Bipolar disorder is characterized by the occurrence of one or more manic, hypomanic, or mixed episodes and is typified by periods of mood instability. Pharmacologic treatment of bipolar disorder is associated with significant problems of medication adherence. Cognitive-behavioral therapy is an effective and empirically supported psychosocial treatment for bipolar disorder. Key elements of the CBT intervention include psychoeducation, training in medication adherence, stress management, and cognitive restructuring. In addition to CBT, several other psychosocial treatments have been applied to bipolar disorder. Group treatment has been used for bipolar disorder as a potentially cost-effective method to prevent recurrence. High rates of comorbidity exist among patients with bipolar disorder. At the present time, the evidence for the efficacy of psychosocial interventions for bipolar disorder has never been stronger. The efficacy of psychosocial treatment on specific symptom areas, prominently including the role of anger and anxiety management, needs to be investigated.