol 1996;27:12141218.Google Scholar
Okin, PM, Devereux, RB, Jern, S, et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events. JAMA 2004;292:23432349.CrossRefGoogle ScholarPubMed
Goldman, L, Hashimoto, B, Cook, EF, Loscalzo, A. Comparative reproducibility and validity of systems for assessing cardiovascular functional class: advantages of a new specific activity scale. Circulation 1981;64:12271234.Google Scholar
Maisel, AS, Krishnaswamy, P, Nowak, RM, et al. for the Breathing Not Properly Multinational Study Investigators. Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure. N Engl J Med 2002;347:161167.Google Scholar
Gaggin, HK, Mohammed, AA, Bhardwaj, A, et al. Heart failure outcomes and benefits of NT-proBNP-guided management in the elderly: Results from the Prospective, Randomized ProBNP Outpatient Tailored Chronic Heart Failure Therapy (PROTECT Study). J Cardiac Fail 2012;18:626634.Google Scholar
Redfield, MM, Rodeheffer, RJ, Jacobsen, SJ, et al. Plasma brain natriuretic peptide concentration: impact of age and gender. J Am Coll Cardiol 2002;40:976982.Google Scholar
Wang, TJ, Larson, MG, Levy, D, et al. Impact of age and sex on plasma natriuretic peptide levels in healthy adults. Am J Cardiol 2002;90:254258.Google Scholar
Heiat, A, Gross, CP, Krumholz, HM. Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med 2002;162:16821688.CrossRefGoogle ScholarPubMed
Rich, MW, Beckham, V, Wittenberg, C, et al. A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl J Med 1995;333:11901195.Google Scholar
Whellan, DJ, Hasselblad, V, Peterson, E, O’Connor, CM, Schulman, KA. Meta-analysis and review of heart failure disease management randomized controlled clinical trials. Am Heart J 2005;149:722729.Google Scholar
Ades, PA, Keteyian, SJ, Balady, GJ, et al. Cardiac rehabilitation exercise and self-care for chronic heart failure. J Am Coll Cardiol HF 2013;1(6):540547.Google ScholarPubMed
Faris, R, Flather, M, Purcell, H, et al. Current evidence supporting the role of diuretics in heart failure: a meta analysis of randomised controlled trials. Int J Cardiol 2002;82:149158.Google Scholar
Domanski, M, Norman, J, Pitt, B, et al. Diuretic use, progressive heart failure, and death in patients in the Studies of Left Ventricular Dysfunction (SOLVD). J Am Coll Cardiol 2003;42:705708.CrossRefGoogle ScholarPubMed
Neuberg, GW, Miller, AB, O’Connor, CM, et al. Diuretic resistance predicts mortality in patients with advanced heart failure. Am Heart J 2002;144:3138.Google Scholar
Gheorghiade, M, Zannad, F, Sopko, G, et al. Acute heart failure syndromes: current state and framework for future research. Circulation 2005;112:39583968.Google Scholar
Gupta, D, Georgiopoulou, VV, Kalogeropoulos, AP, et al. Dietary sodium intake in heart failure. Circulation 2012;126:479485.Google Scholar
Flather, MD, Yusuf, S, Kober, L, et al. for the ACEI-Inhibitor Myocardial Infarction Collaborative Group. Long-term ACEI-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. Lancet 2000;355:15751581.CrossRefGoogle ScholarPubMed
Garg, R, Yusuf, S for the Collaborative Group on ACE Inhibitor Trials. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA 1995;273:14501456.CrossRefGoogle ScholarPubMed
The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fraction. N Engl J Med 1992;327:685691.Google Scholar
Maggioni, AP, Anand, I, Gottlieb, SO, et al. Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors. J Am Coll Cardiol 2002;40:14141421.Google Scholar
Granger, CB, McMurray, JJV, Yusuf, S, et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet 2003;362:772776.CrossRefGoogle ScholarPubMed
Pfeffer, MA, Swedberg, K, Granger, CB, et al. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 2003;362:759766.Google Scholar
Kuenzli, A, Bucher, HC, Anand, I, et al. Meta-analysis of combined therapy with angiotensin receptor antagonists versus ACE inhibitors alone in patients with heart failure. PloS One 2010;5:e9946.CrossRefGoogle ScholarPubMed
Cohn, JN, Archibald, DG, Ziesche, S, et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure: results of a Veterans Administration Cooperative Study. N Engl J Med 1986;314:15471552.Google Scholar
Cohn, JN, Johnson, G, Ziesche, S, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1991;325:303310.Google Scholar
Taylor, AL, Ziesche, S, Yancy, C, et al. for the African-American Heart Failure Trial Investigators. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 2004;351:20492057.Google Scholar
MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999;353:20012007.CrossRefGoogle Scholar
Packer, M, Coats, AJS, Fowler, MB, et al. for the Carvedilol Prospective Randomized Cumulative Survival Study Group. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 2001;344:16511658.CrossRefGoogle ScholarPubMed
Deedwania, PC, Gottlieb, S, Ghali, JK, et al. Efficacy, safety and tolerability of beta-adrenergic blockade with metoprolol CR/XL in elderly patients with heart failure. Eur Heart J 2004;25:13001309.Google Scholar
Pitt, B, Zannad, F, Remme, WJ, et al. for the Randomized Aldactone Evaluation Study Investigators. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999;341:709717.Google Scholar
Zannad, F, McMurray, JJV, Krum, H, et al. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med 2011;364:1121.CrossRefGoogle ScholarPubMed
Juurlink, DN, Mamdani, MM, Lee, DS, et al. Rates of hyperkalemia after publication of the Randomized Aldactone Evaluation Study. N Engl J Med 2004;351:543551.Google Scholar
The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 1997;336:525533.Google Scholar
Rich, MW, McSherry, F, Williford, WO, Yusuf, S, for the Digitalis Investigation Group. Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study. J Am Coll Cardiol 2001;38:806813.Google Scholar
Ahmed, A, Rich, MW, Love, TE, et al. Digoxin and reduction in mortality and hospitalization in heart failure: a comprehensive post hoc analysis of the DIG trial. Eur Heart J 2006;27:178186.Google Scholar
Massie, BN, Collins, JF, Ammon, SE, et al. Randomized trial of warfarin, aspirin, and clopidogrel in patients with chronic heart failure: the Warfarin and Antiplatelet Therapy in Chronic Heart Failure (WATCH) Trial. Circulation 2009;119:16161624.Google Scholar
Homma, S, Thompson, JLP, Pullicino, PM, et al. Warfarin and aspirin in patients with heart failure and sinus rhythm. N Engl J Med 2012;366:18591869.Google Scholar
O’Connor, CM, Gattis, WA, Uretsky, BF, et al. Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: Insights from the Flolan International Randomized Survival Trial (FIRST). Am Heart J 1999;138:7886.Google Scholar
Cuffe, MS, Califf, RM, Adams, KFJ, et al. Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. JAMA 2002;287:15411547.Google Scholar
Publication Committee for the VMAC Investigators (Vasodilation in the Management of Acute CHF). Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. JAMA 2002;287:15311540.Google Scholar
O’Connor, CM, Starling, RC, Hernandez, AF, et al. Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med 2011;365:3243.Google Scholar
Daneshvar, DA, Czer, LS, Phan, A, Trento, A, Schwarz, ER. Heart transplantation in the elderly: why cardiac transplantation does not need to be limited to younger patients but can be safely performed in patients above 65 years of age. Ann Transplant 2010;15:110119.Google Scholar
Atluri, P, Goldstone, AB, Kobrin, DM, et al. Ventricular assist device implant in the elderly is associated with increased, but respectable risk: A multi-institutional study. Ann Thorac Surg 2013;96:141147.Google Scholar
Kitzman, DW, Gardin, JM, Gottdiener, JS, et al. for the Cardiovascular Health Study Research Group. Importance of heart failure with preserved systolic function in patients > or = 65 years of age. Am J Cardiol 2001;87:413419.Google Scholar
Owan, TE, Hodge, DO, Herges, RM, Jacobsen, SJ, Roger, VL, Redfield, MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 2006;355:251259.Google Scholar
Bhatia, RS, Tu, JV, Lee, DS, et al. Outcome of heart failure with preserved ejection fraction in a population-based study. New Engl J Med 2006;355:260269.CrossRefGoogle ScholarPubMed
Owan, TE, Hodge, DO, Herges, RM, et al. Trends in prevalence and outcome of heart failure with preserved ejection fraction. New Engl J Med 2006;355:251259.Google Scholar
Meta-analysis Global Group in Chronic Heart Failure (MAGGIC). The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis. Eur Heart J 2011; doi:10.1093/eurheartj/ehr254.Google Scholar
Yusuf, S, Pfeffer, MA, Swedberg, K, et al. for the CHARM investigators and Committees. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 2003;362:777781.Google Scholar
Ahmed, A, Rich, MW, Fleg, JL, et al. Effects of digoxin on morbidity and mortality in diastolic heart failure: the Ancillary Digitalis Investigation Group Trial. Circulation 2006;114:397403.Google Scholar
Cleland, JGF, Tendera, M, Adamus, J, et al. The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J 2006;27:23382345.Google Scholar
Massie, BM, Carson, PE, McMurray, JJ, et al. Irbesartan in patients with heart failure and preserved ejection fraction. N Engl J Med 2008;359:24562467.Google Scholar
Van Veldhuisen, DJ, Cohen-Solal, A, Bohm, M, et al. Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction. J Am Coll Cardiol 2009;53:21502158.Google Scholar
Pitt, B, Pfeffer, MA, Assmann, SF, et al. Spironolactone for heart failure with preserved ejection fraction. N Engl J Med 2014;370:13831392.Google Scholar
Edelmann, F, Wachter, R, Schmidt, AG, et al. Effect of spironolactone on diastolic function and exercise capacity in patients with heart failure with preserved ejection fraction: the Aldo-DHF randomized controlled trial. JAMA 2013;309:781791.Google Scholar
Redfield, MM, Chen, HH, Borlaug, BA, et al. Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA 2013;309:12681277.Google Scholar
Zile, MR, Bourge, RC, Redfield, MM, Zhou, D, Baicu, CF, Little, WC. Randomized, double-blind, placebo-controlled study of sitaxsentan to improve impaired exercise tolerance in patients with heart failure and a preserved ejection fraction. J Am Coll Cardiol HF 2014;2:123130.Google Scholar
Conraads, VM, Metra, M, Kamp, O, et al. Effects of long-term administration of nebivolol on the clinical symptoms, exercise capacity, and left ventricular function of patients with diastolic dysfunction: results of the ELANDD study. Eur J Heart Fail 2012;14:219225.Google Scholar
Bristow, MR, Saxon, LA, Boehmer, J, et al. for the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004;350:21402150.Google Scholar
Cleland, JGF, Daubert, JC, Erdmann, E, et al. for the Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. New Engl J Med 2005;352:15391549.Google Scholar
Tracy, CM, Epstein, AE, Darbar, D, et al. 2012 ACCF/AHA/HRS Focused update incorporated into the ACCF/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities. Circulation 2013;127:e283e352.Google Scholar
Cheng, YJ, Zhang, J, Li, WJ, et al. More favorable response to cardiac resynchronization therapy in women than in men. Circ Arrhythm Electrophysiol 2014;7(5):807815.Google Scholar
Zusterzeel, R, Selzman, KA, Sanders, WE, et al. Cardiac resynchronization therapy in women: US Food and Drug Administration meta-analysis of patient-level data. JAMA Intern Med 2014;174:13401348.Google Scholar
Verbrugge, FH, Dupont, M, De Vusser, P, et al. Response to cardiac resynchronization therapy in elderly patients (≥70 years) and octogenarians. Eur J Heart Fail 2013;15:203210.Google Scholar
Moss, AJ, Zareba, W, Hall, WJ, et al. for the Multicenter Automatic Defibrillator Implantation Trial II Investigators. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 2002;346:877883.Google Scholar
Bardy, GH, Lee, KL, Mark, DB, et al. for the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005;352:225237.Google Scholar
Santangeli, P, Di Biase, L, Dello Russo, A, et al. Meta-analysis: age and effectiveness of prophylactic implantable cardioverter-defibrillators. Ann Intern Med 2010;153:592599.Google Scholar
Lampert, R, Hayes, DL, Annas, GJ, et al. HRS Expert Consensus Statement on the Management of Cardiovascular Implantable Electronic Devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm 2010;7:10081026.Google Scholar
Feltner, C, Jones, CD, Cene, CW, et al. Transitional care interventions to reduce readmissions for persons with heart failure: a systematic review and meta-analysis. Ann Intern Med 2014;160:774784.Google Scholar
Huynh, BC, Rovner, A, Rich, MW. Long-term survival in elderly patients hospitalized for heart failure: 14 year follow-up from a prospective randomized trial. Arch Intern Med 2006;166:18921898.Google Scholar
Whellan, DJ, Goodlin, SJ, Dickinson, MG, et al. End-of-life care in patients with heart failure. J Cardiac Failure 2014;20:121134.Google Scholar
Otto, CM, Prendergast, B. Aortic-valve stenosis – from patients at risk to severe valve obstruction. N Engl J Med 2014;371:744756.Google Scholar
Nishimura, RA, Otto, CM, Bonow, RO, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease. J Am Coll Cardiol 2014;63:e57e185.Google Scholar
Leon, MB, Smith, CR, Mack, M, et al. Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery. N Engl J Med 2010;363:15971607.Google Scholar
Smith, CR, Leon, MB, Mack, MJ, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients. N Engl J Med 2011;364:21872198.Google Scholar
Kodali, SK, Williams, MR, Smith, CR, et al. Two-year outcomes after transcatheter or surgical aortic-valve replacement. N Engl J Med 2012;366:16861695.Google Scholar
Reynolds, MR, Magnuson, EA, Lei, Y, et al. Health-related quality of life after transcatheter aortic valve replacement in inoperable patients with severe aortic stenosis. Circulation 2011;124:19641972.Google Scholar
Lindman, BR, Alexander, KP, O’Gara, PT, Afilalo, J. Futility, benefit, and transcatheter aortic valve replacement. J Am Coll Cardiol Cardiovasc Intervent; 2014;7:707716.CrossRefGoogle ScholarPubMed
Scognamiglio, R, Rahimtoola, SH, Fasoli, G, et al. Nifedipine in asymptomatic patients with severe aortic regurgitation and normal left ventricular function. N Engl J Med 1994;331:689694.Google Scholar
Evangelista, A, Tornos, P, Sambola, A, et al. Long-term vasodilator therapy in patients with severe aortic regurgitation. N Engl J Med 2005;353:13421349.Google Scholar
Mathew, JP, Fontes, ML, Tudor, IC, et al. A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA 2004;291:17201729.Google Scholar
Crystal, E, Connolly, SJ, Sleik, K, et al. Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery: a meta-analysis. Circulation 2002;106:7580.Google Scholar
Mitchell, LB, Exner, DV, Wyse, DG, et al. Prophylactic oral amiodarone for the prevention of arrhythmias that begin early after revascularization, valve replacement, or repair – PAPABEAR: a randomized controlled trial. JAMA 2005;294:30933100.Google Scholar
Enriquez-Sarano, M, Avierinos, JF, Messika-Zeitoun, D, et al. Quantitative determinants of the outcome of asymptomatic mitral regurgitation. N Engl J Med 2005;352:875883.Google Scholar
Feldman, T, Foster, E, Glower, DD, et al. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med 2011;364:13951406.Google Scholar
Wan, B, Rahnvavardi, M, Tian, DH, et al. A meta-analysis of MitraClip system versus surgery for treatment of severe mitral regurgitation. Ann Cardiothorac Surg 2013;2:683692.Google ScholarPubMed
Lamas, GA, Lee, KL, Silverman, R, et al. Ventricular pacing or dual-chamber pacing for sinus-node dysfunction. N Engl J Med 2002;346:18541862.Google Scholar
Go, AS, Hylek, EM, Phillips, KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA) study. JAMA 2001;285:23702375.CrossRefGoogle ScholarPubMed
January, CT, Wann, LS, Alpert, JS, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation. J Am Coll Cardiol 2014;64(21):e1e76.Google Scholar
Coleman, CI, Perkerson, KA, Gillespie, EL, et al. Impact of prophylactic beta blockade on post-cardiothoracic surgery length of stay and atrial fibrillation. Ann Phamacother 2004;38:20122016.Google Scholar
Kluger, J, White, CM. Amiodarone prevents symptomatic atrial fibrillation and reduces the risk of cerebrovascular events and ventricular tachycardia after open heart surgery: results of the Atrial Fibrillation Suppression Trial (AFIST). Card Electrophysiol Rev 2003;7:165167.Google Scholar
Wyse, DG, Waldo, AL, DiMarco, JP, et al. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med 2002;347:18251833.Google Scholar
The AFFIRM Investigators. Quality of life in atrial fibrillation: the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am Heart J 2005;149:112120.Google Scholar
Wolf, PA, Abbott, RD, Kannel, WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke 1991;22:983988.Google Scholar
Gage, BF, Waterman, AD, Shannon, W, et al. Validation of clinical classification schemes for predicting stroke: results from the National Registry of Atrial Fibrillation. JAMA 2001;285:28642870.Google Scholar
Lip, GY, Nieuwlaat, R, Pisters, R, Lane, DA, Crijns, HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the Euro Heart Survey on Atrial Fibrillation. Chest. 2010;137:263–72.Google Scholar
Connolly, SJ, Ezekowitz, MD, Yusuf, S, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009;361:11391151.Google Scholar
Patel, MR, Mahaffey, KW, Garg, J, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011;365:883891.Google Scholar
Granger, CB, Alexander, JH, McMurray, JJV, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011;365:981992.Google Scholar
Pisters, R, Lane, DA, Nieuwlaat, R, Vos, CB, Crijns, HJ, Lip, GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest 2010;138:10931100.Google Scholar
Lane, DA, Lip, GYH. Clinician update: use of the CHA2DS2-VASc and HAS-BLED scores to aid decision making for thromboprophylaxis in nonvalvular atrial fibrillation. Circulation 2012;126:860865.Google Scholar
Gage, BF, Birman-Deych, E, Kerzner, R, Radford, MJ, Nilasena, DS, Rich, MW. Incidence of intracranial hemorrhage in patients with atrial fibrillation who are prone to fall. Am J Med 2005;118:612617.Google Scholar
Donze, J, Clair, C, Hug, B, et al. Risk of falls and major bleeds in patients on oral anticoagulation therapy. Am J Med 2012;125:773778.Google Scholar
Sardar, P, Chatterjee, S, Chaudhari, S, Lip, GY. New oral anticoagulants in elderly adults: evidence from a meta-analysis of randomized trials. J Am Geriatr Soc 2014;62:857864.Google Scholar
Buxton, AE, Lee, KL, Fisher, JD, et al. for the Multicenter Unsustained Tachycardia Trial Investigators. A randomized study of the prevention of sudden death in patients with coronary artery disease. N Engl J Med 1999;341:18821890.Google Scholar

References

US Census Bureau, Statistical Abstract of the United States: 2012. Table 169. Visits to Office-Based Physicians and Hospital Outpatient Departments by Diagnosis: 2003 and 2008. Health and Nutrition, page 117. Available at: www.census.gov/prod/2011pubs/12statab/health.pdf (accessed August 15, 2014).Google Scholar
Gillespie, CD, Hurvitz, KA, National Center for Chronic Disease Prevention and Health Promotion, National Center for Health Statistics. Prevalence of hypertension and controlled hypertension – United States, 2007–2010. CDC Health Disparities and Inequalities Report – United States, 2013. MMWR Supplement. 2013;62(3):144–8.Google Scholar
Vasan, RS, Larson, MG, Leip, EP, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med. 2001;345:1291–7.Google Scholar
James, PA, Oparil, S, Carter, BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the eighth joint national committee (JNC 8). JAMA. 2014;311(5):507–20.Google Scholar
Perry, HM Jr, Davis, BR, Price, TR, et al. Effect of treating isolated systolic hypertension on the risk of developing various types and subtypes of stroke: The systolic hypertension in the elderly program (SHEP). JAMA. 2000;824:465–71.Google Scholar
Beckett, NS, Peters, R, Fletcher, AE, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358:1887–98.Google Scholar
Laubscher, T, Regier, L, Stone, S. Hypertension in the elderly: new blood pressure targets and prescribing tips. Canadian Family Physician. 2014;60(5):453–6.Google Scholar
Sica, D. Assessment of the role of ACE inhibitors in the elderly. In: Prisant, LM, ed. Hypertension in the Elderly. Totowa, NJ: Humana Press, 2005: 321–48.Google Scholar
JNC7 Express: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Bethesda, MD: National High Blood Pressure Education Program, Department of Health and Human Services, 2003:3 (table 1).Google Scholar

References

McDermott, M, Hoff, F, Ferrucci, L, et al. Lower extremity ischemia, calf skeletal muscle characteristics, and functional impairment in peripheral arterial disease. J Am Ger Soc. 2007;55(3):400406.Google Scholar
Parmenter, B, Baker, M, Barry, B, et al. Muscle strength is impaired in peripheral arterial disease and predicts over ground walking ability. Submitted to J Gerontol. 30 Jun 2014.Google Scholar
Parmenter, BJ, Raymond, J, Fiatarone Singh, M. The effect of exercise on fitness and functional outcomes in intermittent claudication: a systematic review of randomized controlled trials. Sports Med. 2013;43(6):513552.Google Scholar
McDermott, M, Greenland, P, Liu, K, et al. Leg symptoms in peripheral arterial disease. Associated clinical characteristics and functional impairment. JAMA. 2001;286(13):1599.Google Scholar
Long, J, Modrall, J, Parker, B, Swann, A, Welborn III, M, Anthony, T. Correlation between ankle-brachial index, symptoms, and health-related quality of life in patients with peripheral vascular disease. J Vasc Surg. 2004;39:723727.Google Scholar
Caro, J, Migliaccio-Walle, K, Ishak, K, Proskorovsky, I. The morbidity and mortality following a diagnosis of peripheral arterial disease: long-term follow-up of a large database. BMC Cardiovascular Disorders. 2005;5(14):18.CrossRefGoogle ScholarPubMed
Criqui, M, Deneberg, J, Langer, R, Fronek, A. The epidemiology of peripheral arterial disease: importance of identifying the population at risk. Vasc Med. 1997;2(3):221226.Google Scholar
Kannel, W, Shurtleff, D. The Framingham Study: cigarettes and the development of intermittent claudication. Geriatrics. 1973;28(2):6168.Google Scholar
Smith, G, Shipley, M, Rose, G. Intermittent claudication, heart disease risk factors, and mortality: the Whitehall Study. Circulation. 1990;82(6):19251931.Google Scholar
Anderson, J, Halperin, J, Albert, N, et al. Management of patients with peripheral artery disease ACC/AHA 2005 and 2011 guidelines. Circulation. 2013;127. doi: 10.1161/CIR.1160b1013e31828b31882aa.Google Scholar
Pradhan, A, Shrivastava, S, Cook, N, Rifai, N, Creager, M, Ridker, P. Symptomatic peripheral arterial disease in women: nontraditional biomarkers of elevated risk. Circulation. 2008;117:823831.Google Scholar
Fowkes, F, Housley, E, Riemersma, R, et al. Smoking, lipids, glucose intolerance, and blood pressure as risk factors for peripheral atherosclerosis compared with ischemic heart disease in the Edinburgh Artery Study. Am J Epidemiol. 1992;135:331340.Google Scholar
Subherwal, S, Patel, M, Kober, L, et al. Peripheral artery disease is a coronary heart disease risk equivalent among both men and women: results from a nationwide study. Eur J Prev Cardiol. 2014;22(3). doi: 10.1177/2047487313519344.Google Scholar
McDermott, M, Mehta, S, Ahn, H, Greenland, P. Atherosclerotic risk factors are less intensively treated in patients with peripheral arterial disease than in patients with coronary artery disease. J Gen Intern Med. 1997;12(4):209215.Google Scholar
Criqui, M, Langer, R, Fronek, A, et al. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med. 1992;326:381386.Google Scholar
Rooke, T, Hirsch, A, Misra, S, et al. ACCF/AHA focused update of the Guideline for the Management of Patients with Peripheral Artery Disease (updating the 2005 guideline). J Am Coll Cardiol. 2011;58(19):20202045.Google Scholar
Allison, M, Ho, E, Denenberg, J, et al. Ethnic-specific prevalence of peripheral arterial disease in the United States. Am J Prev Med. 2007;32:328333.Google Scholar
Go, A, Mozaffarian, D, Roger, V, et al. Heart Disease and Stroke Statistics 2013 Update: a report from the American Heart Association. Circulation. 2013;127(2):e6e245.Google Scholar
Norgren, L, Hiatt, WR, Dormandy, JA, Nehler, MR, Harris, KA, Fowkes, FGR. Inter-society consensus for the management of peripheral arterial disease. J Vasc Surg. 2007;45(1):S5S67.Google Scholar
Eraso, L, Fukaya, E, Mohler, E, Xie, D, Sha, D, Berger, J. Peripheral arterial disease, prevalence and cumulative risk factor profile analysis. Eur J Prev Cardiol. 2014;21:704711.Google Scholar
Hirsch, AT, Criqui, MH, Treat-Jacobson, D. Peripheral arterial disease detection, awareness, and treatment in primary care. JAMA. 2001;286(11):13171324.Google Scholar
Centers for Disease Control and Prevention (CDC). Lower extremity disease among persons aged > or =40 years with and without diabetes: United States, 1999–2002. MMWR. 2005;54:11581160.+or+=40+years+with+and+without+diabetes:+United+States,+1999–2002.+MMWR.+2005;54:1158–1160.>Google Scholar
Heald, C, Fowkes, F, Murray, G, Price, J, Ankle Brachial Index Collaboration. Risk of mortality and cardiovascular disease associated with the ankle-brachial index: systematic review. Atherosclerosis. 2006;189:6169.CrossRefGoogle ScholarPubMed
Ankle Brachial Index Collaboration, Fowkes, FG, Murray, GD, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008;300(2):197208.Google Scholar
Criqui, M, Ninomiya, J, Fronek, A. Progression of peripheral arterial disease predicts cardiovascular disease morbidity and mortality. J Am Coll Cardiol. 2008;52(21):17361742.Google Scholar
Garcia, L. Epidemiology and pathophysiology of lower extremity peripheral arterial disease. J Endovasc Surg. 2006;13(S2):113119.Google Scholar
Kroger, K, Buss, C, Renzing-Kohler, K, Santosa, F, Rudofsky, G. Segmental manifestation of peripheral atherosclerosis and its association to risk factors. VASA. 2000;29(3):199203.Google Scholar
Van Zitteren, M, Vriens, P, Heyligers, J, et al. Self-reported symptoms on questionnaires and anatomic lesions on duplex ultrasound examinations in patients with peripheral arterial disease. J Vasc Surg. 2012;55:10251034.Google Scholar
Gutstein, D, Fuster, V. Pathophysiology and clinical significance of atherosclerotic plaque rupture. Cardiovasc Res. 1999;41:323333.Google Scholar
Okura, H, Asawa, K, Kubo, T, et al. Incidence and predictors of plaque rupture in the peripheral arteries. Circ Cardiovasc Interv. 2010;3:6370.Google Scholar
Chen, Q, Shi, Y, Wang, Y, Li, X. Patterns of disease distribution of lower extremity peripheral arterial disease. Angiology. 2015 Mar 19;66(3):211218.Google Scholar
Brevetti, G, Schiano, V, Chiariello, M. Endothelial dysfunction: a key to the pathophysiology and natural history of peripheral arterial disease? Atherosclerosis. 2008;197:111.Google Scholar
O’hare, A. Management of peripheral arterial disease in chronic kidney disease. Cardiol Clin. 2005;23(3):225236.Google Scholar
Graham, I, Daly, L, Refsum, H, et al. Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project. JAMA. 1997;277(22):17751781.Google Scholar
McDermott, M, Greenland, P, Guralnik, J, et al. Inflammatory markers, D-dimer, pro-thrombotic factors, and physical activity levels in patients with peripheral arterial disease. Vascular Medicine. 2004;9(2):107115.Google Scholar
Hirsch, A, Allison, M, Gomes, A, et al. A call to action: women and peripheral artery disease: a scientific statement from the American Heart Association. Circulation. 2012;125:14491472.Google Scholar
Rose, G. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bulletin of the World Health Organisation. 1962;27:645658.Google Scholar
Schorr, E, Treat-Jacobson, D. Methods of symptom evaluation and their impact on peripheral artery disease (PAD) symptom prevalence: a review. Vasc Med. 2013;18:95111.Google Scholar
McDermott, M, Mehta, S, Greenland, P. Exertional leg symptoms other than intermittent claudication are common in peripheral arterial disease. Arch Intern Med. 1999;159:387392.Google Scholar
Au, T, Golledge, J, Walker, P, Haigh, K, Nelson, M. Peripheral arterial disease – diagnosis and management in general practice. Aust Fam Physician. 2013;42(6):397400.Google ScholarPubMed
Haigh, K, Bingley, J, Golledge, J, Walker, P. Peripheral arterial disease – screening in general practice. Aust Fam Physician. 2013;42(6):391395.Google Scholar
Golledge, J. Lower-limb arterial disease. Lancet. 1997;350(9089):14591465.Google Scholar
McDermott, M, Applegate, W, Bonds, D, et al. Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. J Am Heart Assoc. 2013;2(6):e0000257.Google Scholar
Fowkes, F, Murray, G, Butcher, I, et al. Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events. Eur J Prev Cardiol. 2014;21(3):310320.Google Scholar
Hirsch, A, Haskal, Z, Hertzer, N, et al. ACC/AHA 2005 guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): executive summary a collaborative report. J Am Coll Cardiol. 2006;47(6):12391312.Google Scholar
Haigh, K, Bingley, J, Golledge, J, Walker, P. Barriers to screening and diagnosis of peripheral artery disease by general practitioners. Vasc Med. 2013;18(6):325330.Google Scholar
Jens, S, Koelemay, M, Reekers, J, Bipat, S. Diagnostic performance of computed tomography angiography and contrast-enhanced magnetic resonance angiography in patients with critical limb ischaemia and intermittent claudication: systematic review and meta-analysis. Eur Radiol. 2013;23(11):31043114.Google Scholar
Gardner, A, Afaq, A. Management of lower extremity peripheral arterial disease. J Cardiopulm Rehabil Prev. 2008;28(6):349357.Google Scholar
Li, Y, Burrows, N, Gregg, E, Albright, A, Geiss, L. Declining rates of hospitalization for nontraumatic lower-extremity amputation in the diabetic population aged 40 years or older: US, 1988–2008. Diabetes Care. 2012;35(2):273277.Google Scholar
Stratton, I, AI, A, Neil, H, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405412.Google Scholar
Askew, CD, Parmenter, BJ, Leight, AS, Walker, PJ, Golledge, J. Exercise prescription for patients with peripheral arterial disease and intermittent claudication: a position statement from Exercise and Sports Science Australia. Journal of Science and Medicine in Sport. 2013; http://dx.doi.org/10.1016/j.jsams.2013.10.251.Google Scholar
Parmenter, BJ, Raymond, J, Dinnen, PJ, Fiatarone Singh, MA. Systematic, A Review of randomized controlled trials: walking versus alternative exercise prescription as treatment for intermittent claudication. Atherosclerosis 2011;218(1):112.Google Scholar
Lauret, G, Fakhry, F, Fokkenrood, H, Hunink, M, Teijink, J, Spronk, S. Modes of exercise training for intermittent claudication. Cochrane Database Syst Rev. 2014;7;CD009638.Google Scholar
Parmenter, B, Dieberg, G, Smart, N. Meta, A Analysis of exercise training to improve health related quality of life in peripheral arterial disease. Accepted for publication in Vascular Medicine 18 Oct 2014.Google Scholar
McDermott, M, Criqui, M, Greenland, P, et al. Leg strength in peripheral arterial disease: associations with disease severity and lower-extremity performance. J Vasc Surg. 2004;39(3):523530.Google Scholar
McDermott, M, Greenland, P, Liu, K, et al. The ankle brachial index is associated with leg function and physical activity: the Walking and Leg Circulation Study. Ann Intern Med. 2002;136(12):873883.Google Scholar
McDermott, M, Guralnik, J, Albay, M, Bandinelli, S, Miniati, B, Ferrucci, L. Impairments of muscles and nerves associated with peripheral arterial disease and their relationship with lower extremity functioning: the InCHIANTI Study. J Am Ger Soc. 2004;52(3):405410.Google Scholar
Gardner, A, Montgomery, P, Parker, D. Physical activity is a predictor of all-cause mortality in patients with intermittent claudication. J Vasc Surg. 2008;47(1):117122.Google Scholar
Gardner, AW, Katzel, LI, Sorkin, JD, et al. Exercise rehabilitation improves functional outcomes and peripheral circulation in patients with intermittent claudication: a randomized controlled trial. J Americ Geriatrics Soc. 2001;49(6):755762.Google Scholar
Leeper, N, Myers, J, Zhou, M, et al. Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease. J Vasc Surg. 2013;57(3):728733.Google Scholar
Askew, C, Green, S, Walker, P, et al. Skeletal muscle phenotype is associated with exercise tolerance in patients with peripheral arterial disease. J Vasc Surg. 2005;41:802807.Google Scholar
Hiatt, W. Medical treatment of peripheral arterial disease and claudication. N Engl J Med. 2001;344:16081621.Google Scholar
Garg, P, Liu, K, Tian, L, et al. Physical activity during daily life and functional decline in peripheral arterial disease. Circulation. 2009;119:251260.Google Scholar
Garg, P, Tian, L, Criqui, M, et al. Physical activity during daily life and mortality in patients with peripheral arterial disease. Circulation. 2006;114:242248.Google Scholar
Kurvers, H, van der Graaf, Y, Blankensteijn, J, Visseren, F, Eikelboom, B, SMART Study Group. Screening for asymptomatic internal carotid artery stenosis and aneurysm of the abdominal aorta: comparing the yield between patients with manifest atherosclerosis and patients with risk factors for atherosclerosis only. J Vasc Surg. 2003;37(6):12261233.Google Scholar

References

Drachman, D.A., Swearer, J.M.. Neurological Evaluation of the Elderly Patient. In: Albert, M.L., Knoefel, J.E., eds. Clinical Neurology of Aging. 3rd Edition. New York, Oxford University Press, 2011; 4153.Google Scholar
Sirven, J.I., Mancall, E.L.. Neurological Examination of the Older Adult. In: Sirven, J.I., Malamut, B.L., eds. Clinical Neurology of the Older Adult. 2nd Edition. Philadelphia, Lippincott Williams and Wilkins, 2008; 57.Google Scholar
Manini, T.M., Hong, S.L., Clark, B.C.. Aging and muscle: a neuron’s perspective. Curr Opin Clini Nutr Metab Care 2013; 16(1): 110.Google Scholar
Chitnus, T., Weiner, H.L.. Multiple Sclerosis in the Elderly. In: Albert, M.L., Knoefel, J.E., eds. Clinical Neurology of Aging. 3rd Edition. New York, Oxford University Press, 2011; 536543.Google Scholar
Scalfari, A., Knappertz, V., Cutter, G., et al. Mortality in patients with multiple sclerosis. Neurology 2013; 81: 184192.Google Scholar
Hughes, R.A., Rees, J.H.. Clinical and epidemiologic features of Guillain-Barré syndrome. The Journal of Infectious Diseases 1997; 176: S92–8.Google Scholar
Yuki, N., Hartung, H.P.. Guillain-Barré syndrome. N Engl J Med 2012; 366: 22942304.Google Scholar
Worms, P.M.. The epidemiology of motor neuron disease: a review of recent studies. Journal of the Neurological Sciences 2001; 191: 39.Google Scholar
Rowland, L.P., Shneider, N.A.. Amyotrophic lateral sclerosis. N Engl J Med 2001; 344: 16881700.Google Scholar
Donaghy, M.. Classification and clinical features of motor neurone diseases and motor neuropathies in adults. J. Neurol 1999; 246: 331333Google Scholar
Sieb, J.P.. Myasthenia gravis: an update for the clinician. Clinical and Experimental Immunology 2013; 175: 408418.Google Scholar
Drachman, D.B.. Myasthenia gravis. N Engl J Med 1994; 330: 17971810.Google Scholar
Bitzur, R., Cohen, H., Kamai, Y., Harats, D.. Intolerance to statins: mechanisms and management. Diabetes Care 2013; 36: S325S330.Google Scholar
Macedo, A.F., Taylor, F.C., Casas, J.P., et al. Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis. BMC Medicine 2014; 12: 5164.Google Scholar
Mold, J.W., Vesely, S.K., Keyl, B.A.. The prevalence, predictors, and consequences of peripheral sensory neuropathy in older patients. J Am Board Fam Pract 2004; 17: 309318.Google Scholar
Hreib, K.K., Jones, H.R.. Clinical Neurologic Evaluation. In: Jones, H.R., ed. Netter’s Neurology. New Jersey, Icon Learning Systems, 2005; 239.Google Scholar
Hoffman Snyder, C.R., Smith, B.E.. Common Peripheral Neuropathies in the Older Adult. In: Sirven, J.I., Malamut, B.L., eds. Clinical Neurology of the Older Adult. 2nd Edition. Philadelphia, Lippincott Williams and Wilkins, 2008; 402419.Google Scholar
Zawora, M., Liang, T.W., Jarra, H.. Neurological Problems in the Elderly. In: Arenson, S., Busby-Whitehead, J., Brummel-Smith, K., et al., eds. Reichel’s Care of the Elderly: Clinical Aspects of Aging. 6th Edition. New York, Cambridge University Press, 2009; 140170.Google Scholar
Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services; 2014. Available at: www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf (accessed August 3, 2014).Google Scholar
Charnogursky, G., Lee, H., Lopez, N.. Diabetic neuropathy. Handbook of Clinical Neurology 2014; 120: 773785.Google Scholar
Schmader, K.E.. Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy. Clinical Journal of Pain 2002; 18: 350354.Google Scholar
Lacomis, D.. Small-fiber neuropathy. Muscle and Nerve 2002; 26: 173188.Google Scholar
Brannagan, T.H., Weimer, L.H., Latov, N.. Acquired Neuropathies. In: Rowland, L.P., ed. Merritt’s Neurology. 11th Edition. Philadelphia, Lippincott Williams and Wilkins, 2005; 748767.Google Scholar
Ghaznawi, N., Virdi, A., Dayan, A., et al. Herpes zoster ophthalmicus: comparison of disease in patients 60 years and older versus younger than 60 years. Ophthalmology 2011; 118: 22422250.Google Scholar
Gnann, J.W., Whitley, R.J.. Herpes zoster. N Engl J Med 2002; 347: 340346.Google Scholar
Eldar, A.H., Chapman, J.. Guillain-Barré syndrome and other immune mediated neuropathies: diagnosis and classification. Autoimmunity Reviews 2014; 13: 525530.Google Scholar
Mahdi-Rogers, M., Hughes, R.A.. Epidemiology of chronic inflammatory neuropathies in southeast England. European Journal of Neurology 2014; 21: 2833.Google Scholar
Lijima, M., Koike, H., Nattori, N., et al. Prevalence and incidence rates of chronic inflammatory demyelinating polyneuropathy in the Japanese population. J Neurol Neurosurgery Psychiatry 2008; 79(9): 10401043.Google Scholar
Rigler, S.K.. Alcoholism in the elderly. American Family Physician 2000; 61: 17101716.Google Scholar
Mellion, M., Gilchrist, J.M., De La Monte, S.. Alcohol-related peripheral neuropathy: nutritional, toxic, or both? Muscle and Nerve 2011; 43: 309316.Google Scholar
Kumar, N.. Neurologic aspects of cobalamin (B12) deficiency. Handbook of Clinical Neurology 2014; 120: 915926.Google Scholar
Nemni, R., Gerosa, E., Piccolo, G., Merlinii, G.. Neuropathies associated with monoclonal Gammopathies. Haematologica 1994; 79: 557566.Google Scholar
Pop-Busui, R., Roberts, L., Pennathur, S., et al. The management of diabetic neuropathy in CKD. Am J Kidney Dis 2010; 55: 365385Google Scholar
Dworkin, R.H., O’Connor, A.B., Backonja, M., et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007; 132: 237251.Google Scholar
Laccheo, I., Ablah, E., Heinrichs, R., et al. Assessment of quality of life among the elderly with epilepsy. Epilepsy Behav 2008; 12: 257261.Google Scholar
Stephen, L.J., Brodie, M.J.. Epilepsy in elderly people. Lancet 2000; 355: 14411446.Google Scholar
Leppik, I.E., Birnbaum, A.K.. Epilepsy in the elderly. Annals of the New York Academy of Sciences 2010; 1184: 208224.Google Scholar
Ramsay, R.E., Rowan, A.J., Pryor, F.M.. Special considerations in treating the elderly patient with epilepsy. Neurology 2004; 62: S24–9.Google Scholar
Huying, F., Limpe, S., Werhahn, K.J.. Antiepileptic drug use in nursing home residents: a cross-sectional, regional study. Seizure 2006; 15: 194197Google Scholar
Hardie, N.A., Garrard, J., Gross, C.R., et al. The validity of epilepsy or seizure documentation in nursing homes. Epilepsy Research 2007; 74: 171175.Google Scholar
Brodie, M.J., Kelly, K., Stephen, L.J.. Prospective adults with new antiepileptic drugs in focal epilepsy: insights into population responses? Epilepsy and Behavior 2014; 31: 7376.Google Scholar
Wallace, H., Shorwon, S., Tallis, R.. Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2,052,922 and age-specific fertility rates of women with epilepsy. Lancet 1998; 352: 1970–73.Google Scholar
Bladin, C.F., Alexandrov, A.V., Bellavance, A., et al. Seizures after stroke: a prospective multicenter study. Arch Neurol 2000; 57: 16171622.Google Scholar
Brodie, M.J., Elder, A.T., Kwan, P.. Epilepsy in later life. Lancet Neurol 2009; 8: 1019–30.Google Scholar
Imfeld, P., Bodmer, M., Schuerch, M., et al. Seizures in patients with Alzheimer’s disease or vascular dementia: a population-based nested case control analysis. Epilepsia 2013; 54: 700707.Google Scholar
Irizarry, M.C., Jin, S., He, F., et al. Incidence of new-onset seizures in mild to moderate Alzheimer disease. Arch Neurol 2012; 69: 368372.Google Scholar
Sherzai, D., Losey, T., Vega, S., Sherzai, A.. Seizures and dementia in the elderly: nationwide inpatient sample 1999–2008. Epilepsy and Behavior 2014; 36: 5356.Google Scholar
Vossel, K.A., Beagle, A.J., Rabinovici, G.D., et al. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol 2013; 70: 11581166.Google Scholar
Meierkord, H., Holtkamp, M.. Non-convulsive status epilepticus in adults: clinical forms and treatment. Lancet Neurol 2007; 6: 329339.Google Scholar
Jirsch, J., Hirsch, L.J.. Nonconvulsive seizures: developing a rational approach to the diagnosis and management in the critically ill population. Clinical Neurophysiology 2007; 118: 16601670.Google Scholar
McBride, A.E., Shih, T.T., Hirsch, L.J.. Video-EEG monitoring in the elderly: a review of 94 patients. Epilepsia 2002; 43: 165.Google Scholar
Rowan, A.J., Ramsay, R.E., Collins, J.F., et al. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005; 64: 18681873.Google Scholar
Cumbo, E., Ligori, L.D.. Levitiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease. Epilepsy Behavior 2010; 17: 461.Google Scholar
Glauser, T., Ben-Menachem, E., Bourgeois, B., et al. ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2006; 47: 10941120.Google Scholar
Glauser, T., Ben-Menachem, E., Bourgeois, B., et al. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia 2013; 54: 551563.Google Scholar
Speechio, L.M., Tramacere, L., La Neve, A., Beghi, E.. Discontinuing antiepileptic drugs in patients who are seizure free on monotherapy. J Neurol, Neurosurg Psychiatry 2002; 72: 2225.Google Scholar
Robbins, M.S., Lipton, R.B.. Management of headache in the elderly. Drugs Aging 2010; 27: 377398.Google Scholar
Schwaiger, J., Kiechl, S., Seppi, K., et al. Prevalence of primary headaches and cranial neuralgias in men and women aged 55–94 years (Bruneck Study). Cephalagia 2009; 29: 179187.Google Scholar
Walker, R.A., Wadman, M.C.. Headache in the elderly. Clin Geriatr Med 2007; 23: 291305.Google Scholar
Prencipe, M., Casini, A., Ferretti, C., et al. Prevalence of headache in an elderly population: attack frequency, disability and use of medication. J Neurol Neurosurg Psychiatry 2001; 70: 377–81.Google Scholar
Pringsheim, T., Davenport, J., Becker, W.. Prophylaxis of migraine headache. CMAJ 2010; 182: E269276.Google Scholar
Charles, A.. The evolution of a migraine attack – a review of recent evidence. Headache 2013; 53: 413419.Google Scholar
Bamford, C.C., Mays, M., Tepper, S.J.. Unusual headaches in the elderly. Curr Pain Headache Rep 2011; 15: 295301.Google Scholar
Özge, A.. Chronic daily headache in the elderly. Curr Pain Headache Rep 2013; 17: 382389.Google Scholar
Weyand, C.M., Goronzy, J.J.. Giant-cell arteritis and polymalgia rheumatica. N Engl J Med 2014; 371: 5057Google Scholar
Kermani, T.A., Schmidt, J.S., Crowson, C.S., et al. Utility of erythrocyte sedimentation rate and C-reactive protein for the diagnosis of giant cell arteritis. Semin Arthritis Rheum 2012; 41: 866871.Google Scholar
Kristoffersen, E.S., Lundqvist, C.. Medication-overuse headache: epidemiology, diagnosis and treatment. TherAdv Drug Saf. 2014; 5: 8799.Google Scholar
Dodick, D.W., Capobianco, D.J.. Headaches. In: Sirven, J.I., Malamut, B.L., eds. Clinical Neurology of the Older Adult. 2nd Edition. Philadelphia, Lippincott Williams and Wilkins, 2008; 197212.Google Scholar

