This chapter places race and disability in dialogue to highlight the complex, often contradictory, negotiations of exclusionary discourse within sensation narratives of the 1860s. The first half of the chapter discusses Mary Elizabeth Braddon’s The ital Octoroon (1861–62), as a sensational text which places issues of race center stage and demonstrates how racial rhetoric is encoded through melodrama. Through exploiting the heightened topicality of racial questions in the midst of public discussions about the American Civil War, the novel exposes contradictory constructions of racial difference in the decade and implicitly displaces and elides British imperial violence. Issues of miscegenation and hybridity are analyzed in relation to the “octoroon fever” of the 1860s, before moving to a consideration of the ways in which contemporary discourses of race and mental disability converge in the slave figure, Tristan. The final part of the chapter extends this analysis of the constitutive relationship of race and disability in two of Wilkie Collins’s major novels of this no quote marks. Ital. all titles decade, Armadale (1866) and The Moonstone (1868).