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Chapter 7 - Screening for Fetal Abnormality in the First and Second Trimesters (Content last reviewed: 15th March 2020)

from Section 2 - Early Prenatal Problems

Published online by Cambridge University Press:  15 November 2017

David James
Affiliation:
University of Nottingham
Philip Steer
Affiliation:
Imperial College London
Carl Weiner
Affiliation:
University of Kansas
Bernard Gonik
Affiliation:
Wayne State University, Detroit
Stephen Robson
Affiliation:
University of Newcastle
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Summary

Congenital anomalies are found in 3–8% of all fetuses and newborns. They include embryological defects but also destructive sequences that usually start with a vascular, infectious, or chemical insult that later results in various defects in different parts of the body, though the brain and spinal cord are particularly sensitive. Prenatal fetal abnormality screening programs developed to detect these anomalies normally comprise a combination of ultrasound examinations and biochemical investigations. Their use results in a suspected or actual diagnosis in 40–90% of screened women.

Type
Chapter
Information
High-Risk Pregnancy
Management Options
, pp. 148 - 188
Publisher: Cambridge University Press
First published in: 2017

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