References

Feigin, VL, Lawes, CM, Bennett, DA, Anderson, CS. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol 2003 Jan;2(1):4353.Google Scholar
Koton, S, Schneider, AL, Rosamond, WD, et al. Stroke incidence and mortality trends in US communities, 1987 to 2011. JAMA 2014 Jul 16;312(3):259268.Google Scholar
Go, AS, Mozaffarian, D, Roger, VL, et al. Executive summary: heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation 2014 Jan 21;129(3):399410.Google Scholar
Yusuf, S, Rangarajan, S, Teo, K, et al. Cardiovascular risk and events in 17 low-, middle-, and high-income countries. N Engl J Med 2014 Aug 28;371(9):818827.Google Scholar
Sacco, RL, Kasner, SE, Broderick, JP, et al. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013 Jul;44(7):20642089.Google Scholar
Marini, C, Baldassarre, M, Russo, T, et al. Burden of first-ever ischemic stroke in the oldest old: evidence from a population-based study. Neurology 2004 Jan 13;62(1):7781.Google Scholar
Burke, JF, Freedman, VA, Lisabeth, LD, et al. Racial differences in disability after stroke: results from a nationwide study. Neurology 2014 Jul 29;83(5):390397.Google Scholar
Kelly, AG, Hoskins, KD, Holloway, RG. Early stroke mortality, patient preferences, and the withdrawal of care bias. Neurology 2012 Aug 28;79(9):941944.Google Scholar
Qureshi, AI, Chaudhry, SA, Connelly, B, et al. Impact of advanced healthcare directives on treatment decisions by physicians in patients with acute stroke. Crit Care Med 2013 Jun;41(6):14681475.Google Scholar
Silveira, MJ, Wiitala, W, Piette, J. Advance directive completion by elderly Americans: a decade of change. J Am Geriatr Soc 2014 Apr;62(4):706710.Google Scholar
Barber, PA, Kleinig, TJ. INTERACT2: a reason for optimism with spontaneous intracerebral hemorrhage? Int J Stroke 2014 Jan;9(1):5960.Google Scholar
McArdle, PF, Kittner, SJ, Ay, H, et al. Agreement between TOAST and CCS ischemic stroke classification: The NINDS SIGN Study. Neurology 2014 Oct 28;83(18):16531660. Epub 2014 Sep 26.Google Scholar
Adams, HP Jr, Bendixen, BH, Kappelle, LJ, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993 Jan;24(1):3541.Google Scholar
Arsava, EM, Ballabio, E, Benner, T, et al. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology 2010 Oct 5;75(14):12771284.Google Scholar
Asimos, AW, Johnson, AM, Rosamond, WD, et al. A multicenter evaluation of the ABCD2 score’s accuracy for predicting early ischemic stroke in admitted patients with transient ischemic attack. Ann Emerg Med 2010 Feb;55(2):201210.e5.Google Scholar
Easton, JD, Saver, JL, Albers, GW, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease. The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke 2009 Jun;40(6):22762293.Google Scholar
Giles, MF, Albers, GW, Amarenco, P, et al. Early stroke risk and ABCD2 score performance in tissue- vs time-defined TIA: a multicenter study. Neurology 2011 Sep 27;77(13):12221228.Google Scholar
Kleindorfer, D, Panagos, P, Pancioli, A, et al. Incidence and short-term prognosis of transient ischemic attack in a population-based study. Stroke 2005 Apr;36(4):720723.Google Scholar
Johnston, SC, Gress, DR, Browner, WS, Sidney, S. Short-term prognosis after emergency department diagnosis of TIA. JAMA 2000 Dec 13;284(22):29012906.Google Scholar
Rojas, JI, Zurru, MC, Romano, M, et al. Acute ischemic stroke in patients aged 80 or older. Medicina (B Aires) 2007;67(6 Pt 2):701704.Google Scholar
Agyemang, C, van Oeffelen, AA, Norredam, M, et al. Ethnic disparities in ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage incidence in the Netherlands. Stroke 2014 Sep 30;45(11):32363242.Google Scholar
Talahma, M, Strbian, D, Sundararajan, S. Sickle cell disease and stroke. Stroke 2014 Jun;45(6):e98e100.Google Scholar
Gueguen, A, Mahevas, M, Nzouakou, R, et al. Sickle-cell disease stroke throughout life: a retrospective study in an adult referral center. Am J Hematol 2014 Mar;89(3):267272.Google Scholar
Tinetti, ME, Han, L, Lee, DS, et al. Antihypertensive medications and serious fall injuries in a nationally representative sample of older adults. JAMA Intern Med 2014 Apr;174(4):588595.Google Scholar
Aronow, WS, Fleg, JL, Pepine, CJ, et al. ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents developed in collaboration with the American Academy of Neurology, American Geriatrics Society, American Society for Preventive Cardiology, American Society of Hypertension, American Society of Nephrology, Association of Black Cardiologists, and European Society of Hypertension. J Am Soc Hypertens 2011 Jul–Aug;5(4):259352.Google Scholar
Gouya, G, Arrich, J, Wolzt, M, et al. Antiplatelet treatment for prevention of cerebrovascular events in patients with vascular diseases: a systematic review and meta-analysis. Stroke 2014 Feb;45(2):492503.Google Scholar
Kernan, WN, Ovbiagele, B, Black, HR, et al. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014 Jul;45(7):21602236.Google Scholar
Shin, JY, Choi, NK, Jung, SY, et al. Risk of ischemic stroke with the use of risperidone, quetiapine and olanzapine in elderly patients: a population-based, case-crossover study. J Psychopharmacol 2013 Jul;27(7):638644.Google Scholar
Everson-Rose, SA, Roetker, NS, Lutsey, PL, et al. Chronic stress, depressive symptoms, anger, hostility, and risk of stroke and transient ischemic attack in the multi-ethnic study of atherosclerosis. Stroke 2014 Aug;45(8):23182323.Google Scholar
Lambiase, MJ, Kubzansky, LD, Thurston, RC. Prospective study of anxiety and incident stroke. Stroke 2014 Feb;45(2):438443.Google Scholar
Helms, TM, Duong, G, Zippel-Schultz, B, et al. Prediction and personalised treatment of atrial fibrillation-stroke prevention: consolidated position paper of CVD professionals. EPMA J 2014 Sep 2;5(1):15.Google Scholar
Coppens, M, Hart, RG, Eikelboom, JW. Stroke prevention in older adults with atrial fibrillation. CMAJ 2013 Nov 19;185(17):14791480.Google Scholar
Quinn, GR, Fang, MC. Atrial fibrillation: stroke prevention in older adults. Clin Geriatr Med 2012 Nov;28(4):617634.Google Scholar
Moran, PS, Flattery, MJ, Teljeur, C, et al. Effectiveness of systematic screening for the detection of atrial fibrillation. Cochrane Database Syst Rev 2013 Apr 30;4:CD009586.Google Scholar
Sanna, T, Diener, HC, Passman, RS, et al. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med 2014 Jun 26;370(26):24782486.Google Scholar
Gladstone, DJ, Spring, M, Dorian, P, et al. Atrial fibrillation in patients with cryptogenic stroke. N Engl J Med 2014 Jun 26;370(26):24672477.Google Scholar
Weber-Kruger, M, Gelbrich, G, Stahrenberg, R, et al. Finding atrial fibrillation in stroke patients: randomized evaluation of enhanced and prolonged Holter monitoring – Find-AFRANDOMISED – rationale and design. Am Heart J 2014 Oct;168(4):438445.e1.Google Scholar
Halperin, JL, Hankey, GJ, Wojdyla, DM, et al. Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). Circulation 2014 Jul 8;130(2):138146.Google Scholar
Sardar, P, Chatterjee, S, Chaudhari, S, Lip, GY. New oral anticoagulants in elderly adults: evidence from a meta-analysis of randomized trials. J Am Geriatr Soc 2014 May;62(5):857864.Google Scholar
Dzik, WS. Reversal of drug-induced anticoagulation: old solutions and new problems. Transfusion 2012 May;52 Suppl 1:45S55S.Google Scholar
Salvi, F, Marchetti, A, D’Angelo, F, et al. Adverse drug events as a cause of hospitalization in older adults. Drug Saf 2012 Jan;35 Suppl 1:2945.Google Scholar
Wang, C, Yi, X, Zhang, B, et al. Clopidogrel plus aspirin prevents early neurologic deterioration and improves 6-month outcome in patients with acute large artery atherosclerosis stroke. Clin Appl Thromb Hemost 2015 Jul;21(5):453461. Epub 2014 Sep 23.Google Scholar
Wong, KS, Chen, C, Fu, J, et al. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial. Lancet Neurol 2010 May;9(5):489497.Google Scholar
Markus, HS, Droste, DW, Kaps, M, et al. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the clopidogrel and aspirin for reduction of emboli in symptomatic carotid stenosis (CARESS) trial. Circulation 2005 May 3;111(17):22332240.Google Scholar
Boan, AD, Lackland, DT, Ovbiagele, B. Lowering of blood pressure for recurrent stroke prevention. Stroke 2014 Aug;45(8):25062513.Google Scholar
De Lima, LG, Saconato, H, Atallah, AN, da Silva, EM. Beta-blockers for preventing stroke recurrence. Cochrane Database Syst Rev 2014 Oct 15;10:CD007890.Google Scholar
Udell, JA, Opotowsky, AR, Khairy, P, et al. Patent foramen ovale closure vs medical therapy for stroke prevention: meta-analysis of randomized trials and review of heterogeneity in meta-analyses. Can J Cardiol 2014 Oct;30(10):12161224.Google Scholar
Kmietowicz, Z. Geriatrician questions prescribing for stroke prevention in people over 80. BMJ 2014 Feb 26;348:g1788.Google Scholar
Byatt, K. Overenthusiastic stroke risk factor modification in the over-80s: are we being disingenuous to ourselves, and to our oldest patients? Evid Based Med 2014 Aug;19(4):121122.Google Scholar
Manocha, D, Bansal, N, Gumaste, P, Brangman, S. Safety profile of high-dose statin therapy in geriatric patients with stroke. South Med J 2013 Dec;106(12):658664.Google Scholar
Raley, KA, Hutchison, AM. Statin use and cognitive changes in elderly patients with dementia. Consult Pharm 2014;29(7):487489.Google Scholar
Mandas, A, Congiu, MG, Abete, C, et al. Cognitive decline and depressive symptoms in late-life are associated with statin use: evidence from a population-based study of Sardinian old people living in their own home. Neurol Res 2014 Mar;36(3):247254.Google Scholar
Tapia-Perez, JH, Gehring, S, Zilke, R, Schneider, T. Effect of increased glucose levels on short-term outcome in hypertensive spontaneous intracerebral hemorrhage. Clin Neurol Neurosurg 2014 Mar;118:3743.Google Scholar
Tanaka, R, Ueno, Y, Miyamoto, N, et al. Impact of diabetes and prediabetes on the short-term prognosis in patients with acute ischemic stroke. J Neurol Sci 2013 Sep 15;332(1–2):4550.Google Scholar
Nardi, K, Milia, P, Eusebi, P, et al. Predictive value of admission blood glucose level on short-term mortality in acute cerebral ischemia. J Diabetes Complications 2012 Mar–Apr;26(2):7076.Google Scholar
Murphy, RA, Patel, KV, Kritchevsky, SB, et al. Weight change, body composition, and risk of mobility disability and mortality in older adults: a population-based cohort study. J Am Geriatr Soc 2014 Aug;62(8):14761483.Google Scholar
Alamowitch, S, Eliasziw, M, Algra, A, et al. Risk, causes, and prevention of ischaemic stroke in elderly patients with symptomatic internal-carotid-artery stenosis. Lancet 2001 Apr 14;357(9263):11541160.Google Scholar
Brott, TG, Hobson, RW 2nd, Howard, G, et al. Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med 2010 Jul 1;363(1):1123.Google Scholar
Gonzales, NR, Demaerschalk, BM, Voeks, JH, et al. Complication rates and center enrollment volume in the carotid revascularization endarterectomy versus stenting trial. Stroke 2014 Sep 25.Google Scholar
Rerkasem, K, Rothwell, PM. Carotid endarterectomy for symptomatic carotid stenosis. Cochrane Database Syst Rev 2011 Apr 13;(4):CD001081.Google Scholar
Antoniou, GA, Georgiadis, GS, Georgakarakos, EI, et al. Meta-analysis and meta-regression analysis of outcomes of carotid endarterectomy and stenting in the elderly. JAMA Surg 2013 Dec;148(12):11401152.Google Scholar
Kasner, SE, Lynn, MJ, Chimowitz, MI, et al. Warfarin vs aspirin for symptomatic intracranial stenosis: subgroup analyses from WASID. Neurology 2006 Oct 10;67(7):12751278.Google Scholar
Birkbak, J, Clark, AJ, Rod, NH. The effect of sleep disordered breathing on the outcome of stroke and transient ischemic attack: a systematic review. J Clin Sleep Med 2014 Jan 15;10(1):103108.Google Scholar
Petrov, ME, Howard, VJ, Kleindorfer, D, et al. Over-the-counter and Prescription Sleep Medication and Incident Stroke: The REasons for Geographic And Racial Differences in Stroke Study. J Stroke Cerebrovasc Dis 2014 Sep;23(8):21102116.Google Scholar
Birkbak, J, Clark, AJ, Rod, NH. The effect of sleep disordered breathing on the outcome of stroke and transient ischemic attack: a systematic review. J Clin Sleep Med 2014 Jan 15;10(1):103108.Google Scholar
Diaz, KM, Booth, JN 3rd, Calhoun, DA, et al. Healthy lifestyle factors and risk of cardiovascular events and mortality in treatment-resistant hypertension: the reasons for geographic and racial differences in stroke study. Hypertension 2014 Sep;64(3):465471.Google Scholar
Marler, JR. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995 Dec 14;333(24):15811588.Google Scholar
Yayan, J. Effectiveness of alteplase in the very elderly after acute ischemic stroke. Clin Interv Aging 2013;8:963974.Google Scholar
Gomez-Choco, M, Obach, V, Urra, X, et al. The response to IV rt-PA in very old stroke patients. Eur J Neurol 2008 Mar;15(3):253256.Google Scholar
Engelter, ST, Bonati, LH, Lyrer, PA. Intravenous thrombolysis in stroke patients of > or = 80 versus < 80 years of age – a systematic review across cohort studies. Age Ageing 2006 Nov;35(6):572580.Google Scholar
Jonsson, AC, Delavaran, H, Iwarsson, S, et al. Functional status and patient-reported outcome 10 years after stroke: the Lund Stroke Register. Stroke 2014 Jun;45(6):17841790.Google Scholar
Camara-Lemarroy, CR, Ibarra-Yruegas, BE, Gongora-Rivera, F. Gastrointestinal complications after ischemic stroke. J Neurol Sci 2014 Aug 28.Google Scholar
Martino, R, Foley, N, Bhogal, S, et al. Dysphagia after stroke: incidence, diagnosis, and pulmonary complications. Stroke 2005 Dec;36(12):27562763.Google Scholar
Lin, CJ, Hung, JW, Cho, CY, et al. Poststroke constipation in the rehabilitation ward: incidence, clinical course and associated factors. Singapore Med J 2013 Nov;54(11):624629.Google Scholar
Douds, GL, Hellkamp, AS, Olson, DM, et al. Venous thromboembolism in the Get with the Guidelines-Stroke acute ischemic stroke population: incidence and patterns of prophylaxis. J Stroke Cerebrovasc Dis 2014 Jan;23(1):123129.Google Scholar
Naccarato, M, Chiodo Grandi, F, Dennis, M, Sandercock, PA. Physical methods for preventing deep vein thrombosis in stroke. Cochrane Database Syst Rev 2010 Aug 4;8:CD001922.Google Scholar
Drury, P, Levi, C, McInnes, E, et al. Management of fever, hyperglycemia, and swallowing dysfunction following hospital admission for acute stroke in New South Wales, Australia. Int J Stroke 2014 Jan;9(1):2331.Google Scholar
Allan, LM, Rowan, EN, Thomas, AJ, et al. Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors. Br J Psychiatry 2013 Dec;203(6):453460.Google Scholar
Tang, WK, Caeiro, L, Lau, CG, et al. Apathy and suicide-related ideation 3 months after stroke: a cross-sectional study. BMC Neurol 2015 Apr 23;15(1):60.Google Scholar
Santos, CO, Caeiro, L, Ferro, JM, Figueira, ML. A study of suicidal thoughts in acute stroke patients. J Stroke Cerebrovasc Dis 2012 Nov;21(8):749754.Google Scholar
Vallury, KD, Jones, M, Gray, R. Do family-oriented interventions reduce poststroke depression? A systematic review and recommendations for practice. Top Stroke Rehabil 2015 Dec;22(6):459465. doi: 10/1179/1074935715Z00000000061. Epub 2015 Mar 28.Google Scholar
Cai, W, Wang, J, Wang, L, et al. Prevalence and risk factors of urinary incontinence for post-stroke inpatients in Southern China. Neurourol Urodyn 2015;34(3):231235.Google Scholar
Gregory, P, Edwards, L, Faurot, K, et al. Patient preferences for stroke rehabilitation. Top Stroke Rehabil 2010 Sep–Oct;17(5):394400.Google Scholar
DuGoff, EH, Canudas-Romo, V, Buttorff, C, et al. Multiple chronic conditions and life expectancy: a life table analysis. Med Care 2014 Aug;52(8):688694.Google Scholar
Bilbao, G, Garibi, J, Pomposo, I, et al. A prospective study of a series of 356 patients with supratentorial spontaneous intracerebral haematomas treated in a neurosurgical department. Acta Neurochir (Wien) 2005 Aug;147(8):823829.Google Scholar
Bhatia, R, Singh, H, Singh, S, et al. A prospective study of in-hospital mortality and discharge outcome in spontaneous intracerebral hemorrhage. Neurol India 2013 May–Jun;61(3):244248.Google Scholar
Flemming, KD, Wijdicks, EF, Li, H. Can we predict poor outcome at presentation in patients with lobar hemorrhage? Cerebrovasc Dis 2001;11(3):183189.Google Scholar

References

Schneider, SA, Deuschl, G. The treatment of tremor. Neurotherapeutics 2014; 11: 128–38.Google Scholar
Zesiewicz, TA, Elble, R, Louis, ED, et al. Practice parameter: therapies for essential tremor: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2005; 64:2008–20.Google Scholar
Koller, W, Pahwa, R, Busenbark, K, et al. High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol 1997; 42:292–9.Google Scholar
Schuurman, PR, Bosch, DA, Bossuyt, PM, et al. A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med 2000; 342:461–8.Google Scholar
Deuschl, G, Bain, P, Brin, M. Consensus statement of the Movement Disorder Society on Tremor: ad hoc scientific committee. Mov Disord 1998; 13(Suppl 3):223.Google Scholar
Tyrer, P, Alexander, MS, Regan, A, Lee, I. An extrapyramidal syndrome after lithium therapy. Br J Psychiatry 1980; 136:191–4.Google Scholar
Niethammer, M, Ford, B. Permanent lithium-induced cerebellar toxicity: three cases and review of literature. Mov Disord 2007; 22:570–3.Google Scholar
Baumann, C. Epidemiology, diagnosis and differential diagnosis in Parkinson’s disease tremor. Parkinsonism and Related Disorders 2012; 18(Suppl 1):S9092.Google Scholar
Hughes, AJ, Daniel, SE, Blankson, S, Lees, AJ. A clinicopathologic study of 100 cases of Parkinson’s disease. Arch Neurol 1993; 50:140–8.Google Scholar
Respondek, G, Stamelou, M, Kurz, C, et al. The phenotypic spectrum of progressive supranuclear palsy: a retrospective multicenter study of 100 definite cases. Mov Disord. 2014 Dec;29(14):1758–66.Google Scholar
Cummings, JL. Reconsidering diagnostic criteria for dementia with lewy bodies. Highlights from the Third International Workshop on Dementia with Lewy Bodies and Parkinson’s Disease Dementia, September 17–20, 2003, Newcastle Upon Tyne, United Kingdom. Rev Neurol Dis 2004 Winter;1(1):31–4.Google Scholar
Wenning, GK, Geser, F, Krismer, F, et al. The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol 2013 Mar;12(3):264–74.Google Scholar
Armstrong, MJ, Litvan, I, Lang, AE, et al. Criteria for the diagnosis of corticobasal degeneration. Neurology 2013 Jan 29;80(5):496503.Google Scholar
Winikates, J, Jankovic, J. Clinical correlates of vascular parkinsonism. Arch Neurol 1999; 56:98102.Google Scholar
Langston, JW, Ballard, P. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson’s disease. Can J Neurol Sci 1984; 11:160–5.Google Scholar
Olanow, CW. Manganese-induced parkinsonism and Parkinson’s disease. Ann N Y Acad Sci 2004; 1012:209–23.Google Scholar
Klawans, HL, Stein, RW, Tanner, CM, Goetz, CG. A pure parkinsonian syndrome following acute carbon monoxide intoxication. Arch Neurol 1982; 39:302–4.Google Scholar
Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson’s disease. N Engl J Med 1993; 328:176–83.Google Scholar
Shults, CW, Oakes, D, Kieburtz, K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol 2002; 59:1541–50.Google Scholar
Whone, AL, Watts, RL, Stoessl, AJ, et al. Slower progression of Parkinson’s disease with ropinirole versus levodopa: the REAL-PET study. Ann Neurol 2003; 54:93101.Google Scholar
Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs. levodopa on Parkinson disease progression. JAMA 2002; 287:1653–61.Google Scholar
Parkinson Study Group. A controlled trial of rasagiline in early Parkinson disease: the TEMPO Study. Arch Neurol 2002; 59:1937–43.Google Scholar
Calne, DB. The role of various forms of treatment in the management of Parkinson’s disease. Clin Neuropharmacol 1982; 5(Suppl 1):S3843.Google Scholar
Pritchett, AM, Morrison, JF, Edwards, WD, et al. Valvular heart disease in patients taking pergolide. Mayo Clin Proc 2002; 77:1280–6.Google Scholar
Voon, V, Sohr, M, Lang, AE, et al. Impulse control disorders in Parkinson disease: a multicenter case–control study. Ann Neurol. 2011 Jun;69(6):986–96.Google Scholar
Rascol, O, Brooks, DJ, Korczyn, AD, et al. A five-year study of the incidence of dyskinesia in patients with early Parkinson’s disease who were treated with ropinirole or levodopa: 056 study group. N Engl J Med 2000; 342: 1484–91.Google Scholar
Parkinson Study Group. Pramipexole vs levodopa as initial treatment for Parkinson disease: a randomized controlled trial. Parkinson Study Group. JAMA 2000; 284:1931–8.Google Scholar
Cilia, R, Akpalu, A, Sarfo, FS, et al. “The modern pre-levodopa era of Parkinson’s disease: insights into motor complications from sub-Saharan Africa.” Brain 137 2014;10:2731–42.Google Scholar
Stowe, RL, Ives, NJ, Clarke, C, et al. Dopamine agonist therapy in early Parkinson’s disease. Cochrane Database Syst Rev 2008;2:CD006564.Google Scholar
PD MED Collaborative Group. Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson’s disease (PD MED): a large, open-label, pragmatic randomised trial.The Lancet 2014;384(9949):1196–205.Google Scholar
Hauser, RA, Hsu, A, Kell, S, et al. Extended-release carbidopa-levodopa (IPX066) compared with immediate-release carbidopa-levodopa in patients with Parkinson’s disease and motor fluctuations: a phase 3 randomised, double-blind trial. Lancet Neurol 2013;12(4):346–56.Google Scholar
Fernandez, HH, Standaert, DG, Hauser, RA, et al. Levodopa-carbidopa intestinal gel in advanced Parkinson’s disease: final 12-month, open-label results. Mov Disord 2015 Apr;30(4):500–9.Google Scholar
Zibetti, M, Merola, A, Artusi, CA, et al. Levodopa/carbidopa intestinal gel infusion in advanced Parkinson’s disease: a 7-year experience. Eur J Neurol 2014 Feb;21(2):312–18.Google Scholar
Uncini, A, Eleopra, R, Onofrj, M. Polyneuropathy associated with duodenal infusion of levodopa in Parkinson’s disease: features, pathogenesis and management. J Neurol Neurosurg Psychiatry 2015 May;86(5):490–5.Google Scholar
Rinne, UK, Rinne, JO, Rinne, JK, et al. Brain receptor changes in Parkinson’s disease in relation to the disease process and treatment. J Neural Transm Suppl 1983; 18:279–86.Google Scholar
Lew, MF, Kricorian, G. Results from a 2-year centralized tolcapone liver enzyme monitoring program. Clin Neuropharmacol 2007 Sep–Oct;30(5):281–6.Google Scholar
Martinez-Ramirez, D, Okun, MS. Rationale and clinical pearls for primary care doctors referring patients for deep brain stimulation. Gerontology 2014;60(1):3848.Google Scholar
Perestelo-Pérez, L, Rivero-Santana, A, Pérez-Ramos, J, et al. Deep brain stimulation in Parkinson’s disease: meta-analysis of randomized controlled trials. J Neurol 2014 Nov;261(11):2051–60.Google Scholar
Mouradian, MM, Heuser, IJ, Baronti, F, Chase, TN. Modification of central dopaminergic mechanisms by continuous levodopa therapy for advanced Parkinson’s disease. Ann Neurol 1990; 27:1823.Google Scholar
Block, G, Liss, C, Reines, S, et al. Comparison of immediate-release and controlled release carbidopa/levodopa in Parkinson’s disease: a multicenter 5-year study. The CR First Study Group. Eur Neurol 1997;37:23–7.Google Scholar
Nutt, JG, Woodward, WR, Beckner, RM, et al. Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients. Neurology 1994;44:913–9.Google Scholar
Parkinson Study Group. Entacapone improves motor fluctuations in levodopa-treated Parkinson’s disease patients. Ann Neurol 1997;42:747–55.Google Scholar
Rajput, AH, Martin, W, Saint-Hilaire, MH, Dorflinger, E, Pedder, S. Tolcapone improves motor function in parkinsonian patients with the “wearing-off” phenomenon: a double-blind, placebo-controlled, multicenter trial. Neurology 1997;49:1066–71.Google Scholar
Pourfar, M, Feigin, A, Eidelberg, D. Natural history. In: Factor, SA, Weiner, WJ, editors, Parkinson’s Disease: Diagnosis and Clinical Management. 2nd ed. New York: Demos; 2008: 127–33.Google Scholar
Ostergaard, K, Aa Sunde, N. Evolution of Parkinson’s disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus. Mov Disord 2006;21:624631.Google Scholar
Marras, C, McDermott, MP, Rochon, PA, et al. Survival in Parkinson disease: thirteen-year follow-up of the DATATOP cohort. Neurology 2005;64(1):8793.Google Scholar
Tuck, K, Brod, L, Nutt, J, Fromme, EK. Preferences of patients with Parkinson. American Journal of Hospice & Palliative Medicine 2015;32(1):6877.Google Scholar
Verghese, J, Le Valley, A, Hall, CB, et al. Epidemiology of gait disorders in community-residing older adults. Journal of American Geriatric Society 2006;54:255–61.Google Scholar
Sudarsky, LR. Gait impairment and falls. In: Samuels, S and Feske, S, eds. Office Practice of Neurology. Philadelphia: Churchill Livingstone; 2003: 25.Google Scholar
Marmarou, A, Black, P, Bergsneider, M, et al. Guidelines for management of idiopathic normal pressure hydrocephalus: progress to date. Acta Neurochir Suppl 2005;95:237–40.Google Scholar
Perlman, SL. Ataxias. Clin Geriatr Med 2006; 22:859–77.Google Scholar
Zesiewicz, TA, Sullivan, KL, Arnulf, I, et al. Practice parameter: treatment of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2010;74(11):924–31.Google Scholar
Ruzicka, E, Jankovic, JJ. Disorders of gait. In: Jankovic, J and Tolosa, E, eds. Parkinsons Disease and Movement Disorders. Philadelphia: Lippincott Williams & Wilkins; 2007: 409.Google Scholar
Mouton, CP, Espino, DV. Health screening in older women. Am Fam Physician 1999;59(7):1835–42.Google Scholar
Barak, Y, Wagenaar, RC, Holt, KG. Gait characteristic of elderly people with a history of falls: a dynamic approach. Phys Ther 2006 86:1501–10.Google Scholar
Gilman, S. Merritt’s Neurology. 10th ed. Philadelphia: Lippincott Williams & Wilkins, 2000.Google Scholar
Ondo, W. Gait and balance disorders. Med Clin N Am 2003;87(4): 793801.Google Scholar
Hyndman, D, Ashburn, A, Yardley, L, Stack, E. Interference between balance, gait, and cognitive task performance among people with stroke living in the community. Disability and Rehabilitation. 2006;28(13–14):849–56.Google Scholar
Nutt, JG. Abnormalities of posture and movement. In: Cassel, CK, Cohen, HJ, Larson, EB, et al. (eds). Geriatric Medicine. 3rd ed. New York: Spring-Verlag; 1997: 939–48.Google Scholar
Factora, R, Luciano, M. Normal pressure hydrocephalus: diagnosis and new approaches to treatment. Clin Geriatr Med 2006;22:645–57.Google Scholar
Kanade, RV, van Deursen, RWM, Harding, K, Price, P. Walking performance in people with diabetic neuropathy: benefits and threats. Diabetologia 2006;49:1747–54.Google Scholar

References

Foley, DJ, Monjan, AA, Brown, SL, et al. Sleep complaints among elderly persons: an epidemiological study of 3 communities. Sleep. 1995;18:425432.Google Scholar
Mellinger, GD, Balter, MB, Uhlenhuth, EH. Insomnia and its treatment: prevalence and correlates. Arch Gen Psychiatry. 1985;42:225232.Google Scholar
Morgan, K. Sleep and aging. In: Lichstein, K, Morin, C, eds. Treatment of Late Life Insomnia. Thousand Oaks, CA: Sage Publications, 2000.Google Scholar
Floyd, JA, Medler, SM, Ager, JW, et al. Age-related changes in initiation and maintenance of sleep: a meta-analysis. Res Nurs Health. 2000;23:106117.Google Scholar
Diagnostic Classification Steering Committee TMJC. International Classification of Sleep Disorders, 3rd edition. Rochester, NY: American Academy of Sleep Medicine, 2014.Google Scholar
Ford, DE, Kamerow, DB. Epidemiological study of the sleep disturbances and psychiatric disorders. JAMA. 1989;262:14791484.Google Scholar
Vitiello, MV, Moe, KE, Prinz, PN. Sleep complaints cosegregate with illness in older adults: clinical research informed by and informing epidemiological studies of sleep. J Psychosom Res. 2002;53:555559.Google Scholar
Bloom, HG, Ahmed, I, Alessi, CA, et al. Evidence-based recommendations for the assessment and management of sleep disorders in older persons. J Am Geriatr Soc. 2009;57:761789.Google Scholar
Rodriguez, JC, Dzierzewski, JM, Alessi, CA. Sleep problems in the elderly. Med Clin North Am. 2015;99:431439.Google Scholar
Insomnia, Roth T.: Definition, prevalence, etiology, and consequences. J Clin Sleep Med. 2007;3:S7S10.Google Scholar
Dzierzewski, JM, O’Brien, E, Kay, DB, et al. Tackling sleeplessness: psychological treatment options for insomnia in older adults. Nat Sci Sleep. 2010;2:4761.Google Scholar
Spielman, AJ, Caruso, LS, Glovinsky, PB. A behavioral perspective on insomnia treatment. Psychiat Clinics of N Amer. 1987;10:541553.Google Scholar
Bastien, CH, Vallieres, A, Morin, CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep Med. 2001;2:297307.Google Scholar
Buysse, DJ, Reynolds, CFI, Monk, TH, et al. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193213.Google Scholar
Morin, CM, Colecchi, C, Stone, J, et al. Behavioral and pharmacological therapies for late life insomnia: a randomized controlled trial. JAMA. 1999;281:991999.Google Scholar
Sivertsen, B, Omvik, S, Pallesen, S, et al. Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults. JAMA. 2006;295:28512858.Google Scholar
McCurry, SM, Logsdon, RG, Teri, L, et al. Evidence-based psychological treatments for insomnia in older adults. Psychol Aging. 2007;22:1827.Google Scholar
Morgenthaler, T, Kramer, M, Alessi, CA, et al. Practice parameters for the psychological and behavioral treatment of insomnia: an update. An American Academy of Sleep Medicine report. Sleep. 2006;29:14151419.Google Scholar
Siebern, AT, Manber, R. New developments in cognitive behavioral therapy as the first-line treatment of insomnia. Psychol Res Behav Manag. 2011;4:2128.Google Scholar
Stewart, R, Besset, A, Bebbington, P, et al. Insomnia comorbidity and impact and hypnotic use by age group in a national survey population aged 16 to 74 years. Sleep. 2006;29:13911397.Google Scholar
Alessi, CA. Sleep problems. In: Durso, SC, Sullivan, GM, eds. Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine, 8th edition. New York: American Geriatrics Society, 2013: 316339.Google Scholar
Young, T, Peppard, PE, Gottlieb, DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002;165:12171239.Google Scholar
George, CFP. Sleep apnea, alertness, and motor vehicle crashes. American Journal of Respiratory and Critical Care Medicine. 2007;176(10):954956.Google Scholar
Punjabi, NM, Caffo, BS, Goodwin, JL, et al. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Medicine. 2009;6(8):e1000132.Google Scholar
Kales, A, Cadieux, RJ, Bixler, EO, et al. Severe obstructive sleep apnea – I: onset, clinical course, and characteristics. Journal of Chronic Diseases. 1985;38(5):419425.Google Scholar
Cowan, DC, Allardice, G, MacFarlane, D, et al. Predicting sleep disordered breathing in outpatients with suspected OSA. BMJ Open. 2014;4:e004519.Google Scholar
Epstein, LJ, Kristo, D, Strollo, PJ Jr, et al. Clinical guidelines for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009;15:263276.Google Scholar
Qaseem, A, Holty, JE, Owens, DK, et al. Management of obstructive sleep apnea in adults: a clinical practice guideline from the American College of Physicians. Annals of Internal Medicine. 2013;159(7):471483.Google Scholar
Strohl, KP, Brown, DB, Collop, N, et al. An official American Thoracic Society Clinical Practice Guideline: sleep apnea, sleepiness, and driving risk in noncommercial drivers. An update of a 1994 Statement. American Journal of Respiratory and Critical Care Medicine. 2013;187(11):12591266.Google Scholar
Campos-Rodriguez, F, Pena-Grinan, N, Reyes-Nuñez, N, et al. Mortality in obstructive sleep apnea-hypopnea patients treated with positive airway pressure. Chest. 2005;128:624633.Google Scholar
Giles, TL, Lasserson, TJ, Smith, BJ, et al. Continuous positive airway pressure for obstructive sleep apnoea in adults. Cochrane Database Syst Rev. 2006;25:CD001106.Google Scholar
Rosenthal, L, Gerhardstein, R, Lumley, A, et al. CPAP therapy in patients with mild OSA: implementation and treatment outcome. Sleep Medicine. 2000;1(3);215220.Google Scholar
Krahn, LE, Lin, SC, Wisbey, J, et al. Assessing sleep in psychiatric inpatients: nurse and patient reports versus wrist actigraphy. Ann Clin Psychiatry. 1997;9:203210.Google Scholar
Venkateshiah, SB, Collop, NA. Sleep and sleep disorders in the hospital. Chest. 2012;141:13371345.Google Scholar
Iranzo, A, Santamaria, J, Bereguer, J, et al. Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction. Neurology. 2002;58:911916.Google Scholar
Kaw, R, Chung, F, Pasupuleti, V, et al. Meta-analysis of the association between obstructive sleep apnoea and postoperative outcome. British Journal of Anaesthesia. 2012;109;897906.Google Scholar
D’Apuzzo, MR, Browne, JA. Obstructive sleep apnea as a risk factor for postoperative complications after revision joint arthroplasty. The Journal of Arthroplasty. 2012;27(8):9598.Google Scholar
Koch, S, Haesler, E, Tiziani, A, Wilson, J. Effectiveness of sleep management strategies for residents of aged care facilities: findings of a systematic review. Journal of Clinical Nursing. 2006;15(10):12671275.Google Scholar
Ancoli-Israel, S, Klauber, MR, Kripke, DF, et al. Sleep apnea in female patients in a nursing home. Increased risk of mortality. CHEST. 1989;96(5):10541058.Google Scholar
Alessi, CA, Martin, JL, Webber, AP, et al. Randomized, controlled trial of a nonpharmacological intervention to improve abnormal sleep/wake patterns in nursing home residents. J Am Geriatr Soc. 2005;53:803810.Google Scholar
Koch, S, Haesler, E, Tiziani, A, et al. Effectiveness of sleep management strategies for residents of aged care facilities: findings of a systematic review. J Clin Nurs. 2006;15:12671275.Google Scholar
Roth, HL. Dementia and sleep. Neurol Clin. 2012;30:12131248.Google Scholar
McCleery, J, Cohen, DA, Sharpley, AL. Pharmacotherapies for sleep disturbances in Alzheimer’s disease. Cochrane Database Syst Rev. 2014;3:CD009178.Google Scholar

References

Stahl, S. 2013. Stahl’s Essential Psychopharmacology. 4th ed. Cambridge: Cambridge University Press.Google Scholar
Institute of Medicine. 2012. The Mental Health Workforce for Geriatric Population. Washington, DC: IOM Press.Google Scholar
Inouye, SK, Bogardus, ST, Charpentier, PA, et al. 1999. A multicomponent intervention to prevent delirium in hospitalized patients. NEJM. 340:669–74.Google Scholar
Rovner, BW, Kalonek, S, Filipp, L, et al. 1986. Prevalence of mental illness in a community nursing home. Am J Psychiatry. 143:14461449.Google Scholar
Blazer, DG. 2001. Depression in Late Life. 3rd ed. St. Louis: Mosby-Year Book.Google Scholar
Blazer, DG. 1994. Is depression more frequent in late life? J Geriatr Psychiatry. 2:193199.Google Scholar
Lipsey, JR, Robinson, RG, Pearlson, GD, et al. 1985. The dexamethasone suppression test and mood following stroke. Am J Psychiatry. 142:318323.Google Scholar
Jorm, A. 2000. Does old age reduce the risk of anxiety and depression? Psychol Med. 30:1122.Google Scholar
Philibert, RA, Richards, L, Lynch, CF, et al. 1995. Effect of ECT on mortality and clinical outcome in geriatric unipolar depression. J Clin Psychiatry. 56:390394.Google Scholar
Stoppe, A, Louza, M, Moacyr, R, et al. 2006. Fixed high-dose ECT in the elderly with depression. J ECT. 22:9299.Google Scholar
Lehmann, SW, Rabins, PV. 2006. Factors related to hospitalization in elderly manic patients with early and late onset bipolar disorder. Int J Geri Psych. 21: 10601064.Google Scholar
Blazer, D, Hughes, DC, George, LK. 1987. The epidemiology of depression in an elderly community population. Gerontologist. 27:281287.Google Scholar
Bruce, ML, Kim, K, Leaf, PJ. 1990. Depressive episodes and dysphoria resulting from conjugal bereavement in a prospective community sample. Am J Psychiatry. 147:608611.Google Scholar
Meehan, PJ, Saltzman, LE, Sattin, RW. 1991. Suicides among older United States residents: epidemiologic characteristics and trends. Am J Public Health. 81:11981200.Google Scholar
Howard, R, Rabins, PV, Seeman, MV, et al. 2000. Late- onset schizophrenia and very-late-onset schizophrenia-like psychosis: an international consensus. Am J Psychiatry. 157:172178.Google Scholar
Holroyd, S, Rabins, PV, Finkelstein, D, et al. 1994. Visual hallucinations in patients from an ophthalmology clinic and medical clinic population. J Nerv Ment Dis. 182:272276.Google Scholar
Myers, WA. 1991. New Techniques in the Psychotherapy of Older Patients. Washington, DC: American Psychiatry Press.Google Scholar

References

US Census Bureau. Population profile of the United States. 2012.Google Scholar
Kerr, WC, Greenfield, TK, Bond, J, et al. Age-period-cohort modelling of alcohol volume and heavy drinking days in the US National Alcohol Surveys: divergence in younger and older adult trends. Addiction. 2009 Jan;104(1):2737. doi: 10.1111/j.1360-0443.2008.02391.x.Google Scholar
Substance Abuse and Mental Health Services Administration. Results from the 2012 National Survey on Drug Use and Health: Summary of national findings. NSDUH Series H-46, HHS Publication No. (SMA) 13–4795. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2013.Google Scholar
Duncan, DF, Nicholson, T, White, JB, et al. The baby boomer effect: changing patterns of substance abuse among adults ages 55 and older. J Aging Soc Policy. 2010 Jul;22(3):237248. doi: 10.1080/08959420.2010.485511.Google Scholar
Cummings, SM, Bride, B, Rawlins-Shaw, AM. Alcohol abuse treatment for older adults: a review of recent empirical research. Journal of Evidence-Based Social Work. 2006;3(1):7999.Google Scholar
Saitz, R. Unhealthy alcohol use. New Eng J Med. 2005;352(6):596607.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Publishing; 2013.Google Scholar
Moore, AA, Karno, MP, Grella, CE, et al. Alcohol, tobacco, and nonmedical drug use in older US adults: Data from the 2001/02 National Epidemiologic Survey of Alcohol and Related Conditions. Journal of the American Geriatrics Society. 2009;57(12):22752281.Google Scholar
Arndt, S, Clayton, R, Schultz, S. Trends in substance abuse treatment 1998–2008: Increasing older adult first time admissions for illicit drugs. American Journal of Geriatric Psychiatry. 2011;19:704711.Google Scholar
Moos, RH, Schutte, KK, Brennan, PL, Moos, BS. Older adults’ alcohol consumption and late-life drinking problems: a 20-year perspective. Addiction. 2009;104:12931302.Google Scholar
Kirchner, J, Zubritsky, C, Cody, M, et al. Alcohol consumption among older adults in primary care. Journal of General Internal Medicine. 2007;22:9297.Google Scholar
Center for Substance Abuse Treatment. Substance Abuse among Older Adults: Treatment Improvement Protocol (TIP) Series 26. Rockville, MD: Substance Abuse and Mental Health Services Administration; 1998.Google Scholar
Moore, AA, Gould, R, Reuben, DB, et al. Longitudinal patterns and predictors of alcohol consumption in the United States. American Journal of Public Health. 2005;95(3):458465.Google Scholar
Blazer, DG, Wu, L. The epidemiology of at risk and binge drinking among middle-aged and elderly community adults: National Survey on Drug Use and Health. Am J Psychiat. 2009;166:11621169.Google Scholar
National Institute on Alcohol Abuse and Alcoholism. Rethinking Drinking. NIH Publication No. 13–3770. Bethesda, MD: NIH; 2010.Google Scholar
Grant, BF, Dawson, DA, Stinson, FS, et al. The 12-month prevalence and trends in DSM-IV alcohol abuse and dependence: United States, 1991–1992 and 2001–2002. Drug Alcohol Depen. 2004;74:223234.Google Scholar
King, BA, Dube, SR, Tynan, MA. Current tobacco use among adults in the United States: findings from the National Adult Tobacco Survey. Am J Public Health. 2012 Nov;102(11):e93e100. doi: 10.2105/AJPH.2012.301002. Epub 2012 Sep 20.Google Scholar
Wu, LT, Blazer, DG. Illicit and nonmedical drug use among older adults: a review. J Aging Health. 2011;23:481504.Google Scholar
Lin, JC, Karno, MP, Grella, CE, et al. Alcohol, tobacco, and nonmedical drug use disorders in US adults aged 65 years and older: data from the 2001–2002 National Epidemiologic Survey of Alcohol and Related Conditions. Am J Geriatr Psychiatry. 2011 Mar;19(3):292–9. doi: 10.1097/JGP.0b013e3181e898b4.Google Scholar
Blazer, DG, Wu, L. The epidemiology of substance use and disorders among middle aged and elderly community adults: national survey on drug use and health. Am J Geriatr Psychiatry. 2009;17:237245.Google Scholar
Blazer, DG, Wu, L. Nonprescription use of pain relievers by middle-aged and elderly community-living adults: national survey on drug use and health. J Am Geriatr Soc. 2009;57:12521257.Google Scholar
Bartels, SJ, Coakley, EH, Zubritsky, C, et al. Improving access to geriatric mental health services: a randomized trial comparing treatment engagement with integrated versus enhanced referral care for depression, anxiety, and at-risk alcohol use. American Journal of Psychiatry. 2004;161:14551462.Google Scholar
Kennedy, GJ, Efremova, I, Frazier, A, Saba, A. The emerging problems of alcohol and substance abuse in late life. J Soc Distress Homel. 1999;8(4):227239.Google Scholar
Oslin, DW. Alcohol use in late life: disability and comorbidity. J Geriatr Psychiat Neur. 2000;13:134140.Google Scholar
Gilbertson, R, Ceballos, NA, Prather, R, Nixon, SJ. Effects of acute alcohol consumption in older and younger adults: perceived impairment versus psychomotor performance. J Stud Alcohol Drugs. 2009;70(2):242252.Google Scholar
Blow, FC, Barry, KL. Older patients with at-risk and problem drinking patterns: new developments in brief interventions. J Geriatr Psychiat Neur. 2000;13:115123.Google Scholar
Sklar, AR, Gilbertson, R, Boissoneault, J, et al. Differential effects of moderate alcohol consumption on performance among older and younger adults. Alcoholism: Clinical & Experimental Research. 2012;36(12):21502156.Google Scholar
Linnoila, M, Erwin, CW, Cleveland, WP, et al. Effects of alcohol on psychomotor performance of men and women. J Stud Alcohol. 1978;39:745758.Google Scholar
Vestal, RE, McGuire, EA, Tobin, JD, et al. Aging and ethanol metabolism. Clin Pharmacol Ther. 1977;21:343354.Google Scholar
Moore, AA, Whiteman, EJ, Ward, KT. Risks of combined alcohol/medication use in older adults. Am J Geriatr Pharmacother. 2007;5:6474.Google Scholar
Moore, AA, Morton, SC, Beck, JC, et al. A new paradigm for alcohol use in older persons. Med Care. 1999;37:165179.Google Scholar
LaCroix, AZ, Guralnik, JM, Berkman, LF, et al. Maintaining mobility in late life. II. Smoking, alcohol consumption, physical activity and body mass index. American Journal of Epidemiology. 1993;137(8):858869.Google Scholar
LaCroix, AZ, Omenn, GS. Older adults and smoking. Clinics in Geriatric Medicine. 1992;8(1):6987.Google Scholar
Rimer, BK, Orleans, CT, Keintz, MK, et al. The older smoker: status, challenges and opportunities for intervention. Chest. 1990;97:547–53Google Scholar
Simoni-Wastila, L, Yang, HK. Psychoactive drug abuse in older adults. American Journal of Geriatric Pharmacotherapy. 2006;4(4):380394.Google Scholar
National Institute on Drug Abuse. Marijuana Abuse. Bethesda, MD: National Institute on Drug Abuse; 2012.Google Scholar
Kuerbis, A, Sacco, P, Blazer, DG, Moore, AA. Substance abuse among older adults. Clin Geriatr Med. 2014 Aug;30(3):629654. doi: 10.1016/j.cger.2014.04.008. Epub 2014 Jun 12.Google Scholar
Merrick, EL, Horgan, CM, Hodgkin, D, et al. Unhealthy drinking patterns in older adults: prevalence and associated characteristics. J AmGeriatr Soc. 2008;56:214223.Google Scholar
Platt, A, Sloan, FA, Costanzo, P. Alcohol-consumption trajectories and associated characteristics among adults older than age 50. J Stud Alcohol Drugs. 2010;71:169179.Google Scholar
Moos, RH, Brennan, PL, Schutte, KK, Moos, BS. Older adults’ health and late-life drinking patterns: a 20-year perspective. Aging Ment Health. 2010;14(1):3343.Google Scholar
Collins, PM, Kayser, K, Platt, S. Conjoint marital therapy: a practitioner’s approach to single-system evaluation. Families in Society. 1994;75:131141.Google Scholar
Sacco, P, Bucholz, KK, Spitznagel, EL. Alcohol use among older adults in the National Epidemiologic Survey on Alcohol and Related Conditions. J Stud Alcohol Drugs. 2009;70(6):829838.Google Scholar
Balsa, AI, Homer, JF, Fleming, MF, French, MT. Alcohol consumption and health among elders. Gerontologist. 2008;48(5):622636.Google Scholar
Adams, WL. Alcohol use in the retirement communities. J Am Geriatr Soc. 1996;44:10821085.Google Scholar
Brennan, PL, Schutte, KK, Moos, RH. Reciprocal relations between stressors and drinking behavior: a three-wave panel study of late middle-aged and older women and men. Addiction. 1999;94(5):737749.Google Scholar
Center for Substance Abuse Treatment. Substance Abuse Relapse Prevention for Older Adults: A Group Treatment Approach. Rockville, MD: Substance Abuse and Mental Health Services Administration; 2005.Google Scholar
Myers, JE, Harper, MC. Evidence-based effective practices with older adults. Journal of Counseling & Development. 2004;82:207218.Google Scholar
Laidlaw, K, Pachana, NA. Aging, mental health, and demographic change: challenges for psychotherapists. Professional Psychology: Research and Practice. 2009;40(6):601608.Google Scholar
Kuerbis, A, Sacco, P. The impact of retirement on the drinking patterns of older adults: a review. Addict Behav. 2012;37:587595.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed., text revision ed. Washington, DC: Author; 2000.Google Scholar
Sacco, P, Kuerbis, A. Older adults. In: Vaughn, MG, Perron, BE, eds. Social Work Practice in the Addictions. New York: Springer; 2013:213229.Google Scholar
Kuerbis, A, Hagman, BT, Sacco, P. Functioning of alcohol use disorders criteria among middle-aged and older adults: Implications for DSM-5. Substance Use & Misuse. 2013;48(4):309322.Google Scholar
Barry, KL, Blow, FC, Oslin, DW. Substance abuse in older adults: review and recommendations for education and practice in medical settings. Substance Abuse. 2002;23(3 Suppl):109.Google Scholar
Moyer, VA, US Preventive Services Task Force. Screening and behavioral counseling interventions in primary care to reduce alcohol misuse: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2013 Aug 6;159(3):210–8. doi: 10.7326/0003-4819-159-3-201308060-00652.Google Scholar
Duru, OK, Xu, H, Tseng, C-H, et al. Correlates of alcohol-related discussions between older adults and their physicians. J AmGeriatr Soc. 2010;58(12):23692374.Google Scholar
D’Amico, EJ, Paddock, SM, Burnam, A, Kung, FY. Identification of and guidance for problem drinking by general medical providers: results from a national survey. Medical Care. 2005;43(3):229236.Google Scholar
Dar, K. Alcohol use disorders in elderly people: fact or fiction? Advances in Psychiatric Treatment. 2006;12:173181.Google Scholar
Barry, KL, Oslin, DW, Blow, FC. Alcohol Problems in Older Adults. New York: Springer Publishing Company; 2001.Google Scholar
Rodin, J. Aging and health: effects of the sense of control. Science. 1986;233:12711276.Google Scholar
Klein, WC, Jess, C. One last pleasure? Alcohol use among elderly people in nursing homes. Health & Social Work. 2002;27(3):193203.Google Scholar
Barry, KL, Blow, FC, Oslin, DW. Substance abuse in older adults: review and recommendations for education and practice in medical settings. Substance Abuse. 2002;23(3 Suppl):105131.Google Scholar
Dupree, LW, Broskowski, H, Schonfeld, L. The Gerontology Alcohol Project: a behavioral treatment program for elderly alcohol abusers. Gerontologist. 1984;24:510516.Google Scholar
Schonfeld, L, Dupree, LW. Treatment approaches for older problem drinkers. International Journal of the Addictions. 1995;30(13–14):18191842.Google Scholar
Schonfeld, L, Dupree, LW, Dickson-Fuhrman, E, et al. Cognitive-behavioral treatment of older veterans with substance abuse problems. J Geriatr Psychiat Neur. 2000;13:124128.Google Scholar
National Institute on Alcohol Abuse and Alcoholism. Helping Patients Who Drink Too Much: A Clinician’s Guide. 2005 Edition. Bethesda, MD: Author; 2007.Google Scholar
Babor, TF, Higgins-Biddle, JC, Saunders, JB, Monteiro, MG. The Alcohol Use Disorders Identification Test (AUDIT): Guidelines for Use in Primary Care. 2nd ed. Geneva: Department of Mental Health and Substance Dependence, World Health Organization; 2001.Google Scholar
Piccinelli, M, Tessari, E, Bortolomasi, M, et al. Efficacy of the alcohol use disorders identification test as a screening tool for hazardous alcohol intake and related disorders in primary care: a validity study. British Medical Journal. 1997;314(8):420424.Google Scholar
Humeniuk, R, Henry-Edwards, S, Ali, R, et al. The Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST). Geneva: World Health Organization; 2010.Google Scholar
Moore, AA, Beck, JC, Babor, TF, et al. Beyond alcoholism: identifying older, at-risk drinkers in primary care. J Stud Alcohol. 2002;63(3):316324.Google Scholar
Barnes, AJ, Moore, AA, Xu, H, et al. Prevalence and correlates of at-risk drinking among older adults: the Project SHARE study. JGIM. 2010;25(8):840846.Google Scholar
Moore, AA, Blow, FC, Hoffing, M, et al. Primary care-based intervention to reduce at-risk drinking in older adults: a randomized controlled trial. Addiction. 2011;106(1):111120.Google Scholar
Stewart, D, Oslin, DW. Recognition and treatment of late-life addictions in medical settings. Journal of Clinical Geropsychology. 2001;7(2):145158.Google Scholar
Buchsbaum, DG, Buchanan, R, Welsh, J, et al. Screening for drinking disorders in the elderly using the CAGE questionnaire. J Am Geriatr Soc. 1992;40:662665.Google Scholar
Brennan, PL, Nichol, AC, Moos, RH. Older and younger patients with substance use disorders: Outpatient mental health service use and functioning over a 12-month interval. Psychol Addict Behav. 2003;17(1):4248.Google Scholar
Ewing, JA. Detecting alcoholism: the CAGE questionnaire. JAMA. 1984 Oct 12;252(14):1905–7.Google Scholar
Brown, RL, Rounds, LA. Conjoint screening questionnaires for alcohol and other drug abuse. Wisconsin Medical Journal. 1995;94(3):135140.Google Scholar
Barry, KL, Blow, FC. Screening, assessing and intervening for alcohol and medication misuse in older adults. In: Lichtenberg, PA, ed. Handbook of Assessment in Clinical Gerontology. Burlington, MA: Elsevier; 2010:307330.Google Scholar
O’Connell, H, Chin, A-V, Hamilton, F, et al. A systematic review of the utility of self-report alcohol screening instruments in the elderly. International Journal of Geriatric Psychiatry. 2004;19:10741086.Google Scholar
Fink, A, Morton, SC, Beck, JC, et al. The Alcohol-Related Problems Survey: identifying hazardous and harmful drinking in older primary care patients. J Am Geriatr Soc. 2002;50:17171722.Google Scholar
Brennan, PL, Nichol, AC, Moos, RH. Older and younger patients with substance use disorders: outpatient mental health service use and functioning over a 12-month interval. Psychol Addict Behav. 2003;17(1):4248.Google Scholar
Kuerbis, AN, Sacco, P. A review of existing treatments for substance abuse among the elderly and recommendations for future directions. Substance Abuse: Research and Treatment. 2013;7:1337.Google Scholar
Han, B, Gfroerer, JC, Colliver, JD, Penne, MA. Substance use disorder among older adults in the United States in 2020. Addiction. 2009;104:8896.Google Scholar
Schultz, SK, Arndt, S, Liesveld, J. Locations of facilities with special programs for older substance abuse clients in the US. International Journal of Geriatric Psychiatry. 2003;18(9):839843.Google Scholar
Fleming, MF, Manwell, LB, Barry, KL, et al. Brief physician advice for alcohol problems in older adults: a randomized community-based trial. Journal of Family Practice. 1999;48(5):378384.Google Scholar
Fink, A, Elliot, MN, Tsai, M, Beck, JC. An evaluation of an intervention to assist primary care physicians in screening and educating older patients who use alcohol. J Am Geriatr Soc. 2005;53:19371943.Google Scholar
Miller, WR, Rollnick, S. Motivational Interviewing: Preparing People for Change. 2nd ed. New York: The Guilford Press; 2002.Google Scholar
Miller, WR, Zweben, A, DiClemente, CC, Rychtarik, RG. Motivational Enhancement Therapy Manual: A Clinical Research Guide for Therapists Treating Individuals with Alcohol Abuse and Dependence. Rockville, MD: National Institute on Alcohol Abuse and Alcoholism; 1992.Google Scholar
Kofoed, LL, Tolson, RL, Atkinson, RM, et al. Treatment compliance of older alcoholics: an elder-specific approach is superior to “mainstreaming.” J Stud Alcohol. 1987;48:4751.Google Scholar
Rice, C, Longabaugh, R, Beattie, M, Noel, N. Age group differences in response to treatment for problematic alcohol use. Addiction. 1993;88:13691375.Google Scholar
Schonfeld, L, Dupree, LW. Age-specific cognitive behavioral and self management treatment approaches. In: Gurnack, AM, Atkinson, RM, Osgood, NJ, eds. Treating Alcohol and Drug Abuse in the Elderly. New York: Springer Publishing Company; 2002:109130.Google Scholar
Rotgers, F. Cognitive-behavioral theories of substance abuse. In: Rotgers, F, Morgenstern, J, Walters, ST, eds. Treating Substance Abuse: Theory and Technique. 2nd ed. New York: The Guilford Press; 2003:166189.Google Scholar
Oslin, DW, Liberto, JG, O’Brien, J, et al. Naltrexone as an adjunctive treatment for older patients with alcohol dependence. American Journal of Geriatric Psychiatry. 1997;5(4):324332.Google Scholar
Oslin, DW, Pettinati, H, Volpicelli, JR. Alcoholism treatment adherence: older age predicts better adherence and drinking outcomes. American Journal of Geriatric Psychiatry. 2002;10(6):740747.Google Scholar
Rösner, S, Hackl-Herrwerth, A, Leucht, S, et al. Opioid antagonists for alcohol dependence. Cochrane Database Syst Rev. 2010;12:CD001867.Google Scholar
Barrick, C, Connors, GD. Relapse prevention and maintaining abstinence in older adults with alcohol-use disorders. Drugs & Aging. 2002;19(8):583594.Google Scholar
Tempesta, E, Janiri, L, Bignamini, A, et al. Acamprosate and relapse prevention in the treatment of alcohol dependence: a placebo controlled trial. Pharmacopsychiatry. 2000;29:2729.Google Scholar
US National Library of Congress. DailyMed. 2013; http://dailymed.nlm.nih.gov/dailymed/about.cfm.Google Scholar
Hays, JT, Ebbert, JO. Adverse effects and tolerability of medications for the treatment of tobacco use and dependence. Drugs. 2010;70(18):23572372.Google Scholar
Smith, SS, McCarthy, DE, Japuntich, SJ, et al. Comparative effectiveness of five smoking cessation pharmacotherapies in primary care clinics. Arch Intern Med. 2009;169(22):2148.Google Scholar
Keating, GM, Lyseng-Williamson, KA. Varenicline: a pharmacoeconomic review of its use as an aid to smoking cessation. Pharmacoeconomics. 2010;28(3):231254.Google Scholar
Garrison, GD, Dugan, SE. Varenicline: a first-line treatment option for smoking cessation. Clinical Therapeutics. 2009;31(3):463491.Google Scholar
Fudala, PJ, Bridge, TP, Herbert, S, et al. Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone. N Engl J Med. 2003;349(10):949958.Google Scholar

