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Set-maintenance and set-shifting problems in schizophrenic subtypes: relationship to dysfunctions of the fronto-striatal loops

Published online by Cambridge University Press:  18 September 2015

M.G. Lanser ,
B.A. Ellenbroek ,
A.R. Cools  and
F.G. Zitman
M.G. Lanser
Affiliation:
Afdeling Psychoneurofarmacologie, Katholieke Universiteit Nijmegen Afdeling Psychiatrie, St. Radboud Ziekenhuis, Nijmegen
B.A. Ellenbroek
Affiliation:
Afdeling Psychoneurofarmacologie, Katholieke Universiteit Nijmegen
A.R. Cools
Affiliation:
Afdeling Psychoneurofarmacologie, Katholieke Universiteit Nijmegen
F.G. Zitman
Affiliation:
Afdeling Psychiatrie, St. Radboud Ziekenhuis, Nijmegen
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Summary

Research with patients suffering from Parkinson's disease and frontal lobe lesions has shown that disturbances in the fronto-striatal loops in the brain can cause perseveration. Perseveration is a core symptom of schizophrenia, yet the cause is not known. For schizophrenic patients disorders of many parts of the fronto-striatal loops are found, for example disturbances of the prefrontal cortex and the striatum. Perseveration in schizophrenia can be explained with set-maintenance problems, related to dysfunction of the prefrontal cortex, or with set-shifting problems that are related to disorders in the striatum. These set-maintenance and set-shifting problems can be distinguished with neuropsychological tests. Regarding the bloodflow patterns for the different subtypes of schizophrenia three problems are expected as explanations for perseveration: set-maintenance problems concerning abstract information, set-maintenance problems shifting between stimuli and enhanced set-shifting with cues.

Keywords

schizophreniaperseverationsfronto-striatal loopsset-maintenanceset-shiftingcues
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 1 , March 2000 , pp. 32 - 38
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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