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Chapter 19 - Spinal Tumors

from Section 2 - Clinical Neurosurgical Diseases

Published online by Cambridge University Press:  04 January 2024

By
Ziev B. Moses ,
Matthew Trawczynski  and
John E. O’Toole
Edited by
Farhana Akter ,
Nigel Emptage ,
Florian Engert  and
Mitchel S. Berger
Farhana Akter
Affiliation:
Harvard University, Massachusetts
Nigel Emptage
Affiliation:
University of Oxford
Florian Engert
Affiliation:
Harvard University, Massachusetts
Mitchel S. Berger
Affiliation:
University of California, San Francisco
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Summary

Tumors of the spine are a heterogeneous group of neoplasms involving the spinal column and spinal cord. They can be distinguished based on their location within the spine into three groups: intradural–intramedullary, intradural–extramedullary, and extradural. Another classification seeks to separate out these tumors based on their cell of origin, with primary spine tumors arising from either the spinal cord itself, its surrounding coverings including the leptomeninges, bone, cartilage, and soft tissue, or as secondary tumors arising from spinal involvement of a systemic neoplasm such as myeloma or as a metastasis from a distant site. This chapter seeks to discuss current evidence on the genetic, epigenetic, and cellular underpinnings of spine tumors with emphasis on the pathobiology and mechanisms underlying these neoplasms.

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Chapter
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Neuroscience for Neurosurgeons , pp. 267 - 277
Publisher: Cambridge University Press
Print publication year: 2024

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