References

Edge, JR, Millard, FJ, Reid, L, Simon, G. The radiographic appearances of the chest in persons of advanced age. British Journal of Radiology. 1964;37:769–74.Google Scholar
Estenne, M, Yernault, JC, De Troyer, A. Rib cage and diaphragm-abdomen compliance in humans: effects of age and posture. J Appl Physiol. 1985;59:1842–8.Google Scholar
Bode, FR, Dosman, J, Martin, RR, et al. Age and sex differences in lung elasticity, and in closing capacity in nonsmokers. J Appl Physiol. 1976;41:129–35.Google Scholar
Polkey, MI, Harris, ML, Hughes, PD, et al. The contractile properties of the elderly human diaphragm. American Journal of Respiratory and Critical Care Medicine. 1997;155:1560–4.Google Scholar
Janssens, JP. Aging of the respiratory system: impact on pulmonary function tests and adaptation to exertion. Clinics in Chest Medicine. 2005;26:469–84, vivii.Google Scholar
Crapo, RO, Jensen, RL, Hegewald, M, Tashkin, DP. Arterial blood gas reference values for sea level and an altitude of 1,400 meters. American Journal of Respiratory and Critical Care Medicine. 1999;160:1525–31.Google Scholar
Hardie, JA, Vollmer, WM, Buist, AS, et al. Reference values for arterial blood gases in the elderly. Chest. 2004;125:2053–60.Google Scholar
Svartengren, M, Falk, R, Philipson, K. Long-term clearance from small airways decreases with age. European Respiratory Journal. 2005;26:609–15.Google Scholar
Centers for Disease Control and Prevention. Chronic obstructive pulmonary disease among adults – United States, 2011. MMWR. 2012;61: 938–43.Google Scholar
Yunginger, JW, Reed, CE, O’Connell, EJ, et al. A community-based study of the epidemiology of asthma: incidence rates, 1964–1983. American Review of Respiratory Disease. 1992;146:888–94.Google Scholar
Pfeifer, MA, Weinberg, CR, Cook, D, et al. Differential changes of autonomic nervous system function with age in man. American Journal of Medicine. 1983;75:249–58.Google Scholar
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Revised 2014. Available at: www.goldcopd.org (accessed Apr 10, 2014).Google Scholar
Minino, AM, Murphy, SL, Xu, J, Kochanek, KD. Deaths: final data for 2008. National vital Statistics Reports: from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System. 2011;59: 1126.Google Scholar
Celli, BR, MacNee, W, Force, AET. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. European Respiratory Journal. 2004;23:932–46.Google Scholar
Rennard, SI. COPD: overview of definitions, epidemiology, and factors influencing its development. Chest. 1998;113:235S–41S.Google Scholar
Mohamed Hoesein, FA, Zanen, P, Lammers, JW. Lower limit of normal or FEV1/FVC <0.70 in diagnosing COPD: an evidence-based review. Respiratory Medicine. 2011;105:907–15.Google Scholar
Chong, J, Karner, C, Poole, P. Tiotropium versus long-acting beta-agonists for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012;9:CD009157.Google Scholar
Calverley, PM, Anderson, JA, Celli, B, et al. Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease. N Engl J Med. 2007;356:775–89.Google Scholar
Tashkin, DP, Celli, B, Senn, S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med. 2008;359:1543–54.Google Scholar
Anthonisen, NR, Connett, JE, Murray, RP. Smoking and lung function of Lung Health Study participants after 11 years. American Journal of Respiratory and Critical Care Medicine. 2002;166:675–9.Google Scholar
Warnier, MJ, van Riet, EE, Rutten, FH, et al. Smoking cessation strategies in patients with COPD. European Respiratory Journal. 2013;41:727–34.Google Scholar
Rigotti, NA, Pipe, AL, Benowitz, NL, et al. Efficacy and safety of varenicline for smoking cessation in patients with cardiovascular disease: a randomized trial. Circulation. 2010;121:221–9.Google Scholar
Puhan, MA, Scharplatz, M, Troosters, T, Steurer, J. Respiratory rehabilitation after acute exacerbation of COPD may reduce risk for readmission and mortality – a systematic review. Respiratory Research. 2005;6:54.Google Scholar
Qaseem, A, Wilt, TJ, Weinberger, SE, et al. Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society. Annals of Internal Medicine. 2011;155:179–91.Google Scholar
Wongsurakiat, P, Maranetra, KN, Wasi, C, Acute respiratory illness in patients with COPD and the effectiveness of influenza vaccination: a randomized controlled study. Chest. 2004;125:2011–20.Google Scholar
Sethi, S, Murphy, TF. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med. 2008;359:2355–65.Google Scholar
Ram, FS, Picot, J, Lightowler, J, Wedzicha, JA. Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2004;3:CD004104.Google Scholar
Niewoehner, DE, Erbland, ML, Deupree, RH, et al. Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease: Department of Veterans Affairs Cooperative Study Group. N Engl J Med. 1999;340:1941–7.Google Scholar
Leuppi, JD, Schuetz, P, Bingisser, R, et al. Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA. 2013;309:2223–31.Google Scholar
Vollenweider, DJ, Jarrett, H, Steurer-Stey, CA, Antibiotics for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012;12:CD010257.Google Scholar
Keam, SJ, Keating, GM. Tiotropium bromide: a review of its use as maintenance therapy in patients with COPD. Treatments in Respiratory Medicine. 2004;3:247–68.Google Scholar
Suissa, S, Assimes, T, Ernst, P. Inhaled short acting beta agonist use in COPD and the risk of acute myocardial infarction. Thorax. 2003;58:43–6.Google Scholar
Kesten, S, Jara, M, Wentworth, C, Lanes, S. Pooled clinical trial analysis of tiotropium safety. Chest. 2006;130:1695–703.Google Scholar
Calverley, PM, Stockley, RA, Seemungal, TA, et al. Reported pneumonia in patients with COPD: findings from the INSPIRE study. Chest. 2011;139:505–12.Google Scholar
Connors, AF Jr, Dawson, NV, Thomas, C, et al. Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments). American Journal of Respiratory and Critical Care Medicine. 1996;154:959–67.Google Scholar
File, TM Jr, Marrie, TJ. Burden of community-acquired pneumonia in North American adults. Postgraduate Medicine 2010;122:130–41.Google Scholar
Ruhnke, GW, Coca-Perraillon, M, Kitch, BT, Cutler, DM. Marked reduction in 30-day mortality among elderly patients with community-acquired pneumonia. American Journal of Medicine. 2011;124:171–8 e1.Google Scholar
Marrie, TJ, Huang, JQ. Epidemiology of community-acquired pneumonia in Edmonton, Alberta: an emergency department-based study. Canadian Respiratory Journal. 2005;12:139–42.Google Scholar
Metlay, JP, Kapoor, WN, Fine, MJ. Does this patient have community-acquired pneumonia? Diagnosing pneumonia by history and physical examination. JAMA. 1997;278:1440–5.Google Scholar
Mandell, LA, Wunderink, RG, Anzueto, A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clinical Infectious Diseases. 2007;44 Suppl 2:S2772.Google Scholar
American Thoracic Society and Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. American Journal of Respiratory and Critical Care Medicine. 2005;171:388416.Google Scholar
Loeb, M, Carusone, SC, Goeree, R, et al. Effect of a clinical pathway to reduce hospitalizations in nursing home residents with pneumonia: a randomized controlled trial. JAMA. 2006;295:2503–10.Google Scholar
Fine, MJ, Auble, TE, Yealy, DM, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997;336:243–50.Google Scholar
Lim, WS, van der Eerden, MM, Laing, R, et al. Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study. Thorax. 2003;58:377–82.Google Scholar
Givens, JL, Jones, RN, Shaffer, ML, et al. Survival and comfort after treatment of pneumonia in advanced dementia. Archives of Internal Medicine. 2010;170:1102–7.Google Scholar
van der Steen, JT, Lane, P, Kowall, NW, et al. Antibiotics and mortality in patients with lower respiratory infection and advanced dementia. Journal of the American Medical Directors Association. 2012;13:156–61.Google Scholar
Kroger, K, Kupper-Nybelen, J, Moerchel, C, et al. Prevalence and economic burden of pulmonary embolism in Germany. Vascular Medicine. 2012;17:303–9.Google Scholar
Horlander, KT, Mannino, DM, Leeper, KV. Pulmonary embolism mortality in the United States, 1979–1998: an analysis using multiple-cause mortality data. Archives of Internal Medicine. 2003;163:1711–7.Google Scholar
Heit, JA, O’Fallon, WM, Petterson, TM, et al. Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Archives of Internal Medicine. 2002;162:1245–8.Google Scholar
Zoller, B, Li, X, Sundquist, J, Sundquist, K. Risk of pulmonary embolism in patients with autoimmune disorders: a nationwide follow-up study from Sweden. Lancet. 2012;379:244–9.Google Scholar
Goldhaber, SZ, Grodstein, F, Stampfer, MJ, et al. A prospective study of risk factors for pulmonary embolism in women. JAMA. 1997;277:642–5.Google Scholar
Stein, PD, Beemath, A, Matta, F, et al. Clinical characteristics of patients with acute pulmonary embolism: data from PIOPED II. American Journal of Medicine. 2007;120:871–9.Google Scholar
Stein, PD, Hull, RD, Patel, KC, et al. D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review. Annals of Internal Medicine. 2004;140:589602.Google Scholar
Stein, PD, Athanasoulis, C, Alavi, A, et al. Complications and validity of pulmonary angiography in acute pulmonary embolism. Circulation. 1992;85:462–8.Google Scholar
Investigators, P. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA. 1990;263:2753–9.Google Scholar
Stein, PD, Fowler, SE, Goodman, LR, et al. Multidetector computed tomography for acute pulmonary embolism. N Engl J Med. 2006;354:2317–27.Google Scholar
van Belle, A, Buller, HR, Huisman, MV, et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography. JAMA. 2006;295:172–9.Google Scholar
Kernohan, RJ, Todd, C. Heparin therapy in thromboembolic disease. Lancet. 1966;1:621–3.Google Scholar
Kearon, C, Akl, EA, Comerota, AJ, et al. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012;141:e419S–94S.Google Scholar
Van Dongen, CJ, van den Belt, AG, Prins, MH, Lensing, AW. Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism. Cochrane Database Syst Rev. 2004;4:CD001100.Google Scholar
Van den Berghe, G, de Zegher, F, Bouillon, R. Clinical review 95: acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab. 1998;83:1827–34.Google Scholar
Righini, M, Goehring, C, Bounameaux, H, Perrier, A. Effects of age on the performance of common diagnostic tests for pulmonary embolism. American Journal of Medicine. 2000;109:357–61.Google Scholar
Raghu, G, Weycker, D, Edelsberg, J, et al. Incidence and prevalence of idiopathic pulmonary fibrosis. American Journal of Respiratory and Critical Care Medicine. 2006;174:810–6.Google Scholar
Bohadana, A, Izbicki, G, Kraman, SS. Fundamentals of lung auscultation. New Eng J Med. 2014;370:744–51.Google Scholar
Spicknall, KE, Zirwas, MJ, English, JC 3rd. Clubbing: an update on diagnosis, differential diagnosis, pathophysiology, and clinical relevance. Journal of the American Academy of Dermatology. 2005;52:1020–8.Google Scholar
Chetta, A, Marangio, E, Olivieri, D. Pulmonary function testing in interstitial lung diseases. Respiration. 2004;71:209–13.Google Scholar
Pipavath, S, Godwin, JD. Imaging of interstitial lung disease. Clinics in Chest Medicine. 2004;25:455–65, vvi.Google Scholar
Wittram, C, Mark, EJ, McLoud, TC. CT-histologic correlation of the ATS/ERS 2002 classification of idiopathic interstitial pneumonias. Radiographics. 2003;23:1057–71.Google Scholar
Carrington, CB, Gaensler, EA, Coutu, RE, et al. Natural history and treated course of usual and desquamative interstitial pneumonia. N Engl J Med. 1978;298:801–9.Google Scholar
Raghu, G, Collard, HR, Egan, JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. American Journal of Respiratory and Critical Care Medicine. 2011;183:788824.Google Scholar
Douglas, WW, Ryu, JH, Schroeder, DR. Idiopathic pulmonary fibrosis: impact of oxygen and colchicine, prednisone, or no therapy on survival. American Journal of Respiratory and Critical Care Medicine. 2000;161:1172–8.Google Scholar
Idiopathic Pulmonary Fibrosis Clinical Research Network, Raghu, G, Anstrom, KJ, et al. Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. N Engl J Med. 2012;366:1968–77.Google Scholar
King, TE Jr, Bradford, WZ, Castro-Bernardini, S, et al. A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis. N Engl J Med. 2014;370:2083–92.Google Scholar
Richeldi, L, du Bois, RM, Raghu, G, et al. Efficacy and safety of Nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 2014;370:2071–82.Google Scholar
Winthrop, KL, McNelley, E, Kendall, B, et al. Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease. American Journal of Respiratory and Critical Care Medicine. 2010;182:977–82.Google Scholar
Teirstein, AS, Damsker, B, Kirschner, PA, et al. Pulmonary infection with Mycobacterium avium-intracellulare: diagnosis, clinical patterns, treatment. Mount Sinai Journal of Medicine. 1990;57:209–15.Google Scholar
Reich, JM, Johnson, RE. Mycobacterium avium complex pulmonary disease presenting as an isolated lingular or middle lobe pattern: the Lady Windermere syndrome. Chest. 1992;101:1605–9.Google Scholar
Prince, DS, Peterson, DD, Steiner, RM, et al. Infection with Mycobacterium avium complex in patients without predisposing conditions. N Engl J Med. 1989;321:863–8.Google Scholar
Griffith, DE, Aksamit, T, Brown-Elliott, BA, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. American Journal of Respiratory and Critical Care Medicine. 2007;175:367416.Google Scholar
Young, T, Palta, M, Dempsey, J, et al. Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study. WMJ: Official Publication of the State Medical Society of Wisconsin. 2009;108:246–9.Google Scholar
Peppard, PE, Young, T, Barnet, JH, et al. Increased prevalence of sleep-disordered breathing in adults. American Journal of Epidemiology. 2013;177:1006–14.Google Scholar
Peppard, PE, Young, T, Palta, M, et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000;284:3015–21.Google Scholar
Wetter, DW, Young, TB, Bidwell, TR, et al. Smoking as a risk factor for sleep-disordered breathing. Archives of Internal Medicine.1994;154:2219–24.Google Scholar
George, CF. Sleep apnea, alertness, and motor vehicle crashes. American Journal of Respiratory and Critical Care Medicine. 2007;176:954–6.Google Scholar
Marin, JM, Agusti, A, Villar, I, et al. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA. 2012;307:2169–76.Google Scholar
Marin, JM, Carrizo, SJ, Vicente, E, Agusti, AG. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365:1046–53.Google Scholar
Monahan, K, Storfer-Isser, A, Mehra, R, et al. Triggering of nocturnal arrhythmias by sleep-disordered breathing events. Journal of the American College of Cardiology. 2009;54:1797–804.Google Scholar
Duchna, HW. [Sleep-related breathing disorders–a second edition of the International Classification of Sleep Disorders (ICSD-2) of the American Academy of Sleep Medicine (AASM)]. Pneumologie. 2006;60:568–75.Google Scholar
Giles, TL, Lasserson, TJ, Smith, BJ, et al. Continuous positive airways pressure for obstructive sleep apnoea in adults. Cochrane Database Syst Rev. 2006;3:CD001106.Google Scholar
Chelluri, L, Grenvik, A, Silverman, M. Intensive care for critically ill elderly: mortality, costs, and quality of life. Review of the literature. Archives of Internal Medicine. 1995;155:1013–22.Google Scholar
Hamel, MB, Teno, JM, Goldman, L, et al. Patient age and decisions to withhold life-sustaining treatments from seriously ill, hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment. Annals of Internal Medicine. 1999;130:116–25.Google Scholar
Knaus, WA, Wagner, DP, Draper, EA, et al. The APACHE III prognostic system: risk prediction of hospital mortality for critically ill hospitalized adults. Chest. 1991;100:1619–36.Google Scholar
Danis, M, Patrick, DL, Southerland, LI, Green, ML. Patients’ and families’ preferences for medical intensive care. JAMA. 1988;260:797802.Google Scholar
Lynn, J, Goldstein, NE. Advance care planning for fatal chronic illness: avoiding commonplace errors and unwarranted suffering. Annals of Internal Medicine. 2003;138:812–8.Google Scholar
McNicoll, L, Pisani, MA, Zhang, Y, et al. Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Ger Soc. 2003;51:591–8.Google Scholar
Thomason, JW, Shintani, A, Peterson, JF, et al. Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Critical Care. 2005;9:R375–81.Google Scholar
Carson, SS, Kress, JP, Rodgers, JE, et al. A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Critical Care Medicine. 2006;34:1326–32.Google Scholar
Angus, DC, Linde-Zwirble, WT, Lidicker, J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical Care Medicine. 2001;29:1303–10.Google Scholar
Carson, SS. Outcomes of prolonged mechanical ventilation. Curr Opin Crit Care. 2006;12:405–11.Google Scholar
Weng, CL, Zhao, YT, Liu, QH, et al. Meta-analysis: noninvasive ventilation in acute cardiogenic pulmonary edema. Annals of Internal Medicine. 2010;152:590600.Google Scholar

References

Becher, A., Dent, J. Systematic review: aging and gastro-oesophageal reflux disease symptoms, oesophageal function and reflux oesophagitis. Aliment Pharmacol Ther. 2011: 33:442–54.Google Scholar
Morganstern, B, Anandasabapathy, S. GERD and Barrett’s esophagus: diagnotic and management strategies in the geriatric population. Geriatrics. 2009. 64:912.Google Scholar
Desilets, AR, Asal, NJ, Dunican, KC. Considerations for the use of proton pump inhibitors in older adults. Consult Pharm. 2012; 27:114–20.Google Scholar
Lee, J, Anggiansah, A, Anggiansah, R. et al. Effects of age on the gastroesophageal junction, esophageal motility, and reflux disease. Clin Gastroenterol Hepatol. 2007; 5:1392–8.Google Scholar
Esfandyari, T, Potter, JW, Vaczi, MF. Dysphagia: a cost analysis of the diagnostic approach. Am J Gastroenterol. 2002: 97–2733–7.Google Scholar
Griffin, MR: Epidemiology of nonsteroidal anti-inflammatory drug-associated gastrointestinal injury. Am J Med 1998;104: 23S.Google Scholar
Rosen, AM: Gastrointestinal bleeding in the elderly. Clin Geriatr Med 1999;15: 511.Google Scholar
Farrell, JJ, Friedman LS: gastrointestinal bleeding in the elderly. Gastroenterol Clin North Am 2001;30:377.Google Scholar
Saif, MW, Makrilia, N, Zalonis, A, et al. Gastric cancer in the elderly: an overview. Eur J Surg Oncol. 2010; 36:709–17.Google Scholar
Williams, JJ, Beck, PL, Andrews, CN, et al. Microscopic colitis – a common cause of diarrhoea in older adults. Age and Aging 2010;39:162–8.Google Scholar
Stollman, NH, et al. Diagnosis and management of diverticular disease of the colon in adults. Am J Gastroenterology 1999;94:3110–21.Google Scholar
Murad, Y, Radi, ZA, Murad, M, Hall, K. Inflammatory bowel disease in the geriatric population. Front Biosci. 2011 Jun;1(3):945–54.Google Scholar
Soffer, EE, Hull, T. Fecal incontinence: a practical approach to evaluation and treatment. Am J Gastroenterology 2000;95:1873–80.Google Scholar
Tariq, SH. Fecal incontinence in older adults. Clin Geriatr Med 2007;23:857–69.Google Scholar
Mertz, H, Naliboff, B, Mayer, EA. Symptoms and physiology in severe chronic constipation. Am J Gastroenterology 1999;94:131–8.Google Scholar
Stevens, TK, Palmer, RM. Fecal incontinence in long-term care patients. Long-Term Care Interface 2007;8:35–9.Google Scholar
Brandt, LJ, Boley, SJ AGA technical review on intestinal ischemia. Gastroenterology 2000;118:954.Google Scholar
Greenwald, DA, Brandt, LJ, Reinus, JF. Ischemic bowel disease in the elderly. Gastroenterol Clin North Am 2001;30:445.Google Scholar
Koutroubakis, IE, Sfiridaki, A, Theodoropoulou, A, et al. Role of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients. Gastroenterology 2001;121:561–5.Google Scholar
Befeler, AS, Di Bisceglie, AM. Infections of the liver: hepatitis B. Infect Dis Clin North Am 2000;14:617–32.Google Scholar
Lauer, GM, Walker, BD. Hepatitis C virus infection. N Engl J Med 2001;345:4152.Google Scholar
Regev, A, Schiff, ER. Liver disease in the elderly. Gastroenterol Clin North Am 2001;30:547–63.Google Scholar
Affronti, J. Biliary disease in the elderly patient. Clin Geriatr Med 1999;15: 571–8.Google Scholar
Spira, RM, Nissan, A, Zamir, O, et al. Percutaneous transhepatic cholecystostomy and delayed laparoscopic cholecystectomy in critically ill patients with acute cholecystitis. Am. J. Surg. 2002; 183:62–6.Google Scholar
Martin, SP, Ulrich, CD. Pancreatic disease in the elderly. Clin Geriatr Med 1999;15:579605.Google Scholar
Ross, SO, Forsmark, CE. Pancreatic and biliary disorders in the elderly. Gastroenterol Clin North Am 2001;30:531–45.Google Scholar
Chapman, IM. Weight loss in older persons. Med Clin North Amer 2011;95:579–93.Google Scholar
Jensen, GL, McGee, M, Binkley, B. Nutrition in the elderly. Gastroenterol Clin North Am 2001;30: 313–34.Google Scholar
Meyyazhagan, S, Palmer, RM. Nutritional requirements with aging: prevention of disease. Clin Geriatr Med 2002;18:557–76.Google Scholar

References

Heron, MP, Smith, BL. Deaths: leading causes for 2003. National Vital Statistics Reports 2007 March 15;55:192Google Scholar
Hyde, Z, Flicker, L, Hankey, GJ, et al. Prevalence of sexual activity and associated factors in men aged 75 to 95 years: a cohort study. Annals of Internal Medicine 2010;153(11):693702.Google Scholar
Van Duin, D. Diagnostic challenges and opportunities in older adults with infectious diseases. Clinical Infectious Diseases: an official publication of the Infectious Diseases Society of America 2012;54(7):973–8.Google Scholar
Grubeck-Loebenstein, B, Wick, G. The aging of the immune system. Adv Immunol 2002;80:243–84.Google Scholar
Linton, PJ, Dorshkind, K. Age-related changes in lymphocyte development and function. Nat Immunol 2004;5:133–9.Google Scholar
Aspinall, R. Age-related changes in the function of T cells. Microsc Res Tech 2003;62:508–13.Google Scholar
Plackett, TP, Boehmer, ED, Faunce, DE, Kovacs, EJ. Aging and innate immune cells. J Leukoc Biol 2004;76:291–9.Google Scholar
Van Duin, D, Allore, HG, Mohanty, S, et al. Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis 2007;195(11):1590–7.Google Scholar
Van Duin, D, Mohanty, S, Thomas, V, et al. Age-associated defect in human TLR-1/2 function. J Immunol 2007;178(2):970–5.Google Scholar
Van Duin, D, Shaw, AC. Toll-like receptors in older adults. J Am Geriatr Soc 2007;55(9):1438–44.Google Scholar
Davenport, RJ. Immunity challenge. Sci Aging Knowledge Environ 2003;23:16.Google Scholar
Vallejo, AN. CD28 extinction in human T cells: altered functions and the program of T-cell senescence. Immunological Reviews 2005;205(1):158–69.Google Scholar
Posnett, DN, Sinha, R, Kabak, S, Russo, C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to “benign monoclonal gammapathy.” J Expl Med 1994;179:609–18.Google Scholar
Howells, CHL, Vesselinova Jenkins, CK, Evans, AD, et al. Influenza vaccination and mortality from bronchopneumonia in the elderly. Lancet 1975;1:381–3.Google Scholar
Ammann, AJ, Schiffman, G, Austrian, R. The antibody responses to pneumococcal capsular polysaccharides in the aged. Proc Soc Exp Biol Med 1980;164:312–6.CrossRefGoogle Scholar
Htwe, TH, Mushtaq, A, Robinson, SB, et al. Infections in the elderly. Infect Clin N Am 2007;21(3):711–43.Google Scholar
Greenberg, S. Administration on Aging: Profile of older Americans: 2005;30. Available at: www.aoa.acl.gov/Aging_Statistics/Profile/2005/2005profile.pdf (accessed February 4, 2016).Google Scholar
Branson, BM, Handsfield, HH, Lampe, MA, et al. Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR 2006;55(RR-14):117.Google Scholar
Mouton, CP, Bazaldua, OV. Common infections in older adults. Am Fam Physician 2001;63:257–68.Google Scholar
Yoshikawa, TT, Norman, DC. Fever in the elderly. Infect Med 1998;15:704–6.Google Scholar
Norman, DC. Special infectious disease problems in geriatrics. Clin Geriatr 1999;(Suppl 1):35.Google Scholar
Fraser, D. Assessing the elderly for infections. J Gerontol Nurs 1997;23:510.Google Scholar
Yoshikawa, TT. Ambulatory management of common infections in elderly patients. Infect Med 1991;20:3743.Google Scholar
Pfisterer, MH, Griffiths, DJ, Schaefer, W, et al. The effect of age on lower urinary tract function: a study in women. J Am Geriatr Soc 2006;54:405–12.CrossRefGoogle ScholarPubMed
McCue, JD. Treatment of urinary tract infections in long-term care facilities: advice, guidelines and algorithms. Clin Geriatr 1999;(Suppl):11–7.Google Scholar
Nicolle, LE. Urinary tract infection in long-term-care facility residents. Clin Infect Dis 2000;31:757–61.Google Scholar
Zhanel, GG, Harding, G. K., Guay, D. R. Asymptomatic bacteriuria. Which patients should be treated? Arch Intern Med 1990;150:1389–96.Google Scholar
Lienderrozos, HJ. Urinary tract infections: management rationale for uncomplicated cystitis. Clin Fam Pract 2004;6:157–73.Google Scholar
Meyer, KC. Lung infections and aging. Ageing Res Rev 2004;3:5567.Google Scholar
Meyer, KC. Aging. Proc Am Thorac Soc 2005;2:433–9.Google Scholar
Venkatesan, P, Gladman, J., MacFarlane, J., et al. A hospital study of community acquired pneumonia in the elderly. Thorax 1990;17:254–8.Google Scholar
Riquelme, R, Torres, AWI, Ebiary, M., et al. Community-acquired pneumonia in the elderly. Am J Respir Crit Care Med 1997;156:1908–14.Google Scholar
Hash, R, Stephens, J., Laurens, M., et al. The relationship between volume status, hydration, and radiographic findings in the diagnosis of community-acquired pneumonia. J Fam Pract 2000;49:833–7.Google ScholarPubMed
Loeb, M. Pneumonia in older persons. Clin Infect Dis 2003;37:1335–9.Google Scholar
Meehan, T, Fine, M, Krumholz, H, et al. Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA 1997;278:2080–4.Google Scholar
Ruiz, M, Ewing, S, Marcos, M, et al. Etiology of community-acquired pneumonia: impact of age, comorbidity, and severity. Am J Respir Crit Care Med 1999;160:397405.Google Scholar
General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recommendations and Reports 2011;60: 164.Google Scholar
Lowen, AC, Mubareka, S, Steel, J, Palese, P. Influenza virus transmission is dependent on relative humidity and temperature. PLoS Pathogens 2007 Oct 19;3(10):1470–6.Google Scholar
Govaert, TME, Dinant, GJ, Aretz, K, et al. The predictive value of influenza symptomatology in elderly people. Fam Pract 1998;15:1622.Google Scholar
Talbot, HK, Falsey, AR. The diagnosis of viral respiratory disease in older adults. Clin Infect Dis 2010;50(5):747–51.Google ScholarPubMed
Winquist, AG, Fukada, K, Bridges, CB, Cox, NJ. Neuraminidase inhibitors for treatment of influenza A and B infections. MMWR 1999;48(RR-14):19.Google Scholar
Kuhle, C, Evans, JM. Prevention and treatment of influenza infections in the elderly. Clin Geriatr 1999;7(2):2735.Google Scholar
Centers for Disease Control and Prevention. Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007–2008. Available at: www.cdc.gov/flu/professionals/acip (accessed June 1, 2008).Google Scholar
Gross, PA, Hermogenes, AW, Sacks, HS, et al. The efficacy of influenza vaccine in elderly persons: a meta-analysis and review of the literature. Ann Intern Med 1995;123:518–27.Google Scholar
Panda, A, Qian, F, Mohanty, S, et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 2010;184(5):2518–27.Google Scholar
Goronzy, JJ, Fulbright, JW, Crowson, CS, et al. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol 2001;75(24):12182–7.CrossRefGoogle ScholarPubMed
Dutt, AK, Stead, WW. Tuberculosis in the elderly. Med Clin North Am 1993;77:1353–68.Google Scholar
Zevallos, M, Justman, JE. Tuberculosis in the elderly. Clin Geriatr Med 2003;19:121–38.Google Scholar
Imperato, J, Sanchez, LD. Pulmonary emergencies in the elderly. Emerg Med Clin N Am 2006;24:317–38.CrossRefGoogle ScholarPubMed
American Thoracic Society Workshop. Rapid diagnostic tests for tuberculosis: what is the appropriate use? Am J Respir Crit Care Med 1997 May;155(5):1804–14.Google Scholar
Menzies, D. Interpretation of repeated tuberculin tests. Boosting, Conversion, and Reversion 1999;159:1521.Google Scholar
Pai, M, Riley, LW, Colford, JM Jr. Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis 2004;4:761–76.Google Scholar
Menzies, D, Pai, M, Comstock, G. Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas of uncertainty and recommendations for research. Ann Intern Med 2007;146:340–54.Google Scholar
Mazurek, GH, Jereb, J, Lobue, P, et al. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR 2005;54:4955.Google Scholar
Bass, J, Farer, L, Hopewell, P, et al. Treatment of tuberculosis and tuberculosis infection in adults and children. American Thoracic Society and the Centers for Disease Control and Prevention. Am J Respir Crit Care Med 1994;149:1359–74.Google Scholar
Blumberg, HM, Burman, WJ, Chaisson, RE, et al. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America. Treatment of tuberculosis. Am J Respir Crit Care Med 2003;167:603–62.Google Scholar
Jasmer, RM, Nahid, P, Hopewell, PC. Clinical practice: latent tuberculosis infection. N Engl J Med 2002;347:1860–6.Google Scholar
Kopanoff, DE, Snider, DE Jr, Caras, GJ. Isoniazid-related hepatitis: a US Public Health Service Cooperative Surveillance Study. Am Rev Respir Dis 1978;117:9911001.Google Scholar
Nolan, CM, Goldberg, SV, Buskin, SE. Hepatotoxicity associated with isoniazid preventive therapy: a 7-year survey from a public health tuberculosis clinic. JAMA 1999;281:1014–18.Google Scholar
Oestreicher, R, Dressler, SH, Middlebrook, G. Peripheral neuritis in tuberculous patients treated with isoniazid. Am Rev Tuberc 1954;70:504–8.Google Scholar
Snider, DE Jr. Pyridoxine supplementation during isoniazid therapy. Tubercle 1980;61:191–6.Google Scholar
Dworkin, RH, Johnson, RW, Breuer, J, et al. Recommendations for the management of herpes zoster. Clin Infect Dis 2007;44:S144.Google Scholar
Weinberg, JM, Vafaie, J, Scheinfeld, NS. Skin infections in the elderly. Dermatol Clin 2004;22:5161.Google Scholar
Heininger, U, Seward, J. Varicella. Lancet 2006;368:1365–76.Google Scholar
Schmader, KE, Studenski, S. Are current therapies useful for the prevention of postherpetic neuralgia? A critical analysis of the literature. J Gen Intern Med 1989;4(2):83–9.Google Scholar
Kost, RG, Straus, SE. Postherpetic neuralgia – pathogenesis, treatment and prevention. N Engl J Med 1996;335:3242.Google Scholar
Kimberlin, D, Whitley, RJ. Varicella-zoster vaccine for the prevention of herpes zoster. N Engl J Med 2007;356:1338–43.Google Scholar
Oxman, MN, Levin, MJ, Johnson, GR, et al. A vaccine to prevent herpes zoster and post-herpetic neuralgia in older adults. N Engl J Med 2005;352(22):2271–84.Google Scholar
Cohen, JI. Clinical practice: Herpes zoster. N Engl J Med 2013;369(3):255–63.Google Scholar
Crossley, KB, Archer, GL. The Staphylococci in Human Disease. New York: Churchill Livingstone, 1997.Google Scholar
Kaplan, AH. Staphylococci infections. Netter’s Internal Medicine. Teterboro, NJ: Icon Learning Systems, 2003.Google Scholar
Chambers, HF. The changing epidemiology of Staphylococcus aureus? Emerg Infect Dis 2001;7:178–82.Google Scholar
Moran, GJ, Krishnadasan, A, Gorwitz, RJ, et al. Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 2006;355: 666–74.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention. Outbreaks of community-associated methicillin-resistant Staphylococcus aureus skin infections – Los Angeles County, California, 2002–2003. MMWR 2003;52:88.Google Scholar
Foster, TJ. The Staphylococcus aureus “superbug.” J Clin Invest 2004;114:1693–6.Google Scholar
Liu, C, Chambers, HF. Staphylococcus aureus with heterogeneous resistance to vancomycin: epidemiology, clinical significance, and critical assessment of diagnostic methods. Antimicrob Agents Chemother 2003;47:3040–5.Google Scholar
Simor, A, Phillips, E, McGeer, A, et al. Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. Clin Infect Dis 2007;44:178–85.Google Scholar

