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6 - Science and Technology of Novel Ultrananocrystalline Diamond (UNCD™) Scaffolds for Stem Cell Growth and Differentiation for Developmental Biology and Biological Treatment of Human Medical Conditions

Published online by Cambridge University Press:  08 July 2022

By
Bing Shi  and
Orlando Auciello
Edited by
Orlando Auciello
Orlando Auciello
Affiliation:
University of Texas, Dallas
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Summary

Biomaterials are being investigated to produce platform as scaffolds for cell/tissue growth and differentiation/regeneration. Cell-materials, chemical and biological interactions enable the application of more functional materials in the area of bioengineering, providing a pathway to novel treatment of humans suffering from tissue/organ damage and facing limitation of donation organs. Many studies were done on the tissue/organ regeneration. Development of new scaffolds for cell/tissue regeneration is a key R&D field. This chapter focuses on describing R&D on the novel ultrananocrystalline diamond (UNCD) film as a unique biomaterial for scaffolds for developmental biology. Recent research showed that cells grown on the surface of UNCD-coated culture dishes are similar to cell culture dishes with little retardation, indicating UNCD films have no or little inhibition on cell proliferation and are potentially appealing as substrate/scaffold materials. The mechanisms of cell adhesion on UNCD surfaces are proposed based on the experimental results. The comparisons of cell cultures on diamond-powder-seeded culture dishes and on UNCD-coated dishes with matrix-assisted laser desorption/ionization - time-of-flight mass spectroscopy (MALDI-TOF MS) and X-ray photoelectron spectroscopy (XPS) analyses provided valuable data to support the mechanisms proposed to explain the adhesion and proliferation of cells on the surface of UNCD scaffolds.

Keywords

Ultrananocrystalline Diamond (UNCD)chemicaltreated surfacescaffoldgrowembryonic cellsdifferentiationotherhuman cells
Type
Chapter
Information
Ultrananocrystalline Diamond Coatings for Next-Generation High-Tech and Medical Devices , pp. 175 - 196
Publisher: Cambridge University Press
Print publication year: 2022

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