References

Centers for Disease Control. HIV among older Americans, 2013. Available at: www.cdc.gov/hiv/risk/age/olderamericans/index.html (accessed December 4, 2014).Google Scholar
O’Keefe, KJ, Scheer, S, Chen, MJ, et al. People fifty years or older now account for the majority of AIDS cases in San Francisco, California, 2010. AIDS Care. 2013;25(9):1145–8.Google Scholar
CDC. HIV Surveillance Report, 2011. Available at: www.cdc.gov/hiv/library/reports/surveillance/2011/surveillance_Report_vol_23.html (accessed December 4, 2014).Google Scholar
Samji, H, Cescon, A, Hogg, RS, et al. Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada. PLoS One. 2013 Dec 18;8(12):e81355.Google Scholar
Luther, VP, Wilkin, AM. HIV infection in older adults. Clin Geriatr Med. 2007 Aug;23(3):567–83, vii.Google Scholar
Illa, L, Brickman, A, Saint-Jean, G, et al. Sexual risk behaviors in late middle age and older HIV seropositive adults. AIDS Behav. 2008 Nov;12(6):935–42.Google Scholar
Lekas, HM, Schrimshaw, EW, Siegel, K. Pathways to HIV testing among adults aged fifty and older with HIV/AIDS. AIDS Care. 2005 Aug;17(6):674–87.Google Scholar
Branson, BM, Handsfield, HH, Lampe, MA, et al. Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR Recomm Rep. 2006 Sep 22;55(RR-14):117.Google Scholar
US Preventive Services Task Force. AHRQ publication number 12–05173-EF-3. April 2013. Available at: www.cdc.gov/nchhstp/preventionthroughhealthcare/preventiveservices/hivaids.htm (accessed February 4, 2016).Google Scholar
Lindau, ST, Schumm, LP, Laumann, EO, et al. A study of sexuality and health among older adults in the United States. N Engl J Med. 2007 Aug 23;357(8):762–74.Google Scholar
CDC and APHL. Laboratory testing for the diagnosis of HIV infection: updated recommendations. Version June 27, 2014. Available at: http://stacks.cdc.gov/view/cdc/23447 (accessed February 4, 2016).Google Scholar
Stoff, DM, Khalsa, JH, Monjan, A, Portegies, P. Introduction: HIV/AIDS and Aging. AIDS. 2004 Jan 1;18(Suppl 1):S12.Google Scholar
Observational HIV Epidemiological Research Europe (COHERE) Study Group, Sabin, CA, Smith, CJ, et al. Response to combination antiretroviral therapy: variation by age. AIDS. 2008 Jul 31;22(12):1463–73.Google Scholar
Heaton, RK, Franklin, DR, Ellis, RJ, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011 Feb;17(1):316.Google Scholar
Ances, BM, Ellis, RJ. Dementia and neurocognitive disorders due to HIV-1 infection. Semin Neurol. 2007 Feb;27(1):8692.Google Scholar
McArthur, JC, Haughey, N, Gartner, S, et al. Human immunodeficiency virus-associated dementia: an evolving disease. J Neurovirol. 2003 Apr;9(2):205–21.Google Scholar
Engels, EA, Biggar, RJ, Hall, HI, et al. Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer. 2008;123:187–94.Google Scholar
Szerlip, MA, DeSalvo, KB, Szerlip, HM. Predictors of HIV-infection in older adults. J Aging Health. 2005 Jun;17(3):293304.Google Scholar
Guaraldi, G, Orlando, G, Zona, S, et al. Premature age-related comorbidities among HIV-infected persons compared with the general population. Clin Infect Dis. 2011 Dec;53(11):1120–6.Google Scholar
Goulet, JL, Fultz, SL, Rimland, D, et al. Aging and infectious diseases: do patterns of comorbidity vary by HIV status, age, and HIV severity? Clin Infect Dis. 2007;45:15931601.Google Scholar
Losina, E, Linas, B, Hyle, E, et al. Projecting 10-year, 20-year, and lifetime risks of cardiovascular disease in HIV+ individuals in the US: competing risks and premature aging. Program and abstracts of the 20th Conference on Retroviruses and Opportunistic Infections; March 3–6, 2013; Atlanta, GA. Abstract 747.Google Scholar
Bhavan, KP, Kampalath, VN, Overton, ET. The aging of the HIV epidemic. Curr HIV/AIDS Rep. 2008;5:150–8.Google Scholar
Triant, VA, Lee, H, Hadigan, C, Grinspoon, SK. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab. 2007 Jul;92(7):2506–12.Google Scholar
Johnsen, S, Dolan, SE, Fitch, KV, et al. Carotid intimal medial thickness in human immunodeficiency virus-infected women: effects of protease inhibitor use, cardiac risk factors, and the metabolic syndrome. J Clin Endocrinol Metab. 2006 Dec;91(12):4916–24.Google Scholar
Post, WS, Budoff, M, Kingsley, L, et al. Associations between HIV infection and subclinical coronary atherosclerosis. Ann Intern Med 2014 Apr 1;160(7):458–67.Google Scholar
Bedimo, R, Zhang, S, Drechsler, H, et al. Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents. Program and abstracts of the 6th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention; July 17–20, 2011; Rome, Italy. Abstract MoAB0101.Google Scholar
Gebo, KA, Justice, A. HIV infection in the elderly. Curr Infect Dis Rep. 2009 May;11(3):246–54.Google Scholar
Margolick, J, Detels, R, Phair, J, et al. Earlier occurrence of the frailty phenotype in HIV+ men than HIV- men: the MACS. Program and abstracts of the 18th Conference on Retroviruses and Opportunistic Infections; February 27–March 2, 2011; Boston, MA. Abstract 794.Google Scholar
Deeks, SG, Lewin, SR, Havlir, DV. The end of AIDS: HIV infection as a chronic disease. Lancet. 2013 Nov 2;382(9903):1525–33.Google Scholar
Hunt, PW, Martin, JN, Sinclair, E, et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003 May 15;187(10):1534–43.Google Scholar
Sandler, NG, Wand, H, Roque, A, et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis. 2011 Mar 15;203(6):780–90.Google Scholar
Brenchley, JM, Prince, DA, Schacker, TW, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006 Dec;12(12):1365–71.Google Scholar
Hunt, PW, Martin, JN, Sinclair, E, et al. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis. 2011 May 15;203(10):1474–83.Google Scholar
Fitch, KV, Looby, SE, Rope, A, et al. Effects of aging and smoking on carotid intima-media thickness in HIV-infection. AIDS. 2013 Jan 2;27(1):4957.Google Scholar
Sabin, C, Reiss, P, Ryom, L, et al. Is there continued evidence for an association between abacavir and myocardial infarction risk? Program and abstracts of the 21st Conference on Retroviruses and Opportunistic Infections; March 3–6, 2013; Boston, MA. Abstract 747LB.Google Scholar
Lichtenstein, KA, Armon, C, Buchacz, K, et al; HIV Outpatient Study (HOPS) Investigators. Low CD4+ T cell count is a risk factor for cardiovascular disease events in the HIV outpatient study. Clin Infect Dis. 2010;51:435–47.Google Scholar
Lichtenstein, KA, Armon, C, Buchacz, K, et al. Initiation of antiretroviral therapy at CD4 cell counts ≥350 cells/mm3 does not increase incidence or risk of peripheral neuropathy, anemia, or renal insufficiency. J Acquir Immune DeficSyndr. 2008;47(1):2735.Google Scholar
Strategies for Management of Antiretroviral Therapy (SMART) Study Group. CD4+ count-guided interruption of antiretroviral treatment. N Engl J Med. 2006 Nov 30;355(22):2283–96.Google Scholar
Klein, DB, Leyden, WA, Chao, CR, et al. No difference in incidence of myocardial infarction for HIV+ and HIV- individuals in recent years. Program and abstracts of the 21st Conference on Retroviruses and Opportunistic Infections; March 3–6, 2013; Boston, MA. Abstract 737.Google Scholar
Llibre, JM, Falco, V, Tural, C, et al. The changing face of HIV/AIDS in treated patients. Curr HIV Res. 2009 Jul;7(4):365–77.Google Scholar
Justice, AC, McGinnis, KA, Skanderson, M, et al.; VACS Project Team. Towards a combined prognostic index for survival in HIV infection: the role of “non-HIV” biomarkers. HIV Med. 2010 Feb;11(2):143–51.Google Scholar
White, JR, Chang, CH, Butt, AA, et al. Depression and HIV are risk factors for incident heart failure among veterans [CROI abstract 726]. In Special Issue: Abstracts from the 2014 Conference on Retroviruses and Opportunistic Infections. Top Antivir Med. 2014;22(e-1):369–70.Google Scholar
Atkinson, JH, Heaton, RK, Patterson, TL, et al. Two-year prospective study of major depressive disorder in HIV-infected men. J Affect Disord. 2008 Jun;108(3):225–34.Google Scholar
Khambaty, T, Stewart, JC, Gupta, SK, et al. Depression predicts incident myocardial infarction in HIV+ veterans: Veterans Aging Cohort Study [CROI abstract 735]. In Special Issue: Abstracts from the 2014 Conference on Retroviruses and Opportunistic Infections. Top Antivir Med. 2014;22(3-1):375.Google Scholar
Batten, SV, Aslan, M, Maciejewski, PK, Mazure, CM. Childhood maltreatment as a risk factor for adult cardiovascular disease and depression. J Clin Psychiatry. 2004 Feb;65(2):249–54.Google Scholar
Dale, S, Franklin, G, Kelso, R, et al. Childhood sexual abuse, traditional gender roles, and coronary heart disease risk among women with HIV. Second International Workshop on HIV & Women; 2012. Abstract P_14.Google Scholar
Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Available at: http://aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf (accessed December 4, 2014).Google Scholar
Garg, S, Furlow-Parmley, C, Frazier, E, et al. Prevalence of chronic kidney disease among HIV+ adults in care in the US: medical monitoring Project 2009. [CROI abstract 809]. Program and abstracts of the 20th Conference on Retroviruses and Opportunistic Infections. March 3–6, 2013; Atlanta, GA.Google Scholar
Wyatt, CM. Antiretroviral therapy and the kidney. Top Antivir Med. 2014 Jun–Jul;22(3):655–8.Google Scholar
Rockwood, N, Mandalia, S, Bower, M, et al. Ritonavir-boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir. AIDS. 2011 Aug 24;25(13):1671–3.Google Scholar
Gebo, KA, Diener-West, M, Moore, RD. Hospitalization rates differ by hepatitis C satus in an urban HIV cohort. J Acquir Immune Defic Syndr. 2003 Oct 1;34(2):165–73.Google Scholar
McCommey, GA, Tebas, P, Shane, E, et al. Bone disease in HIV infection: a practical review and recommendations for HIV care providers. Clin Infect Dis. 2010 Oct 15;51(8):937–46.Google Scholar
Tebas, P, Powderly, WG, Claxton, S, et al. Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy. AIDS. 2000 Mar 10;14(4):F63–7.Google Scholar
Overton, ET, Chan, ES, Brown, TT, et al. High-dose vitamin D and calcium attenuates bone loss with ART initiation: results from ACTG A5280 [CROI abstract 133]. In Special Issue: Abstracts from the 2014 Conference on Retroviruses and Opportunistic Infections. Top Antivir Med. 2014;22(e-1):66–7.Google Scholar
National Osteoporosis Foundation. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Washington, DC: National Osteoporosis Foundation; 2010.Google Scholar
University of Sheffield U. FRAX WHO Fracture Risk Assessment Tool. Available at: www.shef.ac.uk/FRAX/tool.aspx (accessed December 4, 2014).Google Scholar
Skapik, JL, Treisman, GJ. HIV, psychiatric comorbidity, and aging. Clinical Geriatrics. 2007(15):2636.Google Scholar
Gonzalez, JS, Batchelder, AW, Psaros, C, Safren, SA. Depression and HIV/AIDS treatment nonadherence: a review and meta-analysis. J Acquir Immune Defic Syndr. 2011 Oct 1;58(2):181–7.Google Scholar
Goodkin, K. Psychiatric aspects of HIV spectrum disease. Focus Psychiatry Review. 2007;7(3):303–10.Google Scholar
Zanjani, F, Saboe, K, Oslin, D. Age difference in rates of mental health/substance abuse and behavioral care in HIV-positive adults. AIDS Patient Care Stds. 2007 May;21(5):347–55.Google Scholar
Work Group for HIV and Aging Consensus Project. Summary report from the Human Immunodeficiency Virus and Aging Consensus Project: treatment strategies for clinicians managing older individuals with the human immunodeficiency virus. J Am Geriatr Soc. 2012 May;60(5):974–9.Google Scholar
Power, C, Selnes, OA, Grim, JA, McArthur, JC. HIV Dementia Scale: a rapid screening test. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):273–8.Google Scholar
Valcour, V, Paul, R, Chiao, S, et al. Screening for cognitive impairment in human immunodeficiency virus. Clin Infect Dis. 2011 Oct;53(8):836–42.Google Scholar
Oursler, KK, Sorkin, JD, Smith, BA, Katzel, LI. Reduced aerobic capacity and physical functioning in older HIV-infected men. AIDS Res Hum Retroviruses. 2006 Nov;22(11):1113–21.Google Scholar
Shippy, RA, Karpiak, SE. The aging HIV/AIDS population: fragile social networks. Aging Ment Health. 2005 May;9(3):246–54.Google Scholar
Brennan, DJ, Emlet, CA, Eady, A. HIV, sexual health, and psychosocial issues among older adults living with HIV in North America. Ageing International. 2011;36(3):313–33.Google Scholar
Silverberg, MJ, Leyden, W, Horberg, MA, et al. Older age and the response to and tolerability of antiretroviral therapy. Arch Intern Med. 2007 Apr 9;167(7):684–91.Google Scholar
Vance, DE, Burrage, JW. Promoting successful cognitive aging in adults with HIV: strategies for intervention. J Gerontol Nurs. 2006 Nov;32(11):3441Google Scholar
Centers for Disease Control. HIV surveillance report: diagnoses of HIV infection and AIDS in the United States and dependent areas, 2011. Available at: www.cdc.gov/hiv/statistics/basics (accessed December 4, 2014).Google Scholar
Goodroad, BK. HIV and AIDS in people older than 50: a continuing concern. J Gerontol Nurs. 2003 Apr;29(4):1824.Google Scholar
Linsk, NL. HIV among older adults: age-specific issues in prevention and treatment. AIDS Read. 2000 Jul;10(7):430–40.Google Scholar
Skiest, DJ, Keiser, P. Human immunodeficiency virus infection in patients older than 50 years: a survey of primary care physicians’ beliefs, practices, and knowledge. Arch Fam Med. 1997 May–Jun;6(3):289–94.Google Scholar
Orel, NA, Wright, JM, Wagner, J. Scarcity of HIV/AIDS risk-reduction materials targeting the needs of older adults among state departments of public health. Gerontologist. 2004 Oct;44(5):693–6.Google Scholar
Centers for Disease Control and Prevention. HIV-related knowledge and stigma: United States, 2000. MMWR. 2000;49(RR47):1062–4.Google Scholar

References

Lindeman, RD, Tobin, JD, Shock, NW. Association between blood pressure and the rate of decline in renal function with age. Kidney Int 1984;26:861–8.Google Scholar
Coresh, J, Astor, BC, Greene, T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;41:112.Google Scholar
Kaplan, C, Pasternack, B, Shah, H, Gallo, G. Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 1975;80:227–34.Google Scholar
Weidmann, P, De Myttenaere-Bursztein, S, Maxwell, MH, de Lima, J. Effect on aging on plasma renin and aldosterone in normal man. Kidney Int 1975;8:325–33.Google Scholar
Preisser, L, Teillet, L, Aliotti, S, et al. Downregulation of aquaporin-2 and -3 in aging kidney is independent of V(2) vasopressin receptor. Am J Physiol Renal Physiol 2000;279:F144–52.Google Scholar
Fliser, D, Zeier, M, Nowack, R, Ritz, E. Renal functional reserve in healthy elderly subjects. J Am Soc Nephrol 1993;3:1371–7.Google Scholar
Corman, B, Barrault, MB, Klingler, C, et al. Renin gene expression in the aging kidney: effect of sodium restriction. Mech Ageing Dev 1995;84:113.Google Scholar
Levey, AS, Bosch, JP, Lewis, JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group. Ann Intern Med. 1999;130:461–70.Google Scholar
Coresh, J, Selvin, E, Stevens, LA, et al. Prevalence of chronic kidney disease in the United States. JAMA 2007;298:2038–47.Google Scholar
Glassock, RJ, Winearls, C. Screening for CKD with eGFR: doubts and dangers. Clin J Am Soc Nephrol 2008;3:1563–8.Google Scholar
Winearls, CG, Glassock, RJ. Classification of chronic kidney disease in the elderly: pitfalls and errors. Nephron Clin Pract 2011;119(Suppl 1):c24.Google Scholar
Go, AS, Chertow, GM, Fan, D, et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004;351:1296–305.Google Scholar
Henry, RM, Kostense, PJ, Bos, G, et al. Mild renal insufficiency is associated with increased cardiovascular mortality: the Hoorn Study. Kidney Int 2002;62:1402–7.Google Scholar
Deo, R, Fyr, CL, Fried, LF, et al. Kidney dysfunction and fatal cardiovascular disease–an association independent of atherosclerotic events: results from the Health, Aging, and Body Composition (Health ABC) study. Am Heart J 2008;155:62–8.Google Scholar
Fried, LF, Katz, R, Sarnak, MJ, et al. Kidney function as a predictor of noncardiovascular mortality. J Am Soc Nephrol 2005;16:3728–35.Google Scholar
Minutolo, R, Lapi, F, Chiodini, P, et al. Risk of ESRD and death in patients with CKD not referred to a nephrologist: a 7-year prospective study. Clin J Am Soc Nephrol 2014;9(9):1586–93.Google Scholar
White, SL, Polkinghorne, KR, Atkins, RC, Chadban, SJ. Comparison of the prevalence and mortality risk of CKD in Australia using the CKD Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) Study GFR estimating equations: the AusDiab (Australian Diabetes, Obesity and Lifestyle) Study. Am J Kidney Dis 2010;55(4):660–70.Google Scholar
Briasoulis, A, Bakris, GL. Chronic kidney disease as a coronary artery disease risk equivalent. Current Cardiology Reports 2013;15:340.Google Scholar
de Brito-Ashurst, I, Varagunam, M, Raftery, MJ, Yaqoob, MM. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol 2009;20:2075–84.Google Scholar
James, PA, Oparil, S, Carter, BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311(5):507–20.Google Scholar
Locatelli, F, Del Vecchio, L. Optimizing the management of renal anemia: challenges and new opportunities. Kidney Int Suppl 2008;74:S33–7.Google Scholar
KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl 2009:S1130.Google Scholar
Anderson, S, Halter, JB, Hazzard, WR, et al. Prediction, progression, and outcomes of chronic kidney disease in older adults. J Am Soc Nephrol 2009;20:1199–209.Google Scholar
Martinez-Ramirez, HR, Jalomo-Martinez, B, Cortes-Sanabria, L, et al. Renal function preservation in type 2 diabetes mellitus patients with early nephropathy: a comparative prospective cohort study between primary health care doctors and a nephrologist. Am J Kidney Dis 2006;47:7887.Google Scholar
Emamian, SA, Nielsen, MB, Pedersen, JF, Ytte, L. Sonographic evaluation of renal appearance in 665 adult volunteers. Correlation with age and obesity. Acta Radiologica 1993;34:482–5.Google Scholar
Thomas, SE, Anderson, S, Gordon, KL, et al. Tubulointerstitial disease in aging: evidence for underlying peritubular capillary damage, a potential role for renal ischemia. J Am Soc Nephrol 1998;9:231–42.Google Scholar
Abrass, CK, Adcox, MJ, Raugi, GJ. Aging-associated changes in renal extracellular matrix. Am J Pathol 1995;146:742–52.Google Scholar
Hoy, WE, Douglas-Denton, RN, Hughson, MD, et al. A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int Suppl 2003:S31–7.Google Scholar
Hollenberg, NK, Adams, DF, Solomon, HS, et al. Senescence and the renal vasculature in normal man. Circ Res 1974;34:309–16.Google Scholar
Kuhlik, F, Epstein, F, Elahi, D, et al. Urinary prostaglandin E2 and dopamine response to water loading in young and elderly humans. Gertatr Nephrol Urol 1995;5:7983.Google Scholar
Rivas-Cabanero, L, Rodriguez-Barbero, A, Arevalo, M, Lopez-Novoa, JM. Effect of NG-nitro-L-arginine methyl ester on nephrotoxicity induced by gentamicin in rats. Nephron 1995;71:203–7.Google Scholar
Reckelhoff, JF, Manning, RD Jr. Role of endothelium-derived nitric oxide in control of renal microvasculature in aging male rats. American Journal of Physiology 1993;265:R1126–31.Google Scholar
Macias-Nunez, JF, Lopez-Novoa, JM, Martinez-Maldonado, M. Acute renal failure in the aged. Semin Nephrol 1996;16:330–8.Google Scholar
Kleinknecht, D, Landais, P, Goldfarb, B. Pathophysiology and clinical aspects of drug-induced tubular necrosis in man. Contrib Nephrol 1987;55:145–58.Google Scholar
Liano, F, Pascual, J. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group. Kidney Int 1996;50:811–8.Google Scholar
Pascual, J, Liano, F. Causes and prognosis of acute renal failure in the very old. Madrid Acute Renal Failure Study Group. J Am Geriatr Soc 1998;46:721–5.Google Scholar
Sands, JM. Urine-concentrating ability in the aging kidney. Sci Aging Knowledge Environ 2003;24:PE15.Google Scholar
Kenney, WL, Chiu, P. Influence of age on thirst and fluid intake. Med Sci Sports Exerc 2001;33:1524–32.Google Scholar
van Kraaij, DJ, Jansen, RW, Gribnau, FW, Hoefnagels, WH. Diuretic therapy in elderly heart failure patients with and without left ventricular systolic dysfunction. Drugs Aging 2000;16:289300.Google Scholar
Macias Nunez, JF, Garcia Iglesias, C, Bondia Roman, A, et al. Renal handling of sodium in old people: a functional study. Age Ageing 1978;7:178–81.Google Scholar
Cheung, CM, Ponnusamy, A, Anderton, JG. Management of acute renal failure in the elderly patient: a clinician’s guide. Drugs Aging 2008;25:455–76.Google Scholar
Rich, MW, Crecelius, CA. Incidence, risk factors, and clinical course of acute renal insufficiency after cardiac catheterization in patients 70 years of age or older: a prospective study. Archives of Internal Medicine 1990;150:1237–42.Google Scholar
Ivanes, F, Isorni, MA, Halimi, JM, et al. Predictive factors of contrast-induced nephropathy in patients undergoing primary coronary angioplasty. Arch Cardiovasc Dis 2014;107:424–32.Google Scholar
Davidson, CJ, Hlatky, M, Morris, KG, et al. Cardiovascular and renal toxicity of a nonionic radiographic contrast agent after cardiac catheterization: a prospective trial. Ann Intern Med 1989;110:119–24.Google Scholar
Lautin, EM, Freeman, NJ, Schoenfeld, AH, et al. Radiocontrast-associated renal dysfunction: incidence and risk factors. AJR Am J Roentgenol 1991;157:4958.Google Scholar
Watts, RA, Lane, SE, Bentham, G, Scott, DG. Epidemiology of systemic vasculitis: a ten-year study in the United Kingdom. Arthritis Rheum 2000;43:414–9.Google Scholar
Nachman, PH, Hogan, SL, Jennette, JC, Falk, RJ. Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis. J Am Soc Nephrol 1996;7:33–9.Google Scholar
Cole, E, Cattran, D, Magil, A, et al. A prospective randomized trial of plasma exchange as additive therapy in idiopathic crescentic glomerulonephritis. The Canadian Apheresis Study Group. Am J Kidney Dis 1992;20:261–9.Google Scholar
Mekhail, TM, Hoffman, GS. Longterm outcome of Wegener’s granulomatosis in patients with renal disease requiring dialysis. J Rheumatol 2000;27:1237–40.Google Scholar
Jayne, D, Rasmussen, N, Andrassy, K, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med 2003;349:3644.Google Scholar
Schwartz, CJ, White, TA. Stenosis of renal artery: an unselected necropsy study. BMJ 1964;2:1415–21.Google Scholar
Thadhani, RI, Camargo, CA Jr, Xavier, RJ, et al. Atheroembolic renal failure after invasive procedures. Natural history based on 52 histologically proven cases. Medicine (Baltimore) 1995;74:350–8.Google Scholar
Gupta, BK, Spinowitz, BS, Charytan, C, Wahl, SJ. Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator. Am J Kidney Dis 1993;21:659–62.Google Scholar
Hyman, BT, Landas, SK, Ashman, RF, et al. Warfarin-related purple toes syndrome and cholesterol microembolization. Am J Med 1987;82:1233–7.Google Scholar
Fukumoto, Y, Tsutsui, H, Tsuchihashi, M, et al. Cholesterol Embolism Study I: the incidence and risk factors of cholesterol embolization syndrome, a complication of cardiac catheterization: a prospective study. J Am Coll Cardiol 2003;42:211–6.Google Scholar
Haas, M, Spargo, BH, Wit, EJ, Meehan, SM. Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases. Am J Kidney Dis 2000;35:433–47.Google Scholar
Moutzouris, DA, Herlitz, L, Appel, GB, et al. Renal biopsy in the very elderly. Clin J Am Soc Nephrol 2009;4:1073–82.Google Scholar
Groeneveld, AB, Tran, DD, van der Meulen, J, et al. Acute renal failure in the medical intensive care unit: predisposing, complicating factors and outcome. Nephron 1991;59:602–10.Google Scholar
Gentric, A, Cledes, J. Immediate and long-term prognosis in acute renal failure in the elderly. Nephrol Dial Transplant 1991;6:8690.Google Scholar
Schiffl, H. Renal recovery from acute tubular necrosis requiring renal replacement therapy: a prospective study in critically ill patients. Nephrol Dial Transplant 2006;21:1248–52.Google Scholar
Bhandari, S, Turney, JH. Survivors of acute renal failure who do not recover renal function. QJM 1996;89:415–21.Google Scholar
Liano, F, Felipe, C, Tenorio, MT, et al. Long-term outcome of acute tubular necrosis: a contribution to its natural history. Kidney Int 2007;71:679–86.Google Scholar
Chertow, GM, Soroko, SH, Paganini, EP, et al. Mortality after acute renal failure: models for prognostic stratification and risk adjustment. Kidney Int 2006;70:1120–6.Google Scholar
Feest, TG, Round, A, Hamad, S. Incidence of severe acute renal failure in adults: results of a community based study. BMJ 1993;306:481–3.Google Scholar
Bulpitt, CJ, Beckett, N, Peters, R, et al. Does white coat hypertension require treatment over age 80? Results of the hypertension in the very elderly trial ambulatory blood pressure side project. Hypertension 2013;61:8994.Google Scholar
Pickering, TG, Hall, JE, Appel, LJ, et al. Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Circulation 2005;111:697716.Google Scholar
Cruickshank, JM. Coronary flow reserve and the J curve relation between diastolic blood pressure and myocardial infarction. BMJ 1988;297:1227–30.Google Scholar
Kumar, S, Berl, T. Sodium. Lancet 1998;352:220–8.Google Scholar
Kleinfeld, M, Casimir, M, Borra, S. Hyponatremia as observed in a chronic disease facility. J Am Geriatr Soc 1979;27:156–61.Google Scholar
Liamis, G, Rodenburg, EM, Hofman, A, et al. Electrolyte disorders in community subjects: prevalence and risk factors. Am J Med 2013;126:256–63.Google Scholar
Shapiro, DS, Sonnenblick, M, Galperin, I, et al. Severe hyponatraemia in elderly hospitalized patients: prevalence, aetiology and outcome. Internal Medicine Journal 2010;40:574–80.Google Scholar
Bigaillon, C, El Jahiri, Y, Garcia, C, et al. [Inappropriate ADH secretion-induced hyponatremia and associated with paroxetine use]. Rev Med Interne 2007;28:642–4.Google Scholar
Kim, CS, Choi, JS, Bae, EH, Kim, SW. Hyponatremia associated with bupropion. Electrolyte Blood Press 2011;9:23–6.Google Scholar
Rodenburg, EM, Hoorn, EJ, Ruiter, R, et al. Thiazide-associated hyponatremia: a population-based study. Am J Kidney Dis 2013;62:6772.Google Scholar
Renneboog, B, Musch, W, Vandemergel, X, et al. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med 2006;119:71 e18.Google Scholar
Gankam Kengne, F, Andres, C, Sattar, L, et al. Mild hyponatremia and risk of fracture in the ambulatory elderly. QJM 2008;101:583–8.Google Scholar
Barsony, J, Sugimura, Y, Verbalis, JG. Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss. J Biol Chem 2011;286:10864–75.Google Scholar
Tseng, CK, Lin, CH, Hsu, HS, et al. In addition to malnutrition and renal function impairment, anemia is associated with hyponatremia in the elderly. Arch Gerontol Geriatr 2012;55:7781.Google Scholar
Hawkins, RC. Age and gender as risk factors for hyponatremia and hypernatremia. Clin Chim Acta 2003;337:169–72.Google Scholar
Borra, SI, Beredo, R, Kleinfeld, M. Hypernatremia in the aging: causes, manifestations, and outcome. J Natl Med Assoc 1995;87:220–4.Google Scholar
Dinsdale, C, Wani, M, Steward, J, O’Mahony, MS. Tolerability of spironolactone as adjunctive treatment for heart failure in patients over 75 years of age. Age Ageing 2005;34:395–8.Google Scholar
Passarelli, MC, Jacob-Filho, W, Figueras, A. Adverse drug reactions in an elderly hospitalised population: inappropriate prescription is a leading cause. Drugs Aging 2005;22:767–77.Google Scholar
Bowling, CB, Pitt, B, Ahmed, MI, et al. Hypokalemia and outcomes in patients with chronic heart failure and chronic kidney disease: findings from propensity-matched studies. Circ Heart Fail 2010;3:253–60.Google Scholar
USRD. USRDS 2013 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2013. Available at: www.usrds.org/2013/pdf/v1_00_intro_13.pdf (accessed 14 November 2015).Google Scholar
Cooper, BA, Branley, P, Bulfone, L, et al. A randomized, controlled trial of early versus late initiation of dialysis. N Engl J Med 2010;363:609–19.Google Scholar
Steinman, TI. The older patient with end-stage renal disease: is chronic dialysis the best option? Semin Dial 2012;25:602–5.Google Scholar
Couchoud, C, Labeeuw, M, Moranne, O, et al. A clinical score to predict 6-month prognosis in elderly patients starting dialysis for end-stage renal disease. Nephrol Dial Transplant 2009;24:1553–61.Google Scholar
Moss, AH. Revised dialysis clinical practice guideline promotes more informed decision-making. Clin J Am Soc Nephrol 2010;5:2380–3.Google Scholar
O’Hare, AM. Vascular access for hemodialysis in older adults: a “patient first” approach. J Am Soc Nephrol 2013;24:1187–90.Google Scholar
DeSilva, RN, Patibandla, BK, Vin, Y, et al. Fistula first is not always the best strategy for the elderly. J Am Soc Nephrol 2013;24:1297–304.Google Scholar
Abdullah, BJ, Mohammad, N, Sangkar, JV, et al. Incidence of upper limb venous thrombosis associated with peripherally inserted central catheters (PICC). British Journal of Radiology 2005;78:596600.Google Scholar
OPTN/SRTR 2012 Annual Data Report. Rockville, MD: Department of Health and Human Services, Health Resources and Services Administration 2014. Available at: http://onlinelibrary.wiley.com/doi/10.1111/ajt.v14.s1/issuetoc (accessed 14 November 2015).Google Scholar

References

Bragg, E, Hansen, JC. A revelation of numbers: will America’s eldercare workforce be ready to care for an aging America? Generations. 2011;34(4):1119.Google Scholar
Davis, R, Jones, JS, Barocas, DA, et al. Diagnosis, evaluation and follow-up of asymptomatic microhematuria (AMH) in adults: AUA guideline. J Urol. 2012;18(6 Suppl):24732481.Google Scholar
Cowan, NC. CT urography for hematuria. Nat Rev Urol. 2012;9(4):218226.Google Scholar
Zargooshi, J, Nourizad, S, Vaziri, S, et al. Hematospermia: long-term outcome in 165 patients. Int J Impot Res. 2014;26(3):8386.Google Scholar
Griebling, TL. Urologic Diseases in America Project: trends in resource use for urinary tract infections in women. J Urol. 2005;173:12811287.Google Scholar
Griebling, TL. Urologic Diseases in America Project: trends in resource use for urinary tract infections in men. J Urol. 2005;173:12881294.Google Scholar
Eriksson, I, Gustafson, Y, Fagerström, L, Olofsson, B. Prevalence and factors associated with urinary tract infections (UTIs) in very old women. Arch Gerontol Geriatr. 2010;50(2):132135.Google Scholar
Tal, S, Guller, V, Levi, S, et al. Profile and prognosis of febrile elderly patients with bacteremic urinary tract infection. J Infect. 2005;50:296305.Google Scholar
Rodhe, N, Mölstad, S, Englund, L, et al. Asymptomatic bacteriuria in a population of elderly residents living in a community setting: prevalence, characteristics and associated factors. Fam Pract. 2006;23:303307.Google Scholar
Ginde, AA, Rhee, SH, Katz, ED. Predictors of outcome in geriatric patients with urinary tract infections. J Emerg Med. 2004;27:101108.Google Scholar
Dromerick, AW, Edwards, DF. Relation of postvoid residual to urinary tract infection during stroke rehabilitation. Arch Phys Med Rehabil. 2003;84:13691372.Google Scholar
Paillaud, E, Herbaud, S, Caillet, P, et al. Relations between under-nutrition and nosocomial infections in elderly patients. Age Ageing. 2005;34:619625.Google Scholar
Hazelett, SE, Tsai, M, Gareri, M, Allen, K. The association between indwelling urinary catheter use in the elderly and urinary tract infection in acute care. BMC Geriatr. 2006;6:15.Google Scholar
Henig, YS, Leahy, MM. Cranberry juice and urinary-tract health: science supports folklore. Nutrition. 2000;16:684687.Google Scholar
Caljouw, MA, van den Hout, WB, Putter, H, et al. Effectiveness of cranberry capsules to prevent urinary tract infections in vulnerable older persons: a double-blind randomized placebo-controlled trial in long-term care facilities. J Am Geriatr Soc. 2014;62(1):103110.Google Scholar
Parsons, BA, Narshi, A, Drake, MJ. Success rates for learning intermittent self-catheterisation according to age and gender. Int Urol Nephrol. 2012;44(4):11271131.Google Scholar
Pearle, MS, Calhoun, EA, Curhan, GC, et al. Urologic Diseases in America Project: urolithiasis. J Urol. 2005;173:848857.Google Scholar
Daudon, M, Doré, JC, Jungers, P, et al. Changes in stone composition according to age and gender of patients: a multivariate epidemiological approach. Urol Res. 2004;32:241247.Google Scholar
Wong, YV, Cook, P, Somani, BK. The association of metabolic syndrome and urolithiasis. Int J Endocrinol. 2015;2015:570674.Google Scholar
Usui, Y, Matsuzaki, S, Matsushita, K, et al. Urolithiasis in geriatric patients. Tokai J Exp Clin Med. 2003;28:8187.Google Scholar
Siegel, RL, Miller, KD, Jemal, A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:529.Google Scholar
Gupta, M, McCauley, J, Farkas, A, et al. Clinical practice guidelines on prostate cancer: a critical appraisal. J Urol. 2015;193(4):11531158.Google Scholar
US Preventive Services Task Force. Screening for prostate cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2008;148:185191.Google Scholar
Walter, LC, Bertenthal, D, Lindquist, K, Konety, BR. PSA screening among elderly men with limited life expectancies. JAMA. 2006;296:23362342.Google Scholar
Fontana, PP, Gregorio, SA, Rivas, JG, et al. Perioperative and survival outcomes of laparoscopic radical cystectomy for bladder cancer in patients over 70 years. Cent European J Urol. 2015;68(1):2429.Google Scholar
Deliveliotis, C, Papatsoris, A, Chrisofos, M, et al. Urinary diversion in high-risk elderly patients: modified cutaneous ureterostomy or ileal conduit? Urology. 2005;66:299304.Google Scholar
Wheater, MJ, Manners, J, Nolan, L, et al. The clinical features and management of testicular germ cell tumours in patients aged 60 years and older. BJU Int. 2011;108:17941799.Google Scholar
Fonseca, R, Habermann, TM, Colgan, JP, et al. Testicular lymphoma is associated with a high incidence of extranodal recurrence. Cancer. 2000;88:154161.Google Scholar
Fitzpatrick, JM. The natural history of benign prostatic hyperplasia. BJU Int. 2006;97(Suppl 2):36.Google Scholar
Tikkinen, KA, Auvinen, A, Johnson, TM 2nd, et al: A systematic evaluation of factors associated with nocturia: the population-based FINNO study. Am J Epidemiol. 2009;170:361368.Google Scholar
Perchon, LFG, Pintarelli, VL, Bezerra, E, et al.Quality of life in elderly men with aging symptoms and lower urinary tract symptoms (LUTS). Neurourol Urodyn. 2011;30:515519.Google Scholar
DuBeau, CE. The aging lower urinary tract. J Urol. 2006;175:S11S15.Google Scholar
Saigal, CS. Quality indicators for benign prostatic hyperplasia in vulnerable elders. J Amer Geriatr Soc. 2007;55:S253S257.Google Scholar
Resnick, MI, Roehrborn, CG. Rapid onset of action with alfuzosin 10 mg once daily in men with benign prostatic hyperplasia: a randomized, placebo-controlled trial. Prostate Cancer Prostatic Dis. 2007;10:155159.Google Scholar
Giuliano, F. Impact of medical treatments for benign prostatic hyperplasia on sexual function. BJU Int. 2006;97(Suppl 2):3438.Google Scholar
Van Dijk, MM, de la Rosette, JJ, Michel, MC. Effects of alpha(1)-adrenoceptor antagonists on male sexual function. Drugs. 2006;66:287301.Google Scholar
Friedman, AH. Tamsulosin and the intraoperative floppy iris syndrome. JAMA. 2009;301:20442045.Google Scholar
Roehrborn, CG, Bruskewitz, R, Nickel, JC, et al. Sustained decrease in incidence of acute urinary retention and surgery with finasteride for 6 years in men with benign prostatic hyperplasia. J Urol. 2004;171:11941198.Google Scholar
Roehrborn, CG, Siami, P, Barkin, J, et al. The effects of dutasteride, tamsulosin and combination therapy in lower urinary tract symptoms in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the CombAT Study. J Urol. 2008;179(2):616621.Google Scholar
Wang, X, Wang, X, Li, S, et al. Comparative effectiveness of oral drug therapies for lower urinary tract symptoms due to benign prostatic hyperplasia: a systematic review and network meta-analysis. PLoS One. 2014;9(9):e107593.Google Scholar
Espinosa, G. Nutrition and benign prostatic hyperplasia. Curr Opin Urol. 2013;23(1):3841.Google Scholar
Poon, KS, McVary, KT. Dietary patterns, supplement use, and the risk of benign prostatic hyperplasia. Curr Urol Rep. 2009;10(4):279286.Google Scholar
Hoffman, RM, Monga, M, Elliot, SP, et al. Microwave thermotherapy for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2007;17:CD004135.Google Scholar
Aagaard, MF, Niebuhr, MH, Jacobsen, JD, Krøyer Nielsen, K. Transurethral microwave thermotherapy treatment of chronic urinary retention in patients unsuitable for surgery. Scand J Urol. 2014;48(3):290294.Google Scholar
Bozkurt, IH, Yalcinkaya, F, Sertcelik, MN, et al. A good alternative to indwelling catheter owing to benign prostate hyperplasia in elderly: Memotherm prostatic stent. Urology. 2013;82:10041007.Google Scholar
Ogiste, JS, Cooper, K, Kaplan, SA. Are stents still a useful therapy for benign prostatic hyperplasia? Curr Opin Urol. 2003;13:5157.Google Scholar
Krieger, JN, Riley, DE, Cheah, PY, et al. Epidemiology of prostatitis: new evidence for a world-wide problem. World J Urol. 2003;21:7074.Google Scholar
Nickel, JC, Teichman, JMH, Gregore, M, et al. Prevalence, diagnosis, characterization, and treatment of prostatitis, interstitial cystitis, and epididymitis in outpatient urologic practice: the Canadian PIE Study. Urology. 2005;66:935940.Google Scholar
Suskind, AM, Berry, SH, Ewing, BA, et al. The prevalence and overlap of interstitial cystitis / bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome in men: results of the RAND Interstitial Cystitis Epidemiology Male Study. J Urol. 2013;189(1):141145.Google Scholar
Wagenlehner, FM, Weidner, W, Pilatz, A, Naber, KG. Urinary tract infections and bacterial prostatitis in men. Curr Opin Infect Dis. 2014;27(1):97101.Google Scholar
Fistarol, SK, Itin, PH. Diagnosis and treatment of lichen sclerosus: an update. Am J Clin Dermatol. 2013;14(1):2747.Google Scholar
Philippou, P, Shabbir, M, Ralph, DJ, et al. Genital lichen sclerosus/balanitis xerotica obliterans in men with penile carcinoma: a critical analysis. BJU Int. 2013;111(6):970976.Google Scholar
Williams, JC, Morrison, PM, Richardson, JR. Paraphimosis in elderly men. Am J Emerg Med. 1995;13:351353.Google Scholar
Miner, MM, Seftel, AD. Peyronie’s disease: epidemiology, diagnosis and management. Curr Med Res Opin. 2014;30(1):113120.Google Scholar
Garaffa, G, Trost, LW, Serefoglu, EC, et al. Understanding the course of Peyronie’s disease. Int J Clin Pract. 2013;67(8):781788.Google Scholar
Bjekic, MD, Vlajinac, HD, Sipetic, SB, Marinkovic, JM. Risk factors for Peyronie’s disease: a case-control study. BJU Int. 2006;97:570574.Google Scholar
Alwaal, A, Hussein, AA, Zaid, UB, Lue, TF. Management of Peyronie’s disease after collagenase (Xiaflex®). Curr Drug Targets. 2015;16(5):484494.Google Scholar
Kiddoo, DA, Wollin, TA, Mador, DR. A population based assessment of complications following outpatient hydrocelectomy and spermatocelectomy. J Urol. 2004;171:746748.Google Scholar
Menon, VS, Sheridan, WG. Benign scrotal pathology: should all patients undergo surgery? BJU Int. 2001;88:251254.Google Scholar
Barbagli, G, Palminteri, E, Lazzeri, M, et al. Long-term outcomes of urethroplasty after failed urethrotomy versus primary repair. J Urol. 2001;165:19181919.Google Scholar
Ozkurkcugil, C, Ozkan, L, Tarcan, T. The effect of asymptomatic urethral caruncle on micturition in women with urinary incontinence. Korean J Urol. 2010;51:257259.Google Scholar
Ljungqvist, L, Peeker, R, Fall, M. Female urethral diverticulum: 26-year followup of a large series. J Urol. 2007;177:219224.Google Scholar
Wong, MJ, Wong, K, Rezvan, A, et al. Urogenital fistula. Female Pelvic Med Reconstr Surg. 2012;18(2):7178.CrossRefGoogle ScholarPubMed
Tannenbaum, C, Corcos, J, Assalian, P. The relationship between sexual activity and urinary incontinence in older women. J Am Geriatr Soc. 2006;54:12201224.Google Scholar
Griebling, TL. The impact of urinary incontinence on sexual health in older adults. J Am Geriatr Soc. 2006;54:12901292.Google Scholar
Wilson, MM. Sexually transmitted diseases. Clin Geriatr Med. 2003;19:637655.Google Scholar
Greene, M, Justice, AC, Lampiris, HW, Valcour, V. Management of human immunodeficiency virus infection in advanced age. JAMA. 2013;309(13):13971405.Google Scholar
Gerharz, EW, Emberton, M. Quality of life research in urology. World J Urol. 1999;17:191192.Google Scholar

References

Gorina, Y, Schappert, S, Bercovitz, A, et al. Prevalence of incontinence among older Americans. National Center for Health Statistics. Vital Health Stat. 2014;3(36):124.Google Scholar
Hannestad, YS, Rortveit, G, Sandvik, H, Hunskaar, S. A community-based epidemiological survey of female urinary incontinence: the Norwegian EPINCONT study. Epidemiology of Incontinence in the County of Nord-Trondelag. J Clin Epidemiol. 2000;53:11501157.Google Scholar
Thom, DH, Haan, MN, Van Den Eeden, SK.Medically recognized urinary incontinence and risks of hospitalization, nursing home admission and mortality. Age Ageing. 1997;26:367374.Google Scholar
Burgio, KL, Ives, DG, Locher, JL, et al. Treatment seeking for urinary incontinence in older adults. J Am Geriatr Soc. 1994;42:208212.Google Scholar
Umlauf, MG, Goode, S, Burgio, KL. Psychosocial issues in geriatric urology: problems in treatment and treatment seeking. Urol Clin N Am. 1996;23:127136.Google Scholar
Fantl, JA, Newman, DK, Colling, J, et al. Urinary incontinence in adults: Acute and chronic management. Clinical practice guideline 2 (1996 Update). AHCPR 960682. 3–1–1996. Rockville, MD: US Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research.Google Scholar
Schnelle, JF, Leung, FW, Rao, SS, et al. A controlled trial of an intervention to improve urinary and FI and constipation. J Am Geriatr Soc. 2010;58(8):15041511.Google Scholar
Brown, HW, Wexner, SD, Segall, MM, et al. Accidental bowel leakage in the mature women’s health study: prevalence and predictors. Int J Clin Pract. 2012 Nov;66(11):11011108.Google Scholar
Brown, JS, Bradley, CS, Subak, LL, et al. Diagnostic Aspects of Incontinence Study (DAISy) Research Group: the sensitivity and specificity of a simple test to distinguish between urge and stress urinary incontinence. Ann Intern Med. 2006 16;144(10):715723.Google Scholar
DuBeau, CE, Resnick, NM. Evaluation of the causes and severity of geriatric incontinence. A critical appraisal. Urol Clin N Am. 1991;18:243256.Google Scholar
Ouslander, JG, Schapira, M, Schnelle, JF. Urine specimen collection from incontinent female nursing home residents. J Am Geriatr Soc. 1995;43:279281.Google Scholar
Ouslander, JG, Simmons, S, Tuico, E, et al. Use of a portable ultrasound device to measure post-void residual volume among incontinent nursing home residents. J Am Geriatr Soc. 1994;42:11891192.Google Scholar
Goode, PS, Locher, JL, Bryant, RL, et al. Measurement of postvoid residual urine with portable transabdominal bladder ultrasound scanner and urethral catheterization. Int Urogynecol J Pelvic Floor Dysfunct. 2000;11(5):296300.Google Scholar
Holroyd-Leduc, JM, Tannenbaum, C, Thorpe, KE, Straus, SE. What type of urinary incontinence does this woman have? JAMA. 2008 Mar 26;299(12):14461456.Google Scholar
Rao, SS. Advances in diagnostic assessment of fecal incontinence and dyssynergic defecation. Clin Gastroenterol Hepatol. 2010 Nov; 8 (11):910918.Google Scholar
Kincade, JE, Dougherty, MC, Carlson, JR, et al. Randomized clinical trial of efficacy of self-monitoring techniques to treat urinary incontinence in women. Neurourol Urodyn. 2007;26:507511.Google Scholar
Nygaard, IE, Kreder, KJ, Lepic, MM, et al. Efficacy of pelvic floor muscle exercises in women with stress, urge, and mixed urinary incontinence. Am J Obstet Gynecol. 1996;174:120125.Google Scholar
Hartmann, K, McPheeters, M, Biller, D, et al. Treatment of overactive bladder in women. Evidence Report/Technology Assessment No.187 (Prepared by the Vanderbilt Evidence-based Practice Center under Contract No. 290–2007-10065-I) AHRQ Publication No. 09-E017. Rockville, MD: Agency for Healthcare Research and Quality. August 2009.Google Scholar
Dubeau, CE, Kraus, SR, Griebling, TL, et al. Effect of fesoterodine in vulnerable elderly subjects with urgency incontinence: a double-blind, placebo controlled trial. J Urol. 2014 Feb;191(2):395404.Google Scholar
Kegel, AH. Progressive resistance exercise in the functional restoration of the perineal muscles. Am J Obstet Gynecol. 1948;56:238248.Google Scholar
Hay-Smith, EJC, Dumoulin, C. Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women. Cochrane Database Syst Rev. 2006 Jan 25;1:CD005654.Google Scholar
Goode, PS, Burgio, KL, Johnson, TM 2nd, et al. Behavioral therapy with or without biofeedback and pelvic floor electrical stimulation for persistent postprostatectomy incontinence: a randomized controlled trial. JAMA. 2011 Jan 12;305(2):151159.Google Scholar
Hendrix, SL, Cochrane, BB, Nygaard, IE, et al. Effects of estrogen with and without progestin on urinary incontinence. JAMA. 2005;293:935948.Google Scholar
Ogah, J, Cody, DJ, Rogerson, L. Minimally invasive synthetic suburethral sling operations for stress urinary incontinence in women: a short version Cochrane review. Neurourol Urodyn. 2011 Mar;30(3):284291.Google Scholar
Gould, CV, Umscheid, CA, Agarwal, RK, et al. Guideline for prevention of catheter-associated urinary tract infections 2009. Atlanta, GA: Centers for Disease Control and Prevention. 2009.Google Scholar
Svatek, R, Roche, V, Thornberg, J, Zimmern, P. Normative values for the American Urological Association Symptom Index (AUA-7) and short form Urogenital Distress Inventory (UDI-6) in patients 65 and older presenting for non-urological care. Neurourol Urodyn. 2005;24:606610.Google Scholar
Norton, C, Cody, JD. Biofeedback and/or sphincter exercises for the treatment of faecal incontinence in adults. Cochrane Database Syst Rev. 2012 Jul 11;7:CD002111.Google Scholar
Omar, MI, Alexander, CE. Drug treatment for faecal incontinence in adults. Cochrane Database Syst Rev. 2013 Jun 11;6:CD002116.Google Scholar
Maeda, Y, Laurberg, S, Norton, C. Perianal injectable bulking agents as treatment for faecal incontinence in adults. Cochrane Database Syst Rev. 2013 Feb 28;2:CD007959.Google Scholar
Brown, SR, Wadhawan, H, Nelson, RL. Surgery for faecal incontinence in adults. Cochrane Database Syst Rev. 2013 Jul 2;7:CD001757.Google Scholar
Bliss, DZ, Jung, HJ, Savik, K, et al. Supplementation with dietary fiber improves fecal incontinence. Nurs Res. Jul–Aug 2001;50(4):203213.Google Scholar
Horrocks, EJ, Thin, N, Thaha, MA, et al. Systematic review of tibial nerve stimulation to treat faecal incontinence. Br J Surg. 2014 Apr;101(5):457468.Google Scholar
Boyington, JE, Howard, DL, Carter-Edwards, L, et al. Differences in resident characteristics and prevalence of urinary incontinence in nursing homes in the southeastern United States. Nurs Res. 2007;56:97107.Google Scholar
Schnelle, JF. Treatment of urinary incontinence in nursing home patients by prompted voiding. J Am Geriatr Soc. 1990;38:356360.Google Scholar
Schnelle, JF, Keeler, E, Hays, RD, et al. A cost and value analysis of two interventions with incontinent nursing home residents. J Am Geriatr Soc. 1995;43:11121117.Google Scholar

References

Sultana, C. Geriatric gynecology. In: Arenson, C, Busby-Whitehead, J, Brummel-Smith, K, et al., editors. Reichel’s Care of the Elderly, Clinical Aspects of Aging. 6th ed. Cambridge: Cambridge University Press; 2009.Google Scholar
Letvak, S, Schoder, D. Sexually transmitted diseases in the elderly: what you need to know: the young aren’t the only ones at risk for STDs. Geriatric Nursing. 1996;17(4):156160. doi:10.1016/S0197-4572(96)80063-2.Google Scholar
Centers for Disease Control and Prevention (CDC). Clinical prevention guidance. In: Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010 Dec 17;59(RR-12):28. Available at: www.guideline.gov/content.aspx?id=25577&search=sexually+transmitted+infections (accessed November 14, 2015).Google Scholar
Miller, KL, Baraldi, CA. Geriatric gynecology: promoting health and avoiding harm. Am J Obstet Gynecol. 2012 Nov;207(5):355367. Available at: http://dx.doi.org/10.1016/j.ajog.2012.04.014 (accessed November 14, 2015).Google Scholar
Bachmann, GA, Nevadunsky, NS. Diagnosis and Treatment of Atrophic Vaginitis. Am Fam Physician. 2000 May 15;61(10):30903096.Google Scholar
Management of symptomatic vulvovaginal atrophy: 2013 position statement of the North American Menopause Society. Menopause. 2013 Sep;20(9):888902.Google Scholar
Urogenital health. In: Menopause and osteoporosis update 2009. J Obstet Gynaecol Can. 2009 Jan;31(1 Suppl 1):S27S30. Available at: http://sogc.org/wp-content/uploads/2013/01/Menopause_JOGC-Jan_09.pdf (accessed November 14, 2015).Google Scholar
American College of Obstetricians and Gynecologists (ACOG). Management of Menopausal Symptoms. Washington, DC: American College of Obstetricians and Gynecologists (ACOG); 2014 Jan. 15 (ACOG Practice Bulletin No. 141). Available at: www.guideline.gov/content.aspx?id=47751&search=postmenopausal+symptoms (accessed November 14, 2015).Google Scholar
North American Menopause Society. The 2012 hormone therapy position statement of the North American Menopause Society. Menopause. 2012 Mar;19(3):257271.Google Scholar
Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2012. Atlanta: CDC. Available at: www.cdc.gov/std/stats12 (accessed November 14, 2015).Google Scholar
Perkins, KE, King, MC. Geriatric gynecology. Emerg Med Clin N Am. 2012;30(4):10071019.Google Scholar
Walter, LC, Covinsky, KE. Cancer screening in elderly patients: a framework for individualized decision making. JAMA 2001;285(21):27502756.Google Scholar
Canavan, TP, Cohen, D. Vulvar cancer. Am Fam Physician 2002;66(7):12691274.Google Scholar
Jemal, A, Siegel, R, Xu, J, Ward, E. Cancer statistics, 2010. CA Cancer J Clin 2010;60(5):277300.Google Scholar
Johnson, TL, Kumar, NB, White, CD, Morley, GW. Prognostic features of vulvar melanoma: a clinicopathologic analysis. Int J Gynecol Pathol 1986;5(2):110118.Google Scholar
Creasman, WT, Phillips, JL, Menck, HR. The National Cancer Data Base report on cancer of the vagina. Cancer 1998;83(5):10331040.Google Scholar
Daling, JR, Madeleine, MM, Schwartz, SM, et al. A population-based study of squamous cell vaginal cancer: HPV and cofactors. Gynecol Oncol 2002;84(2):263270.Google Scholar
Lee, LJ, Jhingran, A, Kidd, E, et al. ACR appropriateness criteria management of vaginal cancer. Oncology Journal, Gynecologic Cancers 2013. Available at: www.cancernetwork.com/oncology-journal/acr-appropriateness-criteria-management-vaginal-cancer/page/0/1 (accessed September 16, 2014).Google Scholar
Cervical cancer. NIH Consensus Statement. 1996;14:138. Available at: consensus.nih.gov/1996/1996CervicalCancer102PDF.pdf (accessed August 11, 2014).Google Scholar
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 131. Screening for cervical cancer. Obstet Gynecol. 2012;120(5):12221238.Google Scholar
Saslow, D, Solomon, D, Lawson, HW, et al. American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer. CA Cancer J Clin. 2012;62(3):147172.Google Scholar
US Preventive Services Task Force. Screening for Cervical Cancer: Recommendation Statement. Am Fam Physician. 2012;86(6):555559.Google Scholar
Vesco, KK, Whitlock, EP, Eder, M, et al. Risk factors and other epidemiologic considerations for cervical cancer screening: a narrative review for the US Preventive Services Task Force. Ann Intern Med. 2011;155(10):698705.Google Scholar
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 35. Diagnosis and treatment of cervical carcinomas. Obstet Gynecol. 2002;78(1):7991.Google Scholar
Sorosky, JI. Endometrial cancer. Obstet Gynecol 2012;120(2 Pt 1):383397.Google Scholar
Swerdlow, AJ, Jones, ME. British Tamoxifen Second Cancer Study Group. Tamoxifen treatment for breast cancer and risk of endometrial cancer: a case-control study. J Natl Cancer Inst 2005;97(5)375384.Google Scholar
Brinton, LA, Berman, ML, Mortel, R, et al. Reproductive, menstrual and medical risk factors for endometrial cancer: results from a case control study. Am J Obstet Gynecol 1992;167(5):13171325.Google Scholar
Lancaster, JM, Powell, CM, Kauff, ND, et al. Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions. Gynecol Oncol 2007;107(2):159162.Google Scholar
Mueck, AO, Seeger, H, Rabe, T. Hormonal contraception and risk of endometrial cancer: a systematic review. Endocr Relat Cancer 2010;17(4):R263R271.Google Scholar
Zhou, B, Yang, L, Sun, Q, et al. Cigarette smoking and the risk of endometrial cancer: a meta-analysis. Am J Med 2008:121(6):501508.Google Scholar
Moore, SC, Gierach, GL, Schatzkin, A, Matthews, CE. Physical activity, sedentary behaviours, and the prevention of endometrial cancer. Br J Cancer 2010; 103(7):933938.Google Scholar
Yu, X, Bao, Z, Zou, J, Dong, J. Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer 2011;11:96.Google Scholar
Tang, NP, Li, H, Qiu, YL, et al. Tea consumption and risk of endometrial cancer: a metaanalysis. Am J Obstet Gynecol 2009;201(6):605.Google Scholar
Von Greunigen, VE, Karlen, JR. Carcinoma of the endometrium. Am Fam Phys 1995;51(6):15311536.Google Scholar
Buchanan, EM, Weinstein, LC, Hillson, C. Endometrial Cancer. Am Fam Phys 2009;80(10):10751080.Google Scholar
American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 280. The role of the generalist obstetrician-gynecologist in the early detection of ovarian cancer. Obstet Gynecol. 2002;100(6):14131416.Google Scholar
US Preventive Services Task Force. Screening for ovarian cancer: reaffirmation recommendation statement. Ann Intern Med 2012;157(12):900904.Google Scholar
Tortolero-Luna, G, Mitchell, MF, Rhodes-Morris, HE. Epidemiology and screening for ovarian cancer. Obstet Gynecol Clin North Am 1994;21(1):123.Google Scholar
Teneriello, MG, Park, RC. Early detection of ovarian cancer. CA Cancer J Clin 1995;45(2):7187.Google Scholar
McDonald, JM, Modesitt, SC. The incidental postmenopausal adnexal mass. Clin Obstet Gynecol 2006;49(3):506516.Google Scholar
Roett, M, Evans, P. Ovarian cancer: an overview. Am Fam Physician 2009;361:170177.Google Scholar
Modesitt, SC, Pavlik, EJ, Ueland, FR, et al. Risk of malignancy in unilocular ovarian cystic tumors less than 10 centimeters in diameter. Obstet Gynecol 2003;102(3):594599.Google Scholar
Komatsu, T, Konisha, I, Mandai, M, et al. Adnexal masses: transvaginal US and gadolinium-enhanced MR imaging assessment of intratumoral structure. Radiology 1996;198(1):109115.Google Scholar
van Nagell, JR Jr, Hoff, JT. Transvaginal ultrasonagraphy in ovarian cancer screening: current perspectives. Int J Womens Health 2013;6: 2533.Google Scholar
NIH consensus conference. Ovarian cancer: screening, treatment, and follow-up. Development Panel on Ovarian Cancer. JAMA 1995;273(6):491497.Google Scholar
Lowder, JL, Ghetti, C, Nikolajski, C, et al. Body image perceptions in women with pelvic organ prolapse: a qualitative study. Am J Obstet Gynecol 2011;204(5):411.e15.Google Scholar
Jelovsek, JE, Maher, C, Barber, MD. Pelvic organ prolapse. Lancet 2007;369(9566):10271038.Google Scholar
Bump, RC, Mattiasson, A, Bo, K, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol. 1996;175(1):1017.Google Scholar
Culligan, PJ. Nonsurgical management of pelvic organ prolapse. Obstet Gynecol 2012;119(4):852860.Google Scholar
Vasomotor symptoms. In: Menopause and osteoporosis update 2009. J Obstet Gynaecol Can. 2009 Jan;31(1 Suppl 1):S9S10.Google Scholar
North American Menopause Society. The 2012 hormone therapy position statement of the North American Menopause Society. Menopause. 2012 Mar;19(3):257271. doi:10.1097/gme.0b013e31824b970a.Google Scholar
American College of Obstetricians and Gynecologists (ACOG). Female Sexual Dysfunction. Washington, DC: American College of Obstetricians and Gynecologists (ACOG); 2011 Apr: 12 p. (ACOG Practice Bulletin No. 119). Available at: www.guideline.gov/content.aspx?id=32672&search=postmenopausal+symptoms (accessed November 14, 2015).Google Scholar
Wallace Kazer, M. Issues regarding sexuality. In: Boltz, M, Capezuti, E, Fulmer, T, Zwicker, D, editors. Evidence-based Geriatric Nursing Protocols for Best Practice. 4th ed. New York, NY: Springer Publishing Company; 2012: 500515. Available at: www.guideline.gov/content.aspx?id=43928&search=sexual+dysfunction (accessed November 14, 2015).Google Scholar
Health Care Guideline: Diagnosis of Breast Disease, 14th ed. January 2012. Available at: www.icsi.org/_asset/v9l91q/DxBrDis.pdf (accessed November 14, 2015).Google Scholar

References

Pyram, R, Mahajan, G, Gliwa, A. Primary hyperparathyroidism: Skeletal and non-skeletal effects, diagnosis and management. Maturitas. 2011;70(3):246255.Google Scholar
Bilezikian, JP, Khan, AA, Potts, JT Jr. Third International Workshop on the Management of Asymptomatic Primary Hyperthyroidism. Guidelines for the management of asymptomatic primary hyperparathyroidism: Summary statement from the third international workshop. J Clin Endocrinol Metab. 2009;94(2):335339.Google Scholar
Boonen, S, Vanderschueren, D, Pelemans, W, Bouillon, R. Primary hyperparathyroidism: Diagnosis and management in the older individual. Eur J Endocrinol. 2004;151(3):297304.Google Scholar
Grant, P, Velusamy, A. What is the best way of assessing neurocognitive dysfunction in patients with primary hyperparathyroidism? J Clin Endocrinol Metab. 2014;99(1):4955.Google Scholar
Marcocci, C, Cetani, F. Clinical practice: primary hyperparathyroidism. N Engl J Med. 2011;365(25):23892397.Google Scholar
Cesari, M, Incalzi, RA, Zamboni, V, Pahor, M. Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons. Geriatr Gerontol Int. 2011;11(2):133142.Google Scholar
Holick, MF, Binkley, NC, Bischoff-Ferrari, HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):19111930.Google Scholar
Dawson-Hughes, B, Mithal, A, Bonjour, JP, et al. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int. 2010;21(7):11511154.Google Scholar
American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults. Recommendations abstracted from the American geriatrics society consensus statement on vitamin D for prevention of falls and their consequences. J Am Geriatr Soc. 2013;62:147152.Google Scholar
Malik, R. Vitamin D and secondary hyperparathyroidism in the institutionalized elderly: a literature review. J Nutr Elder. 2007;26(3–4):119138.Google Scholar
Avenell, A, Gillespie, WJ, Gillespie, LD, O’Connell, DL. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev. 2005;3:CD000227.Google Scholar
Fraser, WD. Hyperparathyroidism. Lancet. 2009;374(9684):145158.Google Scholar
McCauley, LK, Martin, TJ. Twenty-five years of PTHrP progress: from cancer hormone to multifunctional cytokine. J Bone Miner Res. 2012;27(6):12311239.Google Scholar
Bensenor, IM, Olmos, RD, Lotufo, PA. Hypothyroidism in the elderly: diagnosis and management. Clin Interv Aging. 2012;7:97111.Google Scholar
Boelaert, K. Thyroid dysfunction in the elderly. Nat Rev Endocrinol. 2013;9(4):194204.Google Scholar
Papaleontiou, M, Haymart, MR. Approach to and treatment of thyroid disorders in the elderly. Med Clin North Am. 2012;96(2):297310.Google Scholar
Roos, A, Linn-Rasker, SP, van Domburg, RT, et al. The starting dose of levothyroxine in primary hypothyroidism treatment: a prospective, randomized, double-blind trial. Arch Intern Med. 2005;165(15):17141720.Google Scholar
Pasqualetti, G, Tognini, S, Polini, A, et al. Is subclinical hypothyroidism a cardiovascular risk factor in the elderly? J Clin Endocrinol Metab. 2013;98(6):22562266.Google Scholar
Collet, TH, Gussekloo, J, Bauer, DC, et al. Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med. 2012;172(10):799809.Google Scholar
Biondi, B, Cooper, DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 2008;29(1):76131.Google Scholar
Garber, JR, Cobin, RH, Gharib, H, et al. Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012;18(6):9881028.Google Scholar
Visser, WE, Visser, TJ, Peeters, RP. Thyroid disorders in older adults. Endocrinol Metab Clin North Am. 2013;42(2):287303.Google Scholar
De Alfieri, W, Nistico, F, Borgogni, T, et al. Thyroid hormones as predictors of short- and long-term mortality in very old hospitalized patients. J Gerontol A Biol Sci Med Sci. 2013;68(9):11221128.Google Scholar
Iglesias, P, Ridruejo, E, Munoz, A, et al. Thyroid function tests and mortality in aged hospitalized patients: a 7-year prospective observational study. J Clin Endocrinol Metab. 2013;98(12):46834690.Google Scholar
Cooper, DS. Approach to the patient with subclinical hyperthyroidism. J Clin Endocrinol Metab. 2007;92(1):39.Google Scholar
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper, DS, Doherty, GM, et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19(11):11671214.Google Scholar
Gervasi, R, Orlando, G, Lerose, MA, et al. Thyroid surgery in geriatric patients: a literature review. BMC Surg. 2012;12(Suppl 1):S16.Google Scholar
Regal, M, Paramo, C, Sierra, SM, Garcia-Mayor, RV. Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain. Clin Endocrinol (Oxf) 2001 Dec;55(6):735740.Google Scholar
Ferrante, L, Trillo, G, Ramundo, E, et al. Surgical treatment of pituitary tumors in the elderly: clinical outcome and long-term follow-up. J Neurooncol 2002 Nov;60(2):185191.Google Scholar
Barzaghi, LR, Losa, M, Giovanelli, M, Mortini, P. Complications of transsphenoidal surgery in patients with pituitary adenoma: experience at a single centre. Acta Neurochir (Wien) 2007;149(9):877885; discussion 885886.Google Scholar
Hong, J, Ding, X, Lu, Y. Clinical analysis of 103 elderly patients with pituitary adenomas: transsphenoidal surgery and follow-up. J Clin Neurosci 2008 Oct;15(10):10911095.Google Scholar
Minniti, G, Esposito, V, Piccirilli, M, et al. Diagnosis and management of pituitary tumours in the elderly: a review based on personal experience and evidence of literature. Eur J Endocrinol 2005 Dec;153(6):723735.Google Scholar
Ascoli, P, Cavagnini, F. Hypopituitarism. Pituitary 2006;9(4):335342.Google Scholar
Foppiani, L, Ruelle, A, Bandelloni, R, et al. Hypopituitarism in the elderly: multifaceted clinical and biochemical presentation. Curr Aging Sci 2008 Mar;1(1):4250.Google Scholar
Minniti, G, Esposito, V, Piccirilli, M, et al. Diagnosis and management of pituitary tumours in the elderly: a review based on personal experience and evidence of literature. Eur J Endocrinol 2005 Dec;153(6):723735.Google Scholar
Turner, HE, Adams, CB, Wass, JA. Pituitary tumours in the elderly: a 20 year experience. Eur J Endocrinol 1999 May;140(5):383389.Google Scholar
Locatelli, M, Bertani, G, Carrabba, G, et al. The trans-sphenoidal resection of pituitary adenomas in elderly patients and surgical risk. Pituitary 2013 Jun;16(2):146151.Google Scholar
Ferretti, E, Persani, L, Jaffrain-Rea, ML, et al. Evaluation of the adequacy of levothyroxine replacement therapy in patients with central hypothyroidism. J Clin Endocrinol Metab 1999 Mar;84(3):924929.Google Scholar
Ilias, I, Torpy, DJ, Pacak, K, et al. Cushing’s syndrome due to ectopic corticotropin secretion: twenty years’ experience at the National Institutes of Health. J Clin Endocrinol Metab 2005 Aug;90(8):49554962.Google Scholar
Isidori, AM, Kaltsas, GA, Pozza, C, et al. The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up. J Clin Endocrinol Metab 2006 Feb;91(2):371377.Google Scholar
Herrera, MF, Grant, CS, van Heerden, JA, et al. Incidentally discovered adrenal tumors: an institutional perspective. Surgery 1991 Dec;110(6):10141021.Google Scholar
Zeiger, MA, Thompson, GB, Duh, QY, et al. American Association of Clinical Endocrinologists and American Association of Endocrine Surgeons Medical Guidelines for the Management of Adrenal Incidentalomas: executive summary of recommendations. Endocr Pract 2009 Jul–Aug;15(5):450453.Google Scholar
Young, WF Jr. Management approaches to adrenal incidentalomas: a view from Rochester, Minnesota. Endocrinol Metab Clin North Am 2000 Mar;29(1):159185, x.Google Scholar
Grumbach, MM, Biller, BM, Braunstein, GD, et al. Management of the clinically inapparent adrenal mass (“incidentaloma”). Ann Intern Med 2003 Mar 4;138(5):424429.Google Scholar
Nieman, LK. Approach to the patient with an adrenal incidentaloma. J Clin Endocrinol Metab 2010 Sep;95(9):41064113.Google Scholar
Lo, CY, van Heerden, JA, Grant, CS, et al. Adrenal surgery in the elderly: too risky? World J Surg 1996 Mar–Apr;20(3):368373; discussion 374.Google Scholar
Funder, JW, Carey, RM, Fardella, C, et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2008 Sep;93(9):32663281.Google Scholar
Stowasser, M, Sharman, J, Leano, R, et al. Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type I. J Clin Endocrinol Metab 2005 Sep;90(9):50705076.Google Scholar
Milliez, P, Girerd, X, Plouin, PF, et al. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol 2005 Apr 19;45(8):12431248.Google Scholar
Mulatero, P, Stowasser, M, Loh, KC, et al. Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J Clin Endocrinol Metab 2004 Mar;89(3):10451050.Google Scholar
Kopetschke, R, Slisko, M, Kilisli, A, et al. Frequent incidental discovery of phaeochromocytoma: data from a German cohort of 201 phaeochromocytoma. Eur J Endocrinol 2009 Aug;161(2):355361.Google Scholar
Lenders, JW, Eisenhofer, G, Mannelli, M, Pacak, K. Phaeochromocytoma. Lancet 2005 Aug 20–26;366(9486):665675.Google Scholar
Khoo, JJ, Au, VS, Chen, RY. Recurrent urosepsis and cardiogenic shock in an elderly patient with pheochromocytoma. Case Rep Endocrinol 2011;2011:759523.Google Scholar
Pacak, K. Preoperative management of the pheochromocytoma patient. J Clin Endocrinol Metab 2007 Nov;92(11):40694079.Google Scholar
Nieman, LK, Biller, BM, Findling, JW, et al. The diagnosis of Cushing’s syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2008 May;93(5):15261540.Google Scholar
Arlt, W, Allolio, B. Adrenal insufficiency. Lancet 2003 May 31;361(9372):18811893.Google Scholar
Chen, YC, Chen, YC, Chou, LF, et al. Adrenal insufficiency in the elderly: a nationwide study of hospitalizations in Taiwan. Tohoku J Exp Med 2010 Aug;221(4):281285.Google Scholar
Bornstein, SR. Predisposing factors for adrenal insufficiency. N Engl J Med 2009 May 28;360(22):23282339.Google Scholar
Oelkers, W. Adrenal insufficiency. N Engl J Med 1996 Oct 17;335(16):12061212.Google Scholar
Magnotti, M, Shimshi, M. Diagnosing adrenal insufficiency: which test is best–the 1-microg or the 250-microg cosyntropin stimulation test? Endocr Pract 2008 Mar;14(2):233238.Google Scholar

References

Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services; 2014.Google Scholar
American Diabetes Association. Economic costs of diabetes in the US in 2012. Diabetes Care 2013;36:1033–46.Google Scholar
Boyle, JP, Thompson, TJ, Gregg, EW, et al. Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Population Health Metrics 2010:8:29.Google Scholar
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20;1183–97.Google Scholar
American Diabetes Association. Standards of medical care in diabetes – 2014. Diabetes Care 2014;37:S14S80.Google Scholar
Fletcher, RH, Fletcher, SW, Wagner, EH. Clinical Epidemiology – The Essentials. Baltimore: Williams & Wilkins, 1982.Google Scholar
Screening for Type 2 Diabetes Mellitus in Adults, Topic Page. US Preventive Services Task Force. www.uspreventiveservicestaskforce.org/uspstf/uspsdiab.htm, accessed September 28, 2014.Google Scholar
American Diabetes Association. Standards of medical care in diabetes – 2014. Diabetes Care 2014;37:S14S80.Google Scholar
Von Korff, M, Gruman, J, Schaefer, J, et al. Collaborative management of chronic illness. Ann Intern Med 1997;127:136–45.Google Scholar
Renders, CM, Valk, GD, Griffin, SJ, et al. Interventions to improve the management of diabetes in primary care, outpatient, and community settings; a systematic review. Diabetes Care 2001;24:1821–33.Google Scholar
Caruso, LC, Clough-Gorr, KM, Silliman, RA. Improving quality of care for urban elders with diabetes and cardiovascular disease. J Am Geriatr Soc 2007;55:1656–62.Google Scholar
California Healthcare Foundation/American Geriatrics Society Panel in Improving Care for Elders with Diabetes. Guidelines for improving the care of the older person with diabetes mellitus. J Am Geriatr Soc 2003;51: 265–80.Google Scholar
Kirkman, MS, Briscoe, VJ, Clark, N, et al. Diabetes in older adults: a consensus report. J Am Geriatr Soc 2012;60;2343–56.Google Scholar
American Geriatrics Society Expert Panel on the Care of Older Adults with Diabetes Mellitus. Guidelines abstracted from the American Geriatrics Society guidelines for improving the care of older adults with diabetes mellitus: 2013 update. J Am Geriatr Soc 2013;61:2020–26.Google Scholar
National Heart, Lung, and Blood Institute. Clinical Guidelines on the Identification, Evaluation and Treatment of Overweight and Obesity in Adult. Bethesda, MD: National Institutes of Health, 1998.Google Scholar
Wheeler, ML, Dunbar, SA, Jaacks, LM, et al. Macronutrients, food groups, and eating patterns in the management of diabetes: a systematic review of the literature, 2010. Diabetes Care 2012;35:434–45.Google Scholar
Evert, AB, Boucher, JL, Cypress, M, et al. Nutrition therapy recommendations for the management of adults with diabetes. Diabetes Care 2013;36:3821–42.Google Scholar
American Diabetes Association. Position statement: standards of medical care in diabetes–2007. Diabetes Care 2007;30:S4S41.Google Scholar
LaCroix, AZ, Lang, J, Scherr, P, et al. Smoking and mortality among older men and women in three communities. N Engl J Med 1991;324:1619–25.Google Scholar
United Kingdom Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837–53.Google Scholar
Gerstein, HC, Miller, ME, Byington, RP, et al. Action to control cardiovascular risk in diabetes study group: effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008;358:2545–59.Google Scholar
Patel, A, MacMahon, S, Chalmers, J, et al. ADVANCE Collaborative Group: intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;358:2560–72.Google Scholar
Duckworth, W, Abraira, C, Moritz, T, et al. Investigators of the VADT: glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009;360:129–39.Google Scholar
Currie, CJ, Peters, JR, Tynan, A, et al. Survival as a function of HbA(1c) in people with type 2 diabetes: a retrospective cohort study. Lancet 2010;375:481–89.Google Scholar
Huang, ES, Liu, Jy, Moffet, HH, et al. Glycemic control, compliations, and death in older diabetic patients: the Diabetes and Aging Study. Diabetes Care 2011;34:1329–36.Google Scholar
California Healthcare Foundation/American Geriatrics Society Panel on Improving Care for Elders with Diabetes. Guidelines for improving the care of the older person with diabetes mellitus. J Am Geriatr Soc 2003:51;S265S280.Google Scholar
United Kingdom Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854–65.Google Scholar
Sambol, NC, Chiang, J, Lin, ET, et al. Kidney function and age are both predictors of pharmacokinetics of metformin. J Clin Pharmacol 1995;35:10941102.Google Scholar
Salpeter, S, Greyber, E, Pasternak, G, et al. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev 2006;1:CD002967 [update of Cochrane Database Syst Rev 2003;2:CD002967; PMID: 12804446].Google Scholar
Rachmani, R, Slavachevski, I, Levi, Z, et al. Metformin in patients with type 2 diabetes mellitus: reconsideration of traditional contraindications. Eur J Int Med 2002;13:428–33.Google Scholar
American Geriatrics Society. Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012;60:616–31.Google Scholar
Rajagopalan, R, Perez, A, Ye, Z, et al. Pioglitazone is effective therapy for elderly patients with type 2 diabetes mellitus. Drugs Aging 2004;21:259–71.Google Scholar
Nesto, RW, Bell, D, Bonow, RO, et al. Thiazolidinedione use, fluid retention and congestive heart failure; a consensus statement from the American Heart Association and American Diabetes Association. Diabetes Care 2004;27:256–63.Google Scholar
Kendall, C, Wooltorton, E. Rosiglitazone (Avandia) and macular edema. CMAJ 2006;174:623.Google Scholar
Schwartz, AV, Sellmeyer, DE, Vittinghoff, E, et al. Thiazolidinedione use and bone loss in older diabetic adults. J Clin Endocrinol Metab 2006;91:3349–54.Google Scholar
Kahn, SE, Haffner, SM, Heise, MA, et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 2006;355:2427–43.Google Scholar
Nissen, SE, Wolski, K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007;356:2457–71.Google Scholar
Dormandy, JA, Charbonnel, B, Eckland, J, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (Prospective pioglitazone clinical trial in macrovascular events): a randomized trial. Lancet 2005;366:12791289.Google Scholar
Egan, AG, Blind, E, Dunder, K, et al. Pancreatic safety of incretin-based drugs – FDA and EMA assessment. N Engl J Med 2014;370:794–97.Google Scholar
Van den Berghe, G, Wouters, p, Weekers, F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345:1359–67.Google Scholar
ACE/ADA Task Force on Inpatient Diabetes. American College of Endocrinology and American Diabetes Association Consensus Statement on Inpatient Diabetes and Glycemic Control. Diabetes Care 2006;29:1955–62.Google Scholar
Moghissi, ES, Korytkowski, MT, DiNardo, M, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care 2009;32:1119–31.Google Scholar
Umpierrez, GE, Hellman, R, Korytkowski, MT, et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2012;97:1638.Google Scholar
The American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012;60:616–31.Google Scholar
Expert Panel on Detection, Evaluatoin, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486–97.Google Scholar
American Diabetes Association. Standards of medical care in diabetes – 2014. Diabetes Care 2014;37:S14S80.Google Scholar
James, PA, Oparil, S, Carter, BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC8). JAMA 2014;311:507–20.Google Scholar
Snow, V, Weiss, KB, Mottur-Pilson, C, et al. The evidence base for tight blood pressure control in the management of type 2 diabetes mellitus. Ann Intern Med 2003;138:587–92.Google Scholar
Cushman, WC, Evans, GW, Byington, RP, et al. ACCORD Study Group: effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med 2010;362:1575–85.Google Scholar
Curb, JD, Pressel, SL, Cutler, JA, et al. Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension: Systolic Hypertension in the Elderly Program Cooperative Research Group. JAMA 1996;276:1886–92.Google Scholar
United Kingdom Prospective Diabetes Study (UKPDS) Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes (UKPDS 38). BMJ 1998;317:703713.Google Scholar
Brenner, BM, Cooper, ME, de Zeeuw, D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001;345:861–69.Google Scholar
Stone, NJ, Robinson, JG, Lichtenstein, AH, et al. ACC/AHA Prevention Guideline: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults. Circulation 2014;129:S1S45.Google Scholar
Hernandes-Diaz, S, Garcia Rodriguez, LA. Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications. BMC Med 2006;300:2134–41.Google Scholar
Kohner, EM, Aldington, SJ, Stratton, IM, et al. United Kingdom Prospective Diabetes Study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors. Archives of Ophthalmology 1998;116:297-303.Google Scholar
Singer, DE, Nathan, DM, Fogel, HA, et al. Screening for diabetic retinopathy. Ann Intern Med 1992;116:660–71.Google Scholar
Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation treatment of proliferative diabetic retinopathy: the second report of diabetic retinopathy study findings. Ophthalmology 1978;85:82106.Google Scholar
Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema: Early Treatment Diabetic Retinopathy Study report number 1. Arch Ophthalmol 1985;103:17961806.Google Scholar
Reiber, GE, Pecoraro, RE, Koepsell, TD. Risk factors for amputation in patients with diabetes mellitus: a case-control study. Ann Inter Med 1992;117:97105.Google Scholar
Litzelman, DK, Slemenda, CW, Langefeld, CD, et al. Reduction of lower extremity clinical abnormalities in patients with non-insulin-dependent diabetes mellitus: a randomized, controlled trial. Ann Intern Med 1993;119:3641.Google Scholar
Dorresteijn, JA, Kriegsman, DM, Assendelft, WJ, et al. Patient education for preventing diabetic foot ulceration. Cochrane Database Syst Rev 2012 Oct 17;10:CD001488.Google Scholar
Garg, JP, Bakris, GL. Microalbuminuria: marker of vascular dysfunction, risk factor for cardiovascular disease. Vasc Med 2002;7:3543.Google Scholar
Klausen, K, Borch-Johnsen, K, Feldt-Rasmussen, B, et al. Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes. Circulation 2004;110:3235.Google Scholar
Logroscino, G, Kang, JH, Grodstein, F. Prospective study of type 2 diabetes and cognitive decline in women aged 70–81 years. BMJ 2004;328:548.Google Scholar
Bent, N, Rabbitt, P, Metcalfe, D. Diabetes mellitus and the rate of cognitive ageing. Br J Clin Psychol 2000;39:349–62.Google Scholar
Lu, FP, Lin, KP, Kuo, HK. Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis. PLoS ONE 2009;4:e4144.Google Scholar
Strachan, MWJ, Deary, IJ, Ewing, FME, et al. Is type II diabetes associated with an increased risk of cognitive dysfunction? Diabetes Care 1997;20:438–45.Google Scholar
Wolff, JL, Kasper, JD. Caregivers of frail elders: updating a national profile. Gerontologist 2006;46:344–56.Google Scholar
Silliman, RA, Bhatti, S, Khan, A, et al. The care of older persons with diabetes mellitus: families and primary care physicians. J Am Geriatr Soc 1996;44:1314–21.Google Scholar

References

Stone, N, Robinson, J, Lichtenstein, AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014;129:51545.Google Scholar
Enos, WF, Holmes, RH, Beyer, J. Coronary disease among United States soldiers killed in action in Korea. JAMA 1953;152:1090–3.Google Scholar
Berenson, GS, Wattigney, WA, Tracy, RE, et al. Atherosclerosis of the aorta and coronary arteries and cardiovascular risk factors in persons ages 6 to 30 years and studied at necropsy (the Bogalusa Heart Study). American Journal of Cardiology 1992;70:851–8.Google Scholar
Cohen, JC, Boerwinkle, E, Mosley, TH Jr, Hobbs, HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Eng J Med. 2006;354(12):1264–72.Google Scholar
Brown, M, Goldstein, J. Lowering LDL – not only how low, but how long? Science 2006;311(5768):1721–3.Google Scholar
Ference, BA, Yoo, W, Alesh, I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis. J Am Coll Cardiol. 2012;60(25):2631–9.Google Scholar
National Cholesterol Education Program; National Heart, Lung, and Blood Institute; National Institutes of Health. Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. NIH Publication No. 02–5215. Bethesda, MD: National Cholesterol Education Program, National Heart, Lung, and Blood Institute, National Institutes of Health, 2002.Google Scholar
Persell, SD, Lloyd-Jones, DM, Baker, DW. National Cholesterol Education Program risk assessment and potential for risk misclassification. Prev Med. 2006;43(5):368–71.Google Scholar
Kostis, JB. Disputation on the use of age in determining the need for treatment of hypercholesterolemia and hypertension. J Clin Hypertension 2006;8(7):519–20.Google Scholar
Yusuf, S, Hawken, S, Ounpuu, S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEARTstudy): case-control study. Lancet 2004;364:937–52.Google Scholar
Kuller, LH, Arnold, AM. 10-year follow-up of subclinical cardiovascular disease and risk of coronary heart disease in the Cardiovascular Health Study. Arch Intern Med. 2006;166:71–8.Google Scholar
Pencina, MJ, Navar-Boggan, AM, D’Agostino, RB Sr, et al. Application of new cholesterol guidelines to a population-based sample. N Engl J Med. 2014;370:1422–31.Google Scholar
Grundy, SM, Cleeman, JI. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol. 2004;44:720–32.Google Scholar
LeMaitre, R, Psaty, BM, Heckbert, SR, et al. Therapy with hydroxylmethylglutaryl coenzyme A reductase inhibitors (statins) and associated risk of incident cardiovascular events in older adults: evidence from the Cardiovascular Health Study. Arch Int Med. 2002;162:13951400.Google Scholar
Strandberg, TE, Pyörälä, K, Cook, TJ, et al. Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S). Lancet 2004;364(9436):771–7.Google Scholar
Bulbulia, R, Armitage, J. Does the benefit from statin therapy extend beyond 5 years? Curr Atheroscler Rep. 2013;15(2):297.Google Scholar
Cholesterol Treatment Trialists’ (CTT) Collaborators, Mihaylova, B, Emberson, J, et al. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 2012;380(9841):581–90.Google Scholar
Huddy, K, Dhesi, P, Thompson, PD. Do the frequencies of adverse events increase, decrease, or stay the same with long-term use of statins? Curr Atheroscler Rep. 2013;15(2):301.Google Scholar
Glynn, RJ, Koenig, W, Nordestgaard, B. Rosuvastatin for primary prevention in older individuals with high C-reactive protein and low LDL levels: exploratory analysis of a randomized trial. Ann Intern Med. 2010;152(8):488–96, W174.Google Scholar
Pederson, T, for the Scandinavian Simvastatin Survival Study Group.Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344(8934);1383–9.Google Scholar
Sacks, FM, Pfeffer, MA, Moye, LA, et al., for the Cholesterol and Recurrent Events Trial Investigators. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. N Engl J Med. 1996;335:1001–9.Google Scholar
Hunt, D, Young, P, Simes, J, et al. Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: results from the LIPID trial. Ann Intern Med. 2001;134:931–40.Google Scholar
Afilalo, J, Duque, G, Steele, R, et al. Statins for secondary prevention in elderly patients: a hierarchical bayesian meta-analysis. J Am Coll Cardiol. 2008;51(1):3745.Google Scholar
Aronow, WS. Drug treatment of peripheral arterial disease in the elderly. Drugs Aging 2006;23(1):112.Google Scholar
Sacco, R, Adams, R, Albers, G, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke. Stroke. 2006;37:577617.Google Scholar
The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006;355:549–59.Google Scholar
Eckel, R, Jakicic, J, Ard, J, et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk. Circulation. 2014;129(25 Suppl 2):S76S99.Google Scholar
US Department of Health and Human Services. 2008 Physical Activity Guidelines for Americans. Washington, DC: US Department of Health and Human Services; 2008:161. Available at: www.health.gov/PAGuidelines.Google Scholar
Rosenson, RS. Current overview of statin-induced myopathy. Am J Med. 2004;116:408–16.Google Scholar
Hey-Hadavi, JH, Kuntze, D, Luo, D. Tolerability of atorvastatin in a population aged > or = 65 years: a retrospective pooled analysis of results from fifty randomized clinical trials. Am J Geriatr Pharmacother. 2006;4:112–22.Google Scholar
Finegold, J, Manisty, C, Goldacre, B, et al. What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Systematic review of randomized placebo-controlled trials to aid individual patient choice. Eur J Prevent Cardiol. 2014:21(4):464–74.Google Scholar
Chia, L, Schlenk, EA. Effect of personal and cultural beliefs on medication adherence in the elderly. Drugs Aging 2006;23(3):191202.Google Scholar
Higashi, T, Shekelle, PG, Solomon, DH, et al. The quality of pharmacologic care for vulnerable older patients. Ann Intern Med. 2004;140:714–20.Google Scholar
Ayanian, JZ, Landrum, MB, McNeil, BJ. Use of cholesterol-lowering therapy by elderly adults after myocardial infarction. Arch Intern Med. 2002;162:1013–19.Google Scholar
Ko, DT, Mamdani, M, Alter, D. Lipid-lowering therapy with statins in high-risk elderly patients: the treatment-risk paradox. JAMA 2004;291:1864–70.Google Scholar
Dewilde, S, Carey, IM, Bremner, SA, et al. Evolution of statin prescribing 1994–2001: a case of agism but not of sexism? Heart 2003;89:417–21.Google Scholar
Brenner, JS, Glynn, RJ, Mogun, H, et al. Long-term persistence in use of statin therapy in elderly patients. JAMA 2002;288:445–56.Google Scholar
O’Connor, P. Improving medication adherence: challenges for physicians, payers, and policy makers. Arch Intern Med. 2006;166:1802–4.Google Scholar
Munn, M, Woodard, M, Munter, P. Predictors of non-adherence to statins: a systematic review and meta-analysis. Ann Pharmacother. 2010;44(9):1410–21.Google Scholar
Osterberg, L, Blaschke, T. Adherence to medication. N Engl J Med. 2005;353:487–97.Google Scholar

References

Siris, ES, Adler, R, Bilezikian, J, et al. The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group. Osteoporosis International 2014;25;14391443.Google Scholar
US Preventive Services Task Force. Screening for osteoporosis: US Preventive Services Task Force recommendation statement. Ann Intern Med 2011;154:356364.Google Scholar
Crandall, CJ, Larson, J, Gourlay, ML, et al. Osteoporosis screening in postmenopausal women 50 to 64 years old: comparison of US Preventive Task Force strategy and two traditional strategies in the Women’s Health Initiative. J of Bone and Mineral Research 2014;29:16611666.Google Scholar
National Osteoporosis Foundation. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Washington, DC: National Osteoporosis Foundation, 2014.Google Scholar
Blake, GM, Fogelman, I. Role of dual-energy x-ray absorptiometry in the diagnosis and treatment of osteoporosis. J Clin Densitom 2007;10:102110.Google Scholar
Bolland, MJ, Grey, A, Avenell, A, et al. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative limited access dataset and meta-analysis. BMJ 2011;19:342.Google Scholar
Heany, RP, Kopecky, S, Maki, KC, et al. A review of calcium supplements and cardiovascular risk. Adv Nutr 2012; 3(6): 763771.Google Scholar
American Geriatrics Society Workgroup on Vitamin D Supplementation for Older Adults. Recommendations abstracted from the American Geriatrics Society Consensus Statement on vitamin D for prevention of falls and their consequences. J Am Geriatr Soc 2014 Jan;62(1):147152.Google Scholar
Watts, NB, Bilezikian, JP, Camacho, PM, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract 2010 Nov–Dec;16(Suppl 3):137.Google Scholar
Dell, RM, Adams, AL, Greene, DF. Incidence of atypical nontraumatic diaphyseal fractures of the femur. J Bone Miner Res 2012;27:25442550.Google Scholar
Bauer, D, Krege, J, Lane, N, et al. National bone health alliance bone turnover marker project: current practices and the need for US harmonization, standardization, and common reference ranges. Osteoporosis International 2012;23:24252433.Google Scholar
Kunchur, R, Need, A, Hughes, T, et al. Clinical investigation of C-terminal cross-linking telopeptide test in prevention and management of bisphosphonate-associated osteonecrosis of the jaws. J Oral Maxiollofac Surg 2009;67:11671173.Google Scholar
Kelley, GA, Kelley, KS, Kohrt, WM. Effects of ground and joint reaction force exercise on lumbar spine and femoral neck bone mineral density in postmenopausal women: a meta-analysis of randomized controlled trials. BMC Musculoskeletal Disorders 2012;13:177196.Google Scholar
Cosman, F, Jan de Beur, S, LeBoff, MS, et al. Clinician’s guide to prevention and treatment of osteoporosis. Osteoporosis International 2014;10:23592381.Google Scholar
Marcocci, C, Cetani, F. Primary hyperparathyroidism. New Engl J Med 2011;365:23892397.Google Scholar
Bilezikian, JP, Brandi, ML, Eastell, R, et al. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop. J Clin Endocrinol Metab 2014;99:35613569.Google Scholar
Ralston, SH. Clinical practice. Paget’s disease of bone. N Engl J Med 2013; 368:644650.Google Scholar
Hosking, D, Lyles, K, Brown, JP, et al. Long-term control of bone turnover in Paget’s disease with zoledronic acid and risedronate. J Bone Miner Res 2007;22:142148.Google Scholar
Miller, PD. Chronic kidney disease and osteoporosis: evaluation and management. BoneKEy Reports 2014;3: 542548.Google Scholar
Salam, SN, Eastell, R, Khwaja, A. Fragility fractures and osteoporosis in CKD: Pathophysiology and diagnostic methods. American Journal of Kidney Disease 2014;63:10491059.Google Scholar

References

Deal, CL, Hooker, R, Harrington, T, et al. The United States rheumatology workforce: supply and demand, 2005–2025. Arthritis Rheum. 2007; 56(3): 722729.Google Scholar
Murray, CJL, Vos, T, Lozano, R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380(9859): 21972223.Google Scholar
Lawrence, RC, Felson, DT, Helmick, CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II. Arthritis Rheum. 2008; 58(1): 2635.Google Scholar
Neogi, T, Zhang, Y. Epidemiology of osteoarthritis. Rheum Dis Clic of N Amer. 2013; 39(1): 119.Google Scholar
Blagojevic, M, Jinks, C, Jeffery, A, Jordan, KP. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis and cartilage. 2010; 18(1): 2433.Google Scholar
Roddy, E, Zhang, W, Doherty, M. Prevalence and associations of hallux valgus in a primary care population. Arthritis Care Res. 2008; 59(6): 857862.Google Scholar
Villareal, DT, Chode, S, Parimi, N, et al. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med. 2011; 364(13):12181229.Google Scholar
Towheed, T, Maxwell, L, Judd, M, et al. Acetaminophen for osteoarthritis. Available at: http://summaries.cochrane.org/CD004257/acetaminophen-for-osteoarthritis (accessed 19 June 2014).Google Scholar
The Acetaminophen Hepatotoxicity Working Group. Recommendations for FDA Interventions to Decrease the Occurrence of Acetaminophen Hepatotoxicity. 2008 Available at: www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/DrugSafetyandRiskManagementAdvisoryCommittee/ucm161518.pdf (accessed 20 December 2014).Google Scholar
Underwood, M, Ashby, D, Cross, P et al. Advice to use topical or oral ibuprofen for chronic knee pain in older people: randomized controlled trial and patient preference study. BMJ. 2008; 336:138142.Google Scholar
Rolita, L, Spegman, A, Tang, X, Cronstein, BN. Greater number of narcotic analgesic prescriptions for osteoarthritis is associated with falls and fractures in elderly adults. Jour Am Ger Soc. 2013; 61(3): 335340.Google Scholar
Raynauld, JP, Buckland-Wright, C, Ward, R, et al. Safety and efficacy of long‐term intraarticular steroid injections in osteoarthritis of the knee: A randomized, double‐blind, placebo‐controlled trial Arthritis Rheum. 2003; 48(2): 370377.Google Scholar
Bannura, RR, Vaysbrot, EE, Sullivan, MC, et al. Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis; a systemic review and meta-analysis. Sem Arthritis and Rheum. 2014; 43: 593599.Google Scholar
Rasch, EK, Hirsch, R, Paulose-Ram, R, Hochberg, MC. Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: effect of different methods of case classification. Arthritis Rheum. 2003; 48(4): 917926.Google Scholar
Innala, L, Moller, B, Ljung, L, Smedby, T, Södergren, A, Magnusson, S, et al. Age at onset determines severity and choice of treatment in early rheumatoid arthritis. Arthritis Rheum. 2012; 64(10): S908.Google Scholar
O’Dell, JR, Mikuls, TR, Taylor, TH, et al. Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med. (2103); 369(4): 307318.Google Scholar
Ornetti, P, Chevillotte, H, Zerrak, A, Maillefert, JF. Anti-tumour necrosis factor-α therapy for rheumatoid and other inflammatory arthropathies. Drugs Aging. 2006; 23(11): 855860.Google Scholar
Roddy, F, Mallen, CD, Doherty, M. Gout. BMJ 2013; 1347: f5648. doi:10.1136/bmj.f5648.Google Scholar
Campion, EW, Glynn, RJ, DeLabry, LO. Asymptomatic hyperuricemia: risks and consequences in the Normative Aging Study. Am J Med. 1987; 82: 421426.Google Scholar
Crofford, LJ. Use of NSAIDs in treating patients with arthritis. Arth Res Ther. 2013; 15 (Supplement 3): S2.Google Scholar
Shoji, A, Yamanaka, H, Kamatani, N. A retrospective study of the relationship between serum urate level and recurrent attacks of gouty arthritis: evidence for reduction of recurrent gouty arthritis with antihyperuricemic therapy. Arthritis Rheum. 2004; 51: 321325.Google Scholar
Hande, RK, Noone, RM, Stone, WJ. Severe allopurinol toxicity: description and guidelines for prevention in patients with renal insufficiency. Am J Med. 1984; 76: 4756.Google Scholar
Stamp, LK, O’Donnell, JL, Zhang, M, et al. Using allopurinol above the dose based on creatinine clearance is effective and safe in patients with chronic gout, including those with renal impairment. Arthritis Rheum. 2012; 63(2): 412421.Google Scholar
Wilkins, E, Dieppe, P, Maddison, P, Evison, G. Osteoarthritis and articular chondrocalcinosis in the elderly. Annals Rheum Dis. 1983; 42(3): 280284.Google Scholar
Terkeltaub, RA. Colchicine update: 2008. Sem arthritis rheum. 2008; 38(6): 411419.Google Scholar
Doran, MF, Crowson, CS, O’Fallon, WM, et al. Trends in the incidence of polymyalgia rheumatica over a 30 year period in Olmsted County, Minnesota, USA. J Rheum. 2002; 29(8): 16941697.Google Scholar
Gonzalez‐Gay, MA, Vazquez‐Rodriguez, TR, Lopez‐Diaz, MJ, et al. Epidemiology of giant cell arteritis and polymyalgia rheumatica. Arthritis Care Res. 2009; 61(10): 14541461.Google Scholar
Gonzalez-Gay, MA, Rodriiguez-Valverde, V, Blanco, R, et al. Polymyalgia rheumatica without significantly increased erythrocyte sedimentation rate: a more benign syndrome. Arch Int Med. 1997; 157(3): 317320.Google Scholar
Camellino, D, Cimmino, MA. Imaging of polymyalgia rheumatica: indications on its pathogenesis, diagnosis and prognosis. Rheumatology 2012; 51(1): 7786.Google Scholar
Weyland, CM, Goronzy, JJ. Giant cell arteritis and polymyalgia rheumatic. N Engl J Med. 2014; 371: 5057.Google Scholar
Kermani, TA., Schäfer, VS, Crowson, CS, et al. Increase in age at onset of giant cell arteritis: a population-based study. Annals Rheum Dis. 2010; 69(4): 780781.Google Scholar
Prieto-González, S, Arguis, P, García-Martínez, A, et al. Large vessel involvement in biopsy-proven giant cell arteritis: prospective study in 40 newly diagnosed patients using CT angiography. Annals Rheum Dis. 2012; 71(7): 11701176.Google Scholar
Salvarani, C, Hunder, GG. Giant cell arteritis with low erythrocyte sedimentation rate: Frequency of occurrence in a population‐based study. Arthritis Care Res. 2010; 45(2): 140145.Google Scholar
Nesher, G. The diagnosis and classification of giant cell arteritis. J Autoimmunity. 2014; 48: 7375.Google Scholar
Klauser, A, Frauscher, F, Halpern, EJ, et al. Remitting seronegative symmetrical synovitis with pitting edema of the hands: ultrasound, color doppler ultrasound, and magnetic resonance imaging findings. Arthritis Care Res. 2005; 53(2): 226233.Google Scholar
Moerman, RV, Bootsma, H, Kroese, FG, Vissink, A. Sjögren’s syndrome in older patients. Drugs & Aging. 2013; 30(3): 137153.Google Scholar
Theander, E, Henriksson, G, Ljungberg, O, et al. Lymphoma and other malignancies in primary Sjögren’s syndrome: a cohort study on cancer incidence and lymphoma predictors. Annals Rheum Dis. 2006; 65(6): 796803.Google Scholar
Wilson, FC, Ytterberg, SR, St Sauver, JL, Reed, AM. Epidemiology of sporadic inclusion body myositis and polymyositis in Olmsted County, Minnesota. J Rheum. 2008; 35(3): 445447.Google Scholar
Greenberg, SA. Inclusion body myositis. Current Opinion Rheum. 2011; 23(6): 574578.Google Scholar
Griggs, RC. The current status of treatment for inclusion body myositis. Neurology. 2006; 66(2 Suppl 1): S30S32.Google Scholar

References

Owens, W.D., Felts, J.A., and Spitznagel, E.L. Jr., ASA physical status classifications: a study of consistency of ratings. Anesthesiology, 1978. 49(4): 239–43.Google Scholar
Bloem, B.R., Grimbergen, Y.A., Cramer, M., et al., Prospective assessment of falls in Parkinson’s disease. J Neurol, 2001. 248(11): 950–8.Google Scholar
McClure, J. and Goldsborough, S., Fractured neck of femur and contralateral intracerebral lesions. J Clin Pathol, 1986. 39(8): 920–2.Google Scholar
Soto-Hall, R., Treatment of transcervical fractures complicated by certain common neurological conditions. In: Instructional Course Lectures XVII, Reynolds, F.C., Editor. 1960, St. Louis: CV Mosby; 117120.Google Scholar
Loder, R.T., The influence of diabetes mellitus on the healing of closed fractures. Clin Orthop Relat Res, 1988(232): 210–6.Google Scholar
Ganesh, SP, Pietrobon, R., Cecilio, W.A., et al., The impact of diabetes on patient outcomes after ankle fracture. J Bone Joint Surg Am, 2005. 87(8): 1712–8.Google Scholar
Ahmed, LA, Joakimsen, R.M., Berntsen, G.K., et al., Diabetes mellitus and the risk of non-vertebral fractures: the Tromso study. Osteoporos Int, 2006. 17(4): 495500.Google Scholar
Egol, K.A., Tejwani, N.C., Walsh, M.G., et al., Predictors of short-term functional outcome following ankle fracture surgery. J Bone Joint Surg Am, 2006. 88(5):974–9.Google Scholar
Lane, J.M. and Vigorita, V.J., Osteoporosis. J Bone Joint Surg Am, 1983. 65(2):274–8.Google Scholar
Fulkerson, E., Egol, K.A., Kubiak, E.N., et al., Fixation of diaphyseal fractures with a segmental defect: a biomechanical comparison of locked and conventional plating techniques. J Trauma, 2006. 60(4):830–5.Google Scholar
Bhutani, G. and Gupta, M.C., Emerging therapies for the treatment of osteoporosis. J Midlife Health. 4(3): 147152.Google Scholar
Sammartino, A., Cirillo, D., Mandato, V.D., et al., Osteoporosis and cardiovascular disease: benefit-risk of hormone replacement therapy. J Endocrinol Invest, 2005. 28(10 Suppl):80–4.Google Scholar
Gass, M. and Dawson-Hughes, B., Preventing osteoporosis-related fractures: an overview. Am J Med, 2006. 119(4 Suppl 1):S3S11.Google Scholar
Kalu, D.N. and Masoro, E.J., The biology of aging, with particular reference to the musculoskeletal system. Clin Geriatr Med, 1988. 4(2):257–67.Google Scholar
Tomonaga, M., Histochemical and ultrastructural changes in senile human skeletal muscle. J Am Geriatr Soc, 1977. 25(3):125–31.Google Scholar
McCarter, R., Effects of age on contraction of mammalian skeletal muscle. In: Aging in muscle, Kalkor, J. D. G., Editor. 1978, New York: Raven Press; 122.Google Scholar
Murray, M.P., Duthie, E.H. Jr., Gmbert, S.R., et al., Age-related differences in knee muscle strength in normal women. J Gerontol, 1985. 40(3):275–80.Google Scholar
Broos, P.L., Stappaerts, K.H., Rommens, P.M., et al., Polytrauma in patients of 65 and over: injury patterns and outcome. Int Surg, 1988. 73(2): 119–22.Google Scholar
Martin, R.E. and Teberian, G., Multiple trauma and the elderly patient. Emerg Med Clin North Am, 1990. 8(2):411–20.Google Scholar
DeMaria, E.J., Kenney, P.R., Merriam, M.A., et al., Survival after trauma in geriatric patients. Ann Surg, 1987. 206(6):738–43.Google Scholar
Horst, H.M., Obeid, F.n., Sorensen, V.J., and Biins, B.A., Factors influencing survival of elderly trauma patients. Crit Care Med, 1986. 14(8):681–4.Google Scholar
Oreskovich, M.R., Howard, J.D., Copass, M.K., and Carrocp, C.J., Geriatric trauma: injury patterns and outcome. J Trauma, 1984. 24(7):565–72.Google Scholar
Bone, L. and Bucholz, R., The management of fractures in the patient with multiple trauma. J Bone Joint Surg Am, 1986. 68(6):945–9.Google Scholar
Gustilo, R.B. and Anderson, J.T., Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am, 1976. 58(4):453–8.Google Scholar
Gustilo, R.B., Simpson, L., Nixon, R., et al., Analysis of 511 open fractures. Clin Orthop Relat Res, 1969. 66:148–54.Google Scholar
Cornell, C.N., Lane, J.M., and Poynton, A.R., Orthopedic management of vertebral and long bone fractures in patients with osteoporosis. Clin Geriatr Med, 2003. 19(2):433–55.Google Scholar
Salter, R.B., Simmonds, D.F., Malcolm, B.W., et al., The biological effect of continuous passive motion on the healing of full-thickness defects in articular cartilage. An experimental investigation in the rabbit. J Bone Joint Surg Am, 1980. 62(8): 1232–51.Google Scholar
Scott, R.D., Turner, R.H., Leitzes, S.M., and Aufranc, O.E., Femoral fractures in conjunction with total hip replacement. J Bone Joint Surg Am, 1975. 57(4):494501.Google Scholar
Zickel, R.E., Fietti, V.G. Jr., Lawsing, J.F., and Cochran, G.V., A new intramedullary fixation device for the distal third of the femur. Clin Orthop Relat Res, 1977. 125: 185–91.Google Scholar
Johansson, J.E., McBroom, R., Barrington, T.W., and Hunter, G.A., Fracture of the ipsilateral femur in patients wih total hip replacement. J Bone Joint Surg Am, 1981. 63(9):1435–42.Google Scholar
Clain, A., Secondary Malignant Disease of Bone. Br J Cancer, 1965. 19:1529.Google Scholar
Jaffe, H., Tumors and Tumorous Conditions of Bones and Joint. 1958, Philadelphia: Lea & Febiger.Google Scholar
Parrish, F.F. and Murray, J.A., Surgical treatment for secondary neoplastic fractures. A retrospective study of ninety-six patients. J Bone Joint Surg Am, 1970. 52(4): 665–86.Google Scholar
Harrington, K., Impending pathologic fractures from metastatic malignancy: Evaluation and management. In: American Academy of Orthopaedic Surgeons Instructional Course Lectures XXXV, Anderson, L., Editor. 1986, St. Louis: CV Mosby; 357381.Google Scholar
Harrington, K.D., Sim, F.H., Enis, J.E., et al., Methylmethacrylate as an adjunct in internal fixation of pathological fractures. Experience with three hundred and seventy-five cases. J Bone Joint Surg Am, 1976. 58(8): 1047–55.Google Scholar
Papapetrou, P.D., Bisphosphonate-associated adverse events. Hormones (Athens), 2009. 8(2): 96110.Google Scholar
Neviaser, A.S., Lane, J.M., Lenart, B.A., et al., Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma, 2008. 22(5): 346–50.Google Scholar
Odvina, C.V., Zerwekh, J.E., Rao, D.S., et al., Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab, 2005. 90(3): 1294–301.Google Scholar
Thompson, R.N., Phillips, J.R., McCauley, S.H., et al., Atypical femoral fractures and bisphosphonate treatment: experience in two large United Kingdom teaching hospitals. J Bone Joint Surg Br, 2012. 94(3): 385–90.Google Scholar
Shane, E., Burr, D., Ebeling, P.R., et al., Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res, 1987. 29(1): 123.Google Scholar
Ha, Y.C., Cho, M.R., Park, K.H., et al., Is surgery necessary for femoral insufficiency fractures after long-term bisphosphonate therapy? Clin Orthop Relat Res, 2010. 468(12): 3393–8.Google Scholar
Egol, K.A., Park, J.H., Prensky, C., et al., Surgical treatment improves clinical and functional outcomes for patients who sustain incomplete bisphosphonate-related femur fractures. J Orthop Trauma, 2013. 27(6): 331–5.Google Scholar
Banffy, M.B., Vrahas, M.S., Ready, J.E., and Abraham, J.A., Nonoperative versus prophylactic treatment of bisphosphonate-associated femoral stress fractures. Clin Orthop Relat Res. 469(7): 2028–34.Google Scholar
Sexson, S.B. and Lehner, J.T., Factors affecting hip fracture mortality. J Orthop Trauma, 1987. 1(4):298305.Google Scholar
Kenzora, J.E., McCarthy, R.E., Lowell, J.D., and Sledge, C.B., Hip fracture mortality. Relation to age, treatment, preoperative illness, time of surgery, and complications. Clin Orthop Relat Res, 1984(186): 4556.Google Scholar
Zuckerman, J.D., Skovron, M.L., Koval, K.J., et al., Postoperative complications and mortality associated with operative delay in older patients who have a fracture of the hip. J Bone Joint Surg Am, 1995. 77(10):1551–6.Google Scholar
Davis, F.M., Woolner, D.F., Frampton, C., et al., Prospective, multi-centre trial of mortality following general or spinal anaesthesia for hip fracture surgery in the elderly. Br J Anaesth, 1987. 59(9):1080–8.Google Scholar
Valentin, N., Lomholt, B., Jensen, J.S., et al., Spinal or general anaesthesia for surgery of the fractured hip? A prospective study of mortality in 578 patients. Br J Anaesth, 1986. 58(3):284–91.Google Scholar
Modig, J., Borg, T., Karlstrom, G., et al., Thromboembolism after total hip replacement: role of epidural and general anesthesia. Anesth Analg, 1983. 62(2):174–80.Google Scholar
Brody, J.A., Prospects for an ageing population. Nature, 1985. 315(6019):463–6.Google Scholar
Frandsen, P.A. and Kruse, T., Hip fractures in the county of Funen, Denmark. Implications of demographic aging and changes in incidence rates. Acta Orthop Scand, 1983. 54(5):681–6.Google Scholar
Praemer, A., Furner, S., and Rice, D.P., Musculoskeletal Conditions in the United States. 1992, Park Ridge, IL: American Academy of Orthopaedic Surgeons; vii, 199.Google Scholar
Greenspan, S.L., Myers, S.L., Maitland, L.A., et al., Fall severity and bone mineral density as risk factors for hip fracture in ambulatory elderly. JAMA, 1994. 271(2):128–33.Google Scholar
Hinton, R.Y. and Smith, G.S., The association of age, race, and sex with the location of proximal femoral fractures in the elderly. J Bone Joint Surg Am, 1993. 75(5):752–9.Google Scholar
Hinton, R.Y., Lennox, D.W., Ebert, F.R., et al., Relative rates of fracture of the hip in the United States. Geographic, sex, and age variations. J Bone Joint Surg Am, 1995. 77(5):695702.Google Scholar
Garraway, W.M., Stauffer, R.N., Kurland, L.T., and O’Fallon, W.M., Limb fractures in a defined population. II. Orthopedic treatment and utilization of health care. Mayo Clin Proc, 1979. 54(11): 708–13.Google Scholar
Johnell, O. and Sernbo, I., Health and social status in patients with hip fractures and controls. Age Ageing, 1986. 15(5):285–91.Google Scholar
Uden, G. and Nilsson, B., Hip fracture frequent in hospital. Acta Orthop Scand, 1986. 57(5):428–30.Google Scholar
Rizzo, P.F., Gould, E.S., Lynden, J.P., and Asnis, S.E., Diagnosis of occult fractures about the hip. Magnetic resonance imaging compared with bone-scanning. J Bone Joint Surg Am, 1993. 75(3): 395401.Google Scholar
Parker, M.J., Myles, J.W., CAnandramer, J.K., and Drewett, R., Cost-benefit analysis of hip fracture treatment. J Bone Joint Surg Br, 1992. 74(2):261–4.Google Scholar
Colwell, C.W. Jr., Spiro, T.E., Trowbridge, A.A., et al., Use of enoxaparin, a low-molecular-weight heparin, and unfractionated heparin for the prevention of deep venous thrombosis after elective hip replacement. A clinical trial comparing efficacy and safety. Enoxaparin Clinical Trial Group. J Bone Joint Surg Am, 1994. 76(1):314.Google Scholar
Geerts, W.H., Jay, R.M., Code, K.I., et al., A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma. N Engl J Med, 1996. 335(10):701–7.Google Scholar
Merli, G.J., Update. Deep vein thrombosis and pulmonary embolism prophylaxis in orthopedic surgery. Med Clin North Am, 1993. 77(2): 397411.Google Scholar
Kinov, P., Tanchev, P.P., Ellis, M., and Volpin, G., Antithrombotic prophylaxis in major orthopaedic surgery: an historical overview and update of current recommendations. Int Orthop. 38(1): 169–75.Google Scholar
Koval, K.J., Skovron, M.L., Aharanoff, G.B., et al., Ambulatory ability after hip fracture. A prospective study in geriatric patients. Clin Orthop Relat Res, 1995. 310: 150–9.Google Scholar
White, B.L., Fisher, W.D., and Laurin, C.A., Rate of mortality for elderly patients after fracture of the hip in the 1980’s. J Bone Joint Surg Am, 1987. 69(9):1335–40.Google Scholar
Tajeu, G.S., Delzell, E., Smith, W., et al., Death, debility, and destitution following hip fracture. J Gerontol A Biol Sci Med Sci, 2014. 69(3): 346–53.Google Scholar
Aharonoff, G.B., Koval, K.J., Skovron, M.L., and Zuckerman, J.D., Hip fractures in the elderly: predictors of one year mortality. J Orthop Trauma, 1997. 11(3):162–5.Google Scholar
Seitz, D.P., Anderson, G.M., Austin, P.C., et al., Effects of impairment in activities of daily living on predicting mortality following hip fracture surgery in studies using administrative healthcare databases. BMC Geriatr. 14(1): 9.Google Scholar
Koval, K.J., Friend, K.D., Aharonoff, G.B., and Zuckerman, J.D., Weight bearing after hip fracture: a prospective series of 596 geriatric hip fracture patients. J Orthop Trauma, 1996. 10(8):526–30.Google Scholar
Koval, K.J., Sala, D.A., Kummer, F.J., and Zuckerman, J.D., Postoperative weight-bearing after a fracture of the femoral neck or an intertrochanteric fracture. J Bone Joint Surg Am, 1998. 80(3):352–6.Google Scholar
Probe, R. and Ward, R., Internal fixation of femoral neck fractures. J Am Acad Orthop Surg, 2006. 14(9):565–71.Google Scholar
Schmidt, A.H. and Swiontkowski, M.F., Femoral neck fractures. Orthop Clin North Am, 2002. 33(1): 97111, viii.Google Scholar
Cobb, A.G. and Gibson, P.H., Screw fixation of subcapital fractures of the femur – a better method of treatment? Injury, 1986. 17(4): 259–64.Google Scholar
Garden, R.S., Malreduction and avascular necrosis in subcapital fractures of the femur. J Bone Joint Surg Br, 1971. 53(2):183–97.Google Scholar
Stromqvist, B., Hansson, L.I., Nilsson, L.T., and Thorngren, K.G., Hook-pin fixation in femoral neck fractures. A two-year follow-up study of 300 cases. Clin Orthop Relat Res, 1987(218): 5862.Google Scholar
Bentley, G., Treatment of nondisplaced fractures of the femoral neck. Clin Orthop Relat Res, 1980(152): 93101.Google Scholar
Calder, S.J., Anderson, G.H., Jagger, C., et al., Unipolar or bipolar prosthesis for displaced intracapsular hip fracture in octogenarians: a randomised prospective study. J Bone Joint Surg Br, 1996. 78(3):391–4.Google Scholar
Keating, J.F., Grant, A., Masson, M., et al., Randomized comparison of reduction and fixation, bipolar hemiarthroplasty, and total hip arthroplasty: treatment of displaced intracapsular hip fractures in healthy older patients. J Bone Joint Surg Am, 2006. 88(2):249–60.Google Scholar
Hardy, D.C., Descamps, P.Y., Krallis, P., et al., Use of an intramedullary hip-screw compared with a compression hip-screw with a plate for intertrochanteric femoral fractures. A prospective, randomized study of one hundred patients. J Bone Joint Surg Am, 1998. 80(5):618–30.Google Scholar
Adams, C.I., Robinson, C.M., Court-Brown, C.M., and McQueen, M.M., Prospective randomized controlled trial of an intramedullary nail versus dynamic screw and plate for intertrochanteric fractures of the femur. J Orthop Trauma, 2001. 15(6):394400.Google Scholar
Crawford, C.H., Malkani, A.L., Cordray, S., et al., The trochanteric nail versus the sliding hip screw for intertrochanteric hip fractures: a review of 93 cases. J Trauma, 2006. 60(2): 325–8; discussion 328–9.Google Scholar
Stiell, I.G., McKnight, R.D., Greenberg, G.H., et al., Implementation of the Ottawa ankle rules. JAMA, 1994. 271(11):827–32.Google Scholar
McConnell, T., Creevy, W., and Tornetta, P. 3rd, Stress examination of supination external rotation-type fibular fractures. J Bone Joint Surg Am, 2004. 86-A(10): 2171–8.Google Scholar
Ramsey, P.L. and Hamilton, W., Changes in tibiotalar area of contact caused by lateral talar shift. J Bone Joint Surg Am, 1976. 58(3):356–7.Google Scholar
Beauchamp, C.G., Clay, N.R., and Thexton, P.W., Displaced ankle fractures in patients over 50 years of age. J Bone Joint Surg Br, 1983. 65(3):329–32.Google Scholar
Ali, M.S., McLaren, C.A.N., Rouholamin, E., and O’Connor, B.T., Ankle fractures in the elderly: nonoperative or operative treatment. J Orthop Trauma, 1987. 1(4):275–80.Google Scholar
Neer, C.S. 2nd, Displaced proximal humeral fractures. II. Treatment of three-part and four-part displacement. J Bone Joint Surg Am, 1970. 52(6): 1090–103.Google Scholar
Neer, C.S. 2nd, Displaced proximal humeral fractures. I. Classification and evaluation. J Bone Joint Surg Am, 1970. 52(6): 1077–89.Google Scholar
Alffram, P.A. and Bauer, G.C., Epidemiology of fractures of the forearm: a biomechanical investigation of bone strength. J Bone Joint Surg Am, 1962. 44-A: 105–14.Google Scholar
Rozental, T.D. and Blazar, P.E., Functional outcome and complications after volar plating for dorsally displaced, unstable fractures of the distal radius. J Hand Surg Am, 2006. 31(3):359–65.Google Scholar
Young, B.T. and Rayan, G.M., Outcome following nonoperative treatment of displaced distal radius fractures in low-demand patients older than 60 years. J Hand Surg Am, 2000. 25(1):1928.Google Scholar
Majd, M.E., Farley, S., and Holt, R.T., Preliminary outcomes and efficacy of the first 360 consecutive kyphoplasties for the treatment of painful osteoporotic vertebral compression fractures. Spine J, 2005. 5(3):244–55.Google Scholar
Prather, H., Van Dillen, L., Metzler, J.P., et al., Prospective measurement of function and pain in patients with non-neoplastic compression fractures treated with vertebroplasty. J Bone Joint Surg Am, 2006. 88(2):334–41.Google Scholar
Ma, X.L., Xing, D., Ma, J.X., et al., Balloon kyphoplasty versus percutaneous vertebroplasty in treating osteoporotic vertebral compression fracture: grading the evidence through a systematic review and meta-analysis. Eur Spine J. 21(9): 1844–59.Google Scholar

References

Studdiford, J, Salzman, B, Tully, A. Geriatric Dermatology. In: Arenson, C, Busby-Whitehead, J, Brummel-Smith, K, O’Brien James, G, Palmer, M, Reichel, W, eds. Reichel’s Care of the Elderly: Clinical Aspects of Aging. 6th ed. New York: Cambridge University Press; 2009; 345–68.Google Scholar
Kligman, AM, Koblenzer, C. Demographics and psychological implications for the aging population. Dermatol Clin. 1997 Oct; 15(4):549–53.Google Scholar
Vukmanovic-Stejic, M, Rustin, MH, Nikolich-Zugich, J, Akbar, AN. Immune responses in the skin in old age. Curr Opin Immunol. 2011 Aug; 23(4):525–31.Google Scholar
Kosmadaki, MG, Gilchrest, BA. The demographics of aging in the United States: implications for dermatology. Arch Dermatol. 2002 Nov; 138(11):1427–8.Google Scholar
Vandergriff, T, Bergstresser, P. Anatomy and Physiology. In: Bolognia, J, Jorrizo, J, Schaffer, J, eds. Dermatology. 3rd ed. Philadelphia: Saunders; 2012; 4354.Google Scholar
Gilchrest, BA, Chiu, N. Aging and the Skin. In: Beers, MH, Berkow, R, eds. The Merck Manual of Geriatrics, 3rd ed. Whitehouse Station, NJ: Merck and Co, Inc, 2000; 1231–7.Google Scholar
Balin, AK. Skin Disease, In: Evans, JG, Williams, TF, Beattie, BL, et al., eds. Oxford Textbook of Geriatric Medicine. 2nd ed. Oxford: Oxford University Press, 2000; 721–38.Google Scholar
Rinnerthaler, M, Duschl, J, Steinbacher, P, et al. Age-related changes in the composition of the cornified envelope in human skin. Exp Dermatol. 2013 May; 22(5):329–35.Google Scholar
Stalder, JF1, Tennstedt, D, Deleuran, M, et al. Fragility of epidermis and its consequence in dermatology. J Eur Acad Dermatol Venereol. 2014 Jun; 28(Suppl 4):118.Google Scholar
Fisher, GJ, Varani, J, Voorhees, JJ. Looking older: fibroblast collapse and therapeutic implications. Arch Dermatol. 2008; 144:666–72.Google Scholar
Rabe, JH, Mamelak, AJ, McElgunn, PJ, et al. Photoaging: mechanisms and repair. J Am Acad Dermatol. 2006 Jul; 55(1):119.Google Scholar
Xu, YP, Qi, RQ, Chen, W, et al. Aging affects epidermal Langerhans cell development and function and alters their miRNA gene expression profile. Aging (Albany, NY). 2012 Nov;4(11):742–54.Google Scholar
Laube, S: Skin infections and ageing. Ageing Res Rev. 2004; 13:6989.Google Scholar
Agius, E, Lacy, KE, Vukmanovic-Stejic, M, et al. Decreased TNF-{alpha} synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4+ T cells during aging. J Exp Med. 2009; 206:1929–40.Google Scholar
Yaar, M, Gilchrest, BA. Ageing and photoageing of keratinocytes and melanocytes. Clin Exp Dermatol. 2001; 26:583–91.Google Scholar
Waller, JM, Maibach, HI. Age and skin structure and function, a quantitative approach (I): blood flow, pH, thickness, and ultrasound echogenicity. Skin Res Technol. 2005; 11:221–35.Google Scholar
Hughes, VA, Roubenoff, R, Wood, M, et al. Anthropometric assessment of 10-y changes in body composition in the elderly. Am J Clin Nutr. 2004; 80:475–82.Google Scholar
Fenske, NA, Lober, CW. Structural and functional changes of normal aging skin. J Am Acad Dermatol. 1986; 15:571–85.Google Scholar
Thomas, DR, Burkemper, NM. Aging skin and wound healing. Clin Geriatr Med. 2013 May; 29(2):xixx.Google Scholar
Katz, MH, Kirsner, RS, Eaglstein, WH, et al: Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth. J Am Acad Dermatol. 1991; 25:1054–8.Google Scholar
Kirsner, RS, Eaglstein, WH: The wound healing process. Dermatol Clin. 1993; 11:629–40.Google Scholar
Sandblom, PH, Peterson, P, Muren, A, et al. Determination of the tensile strength of the healing wound as a clinical test. Acta Chir Scand. 1953; 105:252–7.Google Scholar
Freedland, M, Karmiol, S, Rodriguez, J, et al. Fibroblast responses to cytokines are maintained during aging. Ann Plast Surg. 1995; 35:290–6.Google Scholar
Pienta, KJ, Coppey, DS. Characterization of the subtypes of cell motility in ageing human skin fibroblasts. Mech Ageing Dev. 1990; 56:99105.Google Scholar
Raffetto, JD. Dermal pathology, cellular biology, and inflammation in chronic venous disease. Thromb Res. 2009; 123(Suppl 4):S6671.Google Scholar
Bergan, JJ, Schmid-Schonbein, GW, Smith, PD, et al. Chronic venous disease. N Engl J Med. 2006; 355:488–98.Google Scholar
Aharon, I, Etcoff, N, Ariely, D, et al. Beautiful faces have variable reward value: fMRI and behavioral evidence. Neuron. 2001; 32:537–51.Google Scholar
Henderson, JJA. Facial attractiveness predicts longevity. Evol Hum Behav. 2003; 24:351–6.Google Scholar
Alam, M. Dover, JS. On beauty: evolution, psychosocial considerations, and surgical enhancement. Arch Dermatol. 2001; 137:795807.Google Scholar
Rohrich, R, Pessa, J. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. J Plast Reconstr Surg. 2007; 119:2219–27.Google Scholar
Lambros, V. Observations on periorbital and midface aging. Plast Reconstr Surg. 2007; 120:1367–76.Google Scholar
Plewig, G, Koigman, AM. Proliferative activity of the sebaceous glands of the aged. J Invest Dermatol. 1978; 70:314–17.Google Scholar
Iannacone, MR, Hughes, MC, Green, AC. Effects of sunscreen on skin cancer and photoaging. Photodermatol Photoimmunol Photomed. 2014 Apr–Jun; 30(2–3):5561.Google Scholar
Creidi, P, Vienne, M-P, Ochonisky, S, et al. Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment. J Am Acad Dermatol. 1998; 39:960–5.Google Scholar
Olsen, EA, Katz, HI, Levine, N, et al. Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol. 1997 Aug; 37(2 Pt 1):217–26.Google Scholar
Calikoglu, E, Sorg, O, Tran, C, et al. UVA and UVB decrease the expression of CD44 and hyaluronate in mouse epidermis, which is counteracted by topical retinoids. Photochem Photobiol. 2006; 82:1342–7.Google Scholar
Dietre, CM, Griffin, TD, Murphy, GF, et al. Effects of alpha-hydroxy acids on photoaged skin. J Am Acad Dermatol. 1996; 34:187–95.Google Scholar
Akpinar, F, Dervis, E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol. 2012 Jan–Feb; 22(1):106–10.Google Scholar
Fajgenbaum, DC, Rosenbach, M, van Rhee, F, et al. Eruptive cherry hemangiomatosis associated with multicentric Castleman disease: a case report and diagnostic clue. JAMA Dermatol. 2013 Feb; 149(2):204–8.Google Scholar
Derancourt, C, Bourdon-Lanoy, E, Grob, JJ, et al. Multiple large solar lentigos on the upper back as clinical markers of past severe sunburn: a case-control study. Dermatology. 2007; 214(1):2531.Google Scholar
Tanaka, M, Sawada, M, Kobayashi, K. Key points in dermoscopic differentiation between lentigo maligna and solar lentigo. J Dermatol. Jan 2011; 38(1):53–8.Google Scholar
e Dinato, SL, de Oliva, R, e Dinato, MM, et al. [Prevalence of dermatoses in residents of institutions for the elderly]. Rev Assoc Med Bras. Nov–Dec 2008; 54(6):543–7.Google Scholar
Shuster, S. Osteoporosis, a unitary hypothesis of collagen loss in skin and bone. Med Hypotheses. 2005; 65(3):426–32.Google Scholar
Stone, M. Cysts. In: Bolognia, J, Jorrizo, J, Schaffer, J, eds. Dermatology. 3rd ed. Philadelphia: Saunders; 2012: 4354.Google Scholar
Rogers, HW, Weinstock, MA, Harris, AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol. 2010; 146(3):283–7.Google Scholar
American Cancer Society. Cancer Facts and Figures 2014. Available at: www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures2014/index (accessed July 15, 2014).Google Scholar
Stern, RS. Prevalence of a history of skin cancer in 2007: results of an incidence-based model. Arch Dermatol. 2010 Mar; 146(3):279–82.Google Scholar
Mancebo, SE, Hu, JY, Wang, SQ. Sunscreens: a review of health benefits, regulations, and controversies. Dermatol Clin. 2014 Jul; 32(3):427–38.Google Scholar
Green, AC, Williams, GM, Logan, V, Strutton, GM. Reduced melanoma after regular sunscreen use: randomized trial follow-up J Clin Onco. 2011 Jan 20; 29(3):257–63; published online on December 6, 2010.Google Scholar
Lin, JS, Eder, M, Weinmann, S. Behavioral counseling to prevent skin cancer: a systematic review for the US Preventive Services Task Force. Ann Intern Med. 2011 Feb 1; 154(3):190201.Google Scholar
Youssef, KK, Van Keymeulen, A, Lapouge, G, et al. Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol. 2010; 12:299305.Google Scholar
Soyer, HP, Rigel, D, Wurm, E. Actinic Keratosis, Basal Cell Carcinoma, and Squamous Cell Carcinoma In: Bolognia, J, Jorrizo, J, Schaffer, J, eds. Dermatology. 3rd ed. Philadelphia: Saunders; 2012: 1773–94.Google Scholar
Bath, FJ, Bong, J, Perkins, W, Williams, HC. Interventions for basal cell carcinoma of the skin. Cochrane Database Syst Rev. 2003; 2:CD003412.Google Scholar
Chren, MM, Linos, E, Torres, JS, et al. Tumor recurrence 5 years after treatment of cutaneous basal cell carcinoma and squamous cell carcinoma. J Invest Dermatol. 2013 May; 133(5):1188–96.Google Scholar
Röwert-Huber, J, Patel, MJ, Forschner, T, et al. Actinic keratosis is an early in situ squamous cell carcinoma: a proposal for reclassification. Br J Dermatol. 2007; 156:812.Google Scholar
Brantsch, KD, Meisner, C, Schonfisch, B, et al. Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol. 2008; 9:713–20.Google Scholar
Schwartz, RA. Keratoacanthoma. J Am Acad Dermatol. 1994; 30:119.Google Scholar
Rowe, DE, Carroll, RJ, Day, CL Jr. Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol. 1992; 26:976–90.Google Scholar
Marcil, I, Stern, RS. Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer: a critical review of the literature and meta-analysis. Arch Dermatol. 2000; 136:1524–30.Google Scholar
Micali, G, Lacarrubba, F, Nasca, MR, et al. Topical pharmacotherapy for skin cancer: part II. Clinical applications. J Am Acad Dermatol. 2014 Jun; 70(6):979.e112.Google Scholar
Ross, K, Cherpelis, B, Lien, M, Fenske, N. Spotlighting the role of photodynamic therapy in cutaneous malignancy: an update and expansion. Dermatol Surg. 2013 Dec; 39(12):1733–44.Google Scholar
Scope, A, Dusza, SW, Halpern, AC, et al. The “ugly duckling” sign: agreement between observers. Arch Dermatol. 2008 Jan; 144(1):5864.Google Scholar
Garbe, C, Bauer, J. Melanoma In: Bolognia, J, Jorrizo, J, Schaffer, J, eds. Dermatology. 3rd ed. Philadelphia: Saunders; 2012: 18851914.Google Scholar
Zitelli, JA, Brown, C, Hanusa, BH. Mohs micrographic surgery for the treatment of primary cutaneous melanoma. J Am Acad Dermatol. 1997 Aug; 37(2 Pt 1):236–45.Google Scholar
Gershenwald, JE, Thompson, W, Mansfield, PF, et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol. 1999; 17:976–83.Google Scholar
Leiter, U, Buettner, PG, Bohnenberger, K, et al. Sentinel lymph node dissection in primary melanoma reduces subsequent regional lymph node metastasis as well as distant metastasis after nodal involvement. Ann Surg Oncol. 2010; 17:129–37.Google Scholar
Kettlewell, S, Moyes, C, Bray, C, et al. Value of sentinel node status as a prognostic factor in melanoma: prospective Observational Study. BMJ. 2006; 332:1423–7.Google Scholar
Morton, DL, Thompson, JF, Cochran, AJ, et al. Sentinel-node biopsy or nodal observation in melanoma. N Engl J Med. 2006; 355:1307–17.Google Scholar
Sosman, JA, Kim, KB, Schuchter, L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med. 2012 Feb 23; 366(8):707–14.Google Scholar
Chapman, PB, Hauschild, A, Robert, C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011; 364:2507–16.Google Scholar
Elewski, BE, Draelos, Z, Dréno, B, et al. Rosacea – global diversity and optimized outcome: proposed international consensus from the Rosacea International Expert Group. J Eur Acad Dermatol Venereol. 2011; 25:188200.Google Scholar
Berg, M. Epidemiological studies of the influence of sunlight on the skin. Photodermatol. 1989; 6:80–4.Google Scholar
McAleer, MA, Fitzpatrick, P, Powell, FC. Papulopustular rosacea: prevalence and relationship to photodamage. J Am Acad Dermatol. 2010; 63:33–9.Google Scholar
Spoendlin, J, Voegel, JJ, Jick, SS, et al. A study on the epidemiology of rosacea in the UK. Br J Dermatol. 2012 Sept; 167(3):598605.Google Scholar
Wilkin, J, Dahl, M, Detmar, M, et al. Standard classification of rosacea: report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea. J Am Acad Dermatol. 2002; 46:584–7.Google Scholar
Lazararidou, E, Clinical and laboratory study of ocular rosacea in northern Greece. J Eur Acad Dermatol Venereol. 2011 Dec; 25(12):1428–31.Google Scholar
Lazaridou, E, Giannopoulou, C, Fotiadou, C, et al. The potential role of microorganisms in the development of rosacea. J Dtsch Dermatol Ges. 2011; 9:21–5.Google Scholar
Zhao, YE, Wu, LP, Peng, Y, Cheng, H. Retrospective analysis of the association between Demodex infestation and rosacea. Arch Dermatol. 2010; 146:896902.Google Scholar
Kastarinen, H, Oksanen, T, Okokon, EO, et al. Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp. Cochrane Database Syst Rev. 2014; 5:CD009446.Google Scholar
Potts, GA, Hurley, MY. Psoriasis in the geriatric population. Clin Geriatr Med. 2013 May; 29(2):373–95.Google Scholar
Dregan, A, Charlton, J, et al. Chronic inflammatory disorders and risk of type 2 diabetes mellitus, coronary heart disease, and stroke: a population-based cohort study. Circulation. 2014 Sep 2; 130(10):837–44.Google Scholar
Van der Voort, EA et al. Psoriasis is independently associated with nonalcoholic fatty liver disease in patients 55 years or older: Results from a population-based study. J Am Acad Dermatol. 2014 Mar; 70(3):517–24.Google Scholar
Zachariae, H. Prevalence of joint disease in patients with psoriasis: implications for therapy. Am J Clin Dermatol. 2003; 4:441–7.Google Scholar
Eder, L, Chandran, V, Shen, H, et al. Incidence of arthritis in a prospective cohort of psoriasis patients. Arthritis Care Res (Hoboken). 2011; 63:619–22.Google Scholar
Alamanos, Y, Voulgari, PV, Drosos, AA. Incidence and prevalence of psoriatic arthritis: a systematic review. J Rheumatol 2008; 35:1354–8.Google Scholar
Balato, N, Managing moderate-to-severe psoriasis in the elderly. Drugs Aging. 2014 Apr; 31(4):233–8.Google Scholar
Williams, HC, ed. Atopic Dermatitis: The Epidemiology, Causes and Prevention of Atopic Eczema. Cambridge: Cambridge University Press, 2000.Google Scholar
Ozakaya, E. Adult-onset atopic dermatitis. J Am Acad Dermatol. 2005 Apr; 52(4):579–82.Google Scholar
Bonamonte, D, Foti, C, Vestita, M, et al. Nummular eczema and contact allergy: a retrospective study. Dermatitis. 2012 Jul–Aug; 23(4):153–7.Google Scholar
Garritsen, FM, ter Haar, NM, Spuls, PI. House dust mite reduction in the management of atopic dermatitis: a critically appraised topic. Br J Dermatol. 2013; 168:688–91.Google Scholar
Kjaer, HF, Eller, E, Høst, A, et al. The prevalence of allergic diseases in an unselected group of 6-year-old children: the DARC birth cohort study. Pediatr Allergy Immunol. 2008; 19:737–45.Google Scholar
Bath-Hextall, F, Delamere, FM, Williams, HC. Dietary exclusions for established atopic eczema. Cochrane Database Syst Rev. 2008; 1:CD005203.Google Scholar
Ring, J, Alomar, A, Bieber, T, et al. Guidelines for treatment of atopic eczema (atopic dermatitis) part II: European Dermatology Forum; European Academy of Dermatology and Venereology; European Task Force on Atopic Dermatitis; European Federation of Allergy; European Society of Pediatric Dermatology; Global Allergy and Asthma European Network. J Eur Acad Dermatol Venereol. 2012 Sep; 26(9):1176–93.Google Scholar
Berger, TG, Shive, M, Harper, GM. Pruritus in the older patient: a clinical review. JAMA. 2013;310(22);2443–50.Google Scholar
Paul, C, Maumus-Robert, S, Mazereeuw-Hautier, J, et al. Prevalence and risk factors for xerosis in the elderly: a cross-sectional epidermological study in primary care. Dermatology. 2011; 223(3):260–5.Google Scholar
Cohen, AD, Vander, T, Medvendovski, E, et al. Neuropathic scrotal pruritus: anogenital pruritus is a symptoms of lumbosacral radiculopathy. JAAD. 2005; 52(1):61–6.Google Scholar
Savk, O, Savk, E. Investigation of spinal pathology in notalgia paresthetica. J Am Acad Dermatol. 2005; 52:1085–7.Google Scholar
Browning, J, Combes, B, Mayo, MJ. Long-term efficacy of sertraline as a treatment for cholestatic pruritus in patients with primary biliary cirrhosis. Am J Gastroenterol. 2003; 98:2736–41.Google Scholar
Klein, PA, Clark, RA. An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Arch Dermatol. 1999; 135:1522–5.Google Scholar
Ada, S, Seçkin, D, Budakoğlu, I, Ozdemir, FN. Treatment of uremic pruritus with narrowband ultraviolet B phototherapy: an open pilot study. J Am Acad Dermatol. 2005; 53:149–51.Google Scholar
Wang, H, Yosipovitch, G. New insights into the pathophysiology and treatment of chronic itch in patients with end-stage renal disease, chronic liver disease, and lymphoma. Int J Dermatol. 2010; 49:111.Google Scholar
Davis, MP, Frandsen, JL, Walsh, D, et al. Mirtazapine for pruritus. J Pain Symptom Manage. 2003; 25:288–91.Google Scholar
Hundley, JL, Yosipovitch, G. Mirtazapine for reducing nocturnal itch in patients with chronic pruritus: a pilot study. J Am Acad Dermatol. 2004; 50:889–91.Google Scholar
Demierre, MF, Taverna, J. Mirtazapine and gabapentin for reducing pruritus in cutaneous T-cell lymphoma. J Am Acad Dermatol. 2006; 55:543–4.Google Scholar
Sheen, MJ, Ho, ST, Lee, CH, et al. Prophylactic mirtazapine reduces intrathecal morphine-induced pruritus. Br J Anaesth. 2008; 101:711–15.Google Scholar
Ständer, S, Böckenholt, B, Schürmeyer-Horst, F, et al. Treatment of chronic pruritus with the selective serotonin re-uptake inhibitors paroxetine and fluvoxamine: results of an open-labelled, two-arm proof-of-concept study. Acta Derm Venereol. 2009; 89:4551.Google Scholar
Mayo, MJ, Handem, I, Saldana, S, et al. Sertraline as a first-line treatment for cholestatic pruritus. Hepatology. 2007; 45:666–74.Google Scholar
Wallengren, J, Sundler, F. Brachioradial pruritus is associated with a reduction in cutaneous innervation that normalizes during the symptom-free remissions. J Am Acad Dermatol. 2005; 52:142–5.Google Scholar
Goodkin, R, Wingard, E, Bernhard, JD. Brachioradial pruritus: cervical spine disease and neurogenic/neuropathic [corrected] pruritus. J Am Acad Dermatol. 2003; 48:521–4.Google Scholar
Marziniak, M, Phan, NQ, Raap, U, et al. Brachioradial pruritus as a result of cervical spine pathology: the results of a magnetic resonance tomography study. J Am Acad Dermatol. 2011; 65:756–62.Google Scholar
Eschler, DC, Klein, PA. An evidence-based review of the efficacy of topical antihistamines in the relief of pruritus. J Drugs Dermatol. 2010; 9:992–7.Google Scholar
Dawn, AG, Yosipovitch, G. Butorphanol for treatment of intractable pruritus. J Am Acad Dermatol. 2006; 54:527–31.Google Scholar
Kumagai, H, Ebata, T, Takamori, K, et al. Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a phase III, randomized, double-blind, placebo-controlled study. Nephrol Dial Transplant. 2010; 25:1251–7.Google Scholar
Phan, NQ, Bernhard, JD, Luger, TA, Ständer, S. Antipruritic treatment with systemic μ-opioid receptor antagonists: a review. J Am Acad Dermatol. 2010; 63:680–8.Google Scholar
Penning, JP, Samson, B, Baxter, AD. Reversal of epidural morphine-induced respiratory depression and pruritus with nalbuphine. Can J Anaesth. 1988; 35:599604.Google Scholar
Gilchrest, BA, Rowe, JW, Brown, RS, et al. Relief of uremic pruritus with ultraviolet phototherapy. N Engl J Med. 1977; 297:136–8.Google Scholar
Ko, MJ, Yang, JY, Wu, HY, et al. Narrowband ultraviolet B phototherapy for patients with refractory uraemic pruritus: a randomized controlled trial. Br J Dermatol. 2011; 165:633–9.Google Scholar
Yalçin, B, Tamer, E, Toy, GG, et al. The prevalence of skin diseases in the elderly: analysis of 4099 geriatric patients. Int J Dermatol. 2006; 45:672–6.Google Scholar
Tomljanović-Veselski, M, Lipozencić, J, Lugović, L. Contact allergy to special and standard allergens in patients with venous ulcers. Coll Antropol. 2007; 31:751–6.Google Scholar
Jindal, R, Sharma, NL, Mahajan, VK, Tegta, GR. Contact sensitization in venous eczema: preliminary results of patch testing with Indian standard series and topical medicaments. Indian J Dermatol Venereol Leprol. 2009; 75:136–41.Google Scholar
Mimouni, D. Diagnosis and classification of pemphigus and BP. Autoimmunity Reviews. 2014 Apr–May: 13(4–5):477–81.Google Scholar
Bystryn, JC, Rudolph, JL. Pemphigus. Lancet. 2005; 366:6173.Google Scholar
Grando, SA. Pemphigus autoimmunity: hypotheses and realities. Autoimmunity. 2012; 45:735.Google Scholar
Lever, WF. Pemphigus. Medicine (Baltimore). 1953; 32:1123.Google Scholar
Joly, P, Roujeau, JC, Benichou, J, et al. A comparison of oral and topical corticosteroids in patients with bullous pemphigoid. N Engl J Med. 2002; 346:321–7.Google Scholar
Goon, AT, Tan, SH, Khoo, LS, Tan, T. Tetracycline and nicotinamide for the treatment of bullous pemphigoid: our experience in Singapore. Singapore Med J. 2000; 41:327–30.Google Scholar
Gürcan, HM, Ahmed, AR. Efficacy of dapsone in the treatment of pemphigus and pemphigoid: analysis of current data. Am J Clin Dermatol. 2009; 10:383–96.Google Scholar
Singh, S. Evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: a systematic review. Indian J Dermatol Venereol Leprol. 2011 Jul–Aug; 77(4):456–69.Google Scholar
Mutasim, DF. Autoimmune bullous dermatoses in the elderly: diagnosis and management. Drugs Aging. 2003; 20(9):663–81.Google Scholar
Stavropoulos, PG, Soura, E, Antoniou, C. Drug-induced pemphigoid: a review of the literature. J Eur Acad Dermatol Venereol. 2014 Sep; 28(9):1133–40.Google Scholar
Brenner, S, Bialy-Golan, A, Ruocco, V. Drug-induced pemphigus. Clin Dermatol. 1998; 16:393–7.Google Scholar
Brenner, S, Goldberg, I. Drug-induced pemphigus. Clin Dermatol. 2011; 29:455–7.Google Scholar
Feng, S, Zhou, W, Zhang, J, Jin, P. Analysis of 6 cases of drug-induced pemphigus. Eur J Dermatol. 2011; 21:696–9.Google Scholar
Dupuy, A, Benchikhi, H, Roujeau, JC, et al. Risk factors for erysipelas of the leg (cellulitis): case-control study. BMJ. 1999; 318:1591–4.Google Scholar
Semel, JD, Goldin, H. Association of athlete’s foot with cellulitis of the lower extremities: diagnostic value of bacterial cultures of ipsilateral interdigital space samples. Clin Infect Dis 1996; 23:1162–4.Google Scholar
McNamara, DR, Tleyjeh, IM, Berbari, EF, et al. Incidence of lower-extremity cellulitis: a population-based study in Olmsted county, Minnesota. Mayo Clin Proc. 2007; 82:817–21.Google Scholar
Perl, B, Gottehrer, NP, Raveh, D, et al. Cost-effectiveness of blood cultures for adult patients with cellulitis. Clin Infect Dis. 1999; 29:1483–8.Google Scholar
Peralta, G, Padrón, E, Roiz, MP, et al. Risk factors for bacteremia in patients with limb cellulitis. Eur J Clin Microbiol Infect Dis. 2006; 25:619–26.Google Scholar
Harpaz, R, Ortega-Sanchez, IR, Seward, JF, Advisory Committee on Immunization Practices (ACIP) Centers for Disease Control and Prevention (CDC). Prevention of herpes zoster: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2008; 57:130.Google Scholar
Yawn, BP, Saddier, P, Wollan, PC, et al. A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction. Mayo Clin Proc. 2007; 82:1341–9.Google Scholar
Straus, SE, Ostrove, JM, Inchauspé, G, et al. NIH conference. Varicella-zoster virus infections: biology, natural history, treatment, and prevention. Ann Intern Med. 1988; 108:221–37.Google Scholar
Donahue, JG, Choo, PW, Manson, JE, Platt, R. The incidence of herpes zoster. Arch Intern Med. 1995; 155:1605–9.Google Scholar
Zhang, JX, Joesoef, RM, Bialek, S, et al. Association of physical trauma with risk of herpes zoster among Medicare beneficiaries in the United States. J Infect Dis. 2013; 207:1007–11.Google Scholar
McDonald, JR, Zeringue, AL, Caplan, L, et al. Herpes zoster risk factors in a national cohort of veterans with rheumatoid arthritis. Clin Infect Dis. 2009; 48:1364–71.Google Scholar
Bowsher, D. Postherpetic neuralgia and its treatment: a retrospective survey of 191 patients. J Pain Symptom Manage. 1996; 12:290–9.Google Scholar
Rowbotham, M, Harden, N, Stacey, B, et al. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA. 1998; 280:1837–42.Google Scholar
Pavan-Langston, D. Herpes zoster ophthalmicus. Neurology 1995; 45:S50–1.Google Scholar
Ragozzino, MW, Melton, LJ 3rd, Kurland, LT, et al. Population-based study of herpes zoster and its sequelae. Medicine (Baltimore). 1982; 61:310–6.Google Scholar
Tomkinson, A, Roblin, DG, Brown, MJ. Hutchinson’s sign and its importance in rhinology. Rhinology. 1995; 33:180–2.Google Scholar
Diaz, GA, Rakita, RM, Koelle, DM. A case of Ramsay Hunt–like syndrome caused by herpes simplex virus type 2. Clin Infect Dis. 2005; 40:1545–7.Google Scholar
Gnann, JW Jr. Varicella-zoster virus: atypical presentations and unusual complications. J Infect Dis. 2002; 186(Suppl 1):S91–8.Google Scholar
Kost, RG, Straus, SE. Postherpetic neuralgia–pathogenesis, treatment, and prevention. N Engl J Med. 1996; 335:3242.Google Scholar
Choo, PW, Galil, K, Donahue, JG, et al. Risk factors for postherpetic neuralgia. Arch Intern Med. 1997; 157:1217–24.Google Scholar
Adour, KK. Otological complications of herpes zoster. Ann Neurol. 1994; 35(Suppl):S62–4.Google Scholar
Mishell, JH, Applebaum, EL. Ramsay-Hunt syndrome in a patient with HIV infection. Otolaryngol Head Neck Surg. 1990; 102:177–9.Google Scholar
Levin, MJ, Oxman, MN, Zang, JH, et al. Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine. J Infect Dis. 2008 Mar 15; 197(6):825–35.Google Scholar
Oxman, MN, Levin, MJ, Shingles Prevention Study Group. Vaccination against herpes zoster and postherpetic neuralgia. J Infect Dis. 2008; 197(Suppl 2):S228–36.Google Scholar
Fuller, LC. Epidemiology of scabies. Curr Opin Infect Dis. 2013; 26:123–6.Google Scholar
Arlian, LG, Runyan, RA, Achar, S, Estes, SA. Survival and infectivity of Sarcoptes scabiei var. canis and var. hominis. J Am Acad Dermatol. 1984; 11:210–15.Google Scholar
Currie, BJ, McCarthy, JS. Permethrin and ivermectin for scabies. N Engl J Med. 2010; 362:717–25.Google Scholar
Usha, V, Gopalakrishnan Nair, TV. A comparative study of oral ivermectin and topical permethrin cream in the treatment of scabies. J Am Acad Dermatol. 2000; 42:236–40.Google Scholar
Sigurgeirsson, B, Steingrímsson, O. Risk factors associated with onychomycosis. J Eur Acad Dermatol Venereol. 2004; 18:4851.Google Scholar
Piérard, GE, Piérard-Franchimont, C. The nail under fungal siege in patients with type II diabetes mellitus. Mycoses. 2005; 48:339–42.Google Scholar
Muñoz-Pérez, MA, Rodriguez-Pichardo, A, Camacho, F, Colmenero, MA. Dermatological findings correlated with CD4 lymphocyte counts in a prospective 3 year study of 1161 patients with human immunodeficiency virus disease predominantly acquired through intravenous drug abuse. Br J Dermatol. 1998; 139:33–9.Google Scholar
Zaias, N, Tosti, A, Rebell, G, et al. Autosomal dominant pattern of distal subungual onychomycosis caused by Trichophyton rubrum. J Am Acad Dermatol. 1996; 34:302–4.Google Scholar
Faergemann, J, Correia, O, Nowicki, R, Ro, BI. Genetic predisposition–understanding underlying mechanisms of onychomycosis. J Eur Acad Dermatol Venereol. 2005; 19(Suppl 1):1719.Google Scholar
Gupta, AK, Jain, HC, Lynde, CW, et al. Prevalence and epidemiology of onychomycosis in patients visiting physicians’ offices: a multicenter Canadian survey of 15,000 patients. J Am Acad Dermatol. 2000; 43:244–8.Google Scholar
Weinberg, JM, Koestenblatt, EK, Tutrone, WD, et al. Comparison of diagnostic methods in the evaluation of onychomycosis. J Am Acad Dermatol. 2003 Aug; 49(2):193–7.Google Scholar
Gupta, AK, Fleckman, P, Baran, R. Ciclopirox nail lacquer topical solution 8% in the treatment of toenail onychomycosis. J Am Acad Dermatol. 2000; 43:S7080.Google Scholar
Gupta, AK, Ryder, JE, Johnson, AM. Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis. Br J Dermatol. 2004; 150:537.Google Scholar
Sigurgeirsson, B, Olafsson, JH, Steinsson, JB, et al. Long-term effectiveness of treatment with terbinafine vs itraconazole in onychomycosis: a 5-year blinded prospective follow-up study. Arch Dermatol. 2002; 138:353–7.Google Scholar
Drake, LA, Shear, NH, Arlette, JP, et al. Oral terbinafine in the treatment of toenail onychomycosis: North American multicenter trial. J Am Acad Dermatol. 1997; 37:740–5.Google Scholar
Tosti, A, Piraccini, BM, Stinchi, C, Colombo, MD. Relapses of onychomycosis after successful treatment with systemic antifungals: a three-year follow-up. Dermatology. 1998; 197:162–6.Google Scholar
Hollmig, ST, Rahman, Z, Henderson, MT, et al. Lack of efficacy with 1064-nm neodymium:yttrium-aluminum-garnet laser for the treatment of onychomycosis: a randomized, controlled trial. J Am Acad Dermatol. 2014; 70:911–7.Google Scholar
Yosipovitch, G, DeVore, A, Dawn, A. Obesity and the skin: skin physiology and skin manifestations of obesity. J Am Acad Dermatol. 2007 Jun; 56(6):901–16.Google Scholar

References

Levine, JM. Historical notes on pressure ulcers: the cure of Ambrose Pare. Decubitus. 1992 Mar;5(2):23–4, 26.Google Scholar
Levine, JM. Historical perspective on pressure ulcers: the decubitus ominosus of Jean-Martin Charcot. J Am Geriatr Soc. 2005 Jul;53(7):1248–51.Google Scholar
Woodruff, MB. To prevent and cure pressure sores. Am J Nurs. 1952 May;52(5):606.Google Scholar
Pieper, B, Kirsner, RS. Pressure ulcers: even the grading of facilities fails. Ann Intern Med. 2013 Oct 15;159(8):571–2.Google Scholar
Preventing Pressure Ulcers in Hospitals: A Toolkit for Improving Quality of Care [Internet]. Available from: www.ahrq.gov/professionals/systems/long-term-care/resources/pressure-ulcers/pressureulcertoolkit/putoolkit.pdf (accessed May 21, 2014).Google Scholar
Brem, H, Maggi, J, Nierman, D, et al. High cost of stage IV pressure ulcers. Am J Surg. 2010 Oct;200(4):473–7.Google Scholar
Hopkins, A, Dealey, C, Bale, S, et al. Patient stories of living with a pressure ulcer. J Adv Nurs. 2006 Nov;56(4):345–53.Google Scholar
Healthy People 2020 [Internet]. Available from: www.healthypeople.gov/2020/topicsobjectives2020/overview.aspx?topicid=31 (accessed May 30, 2014).Google Scholar
Padula, WV, Mishra, MK, Makic, MB, Sullivan, PW. Improving the quality of pressure ulcer care with prevention: a cost-effectiveness analysis. Med Care. 2011 Apr;49(4):385–92.Google Scholar
Langemo, DK, Brown, G. Skin fails too: acute, chronic, and end-stage skin failure. Adv Skin Wound Care. 2006 May;19(4):206–11.Google Scholar
Bansal, C, Scott, R, Stewart, D, Cockerell, CJ. Decubitus ulcers: a review of the literature. Int J Dermatol. 2005 Oct;44(10):805–10.Google Scholar
Black, JM, Edsberg, LE, Baharestani, MM, et al. Pressure ulcers: avoidable or unavoidable? Results of the National Pressure Ulcer Advisory Panel Consensus Conference. Ostomy Wound Manage. 2011 Feb;57(2):2437.Google Scholar
Coleman, S, Nixon, J, Keen, J, et al. A new pressure ulcer conceptual framework. J Adv Nurs. 2014 Oct;70(10):2222–34.Google Scholar
Tzeng, HM, Grandy, GA, Yin, CY. Staff response time to call lights and unit-acquired pressure ulcer rates in adult in-patient acute care units. Contemp Nurse. 2013 Oct;45(2):182–7.Google Scholar
Sving, E, Gunningberg, L, Hogman, M, Mamhidir, AG. Registered nurses’ attention to and perceptions of pressure ulcer prevention in hospital settings. J Clin Nurs. 2012 May;21(9–10):1293–303.Google Scholar
Backhaus, R, Verbeek, H, van Rossum, E, et al. Nurse Staffing Impact on Quality of Care in Nursing Homes: A Systematic Review of Longitudinal Studies. J Am Med Dir Assoc. 2014 Jun;15(6):383–93.Google Scholar
Sullivan, N, Schoelles, KM. Preventing in-facility pressure ulcers as a patient safety strategy: a systematic review. Ann Intern Med. 2013 Mar 5;158(5 Pt 2):410–16.Google Scholar
Meddings, JA, Reichert, H, Hofer, T, McMahon, LF Jr. Hospital report cards for hospital-acquired pressure ulcers: how good are the grades? Ann Intern Med. 2013 Oct 15;159(8):505–13.Google Scholar
Coomer, NM, McCall, NT. Examination of the accuracy of coding hospital-acquired pressure ulcer stages. Medicare Medicaid Res Rev. 2013 Dec 24;3(4):10.5600/mmrr.003.04.b03. eCollection 2013.Google Scholar
Saliba, D, Jones, M, Streim, J, et al. Overview of significant changes in the Minimum Data Set for nursing homes version 3.0. J Am Med Dir Assoc. 2012 Sep;13(7):595601.Google Scholar
Resource Guide: Pressure Ulcer Prevention and Treatment [10SOW-IIPC NCC-C7-02 110711] [Internet]; 2011. Available from: https://healthinsight.org/Internal/assets/Nursing%20Home/PressureUlcers/PRU_Resource_Guide1_NCC_2012.pdf (accessed May 21, 2014).Google Scholar
NPUAP Pressure Ulcer Stages/Categories [Internet]. Available from: www.npuap.org/resources/educational-and-clinical-resources/npuap-pressure-ulcer-stagescategories (accessed May 30, 2014).Google Scholar
European Pressure Ulcer Advisory Panel and National Pressure Ulcer Advisory Panel. Prevention of pressure ulcers: quick reference guide. Washington, DC: National Pressure Ulcer Advisory Panel; 2009.Google Scholar
Lyder, CH, Wang, Y, Metersky, M, et al. Hospital-acquired pressure ulcers: results from the national Medicare Patient Safety Monitoring System study. J Am Geriatr Soc. 2012 Sep;60(9):1603–8.Google Scholar
Bergquist-Beringer, S, Dong, L, He, J, Dunton, N. Pressure ulcers and prevention among acute care hospitals in the United States. Jt Comm J Qual Patient Saf. 2013 Sep;39(9):404–14.Google Scholar
Magnet Recognition Program® Overview [Internet]; 2014. Available from: www.nursecredentialing.org/Magnet/International/MagnetProgOverview (accessed Apr 22, 2015).Google Scholar
Clements, L, Moore, M, Tribble, T, Blake, J. Reducing skin breakdown in patients receiving extracorporeal membranous oxygenation. Nurs Clin North Am. 2014 Mar;49(1):61–8.Google Scholar
Baumgarten, M, Margolis, DJ, Localio, AR, et al. Pressure ulcers among elderly patients early in the hospital stay. J Gerontol A Biol Sci Med Sci. 2006 Jul;61(7):749–54.Google Scholar
Baumgarten, M, Margolis, DJ, Orwig, DL, et al. Pressure ulcers in elderly patients with hip fracture across the continuum of care. J Am Geriatr Soc. 2009 May;57(5):863–70.Google Scholar
Baumgarten, M, Margolis, D, van Doorn, C, et al. Black/white differences in pressure ulcer incidence in nursing home residents. J Am Geriatr Soc. 2004 Aug;52(8):1293–8.Google Scholar
Rosen, J, Mittal, V, Degenholtz, H, et al. Pressure ulcer prevention in black and white nursing home residents: a QI initiative of enhanced ability, incentives, and management feedback. Adv Skin Wound Care. 2006 Jun;19(5):262–8.Google Scholar
Coleman, S, Gorecki, C, Nelson, EA, et al. Patient risk factors for pressure ulcer development: systematic review. Int J Nurs Stud. 2013 Jul;50(7):9741003.Google Scholar
Sibbald, RG, Goodman, L, Woo, KY, et al. Special considerations in wound bed preparation 2011: an update©. Adv Skin Wound Care. 2011 Sep;24(9):415–36; quiz 437–8.Google Scholar
Baharestani, MM, Black, JM, Carville, K, et al. Dilemmas in measuring and using pressure ulcer prevalence and incidence: an international consensus. Int Wound J. 2009 Apr;6(2):97104.Google Scholar
Spetz, J, Brown, DS, Aydin, C, Donaldson, N. The value of reducing hospital-acquired pressure ulcer prevalence: an illustrative analysis. J Nurs Adm. 2013 Apr;43(4):235–41.Google Scholar
Gorecki, C, Brown, JM, Cano, S, et al. Development and validation of a new patient-reported outcome measure for patients with pressure ulcers: the PU-QOL instrument. Health Qual Life Outcomes. 2013 Jun 13;11:95.Google Scholar
Gefen, A. How much time does it take to get a pressure ulcer? Integrated evidence from human, animal, and in vitro studies. Ostomy Wound Manage. 2008 Oct;54(10):26–8, 30–5.Google Scholar
Lyder, CH. Pressure ulcer prevention and management. JAMA. 2003 Jan 8;289(2):223–6.Google Scholar
Aliano, K, Low, C, Stavrides, S, et al. The correlation between ultrasound findings and clinical assessment of pressure-related ulcers: is the extent of injury greater than what is predicted? Surg Technol Int. 2014 Mar;24:112–16.Google Scholar
Black, J, Clark, M, Dealey, C, et al. Dressings as an adjunct to pressure ulcer prevention: consensus panel recommendations. Int Wound J. 2014 Aug;12(4):484–8.Google Scholar
Smart, H. Deep tissue injury: what is it really? Adv Skin Wound Care. 2013 Feb;26(2):56–8.Google Scholar
Mustoe, TA, O’Shaughnessy, K, Kloeters, O. Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis. Plast Reconstr Surg. 2006 Jun;117(7 Suppl):35S41S.Google Scholar
Gupta, S, Baharestani, M, Baranoski, S, et al. Guidelines for managing pressure ulcers with negative pressure wound therapy. Adv Skin Wound Care. 2004 Nov-Dec;17(Suppl 2):116.Google Scholar
Scott, EM, Buckland, R. Pressure ulcer risk in the peri-operative environment. Nurs Stand. 2005 Oct 26_Nov 1;20(7):74, 76, 78 passim.Google Scholar
Braga, IA, Pirett, CC, Ribas, RM, et al. Bacterial colonization of pressure ulcers: assessment of risk for bloodstream infection and impact on patient outcomes. J Hosp Infect. 2013 Apr;83(4):314–20.Google Scholar
5 Million Lives Campaign: Overview [Internet]; 2015. Available from: www.ihi.org/Engage/Initiatives/Completed/5MillionLivesCampaign/Pages/default.aspx (accessed Apr 22, 2015).Google Scholar
Duncan, KD. Preventing pressure ulcers: the goal is zero. Jt Comm J Qual Patient Saf. 2007 Oct;33(10):605–10.Google Scholar
Braden, BJ, Maklebust, J. Preventing pressure ulcers with the Braden scale: an update on this easy-to-use tool that assesses a patient’s risk. Am J Nurs. 2005 Jun;105(6):70–2.Google Scholar
Pancorbo-Hidalgo, PL, Garcia-Fernandez, FP, Lopez-Medina, IM, Alvarez-Nieto, C. Risk assessment scales for pressure ulcer prevention: a systematic review. J Adv Nurs. 2006 Apr;54(1):94110.Google Scholar
Brown, SJ. The Braden Scale: a review of the research evidence. Orthop Nurs. 2004 Jan–Feb;23(1):30–8.Google Scholar
Maklebust, J, Sieggreen, MY, Sidor, D, et al. Computer-based testing of the Braden Scale for Predicting Pressure Sore Risk. Ostomy Wound Manage. 2005 Apr;51(4):40–2, 44, 46 passim.Google Scholar
He, W, Liu, P, Chen, HL. The Braden Scale cannot be used alone for assessing pressure ulcer risk in surgical patients: a meta-analysis. Ostomy Wound Manage. 2012 Feb;58(2):3440.Google Scholar
Cox, J. Predictive power of the Braden scale for pressure sore risk in adult critical care patients: a comprehensive review. J Wound Ostomy Continence Nurs. 2012 Nov–Dec;39(6):613–21; quiz 622–3.Google Scholar
Stausberg, J. The Braden Scale and Care Dependency Scale each demonstrate at least 70% sensitivity and specificity for identifying inpatients at risk of pressure ulcer. Evid Based Nurs. 2011 Jan;14(1):20–1.Google Scholar
Moore, ZE, Cowman, S. Risk assessment tools for the prevention of pressure ulcers. Cochrane Database Syst Rev. 2014 Feb 5;2:CD006471.Google Scholar
Balzer, K, Kremer, L, Junghans, A, et al. What patient characteristics guide nurses’ clinical judgement on pressure ulcer risk? A mixed methods study. Int J Nurs Stud. 2014 May;51(5):703–16.Google Scholar
Bergquist-Beringer, S, Gajewski, BJ. Outcome and assessment information set data that predict pressure ulcer development in older adult home health patients. Adv Skin Wound Care. 2011 Sep;24(9):404–14.Google Scholar
McInnes, E, Jammali-Blasi, A, Bell-Syer, S, et al. Preventing pressure ulcers–Are pressure-redistributing support surfaces effective? A Cochrane systematic review and meta-analysis. Int J Nurs Stud. 2012 Mar;49(3):345–59.Google Scholar
Call, E, Pedersen, J, Bill, B, et al. Enhancing pressure ulcer prevention using wound dressings: what are the modes of action? Int Wound J. 2015;12(4):408–13.Google Scholar
Clark, M, Black, J, Alves, P, et al. Systematic review of the use of prophylactic dressings in the prevention of pressure ulcers. Int Wound J. 2014;11(5):460–71.Google Scholar
Moore, ZE, Webster, J. Dressings and topical agents for preventing pressure ulcers. Cochrane Database Syst Rev. 2013 Aug 18;8:CD009362.Google Scholar
Gillespie, BM, Chaboyer, WP, McInnes, E, et al. Repositioning for pressure ulcer prevention in adults. Cochrane Database Syst Rev. 2014 Apr 3;4:CD009958.Google Scholar
Moore, Z, Cowman, S, Posnett, J. An economic analysis of repositioning for the prevention of pressure ulcers. J Clin Nurs. 2013 Aug;22(15–16):2354–60.Google Scholar
Bergstrom, N, Horn, SD, Rapp, MP, et al. Turning for ulcer reduction: a multisite randomized clinical trial in nursing homes. J Am Geriatr Soc. 2013 Oct;61(10):1705–13.Google Scholar
Anton, L. Pressure ulcer prevention in older people who sit for long periods. Nurs Older People. 2006 May;18(4):2935.Google Scholar
Levy, A, Kopplin, K, Gefen, A. An air-cell-based cushion for pressure ulcer protection remarkably reduces tissue stresses in the seated buttocks with respect to foams: finite element studies. J Tissue Viability. 2014 Feb;23(1):1323.Google Scholar
Sonenblum, SE, Vonk, TE, Janssen, TW, Sprigle, SH. Effects of wheelchair cushions and pressure relief maneuvers on ischial interface pressure and blood flow in people with spinal cord injury. Arch Phys Med Rehabil. 2014 Jul;95(7):1350–7.Google Scholar
Reddy, M, Gill, SS, Rochon, PA. Preventing pressure ulcers: a systematic review. JAMA. 2006 Aug 23;296(8):974–84.Google Scholar
Moore, ZE, Cowman, S. Wound cleansing for pressure ulcers. Cochrane Database Syst Rev. 2013 Mar 28;3:CD004983.Google Scholar
National Pressure Ulcer Advisory Panel Support Surface Standards Initiative: Terms and Definitions Related to Support Surfaces [Internet]; 2007. Available from: www.npuap.org/wp-content/uploads/2012/03/NPUAP_S3I_TD.pdf (accessed Apr 22, 2015).Google Scholar
Smith, ME, Totten, A, Hickam, DH, et al. Pressure ulcer treatment strategies: a systematic comparative effectiveness review. Ann Intern Med. 2013 Jul 2;159(1):3950.Google Scholar
Moore, ZE, Cowman, S. Repositioning for treating pressure ulcers. Cochrane Database Syst Rev. 2012 Sep 12;9:CD006898.Google Scholar
Rennert, R, Golinko, M, Kaplan, D, et al. Standardization of wound photography using the wound electronic medical record. Adv Skin Wound Care. 2009 Jan;22(1):32–8.Google Scholar
Canadian Agency for Drug Health and Technologies Health. Dressing Materials for the Treatment of Pressure Ulcers in Patients in Long-Term Care Facilities: A Review of the Comparative Clinical Effectiveness and Guidelines. Ottawa, Canada: Canadian Agency for Drugs and Technologies in Health; 2013. CADTH Rapid Response Reports.Google Scholar
Saha, S, Smith, MEB, Totten, A, et al. Pressure Ulcer Treatment Strategies: Comparative Effectiveness. Comparative Effectiveness Review No. 90. (Prepared by the Oregon Evidence-based Practice Center under Contract No. 290–2007-10057-I.) AHRQ Publication No. 13-EHC003-EF. Rockville, MD: Agency for Healthcare Research and Quality; 2013. Available at: www.effectivehealthcare.ahrq.gov/reports/final.cfm (accessed May 27, 2014).Google Scholar
Langer, G, Schloemer, G, Knerr, A, et al. Nutritional interventions for preventing and treating pressure ulcers. Cochrane Database Syst Rev. 2003;(4)(4):CD003216.Google Scholar
Schols, JM, de Jager-v d Ende, MA. Nutritional intervention in pressure ulcer guidelines: an inventory. Nutrition. 2004 Jun;20(6):548–53.Google Scholar
Aziz, Z, Flemming, K. Electromagnetic therapy for treating pressure ulcers. Cochrane Database Syst Rev. 2012 Dec 12;12:CD002930.Google Scholar
Baba-Akbari Sari, A, Flemming, K, Cullum, NA, Wollina, U. Therapeutic ultrasound for pressure ulcers. Cochrane Database Syst Rev. 2006 Jul 19;(3)(3):CD001275.Google Scholar
Gardner, SE, Frantz, RA, Schmidt, FL. Effect of electrical stimulation on chronic wound healing: a meta-analysis. Wound Repair Regen. 1999 Nov–Dec;7(6):495503.Google Scholar
Kawasaki, L, Mushahwar, VK, Ho, C, et al. The mechanisms and evidence of efficacy of electrical stimulation for healing of pressure ulcer: a systematic review. Wound Repair Regen. 2014 Mar–Apr;22(2):161–73.Google Scholar
Kranke, P, Bennett, MH, Martyn-St James, M, et al. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev. 2012 Apr 18;4:CD004123.Google Scholar
Briggs, M, Collinson, M, Wilson, L, et al. The prevalence of pain at pressure areas and pressure ulcers in hospitalised patients. BMC Nurs. 2013 Jul 31; 12(1):19.Google Scholar
Rastinehad, D. Pressure ulcer pain. J Wound Ostomy Continence Nurs. 2006 May–Jun;33(3):252–7.Google Scholar
de Laat, EH, Scholte op Reimer, WJ, van Achterberg, T. Pressure ulcers: diagnostics and interventions aimed at wound-related complaints: a review of the literature. J Clin Nurs. 2005 Apr;14(4):464–72.Google Scholar
Stotts, NA, Puntillo, K, Bonham Morris, A, et al. Wound care pain in hospitalized adult patients. Heart Lung. 2004 Sep–Oct;33(5):321–32.Google Scholar
Gorecki, C, Closs, SJ, Nixon, J, Briggs, M. Patient-reported pressure ulcer pain: a mixed-methods systematic review. J Pain Symptom Manage. 2011 Sep;42(3):443–59.Google Scholar
Sibbald, RG, Krasner, DL, Lutz, J. SCALE: skin changes at life’s end: final consensus statement: October 1, 2009. Adv Skin Wound Care. 2010 May;23(5):225–36; quiz 237–8.Google Scholar
Schim, SM, Cullen, B. Wound care at end of life. Nurs Clin North Am. 2005 Jun;40(2):281–94.Google Scholar
Latimer, S, Chaboyer, W, Gillespie, B. Patient participation in pressure injury prevention: giving patient’s a voice. Scand J Caring Sci. 2014;28(4):648–56.Google Scholar
Fife, CE, Yankowsky, KW, Ayello, EA, et al. Legal issues in the care of pressure ulcer patients: key concepts for healthcare providers–a consensus paper from the International Expert Wound Care Advisory Panel©. Adv Skin Wound Care. 2010 Nov;23(11):493507.Google Scholar
Armstrong, DG, Ayello, EA, Capitulo, KL, et al. New opportunities to improve pressure ulcer prevention and treatment: implications of the CMS inpatient hospital care Present on Admission (POA) indicators/hospital-acquired conditions (HAC) policy. A consensus paper from the International Expert Wound Care Advisory Panel. J Wound Ostomy Continence Nurs. 2008 Sep–Oct;35(5):485–92.Google Scholar
Bosch, M, Halfens, RJ, van der Weijden, T, et al. Organizational culture, team climate, and quality management in an important patient safety issue: nosocomial pressure ulcers. Worldviews Evid Based Nurs. 2011 Mar;8(1):414.Google Scholar
Lynn, J, West, J, Hausmann, S, et al. Collaborative clinical quality improvement for pressure ulcers in nursing homes. J Am Geriatr Soc. 2007 Oct;55(10):1663–9.Google Scholar
Niezgoda, JA, Mendez-Eastman, S. The effective management of pressure ulcers. Adv Skin Wound Care. 2006 Jan–Feb;19(Suppl 1):315.Google Scholar

References

Blanc, B, Finch, C, Hallberg, L, et al. Nutritional anaemia: report of a WHO scientific group. WHO Tech Report Series 1968;405:537.Google Scholar
Zakai, NA, Katz, R, Hirsch, C, et al. A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: the Cardiovascular Health Study. Arch Intern Med 2005;165:2214–20.Google Scholar
Guralnik, JM, Eisenstaedt, RS, Ferrucci, L, et al. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 2004;104:2263–8.Google Scholar
Izaks, GJ, Westendorp, RG, Knook, DL. The definition of anemia in older persons. JAMA 1999;281:1714–7.Google Scholar
Artz, AS, Thirman, MJ. Unexplained anemia predominates despite an intensive evaluation in a racially diverse cohort of older adults from a referral anemia clinic. J Gerontol A Biol Sci Med Sci 2011;66:925–32.Google Scholar
Ferrucci, L, Semba, RD, Guralnik, JM, et al. Proinflammatory state, hepcidin, and anemia in older persons. Blood 2010;115:3810–6.Google Scholar
Adler, AS, Kawahara, TL, Segal, E, Chang, HY. Reversal of aging by NFkappaB blockade. Cell Cycle 2008;7:556–9.Google Scholar
Chambers, SM, Shaw, CA, Gatza, C, et al. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 2007;5:e201.Google Scholar
Chambers, SM, Goodell, MA. Hematopoietic stem cell aging: wrinkles in stem cell potential. Stem Cell Rev 2007;3:201–11.Google Scholar
Culleton, BF, Manns, BJ, Zhang, J, et al. Impact of anemia on hospitalization and mortality in older adults. Blood 2006;107:3841–6.Google Scholar
Zakai, NA, French, B, Arnold, AM, et al. Hemoglobin decline, function, and mortality in the elderly: the cardiovascular health study. Am J Hematol 2013;88:59.Google Scholar
Dong, X, Mendes de Leon, C, Artz, A, et al. A population-based study of hemoglobin, race, and mortality in elderly persons. J Gerontol A Biol Sci Med Sci 2008;63:873–8.Google Scholar
Denny, SD, Kuchibhatla, MN, Cohen, HJ. Impact of anemia on mortality, cognition, and function in community-dwelling elderly. Am J Med 2006;119:327–34.Google Scholar
Penninx, BW, Guralnik, JM, Onder, G, et al. Anemia and decline in physical performance among older persons. Am J Med 2003;115:104–10.Google Scholar
Penninx, BW, Pluijm, SM, Lips, P, et al. Late-life anemia is associated with increased risk of recurrent falls. J Am Geriatr Soc 2005;53:2106–11.Google Scholar
Chaves, PH, Semba, RD, Leng, SX, et al. Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women: the Women’s Health and Aging Studies I and II. J Gerontol A Biol Sci Med Sci 2005;60:729–35.Google Scholar
Deal, JA, Carlson, MC, Xue, QL, et al. Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: The Women’s Health and Aging Study II. J Am Geriatr Soc 2009;57:1604–11.Google Scholar
Zilinski, J, Zillmann, R, Becker, I, et al. Prevalence of anemia among elderly inpatients and its association with multidimensional loss of function. Ann Hematol 2014;93(10):1645–54.Google Scholar
Hong, CH, Falvey, C, Harris, TB, et al. Anemia and risk of dementia in older adults: findings from the Health ABC study. Neurology 2013;81:528–33.Google Scholar
Joosten, E, Ghesquiere, B, Linthoudt, H, et al. Upper and lower gastrointestinal evaluation of elderly inpatients who are iron deficient. Am J Med 1999;107:24–9.Google Scholar
Pang, WW, Schrier, SL. Anemia in the elderly. Curr Opin Hematol 2012;19:133–40.Google Scholar
Cook, JD, Flowers, CH, Skikne, BS. The quantitative assessment of body iron. Blood 2003;101:3359–64.Google Scholar
Keel, SB, Abkowitz, JL. The microcytic red cell and the anemia of inflammation. N Engl J Med 2009;361:1904–6.Google Scholar
Rector, WG Jr. Pica: its frequency and significance in patients with iron-deficiency anemia due to chronic gastrointestinal blood loss. J Gen Intern Med 1989;4:512–3.Google Scholar
Moist, LM, Troyanov, S, White, CT, et al. Canadian Society of Nephrology commentary on the 2012 KDIGO Clinical Practice Guideline for Anemia in CKD. Am J Kidney Dis 2013;62:860–73.Google Scholar
Martin, A, Thompson, AA. Thalassemias. Pediatr Clin North Am 2013;60:1383–91.Google Scholar
Muncie, HL Jr, Campbell, J. Alpha and beta thalassemia. Am Fam Physician 2009;80:339–44.Google Scholar
Price, EA, Mehra, R, Holmes, TH, Schrier, SL. Anemia in older persons: etiology and evaluation. Blood Cells Mol Dis 2011;46:159–65.Google Scholar
Corazza, F, Beguin, Y, Bergmann, P, et al. Anemia in children with cancer is associated with decreased erythropoietic activity and not with inadequate erythropoietin production. Blood 1998;92:1793–8.Google Scholar
Weiss, G, Goodnough, LT. Anemia of chronic disease. N Engl J Med 2005;352:1011–23.Google Scholar
Artz, AS, Xue, QL, Wickrema, A, et al. Unexplained anaemia in the elderly is characterised by features of low grade inflammation. Br J Haematol 2014;167(2):286–9.Google Scholar
Allen, LA, Felker, GM, Mehra, MR, et al. Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. J Card Fail 2010;16:230–8.Google Scholar
Roy, CN. Anemia of inflammation. Hematology Am Soc Hematol Educ Program 2010;2010:276–80.Google Scholar
Merchant, AA, Roy, CN. Not so benign haematology: anaemia of the elderly. Br J Haematol 2012;156:173–85.Google Scholar
Goodnough, LT, Levy, JH, Murphy, MF. Concepts of blood transfusion in adults. Lancet 2013;381:1845–54.Google Scholar
Finch, CA, Lenfant, C. Oxygen transport in man. N Engl J Med 1972;286:407–15.Google Scholar
Kazmi, WH, Kausz, AT, Khan, S, et al. Anemia: an early complication of chronic renal insufficiency. Am J Kidney Dis 2001;38:803–12.Google Scholar
Erslev, AJ. Erythropoietin. N Engl J Med 1991;324:1339–44.Google Scholar
Donnelly, S, Shah, BR. Erythropoietin deficiency in hyporeninemia. Am J Kidney Dis 1999;33:947–53.Google Scholar
Ma, JZ, Ebben, J, Xia, H, Collins, AJ. Hematocrit level and associated mortality in hemodialysis patients. J Am Soc Nephrol 1999;10:610–19.Google Scholar
Fernandez-Rodriguez, AM, Guindeo-Casasus, MC, Molero-Labarta, T, et al. Diagnosis of iron deficiency in chronic renal failure. Am J Kidney Dis 1999;34:508–13.Google Scholar
Phrommintikul, A, Haas, SJ, Elsik, M, Krum, H. Mortality and target haemoglobin concentrations in anaemic patients with chronic kidney disease treated with erythropoietin: a meta-analysis. Lancet 2007;369:381–8.Google Scholar
Andres, E, Loukili, NH, Noel, E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ 2004;171:251–9.Google Scholar
Carmel, R. How I treat cobalamin (vitamin B12) deficiency. Blood 2008;112:2214–21.Google Scholar
Nimo, RE, Carmel, R. Increased sensitivity of detection of the blocking (type I) anti-intrinsic factor antibody. Am J Clin Pathol 1987;88:729–33.Google Scholar
Eussen, SJ, de Groot, LC, Clarke, R, et al. Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med 2005;165:1167–72.Google Scholar
Ades, L, Itzykson, R, Fenaux, P. Myelodysplastic syndromes. Lancet 2014;383:2239–52.Google Scholar
Will, B, Zhou, L, Vogler, TO, et al. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations. Blood 2012;120:2076–86.Google Scholar
Anttila, P, Ihalainen, J, Salo, A, et al. Idiopathic macrocytic anaemia in the aged: molecular and cytogenetic findings. Br J Haematol 1995;90:797803.Google Scholar
Greenberg, PL, Tuechler, H, Schanz, J, et al. Revised international prognostic scoring system for myelodysplastic syndromes. Blood 2012;120:2454–65.Google Scholar
Zeidan, AM, Linhares, Y, Gore, SD. Current therapy of myelodysplastic syndromes. Blood Rev 2013;27:243–59.Google Scholar
Gehrs, BC, Friedberg, RC. Autoimmune hemolytic anemia. Am J Hematol 2002;69:258–71.Google Scholar
Crisp, D, Pruzanski, W. B-cell neoplasms with homogeneous cold-reacting antibodies (cold agglutinins). Am J Med 1982;72:915–22.Google Scholar
Berentsen, S. Cold agglutinin-mediated autoimmune hemolytic anemia in Waldenstrom’s macroglobulinemia. Clin Lymphoma Myeloma 2009;9:110–12.Google Scholar
Berentsen, S, Ulvestad, E, Langholm, R, et al. Primary chronic cold agglutinin disease: a population based clinical study of 86 patients. Haematologica 2006;91:460–6.Google Scholar
Smyth, SS, McEver, RP, Weyrich, AS, et al. Platelet functions beyond hemostasis. J Thromb Haemost 2009;7:1759–66.Google Scholar
Williamson, DR, Albert, M, Heels-Ansdell, D, et al. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest 2013;144:1207–15.Google Scholar
Mendes, FD, Suzuki, A, Sanderson, SO, et al. Prevalence and indicators of portal hypertension in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2012;10(9):1028–33.Google Scholar
Sheikh, MY, Raoufi, R, Atla, PR, et al. Prevalence of cirrhosis in patients with thrombocytopenia who receive bone marrow biopsy. Saudi J Gastroenterol 2012;18:257–62.Google Scholar
Aster, RH. Pooling of platelets in the spleen: role in the pathogenesis of “hypersplenic” thrombocytopenia. J Clin Invest 1966;45:645–57.Google Scholar
Peck-Radosavljevic, M, Zacherl, J, Meng, YG, et al. Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? J Hepatol 1997;27:127–31.Google Scholar
Kuwana, M, Okazaki, Y, Ikeda, Y. Splenic macrophages maintain the anti-platelet autoimmune response via uptake of opsonized platelets in patients with immune thrombocytopenic purpura. J Thromb Haemost 2009;7:322–9.Google Scholar
Frederiksen, H, Schmidt, K. The incidence of idiopathic thrombocytopenic purpura in adults increases with age. Blood 1999;94:909–13.Google Scholar
Neunert, C, Lim, W, Crowther, M, et al. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood 2011;117:4190–207.Google Scholar
Cines, DB, Blanchette, VS. Immune thrombocytopenic purpura. N Engl J Med 2002;346:9951008.Google Scholar
Provan, D, Stasi, R, Newland, AC, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood 2010;115:168–86.Google Scholar
Surveillance, Epidemiology, and End Results Program (SEER) Stat Fact Sheet: Myeloma. National Cancer Institute. Available at: http://seer.cancer.gov/statfacts/html/mulmy.html (accessed June 30, 2014).Google Scholar
DeSantis, CE, Lin, CC, Mariotto, AB, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin 2014;64:252–71.Google Scholar
Kyle, RA, Gertz, MA, Witzig, TE, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003;78:2133.Google Scholar
Katzmann, JA, Clark, RJ, Abraham, RS, et al. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem 2002;48:1437–44.Google Scholar
Kyle, RA, Therneau, TM, Rajkumar, SV, et al. Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med 2006;354:1362–9.Google Scholar
Rajkumar, SV, Kyle, RA, Therneau, TM, et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance. Blood 2005;106:812–17.Google Scholar
Richardson, PG, Weller, E, Lonial, S, et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010;116:679–86.Google Scholar
Cancer Facts and Figures. American Cancer Society. Available at: www.cancer.org/research/cancerfactsstatistics/allcancerfactsfigures/index (accessed July 30, 2014).Google Scholar
Rai, KR, Sawitsky, A, Cronkite, EP, et al. Clinical staging of chronic lymphocytic leukemia. Blood 1975;46:219–34.Google Scholar
Surveillance, Epidemiology, and End Results Program (SEER) Fast Stats 2014. National Cancer Institute. Available at: http://seer.cancer.gov/faststats/selections.php (accessed July 30, 2014).Google Scholar
Mauro, FR, Foa, R, Cerretti, R, et al. Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features. Blood 2000;95:2786–92.Google Scholar
Diehl, LF, Ketchum, LH. Autoimmune disease and chronic lymphocytic leukemia: autoimmune hemolytic anemia, pure red cell aplasia, and autoimmune thrombocytopenia. Semin Oncol 1998;25:8097.Google Scholar
Byrd, JC, Furman, RR, Coutre, SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med 2013;369:3242.Google Scholar
Surveillance, Epidemiology, and End Results Program (SEER) Cancer Statistics Reviews (CSR) 1975–2011. National Cancer Institute. Available at: http://seer.cancer.gov/csr/1975_2011 (accessed July 30, 2014).Google Scholar
Sorror, ML, Sandmaier, BM, Storer, BE, et al. Long-term outcomes among older patients following nonmyeloablative conditioning and allogeneic hematopoietic cell transplantation for advanced hematologic malignancies. JAMA 2011;306:1874–83.Google Scholar
Ania, BJ, Suman, VJ, Sobell, JL, et al. Trends in the incidence of polycythemia vera among Olmsted County, Minnesota residents, 1935–1989. Am J Hematol 1994;47:8993.Google Scholar
Baxter, EJ, Scott, LM, Campbell, PJ, et al. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 2005;365:1054–61.Google Scholar
Marchioli, R, Finazzi, G, Specchia, G, et al. Cardiovascular events and intensity of treatment in polycythemia vera. N Engl J Med 2013;368:2233.Google Scholar
Landolfi, R, Marchioli, R, Kutti, J, et al. Efficacy and safety of low-dose aspirin in polycythemia vera. N Engl J Med 2004;350:114–24.Google Scholar
Passamonti, F. How I treat polycythemia vera. Blood 2012;120:275–84.Google Scholar
Mesa, RA, Silverstein, MN, Jacobsen, SJ, et al. Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: an Olmsted County Study, 1976–1995. Am J Hematol 1999;61:1015.Google Scholar
Beer, PA, Erber, WN, Campbell, PJ, Green, AR. How I treat essential thrombocythemia. Blood 2011;117:1472–82.Google Scholar
Cortelazzo, S, Finazzi, G, Ruggeri, M, et al. Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. N Engl J Med 1995;332:1132–6.Google Scholar
Harrison, CN, Campbell, PJ, Buck, G, et al. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med 2005;353:3345.Google Scholar
Gisslinger, H, Gotic, M, Holowiecki, J, et al. Anagrelide compared with hydroxyurea in WHO-classified essential thrombocythemia: the ANAHYDRET Study, a randomized controlled trial. Blood 2013;121:1720–8.Google Scholar
Harrison, C, Kiladjian, JJ, Al-Ali, HK, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med 2012;366:787–98.Google Scholar
Verstovsek, S, Mesa, RA, Gotlib, J, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med 2012;366:799807.Google Scholar

References

Shih, YC, Hurria, A. Preparing for an epidemic: cancer care in an aging population. Am Soc Clin Oncol Educ Book 2014;34:133137.Google Scholar
Lopez-Otin, C, Blasco, MA, Partridge, L, et al. The hallmarks of aging. Cell 2013 Jun 6;153(6):11941217.Google Scholar
Mariotto, AB, Yabroff, KR, Shao, Y, et al. Projections of the cost of cancer care in the United States: 2010–2020. J Natl Cancer Inst 2011 Jan 19;103(2):117128.Google Scholar
Fried, TR, Bradley, EH, Towle, VR, Allore, H. Understanding the treatment preferences of seriously ill patients. N Engl J Med 2002 Apr 4;346(14):10611066.Google Scholar
Ramsdale, E, Polite, B, Hemmerich, J, et al. The Vulnerable Elders Survey-13 predicts mortality in older adults with later-stage colorectal cancer receiving chemotherapy: a prospective pilot study. J Am Geriatr Soc 2013 Nov;61(11):20432044.Google Scholar
Min, LC, Elliott, MN, Wenger, NS, Saliba, D. Higher vulnerable elders survey scores predict death and functional decline in vulnerable older people. J Am Geriatr Soc 2006 Mar;54(3):507511.Google Scholar
Hurria, A, Cirrincione, CT, Muss, HB, et al. Implementing a geriatric assessment in cooperative group clinical cancer trials: CALGB 360401. J Clin Oncol 2011 Apr 1;29(10):12901296.Google Scholar
Hurria, A, Gupta, S, Zauderer, M, et al. Developing a cancer-specific geriatric assessment: a feasibility study. Cancer 2005 Nov 1;104(9):19982005.Google Scholar
Williams, GR, Deal, AM, Jolly, TA, et al. Feasibility of geriatric assessment in community oncology clinics. J Geriatr Oncol 2014 Jul;5(3):245251.Google Scholar
Hurria, A, Togawa, K, Mohile, SG, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol 2011 Sep 1;29(25):34573465.Google Scholar
Extermann, M, Boler, I, Reich, RR, et al. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score. Cancer 2012 Jul 1;118(13):33773386.Google Scholar
Puts, MT, Santos, B, Hardt, J, et al. An update on a systematic review of the use of geriatric assessment for older adults in oncology. Ann Oncol 2014 Feb;25(2):307315.Google Scholar
Soubeyran, P, Fonck, M, Blanc-Bisson, C, et al. Predictors of early death risk in older patients treated with first-line chemotherapy for cancer. J Clin Oncol 2012 May 20;30(15):18291834.Google Scholar
Hutchins, LF, Unger, JM, Crowley, JJ, et al. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 1999 Dec 30;341(27):20612067.Google Scholar
Sacher, AG, Le, LW, Leighl, NB, Coate, LE. Elderly patients with advanced NSCLC in phase III clinical trials: are the elderly excluded from practice-changing trials in advanced NSCLC? J Thorac Oncol 2013 Mar;8(3):366368.Google Scholar
Kemeny, MM, Peterson, BL, Kornblith, AB, et al. Barriers to clinical trial participation by older women with breast cancer. J Clin Oncol 2003 Jun 15;21(12):22682275.Google Scholar
Ferlay, J, Soerjomataram, I, Ervik, M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide. 2012;11. Available at: http://globocan.iarc.fr (accessed Jan 15, 2014).Google Scholar
Howlader, N, Noone, A, Krapcho, M, et al. SEER Cancer Statistics Review, 1975–2010, based on November 2012 SEER data. Available at: http://seer.cancer.gov/csr/1975_2010 (accessed Jan 15, 2014).Google Scholar
Walter, LC, Schonberg, MA. Screening mammography in older women: a review. JAMA 2014 Apr 2;311(13):13361347.Google Scholar
Van der Kolk, DM, de Bock, GH, Leegte, BK, et al. Penetrance of breast cancer, ovarian cancer and contralateral breast cancer in BRCA1 and BRCA2 families: high cancer incidence at older age. Breast Cancer Res Treat 2010 Dec;124(3):643651.Google Scholar
Cummings, SR, Lee, JS, Lui, LY, et al. Sex hormones, risk factors, and risk of estrogen receptor-positive breast cancer in older women: a long-term prospective study. Cancer Epidemiol Biomarkers Prev 2005 May;14(5):10471051.Google Scholar
Rossouw, JE, Anderson, GL, Prentice, RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2002 Jul 17;288(3):321333.Google Scholar
Van den Brandt, PA, Spiegelman, D, Yaun, SS, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 2000 Sep 15;152(6):514527.Google Scholar
Lynch, B, Neilson, H, Friedenreich, C. Physical activity and breast cancer prevention. Recent Results Cancer Res 2011;186:1342.Google Scholar
Chen, WY, Rosner, B, Hankinson, SE, et al. Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA 2011 Nov 2;306(17):18841890.Google Scholar
Travis, LB, Hill, DA, Dores, GM, et al. Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. JAMA 2003 Jul 23;290(4):465475.Google Scholar
Pukkala, E, Kesminiene, A, Poliakov, S, et al. Breast cancer in Belarus and Ukraine after the Chernobyl accident. Int J Cancer 2006 Aug 1;119(3):651658.Google Scholar
Wishart, GC, Bajdik, CD, Dicks, E, et al. PREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2. Br J Cancer 2012 Aug 21;107(5):800807.Google Scholar
Nelson, HD, Tyne, K, Naik, A, et al. Screening for breast cancer: an update for the US Preventive Services Task Force. Ann Intern Med 2009 Nov 17;151(10):727737, W237W242.Google Scholar
Durso, S, Sullivan, G editors. Geriatrics Review Syllabus, 8th ed. New York: American Geriatric Society; 2013.Google Scholar
Visvanathan, K, Hurley, P, Bantug, E, et al. Use of pharmacologic interventions for breast cancer risk reduction: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 2013 Aug 10;31(23):29422962.Google Scholar
Moyer, VA, US Preventive Services Task Force. Medications to decrease the risk for breast cancer in women: recommendations from the US Preventive Services Task Force recommendation statement. Ann Intern Med 2013 Nov 19;159(10):698708.Google Scholar
National Comprehensive Cancer Network (NCCN) guidelines. Available at: www.nccn.org (accessed Nov 1, 2013).Google Scholar
Siegel, R, Ma, J, Zou, Z, Jemal, A. Cancer statistics, 2014. CA Cancer J Clin 2014 Jan;64(1):929.Google Scholar
Ravdin, PM, Siminoff, LA, Davis, GJ, et al. Computer program to assist in making decisions about adjuvant therapy for women with early breast cancer. J Clin Oncol 2001 Feb 15;19(4):980991.Google Scholar
Kong, I, Narod, SA, Taylor, C, et al. Age at diagnosis predicts local recurrence in women treated with breast-conserving surgery and postoperative radiation therapy for ductal carcinoma in situ: a population-based outcomes analysis. Curr Oncol 2014 Feb;21(1):e96e104.Google Scholar
Hind, D, Wyld, L, Beverley, CB, Reed, MW. Surgery versus primary endocrine therapy for operable primary breast cancer in elderly women (70 years plus). Cochrane Database Syst Rev 2006 Jan 25;1:CD004272.Google Scholar
Hughes, KS, Schnaper, LA, Bellon, JR, et al. Lumpectomy plus tamoxifen with or without irradiation in women age 70 years or older with early breast cancer: long-term follow-up of CALGB 9343. J Clin Oncol 2013 Jul 1;31(19):23822387.Google Scholar
The PRIME II trial: Wide local excision and adjuvant hormonal therapy ± postoperative whole breast irradiation in women ≥ 65 years with early breast cancer managed by breast conservation. Abstract S2–01. 36th Annual San Antonio Breast Cancer Symposium; December 2013.Google Scholar
Biganzoli, L, Wildiers, H, Oakman, C, et al. Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). Lancet Oncol 2012 Apr;13(4):e148e160.Google Scholar
Burstein, HJ, Prestrud, AA, Seidenfeld, J, et al. American Society of Clinical Oncology clinical practice guideline: update on adjuvant endocrine therapy for women with hormone receptor-positive breast cancer. J Clin Oncol 2010 Aug 10;28(23):37843796.Google Scholar
Davies, C, Pan, H, Godwin, J, et al. Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet 2013 Mar 9;381(9869):805816.Google Scholar
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Peto, R, Davies, C, et al. Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 2012 Feb 4;379(9814):432444.Google Scholar
Muss, HB, Woolf, S, Berry, D, et al. Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer. JAMA 2005 Mar 2;293(9):10731081.Google Scholar
Albanell, J, Ciruelos, EM, Lluch, A, et al. Trastuzumab in small tumours and in elderly women. Cancer Treat Rev 2014 Feb;40(1):4147.Google Scholar
Chavez-MacGregor, M, Zhang, N, Buchholz, TA, et al. Trastuzumab-related cardiotoxicity among older patients with breast cancer. J Clin Oncol 2013 Nov 20;31(33):42224228.Google Scholar
Hutchinson, AD, Hosking, JR, Kichenadasse, G, et al. Objective and subjective cognitive impairment following chemotherapy for cancer: a systematic review. Cancer Treat Rev 2012 Nov;38(7):926934.Google Scholar
Mandelblatt, JS, Jacobsen, PB, Ahles, T. Cognitive effects of cancer systemic therapy: implications for the care of older patients and survivors. J Clin Oncol 2014 Aug 20;32(24):26172626.Google Scholar
Macaskill, EJ, Renshaw, L, Dixon, JM. Neoadjuvant use of hormonal therapy in elderly patients with early or locally advanced hormone receptor-positive breast cancer. Oncologist 2006 Nov–Dec;11(10):10811088.Google Scholar
Khatcheressian, JL, Hurley, P, Bantug, E, et al. Breast cancer follow-up and management after primary treatment: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 2013 Mar 1;31(7):961965.Google Scholar
Rock, CL, Demark-Wahnefried, W. Nutrition and survival after the diagnosis of breast cancer: a review of the evidence. J Clin Oncol 2002 Aug 1;20(15):33023316.Google Scholar
Rock, CL, Doyle, C, Demark-Wahnefried, W, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin 2012 Jul–Aug;62(4):243274.Google Scholar
Delongchamps, NB, Singh, A, Haas, GP. The role of prevalence in the diagnosis of prostate cancer. Cancer Control 2006 Jul;13(3):158168.Google Scholar
Hoffman, RM, Gilliland, FD, Eley, JW, et al. Racial and ethnic differences in advanced-stage prostate cancer: the Prostate Cancer Outcomes Study. J Natl Cancer Inst 2001 Mar 7;93(5):388395.Google Scholar
Zheng, SL, Sun, J, Wiklund, F, et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med 2008 Feb 28;358(9):910919.Google Scholar
Kenfield, SA, Stampfer, MJ, Chan, JM, Giovannucci, E. Smoking and prostate cancer survival and recurrence. JAMA 2011 Jun 22;305(24):25482555.Google Scholar
Yan, L, Spitznagel, EL. Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis. Am J Clin Nutr 2009 Apr;89(4):11551163.Google Scholar
Schroder, FH, Hugosson, J, Roobol, MJ, et al. Prostate-cancer mortality at 11 years of follow-up. N Engl J Med 2012 Mar 15;366(11):981990.Google Scholar
Andriole, GL, Crawford, ED, Grubb, RL 3rd, et al. Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up. J Natl Cancer Inst 2012 Jan 18;104(2):125132.Google Scholar
Drazer, MW, Prasad, SM, Huo, D, et al. National trends in prostate cancer screening among older American men with limited 9-year life expectancies: evidence of an increased need for shared decision making. Cancer 2014 May 15;120(10):14911498.Google Scholar
Moyer, VA, US Preventive Services Task Force. Screening for prostate cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med 2012 Jul 17;157(2):120134.Google Scholar
AJCC (American Joint Committee on Cancer). Cancer Staging Manual. 7th ed. New York: Springer-Verlag; 2010.Google Scholar
Sun, L, Caire, AA, Robertson, CN, et al. Men older than 70 years have higher risk prostate cancer and poorer survival in the early and late prostate specific antigen eras. J Urol 2009 Nov;182(5):22422248.Google Scholar
Keyes, M, Crook, J, Morton, G, et al. Treatment options for localized prostate cancer. Can Fam Physician 2013 Dec;59(12):12691274.Google Scholar
Alemozaffar, M, Regan, MM, Cooperberg, MR, et al. Prediction of erectile function following treatment for prostate cancer. JAMA 2011 Sep 21;306(11):12051214.Google Scholar
Shappley, WV 3rd, Kenfield, SA, Kasperzyk, JL, et al. Prospective study of determinants and outcomes of deferred treatment or watchful waiting among men with prostate cancer in a nationwide cohort. J Clin Oncol 2009 Oct 20;27(30):49804985.Google Scholar
Trinh, QD, Bjartell, A, Freedland, SJ, et al. A systematic review of the volume-outcome relationship for radical prostatectomy. Eur Urol 2013 Nov;64(5):786798.Google Scholar
Vordermark, D. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med 2008 Jul 10;359(2):201; author reply 201–2.Google Scholar
Resnick, MJ, Koyama, T, Fan, KH, et al. Long-term functional outcomes after treatment for localized prostate cancer. N Engl J Med 2013 Jan 31;368(5):436445.Google Scholar
Schulman, C, Irani, J, Aapro, M. Improving the management of patients with prostate cancer receiving long-term androgen deprivation therapy. BJU Int 2012 Jun;109(Suppl 6):1321.Google Scholar
Hussain, M, Tangen, CM, Berry, DL, et al. Intermittent versus continuous androgen deprivation in prostate cancer. N Engl J Med 2013 Apr 4;368(14):13141325.Google Scholar
Crook, JM, O’Callaghan, CJ, Duncan, G, et al. Intermittent androgen suppression for rising PSA level after radiotherapy. N Engl J Med 2012 Sep 6;367(10):895903.Google Scholar
Italiano, A, Ortholan, C, Oudard, S, et al. Docetaxel-based chemotherapy in elderly patients (age 75 and older) with castration-resistant prostate cancer. Eur Urol 2009 Jun;55(6):13681375.Google Scholar
Mukherji, D, Pezaro, CJ, Shamseddine, A, De Bono, JS. New treatment developments applied to elderly patients with advanced prostate cancer. Cancer Treat Rev 2013 Oct;39(6):578583.Google Scholar
Papamichael, D, Audisio, R, Horiot, JC, et al. Treatment of the elderly colorectal cancer patient: SIOG expert recommendations. Ann Oncol 2009 Jan;20(1):516.Google Scholar
Atkin, WS, Morson, BC, Cuzick, J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med 1992 Mar 5;326(10):658662.Google Scholar
Kitahara, CM, Berndt, SI, de Gonzalez, AB, et al. Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. J Clin Oncol 2013 Jul 1;31(19):24502459.Google Scholar
Boyle, T, Keegel, T, Bull, F, et al. Physical activity and risks of proximal and distal colon cancers: a systematic review and meta-analysis. J Natl Cancer Inst 2012 Oct 17;104(20):15481561.Google Scholar
Rex, DK, Johnson, DA, Anderson, JC, et al. American College of Gastroenterology guidelines for colorectal cancer screening 2009 [corrected]. Am J Gastroenterol 2009 Mar;104(3):739750.Google Scholar
US Preventive Services Task Force. Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med 2008 Nov 4;149(9):627637.Google Scholar
Lee, SJ, Leipzig, RM, Walter, LC. Incorporating lag time to benefit into prevention decisions for older adults. JAMA 2013 Dec 25;310(24):26092610.Google Scholar
Gross, CP, Soulos, PR, Ross, JS, et al. Assessing the impact of screening colonoscopy on mortality in the medicare population. J Gen Intern Med 2011 Dec;26(12):14411449.Google Scholar
Hewitson, P, Glasziou, P, Watson, E, et al. Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (hemoccult): an update. Am J Gastroenterol 2008 Jun;103(6):15411549.Google Scholar
Lieberman, DA, Weiss, DG, Bond, JH, et al. Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N Engl J Med 2000 Jul 20;343(3):162168.Google Scholar
Colorectal Cancer Collaborative Group. Surgery for colorectal cancer in elderly patients: a systematic review. Lancet 2000 Sep 16;356(9234):968974.Google Scholar
Hoffman, RM, Walter, LC. Colorectal cancer screening in the elderly: the need for informed decision making. J Gen Intern Med 2009 Dec;24(12):13361337.Google Scholar
Rothwell, PM, Wilson, M, Elwin, CE, et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 2010 Nov 20;376(9754):17411750.Google Scholar
Majumdar, SR, Fletcher, RH, Evans, AT. How does colorectal cancer present? Symptoms, duration, and clues to location. Am J Gastroenterol 1999 Oct;94(10):30393045.Google Scholar
Gill, S, Loprinzi, C, Kennecke, H, et al. Prognostic web-based models for stage II and III colon cancer: A population and clinical trials-based validation of numeracy and adjuvant! online. Cancer 2011 Sep 15;117(18):41554165.Google Scholar
Benson, AB 3rd, Schrag, D, Somerfield, MR, et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol 2004 Aug 15;22(16):34083419.Google Scholar
Andre, T, Boni, C, Mounedji-Boudiaf, L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004 Jun 3;350(23):23432351.Google Scholar
Tournigand, C, Andre, T, Bonnetain, F, et al. Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial. J Clin Oncol 2012 Sep 20;30(27):33533360.Google Scholar
Sanoff, HK, Carpenter, WR, Martin, CF, et al. Comparative effectiveness of oxaliplatin vs non-oxaliplatin-containing adjuvant chemotherapy for stage III colon cancer. J Natl Cancer Inst 2012 Feb 8;104(3):211227.Google Scholar
Muss, HB, Bynum, DL. Adjuvant chemotherapy in older patients with stage III colon cancer: an underused lifesaving treatment. J Clin Oncol 2012 Jul 20;30(21):25762578.Google Scholar
Meyerhardt, JA, Mangu, PB, Flynn, PJ, et al. Follow-up care, surveillance protocol, and secondary prevention measures for survivors of colorectal cancer: American Society of Clinical Oncology clinical practice guideline endorsement. J Clin Oncol 2013 Dec 10;31(35):44654470.Google Scholar
Chibaudel, B, Tournigand, C, Andre, T, de Gramont, A. Therapeutic strategy in unresectable metastatic colorectal cancer. Ther Adv Med Oncol 2012 Mar;4(2):7589.Google Scholar
Seymour, MT, Thompson, LC, Wasan, HS, et al. Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial. Lancet 2011 May 21;377(9779):17491759.Google Scholar
Samet, JM, Wiggins, CL, Humble, CG, Pathak, DR. Cigarette smoking and lung cancer in New Mexico. Am Rev Respir Dis 1988 May;137(5):11101113.Google Scholar
Centers for Disease Control and Prevention (CDC). State-specific prevalence of current cigarette smoking among adults, and policies and attitudes about secondhand smoke – United States, 2000. MMWR Morb Mortal Wkly Rep 2001 Dec 14;50(49):11011106.Google Scholar
Brenner, DR, Boffetta, P, Duell, EJ, et al. Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium. Am J Epidemiol 2012 Oct 1;176(7):573585.Google Scholar
Omenn, GS, Goodman, GE, Thornquist, MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996 May 2;334(18):11501155.Google Scholar
World Health Organization. WHO report on the global tobacco epidemic, 2013: enforcing bans on tobacco advertising, promotion and sponsorship; 2013. Available at: www.who.int/tobacco/global_report/2013/en.Google Scholar
Parsons, A, Daley, A, Begh, R, Aveyard, P. Influence of smoking cessation after diagnosis of early stage lung cancer on prognosis: systematic review of observational studies with meta-analysis. BMJ 2010 Jan 21;340:b5569.Google Scholar
National Lung Screening Trial Research Team, Aberle, DR, Adams, AM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011 Aug 4;365(5):395409.Google Scholar
McWilliams, A, Tammemagi, MC, Mayo, JR, et al. Probability of cancer in pulmonary nodules detected on first screening CT. N Engl J Med 2013 Sep 5;369(10):910919.Google Scholar
Moyer, VA. Screening for Lung Cancer: US Preventive Services Task Force Recommendation Statement. Ann Intern Med 2013 Dec 31;160(5):330338.Google Scholar
Chute, CG, Greenberg, ER, Baron, J, et al. Presenting conditions of 1539 population-based lung cancer patients by cell type and stage in New Hampshire and Vermont. Cancer 1985 Oct 15;56(8):21072111.Google Scholar
Detterbeck, FC, Postmus, PE, Tanoue, LT. The stage classification of lung cancer: Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2013 May;143(5 Suppl):e191S210S.Google Scholar
Grills, IS, Mangona, VS, Welsh, R, et al. Outcomes after stereotactic lung radiotherapy or wedge resection for stage I non-small-cell lung cancer. J Clin Oncol 2010 Feb 20;28(6):928935.Google Scholar
Senthi, S, Lagerwaard, FJ, Haasbeek, CJ, et al. Patterns of disease recurrence after stereotactic ablative radiotherapy for early stage non-small-cell lung cancer: a retrospective analysis. Lancet Oncol 2012 Aug;13(8):802809.Google Scholar
Butts, CA, Ding, K, Seymour, L, et al. Randomized phase III trial of vinorelbine plus cisplatin compared with observation in completely resected stage IB and II non-small-cell lung cancer: updated survival analysis of JBR-10. J Clin Oncol 2010 Jan 1;28(1):2934.Google Scholar
Fruh, M, Rolland, E, Pignon, JP, et al. Pooled analysis of the effect of age on adjuvant cisplatin-based chemotherapy for completely resected non-small-cell lung cancer. J Clin Oncol 2008 Jul 20;26(21):35733581.Google Scholar
Hardy, D, Cormier, JN, Xing, Y, et al. Chemotherapy-associated toxicity in a large cohort of elderly patients with non-small cell lung cancer. J Thorac Oncol 2010 Jan;5(1):9098.Google Scholar
Schild, SE, Mandrekar, SJ, Jatoi, A, et al. The value of combined-modality therapy in elderly patients with stage III nonsmall cell lung cancer. Cancer 2007 Jul 15;110(2):363368.Google Scholar
NSCLC Meta-Analyses Collaborative Group. Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data from 16 randomized controlled trials. J Clin Oncol 2008 Oct 1;26(28):46174625.Google Scholar
Quoix, E, Zalcman, G, Oster, JP, et al. Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced non-small-cell lung cancer: IFCT-0501 randomised, phase 3 trial. Lancet 2011 Sep 17;378(9796):10791088.Google Scholar
Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer: the Elderly Lung Cancer Vinorelbine Italian Study Group. J Natl Cancer Inst 1999 Jan 6;91(1):6672.Google Scholar
Ramalingam, SS, Dahlberg, SE, Langer, CJ, et al. Outcomes for elderly, advanced-stage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599. J Clin Oncol 2008 Jan 1;26(1):6065.Google Scholar
Mok, T, Wu, Y, Thongprasert, S, et al. Phase III, randomised, open-label, first-line study of gefitinib vs carboplatin/paclitaxel in clinically selected patients with advanced nonsmall-cell lung cancer (IPASS). Ann Oncol 2010;21 (Suppl 8): 1.Google Scholar
Temel, JS, Greer, JA, Muzikansky, A, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 2010 Aug 19;363(8):733742.Google Scholar
Gaspar, LE, Gay, EG, Crawford, J, et al. Limited-stage small-cell lung cancer (stages I–III): observations from the National Cancer Data Base. Clin Lung Cancer 2005 May;6(6):355360.Google Scholar
Eaton, BR, Kim, S, Marcus, DM, et al. Effect of prophylactic cranial irradiation on survival in elderly patients with limited-stage small cell lung cancer. Cancer 2013 Nov 1;119(21):37533760.Google Scholar
Dietrich, J, Monje, M, Wefel, J, Meyers, C. Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. Oncologist 2008 Dec;13(12):12851295.Google Scholar
Parikh, RB, Temel, JS. Early specialty palliative care. N Engl J Med 2014 Mar 13;370(11):10751076.Google Scholar
Medicare hospice benefits. 2013 August 2013;02154. Available at: www.medicare.gov.Google Scholar
Feldt, KS. The checklist of nonverbal pain indicators (CNPI). Pain Manag Nurs 2000 Mar;1(1):1321.Google Scholar
Schuler, MS, Becker, S, Kaspar, R, et al. Psychometric properties of the German “Pain Assessment in Advanced Dementia Scale” (PAINAD-G) in nursing home residents. J Am Med Dir Assoc 2007 Jul;8(6):388395.Google Scholar
Integration of behavioral and relaxation approaches into the treatment of chronic pain and insomnia: NIH Technology Assessment Panel on Integration of Behavioral and Relaxation Approaches into the Treatment of Chronic Pain and Insomnia. JAMA 1996 Jul 24–31;276(4):313318.Google Scholar
Randomized trial of exercise vs usual care on aromatase inhibitor-associated arthralgias in women with breast cancer. Abstract S3–03. San Antonio Breast Cancer Symposium 2013; December 2013.Google Scholar
Basch, E, Prestrud, A, Hesketh, P, et al. Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol 2011 November 1 2011;29(31):41894198.Google Scholar
Cancer Care Ontario Symptom Assessment and Management Tools. 2014; Available at: www.cancercare.on.ca/toolbox/symptools (accessed on Jan 15, 2014).Google Scholar
Barford, K, D’Olimpio, J. Symptom management in geriatriconcology: practical treatment considerations and current challenges. Curr Treat Options Oncol 2008 June 2008;9(2):204214.Google Scholar
Librach, SL, Bouvette, M, De Angelis, C, et al. Consensus recommendations for the management of constipation in patients with advanced, progressive illness. J Pain Symptom Manage 2010 Nov;40(5):761773.Google Scholar
Smith, EM, Pang, H, Cirrincione, C, et al. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA 2013 Apr 3;309(13):13591367.Google Scholar
Galbraith, S, Fagan, P, Perkins, P, et al. Does the use of a handheld fan improve chronic dyspnea? A randomized, controlled, crossover trial. J Pain Symptom Manage 2010 May;39(5):831838.Google Scholar
Ben-Aharon, I, Gafter-Gvili, A, Paul, M, et al. Interventions for alleviating cancer-related dyspnea: a systematic review. J Clin Oncol 2008 May 10;26(14):23962404.Google Scholar
Hallenbeck, J. Pathophysiologies of dyspnea explained: why might opioids relieve dyspnea and not hasten death? J Palliat Med 2012 Aug;15(8):848853.Google Scholar
Hurria, A, Naylor, M, Cohen, HJ. Improving the quality of cancer care in an aging population: recommendations from an IOM report. JAMA 2013 Nov 6;310(17):17951796.Google Scholar

References

Centers for Disease Control and Prevention. Why is vision loss a public health problem? 2009. www.cdc.gov/visionhealth/basic_information/vision_loss.htm (accessed June 29, 2014).Google Scholar
National Eye Institute. Vision Problems in the US: Prevalence of Adult Vision Impairment and Age-Related Eye Disease in America. 2012. http://visionproblemsus.org/index.html (accessed June 29, 2014).Google Scholar
Tielsch, JM, Sommer, A, Witt, K, et al. Blindness and visual impairment in an American urban population. The Baltimore Eye Survey. Arch Ophthalmol. 1990; 108: 286290.Google Scholar
American Academy of Ophthalmology Preferred Practice Committee. Comprehensive Adult Eye Examination. San Francisco: American Academy of Ophthalmology; 2010.Google Scholar
Rein, DB, Zhang, P, Wirth, KE, et al. The economic burden of major adult visual disorders in the United States. Arch Ophthalmol. 2006; 124: 17541760.Google Scholar
Tantenbaum, MMC. Lacrimal drainage system. In: Tasman, WJE, ed. Duane’s Clinical Ophthalmology. Philadelphia: Lippincott; 2006: vol 4, chap 13.Google Scholar
Rubin, AI, Chen, EH, Ratner, D. Basal-cell carcinoma. N Engl J Med. 2005; 353: 22622269.Google Scholar
Vaughn, GI DR, Gayre, GS. Eyelid malignancies. In: Yanoff, M DJ, Aggsburger, JJ, eds. Ophthalmology. Philadelphia: Mosby; 2004: chap 93.Google Scholar
Shields, JA, Demirci, H, Marr, BP, et al. Sebaceous carcinoma of the eyelids: personal experience with 60 cases. Ophthalmology. 2004; 111: 21512157.Google Scholar
Jacobiec, FA. Sebaceous tumors of the ocular adnexa. In: Albert, DA, Jacobiec, FA, eds. Principles and Practice of Ophthalmology. Philadelphia: Saunders; 1994.Google Scholar
Pepose, JS. The potential impact of the varicella vaccine and new antivirals on ocular disease related to varicella-zoster virus. Am J Ophthalmol. 1997; 123: 243251.Google Scholar
The Eye Disease Prevalence Research Group. Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol. 2004; 122: 487494.Google Scholar
Klein, BE, Klein, R, Lee, KE. Incidence of age-related cataract: the Beaver Dam Eye Study. Arch Ophthalmol. 1998; 116: 219225.Google Scholar
Brenner, MH, Curbow, B, Javitt, IC, et al. Vision change and quality of life in the elderly: response to cataract surgery and treatment of other chronic ocular conditions. Arch Ophthalmol. 1993; 111: 680685.Google Scholar
Javitt, JC, Yitale, S, Canner, JK, et al. National outcomes of cataract extraction: Endophthalmitis following inpatient surgery. Arch Ophthalmol. 1991; 109: 1085l089.Google Scholar
American Academy of Ophthalmology Preferred Practice Committee. Primary Open Angle Glaucoma. San Francisco: American Academy of Ophthalmology; 2010.Google Scholar
Coleman, AL, Brigatti, L. The glaucomas. Minerva Med. 2001; 92: 365379.Google Scholar
Weinand, FS, Althen, F. Long-term clinical results of selective laser trabeculoplasty in the treatment of primary open angle glaucoma. Eur J Ophthalmol. 2006; 16: 100104.Google Scholar
Van Overdam, KA, Bettink-Remeijer, MW, Klaver, CC, et al. Symptoms and finding predictive for the development of new retinal breaks. Arch Ophthalmol. 2005; 123: 479484.Google Scholar
Klein, R, Klein, BE, Moss, SE, et al. The Wisconsin Epidemiologic Study of Diabetic Retinopathy II. Arch Ophthalmol. 1984; 102: 520526.Google Scholar
Early photocoagulation for diabetic retinopathy. ETDRS report number 9. Early Treatment Diabetic Retinopathy Study research group. Ophthalmology. 1991; 98: 766785.Google Scholar
Branch Vein Occlusion Study Group. Argon laser photocoagulation for macular edema in branch vein occlusion. Am I Ophthalmol. 1984; 98: 271282.Google Scholar
Macular Photocoagulation Study Group. Argon laser photocoagulation for neovascular maculopathy: five-year results from randomized clinical trials. Arch Ophthalmol. 1991; 109: 11091114.Google Scholar
Abraham, P, Yue, H, Wilson, L. Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER study year 2. Am J Ophthalmol. 2010; 150: 315324.Google Scholar

References

Weinstein, BE. Aging of the outer, middle and inner ear and neural pathways. In: Geriatric Audiology. 2nd ed. New York, NY: Thieme; 2000:5580.Google Scholar
Seshamani, M, Kashima, ML. Special considerations in managing geriatric patients. In: Flint, PW, Haughey, BH, Lund, VJ, et al., eds. Cummings Otolaryngology Head & Neck Surgery. 5th ed. Philadelphia, PA: Mosby Elsevier; 2010:230238.Google Scholar
Roland, PS, Smith, TL, Schwartz, SR, et al. Clinical practice guideline: cerumen impaction. Otolaryngol Head Neck Surg. 2008;139:S1S21.Google Scholar
Lum, CL, Jeyanthi, S, Prepageran, N, et al. Antibacterial and antifungal properties of human cerumen. J Laryngol Otol. 2009;123:375378.Google Scholar
Kutz, JW, Isaacson, B, Roland, PS. Aging and the auditory and vestibular system. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. Vol 2. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:26152623.Google Scholar
Rubin, J, Yu, VL, Kamerer, DB, Wagener, M. Aural irrigation with water: a potential pathogenic mechanism for inducing malignant external otitis? Ann Otol Rhinol Laryngol. 1990;99:117119.Google Scholar
Weinroth, SE, Schessel, D, Tuazon, CU. Malignant otitis externa in AIDS patients: case report and review of the literature. Ear Nose Throat J. 1994;73:772774, 777778.Google Scholar
Bailey, BJ. Geriatric otolaryngology. In: Bailey, BJ, Johnson, JT, eds. Head and Neck Surgery – Otolaryngology. Vol 1. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006:235245.Google Scholar
Nathan, CO, Lian, TS. Cutaneous malignancy. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:17231738.Google Scholar
Fitzpatrick, TB. Soleil et peau [Sun and skin]. Journal de Médecine Esthétique. 1975;2:3334.Google Scholar
Ussmuller, J, Hartwein, J, Rauchfuss, A, Sanchez-Hanke, M. Primary carcinoma of the ear canal. Clinical aspects, intratemporal growth behavior and surgical strategy. HNO. 2001;49:256263.Google Scholar
Linstrom, CJ, Lucente, FE. Diseases of the external ear. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:23332357.Google Scholar
Rosenfeld, RM, Schwartz, SR, Cannon, CR, et al. Clinical practice guideline: acute otitis externa. Otolaryngol Head Neck Surg. 2014;150:S1S24.Google Scholar
Guss, J, Ruckenstein, MJ. Infections of the exernal ear. In: Flint, PW, Haughey, BH, Lund, VJ, et al., eds. Cummings Otolaryngology Head and Neck Surgery. 5th ed. Philadelphia, PA: Mosby Elsevier; 2010:19441949.Google Scholar
Burke, BL, Steele, RW, Beard, OW, et al. Immune responses to varicella-zoster in the aged. Arch Intern Med. 1982;142:291293.Google Scholar
Vrabec, JT, Lin, JW. Acute paralysis of the facial nerve. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:25032518.Google Scholar
Uscategui, T, Doree, C, Chamberlain, IJ, Burton, MJ. Antiviral therapy for Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults. Cochrane Database Syst Rev. 2008;4:CD006851.Google Scholar
Etholm, B, Belal, A Jr. Senile changes in the middle ear joints. Ann Otol Rhinol Laryngol. 1974;83:4954.Google Scholar
Casselbrant, ML, Mandel, EM. Otitis media in the age of antimicrobial resistance. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:14791506.Google Scholar
Handzel, O, Auwaerter, PG. Acute Otitis Media, Adult. Available at: www.hopkinsguides.com/hopkins/ub/view/Johns_Hopkins_ABX_Guide/540408/3/Acute_Otitis_Media_Adult_?q=otitis%20media. Accessed May 8, 2014.Google Scholar
Ramakrishnan, K, Sparks, RA, Berryhill, WE. Diagnosis and treatment of otitis media. Am Fam Physician. 2007;76:16501658.Google Scholar
O’Reilly, RC, Sando, I. Anatomy and physiology of the eustachian tube. In: Flint, PW, Haughey, BH, Lund, VJ, et al., eds. Cummings Otolaryngology Head and Neck Surgery. 5th ed. Philadelphia, PA: Mobsy Elsevier; 2010:18661875.Google Scholar
Meyer, TA, Strunk, CL, Lambert, PR. Cholesteatoma. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. Vol 2. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:24332446.Google Scholar
Chang, CYJ. Cholesteatoma. In: Lalwani, AK, ed. Current Diagnosis and Treatment in Otolaryngology – Head and Neck Surgery. 3rd ed. New York, NY: McGraw-Hill; 2012.Google Scholar
Sprinzl, GM, Riechelmann, H. Current trends in treating hearing loss in elderly people: a review of the technology and treatment options – a mini-review. Gerontology. 2010;56:351358.Google Scholar
Chen, DS, Clarrett, DM, Li, L, et al. Cochlear implantation in older adults: long-term analysis of complications and device survival in a consecutive series. Otol Neurotol. 2013;34:12721277.Google Scholar
Stachler, RJ, Chandrasekhar, SS, Archer, SM, et al. Clinical practice guideline: sudden hearing loss. Otolaryngol Head Neck Surg. 2012;146:S1S35.CrossRefGoogle ScholarPubMed
Bagai, A, Thavendiranathan, P, Detsky, AS. Does this patient have hearing impairment? JAMA. 2006;295:416428.Google Scholar
Thijs, C, Leffers, P. Sensitivity and specificity of Rinne tuning fork test. BMJ. 1989;298:255.Google Scholar
Oliver, ER, Hashisaki, GT. Sudden sensory hearing loss. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. Vol 2. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:25892595.Google Scholar
Conlin, AE, Parnes, LS. Treatment of sudden sensorineural hearing loss: I. A systematic review. Arch Otolaryngol Head Neck Surg. 2007;133:573581.CrossRefGoogle ScholarPubMed
Cosetti, MK, Roehm, PC. Tinnitus and hyperacusis. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:25972614.Google Scholar
Agrawal, Y, Minor, LB, Carey, JP. Peripheral vestibular disorders. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:27012716.Google Scholar
Bhattacharyya, N, Baugh, RF, Orvidas, L, et al. Clinical practice guideline: benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg. 2008;139:S47S81.CrossRefGoogle ScholarPubMed
Dix, MR, Hallpike, CS. The pathology symptomatology and diagnosis of certain common disorders of the vestibular system. Proc R Soc Med. 1952;45:341354.Google Scholar
Hilton, M, Pinder, D. The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo. Cochrane Database Syst Rev. 2004;2:CD003162.Google Scholar
Ishiyama, G, Ishiyama, A. Central vestibular disorders. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:27172732.Google Scholar
Schuknecht, HF. Meniere’s disease: a correlation of symptomatology and pathology. Laryngoscope. 1963;73:651665.Google Scholar
Phillips, JS, Westerberg, B. Intratympanic steroids for Meniere’s disease or syndrome. Cochrane Database Syst Rev. 2011;7:CD008514.Google Scholar
Kayan, A, Hood, JD. Neuro-otological manifestations of migraine. Brain. 1984;107 (Pt 4):11231142.Google Scholar
Lundy, DS. Swallowing – patient safety and medicinal therapy for ear, nose, and throat disorders. In: Geratric Care Otolaryngology. Alexandria, VA: American Academy of Otolaryngology – Head and Neck Surgery Foundation; 2006:86101.Google Scholar
Eibling, DE. Management of intractable aspiration. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. Vol 1. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:859867.Google Scholar
Benninger, MS, Abitbol, J. Voice – dysphonia and the aging voice. In: Geriatric Care Otolaryngology. Alexandria, VA: American Academy of Otolaryngology – Head and Neck Surgery; 2006:6685.Google Scholar
Varga-Huettner, VE, Pinto, J. Physiology of the aging nose and geriatric rhinitis. In: Onerci, TM, ed. Nasal Physiology and Pathophysiology of Nasal Disorders. Heidelberg: Springer; 2013:165181.CrossRefGoogle Scholar
Kim, SW, Mo, JH, Kim, JW, et al. Change of nasal function with aging in Korean. Acta Otolaryngol Suppl. 2007;(558):9094.Google Scholar
Alford, RH. Effects of chronic bronchopulmonary disease and aging on human nasal secretion IgA concentrations. J Immunol. 1968;101:984988.Google Scholar
Lal, D, Corey, JP. Vasomotor rhinitis update. Curr Opin Otolaryngol Head Neck Surg. 2004;12:243247.Google Scholar
Sur, DK, Scandale, S. Treatment of allergic rhinitis. Am Fam Physician. 2010;81:14401446.Google Scholar
Rosenfeld, RM, Andes, D, Bhattacharyya, N, et al. Clinical practice guideline: adult sinusitis. Otolaryngol Head Neck Surg. 2007;137:S1S31.Google Scholar
Suh, JD, Chiu, AG. Medical management of chronic sinusitis. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:586594.Google Scholar
Venekamp, RP, Thompson, MJ, Hayward, G, et al. Systemic corticosteroids for acute sinusitis. Cochrane Database Syst Rev. 2014;3:CD008115.Google Scholar
Deconde, AS, Mace, JC, Smith, TL. The impact of comorbid migraine on quality of life outcomes after endoscopic sinus surgery. Laryngoscope. 2014;124(8):17501755.Google Scholar
Wein, RO, O’Leary, M. Stomatitis. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:736756.Google Scholar
Adelson, RT, Marple, BF, Ryan, MW. Fungal rhinosinusitis. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:557572.Google Scholar
Bleier, BS, Schlosser, RJ. Epistaxis. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:501508.Google Scholar
Holbrook, EH, Leopold, DA. Olfaction. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:371378.Google Scholar
Gonsalves, WC, Chi, AC, Neville, BW. Common oral lesions: Part I. Superficial mucosal lesions. Am Fam Physician. 2007;75:501507.Google Scholar
Deschler, DG, Erman, AB. Oral cavity cancer. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:18491874.Google Scholar
Vaezi, A, Grandis, JR. Head and neck tumor biology. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:16451671.Google Scholar
Gonsalves, WC, Chi, AC, Neville, BW. Common oral lesions: Part II. Masses and neoplasia. Am Fam Physician. 2007;75:509512.Google Scholar
Coutaz, M, Morisod, J. The acute bacterial parotitis of the elderly. Rev Med Suisse. 2009;5:19421945.Google Scholar
Butt, FY. Benign diseases of the salivary glands. In: Lalwani, AK, ed. Current Diagnosis and Treatment in Otolaryngology-Head and Neck Surgery. 3rd ed. New York, NY: McGraw-Hill; 2012:chap 18.Google Scholar
Rogers, J, McCaffrey, TV. Inflammatory disorders of the salivary glands. In: Flint, PW, Haughey, BH, Lund, VJ, et al., eds. Cummings Otolaryngology Head & Neck Surgery. 5th ed. Philadelphia, PA: Mosby Elsevier; 2010:11511161.Google Scholar
Coutaz, M. Acute bacterial parotitis in the frail elderly subject: a harbinger of death? J Am Med Dir Assoc. 2014;15(5):269270.Google Scholar
Rowlands, S, Hooper, R, Hughes, R, Burney, P. The epidemiology and treatment of Bell’s palsy in the UK. Eur J Neurol. 2002;9:6367.Google Scholar
Baugh, RF, Basura, GJ, Ishii, LE, et al. Clinical practice guideline: Bell’s palsy. Otolaryngol Head Neck Surg. 2013;149:S1S27.Google Scholar
Engstrom, M, Berg, T, Stjernquist-Desatnik, A, et al. Prednisolone and valaciclovir in Bell’s palsy: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet Neurol. 2008;7:9931000.Google Scholar
Gronseth, GS, Paduga, R, American Academy of Neurology. Evidence-based guideline update: steroids and antivirals for Bell palsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2012;79:22092213.Google Scholar
Schwartz, SR, Jones, SL, Getchius, TS, Gronseth, GS. Reconciling the clinical practice guidelines on Bell’s palsy from the AAO-HNSF and the AAN. Otolaryngol Head Neck Surg. 2014;150:709711.Google Scholar
Wei, WI, Chua, DTT. Nasopharyngeal carcinoma. In: Johnson, JT, Rosen, CA, eds. Bailey’s Head and Neck Surgery: Otolaryngology. Vol 2. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2014:18751897.Google Scholar

References

www.ada.org/en (accessed May 9, 2014).Google Scholar
Harris, NO, Godoy, G. Primary Preventive Dentistry. 5th ed. New York: Appleton and Lange; 1999.Google Scholar
Glick, M (ed.). The Oral-Systemic Disease Connection: An Update for the Practicing Dentist. JADA. 2006; 137(special supplement):1S40S.Google Scholar
Paquette, DW, Nichols, T, Williams, RC. Oral Inflammation, CVD, and Systemic Disease. Connections: Oral and Systemic Health Review. July 2005; 1(1): 18.Google Scholar
Paquette, DW. Periodontal Disease and the Risk for Adverse Pregnancy Outcomes. Grand Rounds in Oral and Systemic Medicine. Nov 2006; 1(4): 1424.Google Scholar
Moritz, AJ, Mealey, BL. Periodontal Disease, Insulin Resistance, and Diabetes Mellitus: A Review and Clinical Implications. Grand Rounds in Oral and Systemic Medicine. May 2006; 1(2): 1320.Google Scholar
DePaola, DP (guest ed.). Proceedings and Consensus Opinion from the Global Oral and Systemic Health Summit. Grand Rounds Supplement. Feb 2007; 120.Google Scholar
Beck, JD, Slade, G, Offenbacher, S. Oral Disease, Cardiovascular Disease and Systemic Inflammation. Periodontology. June 2000; 23: 110120.Google Scholar
The American Journal of Cardiology and Journal of Periodontology Editor’s Consensus: Periodontitis and Atherosclerotic Cardiovascular Disease. J Periodontology. 2009; 80: 10211032.Google Scholar
Babu, NC, Gomes, AJ. Systemic Manifestations of Oral Diseases. J Oral Maxillofac Pathol. May–Aug 2011; 15(2): 144147.Google Scholar
Parks, ET, Lancaster, H. Oral Manifestations of Systemic Disease. Dermatol Clin. Jan 2003; 21(1): 171182.Google Scholar
Islam, NM, Bhattacharyya I et.al. Common Oral Manifestations of Systemic Disease. Otolaryngol Clin North Am. Feb 2011; 44(1): 161182.Google Scholar
Swinson, B, Witherow, H et al. Oral Manifestations of Systemic Diseases. Hosp Med. Feb 2004; 65(2): 9299.Google Scholar
Parameters on Systemic Conditions Affected by Periodontal diseases. J Periodontol. 2000; 71: 880883.Google Scholar
Parameters on Periodontitis Associated with Systemic Conditions, J Periodontol. 2000; 71: 876879.Google Scholar
US Department of Health and Human Services. Oral Health in America: A Report of the Surgeon General. Rockville, MD: US Department of Health and Human Services, National Institute of Dental and Craniofacial Research, National Institutes of Health; 2000.Google Scholar
Beltrán-Aguilar, ED, Barker, LK, Canto, MT, et al. Surveillance for Dental Caries, Dental Sealants, Tooth Retention, Edentulism, and Enamel Fluorosis – United States, 1988–1994 and 1999–2002. MMWR 2005; 54(3): 144.Google Scholar
Vargas, CM, Kramarow, EA, Yellowitz, JA. The Oral Health of Older Americans. Aging Trends; No. 3. Hyattsville, MD: National Center for Health Statistics; 2001: 18.Google Scholar
MacEntee, M, Hole, R, Stoler, E. The Significance of the Mouth in Old Age. Soc Sci Med. 1997; 45: 14491458.Google Scholar
Holm-Pederson, P, Löe, H (eds.). Textbook of Geriatric Dentistry. 4th ed. New York: McGraw Hill; 1999.Google Scholar
Hazzard, WR, Blass, JP. Principles of Geriatric Medicine and Gerontology. New York: McGraw-Hill Professional; 2003.Google Scholar
Wade, ML, Suzuki, JB. Issues Related to Diagnosis and Treatment of Bisphosphonate-induced Osteonecrosis of the Jaws. Grand Rounds in Oral and Systemic Medicine May 2007; 2(2): 4653.Google Scholar
Bhaskar, SN. Orban’s Oral Histology and Embryology. 10th ed. Philadelphia: C.V. Mosby; 1986.Google Scholar
Ten Cate, AR. Oral Histology Development, Structure, and Function. 2nd ed. Philadelphia: C.V. Mosby; 1985.Google Scholar
Regezi, JA, Sciubba, JJ. Oral Pathology Clinical-Pathologic Correlations. Philadelphia: W.B. Saunders; 1989.Google Scholar
Montgomery, RL. Head and Neck Anatomy with Clinical Correlations. New York: McGraw-Hill; 1981.Google Scholar
Hollinshead, HW. Anatomy for Surgeons: The Head and Neck. Baltimore: Lippincott Williams & Wilkins; 1982.Google Scholar
Okeson, JP. Management of Temporomandibular Disorders and Occlusion. 4th ed. Philadelphia: C.V. Mosby; 1998.Google Scholar
Sheiham, A. Oral Health, General Health, and Quality of Life (Editorial). Bulletin of the World Health Organization Sep 2005; 83(9): 644645.Google Scholar
Matear, DW. Demonstrating the Need for Oral Health Education in Geriatric Institutions. Probe Mar–Apr 1999; 33(2): 6671.Google Scholar
Federal Nursing Home Reform Act from the Omnibus Budget Reconciliation Act of 1987 (OBRA 1987).Google Scholar
Widmalm, SE, Westesson, PL, Brooks, SL, et al. Temporomandibular Joint Sounds: Correlation to Joint Structure in Fresh Autopsy Specimens. Am J Orthod Dentofacial Orthop. Jan 1992; 101(1): 6069.CrossRefGoogle ScholarPubMed
Al Habashneh, R, Alchalabi, H, Khader, YS, et al. Association between Periodontal Disease and Osteoporosis in Postmenopausal Women in Jordan. J Periodontol. Nov 2010; 81(11): 16131621.Google Scholar
Pelelassi, E, Nocopoulou-Karayianni, K, Archontopoulou, AD, et al. The Relationship Between Osteoporosis and Periodontitis in Women Aged 45–70 Years. Oral Dis. May 2012; 18(4): 353359.Google Scholar
Danesh-Sani, SA, Rahimdoost, A, Soltani, M, et al. Clinical Assessment of Orofacial Manifestation in 500 Patients with Multiple Sclerosis. J Oral Maxillofac Surg. Feb 2013; 71(2): 290294.Google Scholar
Ueda, K. Preventing Aspiration Pneumonia by Oral Health Care. JMAJ. 2011; 54(1): 3943.Google Scholar
Liantonio, J, Salzman, B, Snyderman, D. Preventing Aspiration Pneumonia by Addressing Three Key Risk Factors: Dysphagia, Poor Oral Hygiene, and Medication Use. Annals of Long Term Care Oct 2014; 22(10).Google Scholar
Wolfart, S, Weyer, N, Kern, M. Patient Attendance in a Recall Program After Prosthodontic Rehabilitation: A 5-Year Follow-up. Int J Prosthodont. Sept–Oct 2012; 25(5): 491496.Google Scholar

References

Helfand, AE. Primary considerations in managing the older patient with foot problems, chap 122. In: Halter, JB, Ouslander, JG, Tinetti, ME, et al., editors. Hazzard’s Geriatric Medicine and Gerontology. 6th ed. New York: McGraw Hill Medical; 2009.Google Scholar
Kosinski, M, Ramcharitar, S. In-office management of common geriatric foot problems. Geriatrics. 1994;49(5):43.Google Scholar
Stubbs, B, Binnekade, T, Eggermont, L, et al. Pain and risk for falls in Community dwelling older adults: systematic review and meta-analysis. Archives of Physical Medicine and Rehabilitation. 2014;95:175187.Google Scholar
Stults, BM. Preventive health care for the elderly in personal health maintenance. West J Med. 1984;141:832845.Google Scholar
Albreski, DA. Diseases and disorders of the foot. In: Durso, SC, Sullivan, GM, editors in chief. Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine, 8th ed. New York: American Geriatrics Society; 2013.Google Scholar
Alexander, IJ. The Foot Examination and Diagnosis. 2nd ed. New York: Churchill Livingstone; 1997.Google Scholar
Helfand, AE. Foot health in the elderly: podogeriatric overview. In: Arenson, C, Busby-Whitehead, J, Brummel-Smith, K, et al., editors. Reichel’s Care of the Elderly, Clinical Aspects of Aging. 6th ed. New York: Cambridge; 2009.Google Scholar
Grant-Kels, JM. Dermatologic diseases and disorders. In: Durso, SC, Sullivan, GM, editors in chief. Geriatrics Review Syllabus: A Core Curriculum in Geriatric Medicine. 8th ed. New York: American Geriatrics Society; 2013.Google Scholar
Ward, K, Kosinski, MA, et al. Podiatry. In: Fillit, H, Rockwood, K, editors. Brocklehurst’s Textbook of Geriatric Medicine and Gerontology. 7th ed. Philadelphia: Saunders, an imprint of Elsevier; 2010.Google Scholar
Helfand, AE. Foot problems. In: Evans, J, Williams, T., editors. Oxford Textbook of Geriatric Medicine. 2nd ed. Oxford: Oxford University Press; 2000.Google Scholar
Helfand, AE, Robbins, JM. Foot problems. In: Ham, R, Sloane, P., editors. Ham’s Primary Care Geriatrics: A Case-Based Approach. 6th ed. Philadelphia: Saunders, an imprint of Elsevier; 2014.Google Scholar
Goldstein, BG, Goldstein, AO, et al. Overview of benign lesions of the skin. 2014 Jun [cited 2014 Jul 8]. Available from: www.uptodate.com/contents/overview-of-benign-lesions-of-the-skin?source=search_result&search=corns+and+callus+goldstein&selectedTitle=1%7E150.Google Scholar
Alguire, PC, Scovell, S. Overview and management of lower extremity chronic venous disease. UpToDate. June 2014 [updated 2014 May 5]. Available from: www.uptodate.com/contents/overview-and-management-of-lower-extremity-chronic-venous-disease?source=search_result&search=overview+and+management+of+lower+extremity+chronic+venous+disease&selectedTitle=1%7E150.Google Scholar
Neschis, DG, Golden, MA. Clinical features and diagnosis of lower extremity peripheral artery disease. UpToDate. June 2014 [updated 2014 Jun 12]. Available from: www.uptodate.com/contents/clinical-features-and-diagnosis-of-lower-extremity-peripheral-artery-disease?source=search_result&search=Clinical+features+and+diagnosis+of+lower+extremity+peripheral&selectedTitle=1%7E150.Google Scholar
Baran, R. The nail in the elderly. Clin in Derm. 2011; 29: 5460.Google Scholar
Welsh, O, Ver-Cabrera, L, Welsh, E. Onychomycosis. Clin in Derm. 2010; 28: 151159.Google Scholar
Allevato, MAJ. Diseases mimicking onychomycosis. Clin in Derm. 2010; 28: 164177.Google Scholar
Dufour, AB, Casey, VA, Golightlu, YM, Hannan, MT. Characteristics associated with hallux valgus in a population-based study of older adults: the Framingham foot study. Arthr Care & Research. In Press. Accepted 2014 Jun 17.Google Scholar
Ferrari, J. Hallux valgus deformity. UpToDate. 2014 Jun [updated 2013 May 15]. Available from: www.uptodate.com/contents/hallux-valgus-deformity-bunion?source=search_result&search=hallux+valgus&selectedTitle=1%7E20.Google Scholar
Thomas, JL, Blitch, EL, Chaney, DM, et al. Diagnosis and treatment of forefoot disorders. Section 1: Digital deformities. Journal of Foot and Ankle Surgery. 2009; 48: 230272.Google Scholar
American Health Network. Indiana: American Health Network-Central Services Organization; 2014. Available from: www.ahni.com/Specialties/Foot+and+Ankle/Articles/Common+Disorders/Sesamoiditis.html.Google Scholar
Gravlee, JR, Hatch, RL, et al. Toe fractures in adults. UpToDate. 2014 Jun [updated 2013 Jun 13]. Available from: www.uptodate.com/contents/toe-fractures-in-adults.Google Scholar
Adams, WR II. Morton’s neuroma. Clin Podiatr Med Surg. 2010; 27: 535545.Google Scholar
Jain, S, Mannan, K. The diagnosis and management of Morton’s neuroma: a literature review. Foot Ankle Spec. 2013; 6: 307317.Google Scholar
Caselli, MA, George, DH. Foot deformities: biomechanical and pathomechanical changes associated with aging, part I. Clin Podiatr Med Surg. 2003; 20: 487509.Google Scholar
Katchis, SD. Posterior tibial tendon dysfunction. In: Ranawat, CS, Positano, RG, editors. Disorders of the Heel, Rearfoot and Ankle. Philadelphia: Churchill Livingstone; 1999.Google Scholar
Geideman, WM, Johnson, JE. Posterior tibial tendon dysfunction. Orthop Sports Phys Ther. 2000; 30: 6877.Google Scholar
Healey, K, Chen, K. Plantar fasciitis: current diagnostic modalities and treatments. Clin Podiatr Med Surg. 2010; 27: 369380.Google Scholar
Ahn, JM, El-Khoury, GY. Radiologic evaluation of chronic foot pain. Am Fam Physician. 2007; 76: 975983.Google Scholar
Wallach, DM, Katchis, SD. Tarsal tunnel syndrome. In: Ranawat, CS, Positano, RG, editors. Disorders of the Heel, Rearfoot and Ankle. Philadelphia: Churchill Livingstone; 1999.Google Scholar
Helfand, AE. Assessing and preventing foot problems in older patients who have diabetes mellitus. Clin Podiatr Med Surg. 2003; 20: 573582Google Scholar
Khanolkar, MP, Bain, SC, Stephens, JW. The diabetic foot. Q J Med. 2008; 101: 685695.Google Scholar
Botek, G, Anderson, MS, Taylor, R. Charcot neuroarthropathy: an often overlooked complication of diabetes. Clev Clinic J Med. 2010; 77(9): 593599.Google Scholar
Scott, JT. Gout and other crystal arthropathies. In: Evans, J, Williams, T., editors. Oxford Textbook of Geriatric Medicine. 2nd ed. Oxford: Oxford University Press; 2000.Google Scholar
Dieppe, PA. Investigation and management of gout in the young and the elderly. Annals of Rheumatic Diseases. 1991; 50: 263266.CrossRefGoogle Scholar
Crittenden, DB. New therapies for gout. Annu Rev Med. 2013; 64: 325337.Google Scholar
Bryant, JL, Beinlich, NR. Foot care: focus on the elderly. Orthop Nursing. 1999; 18(6): 5360.Google Scholar
Menant, JC, Steele, JR, Menz, HB et al. Optimizing footwear for older people at risk of falls. J Rehab Research and Development 2008; 45: 11671182.Google Scholar
Esquenazi, A, Thompson, E. Management of Foot Disorders in the Elderly. In: Felsenthal, G, Garrison, SJ, Steinberg, FU, editors. Rehabilitation of the Aging and Elderly Patient. Baltimore: Williams & Wilkins; 1994.Google Scholar

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