Hostname: page-component-848d4c4894-pftt2 Total loading time: 0 Render date: 2024-06-07T21:54:02.123Z Has data issue: false hasContentIssue false
  • English
  • Français

Antidepressive interventions: on state and vulnerability of the brain

Published online by Cambridge University Press:  18 September 2015

J. Korf
Get access Rights & Permissions [Opens in a new window]

Summary

An attempt is made to relate drug and non-drug antidepressive interventions to brain processes. In the present context two concepts are proposed: vulnerability towards depressogenic factors and depression as a state of the brain. Accordingly, it is assumed that the current antidepressants make the brain less vulnerable by inhibiting monoaminergic neurons and by reducing the number or efficacy of their postsynaptic receptors. In contrast, electroconvulsive therapie and sleep-deprivation affect primarily the state of the brain and can produce spectacular (but often short lasting) improvements. It is proposed that the combination of the two aspects may lead to fast and lasting antidepressive effects.

Keywords

Antidepressantsdepressionstate of the brainvulnerabilitydepressogenic factorselectroconvulsive therapysleep-deprivationAntidepressivaslaapdeprivatieelektro-convulsie therapiedepressietoestand van de hersenenvatbaarheid voor depressie
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 8 , Issue 1 , March 1996 , pp. 6 - 11
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Literatuur

1.Joffe, RT, Singer, W, Levitt, AJ, MacDonald, C. A placebo controlled comparison of lithium and triiodothyroxine augmentation of tricyclic antidepressants in unipolar refractory depression. Arch gen Psychiat 1993; 50: 387–93.CrossRefGoogle Scholar
2.Joffe, RT, Schuller, DR. An open study of buspirone augmentation of serotonin reuptake inhibitors in refractory depression. J clin Psychiat 1993; 54: 269–71.Google ScholarPubMed
3.Cappiello, AC, McDougle, CJ, Malison, RT, Heninger, GR, Price, LH. Yohimbine augmentation of fluvoxamine in refractory depression: a preliminary, single-blind study. Miami Beach: 148th Annual Meeting American Psychiatric Association, 05 20-25 1995: Abstract NR 95.Google Scholar
4.Mohammed, KI. Light therapy: an enhancer of antidepressants. Miami Beach: 148th Annual Meeting American Psychiatric Association, 05 20-25 1995: Abstract NR 105.Google Scholar
5.Holsboer-Trachsler, E, Hemmeter, U, Hatziner, M, Seifritz, E, Gerhard, U, Hobi, U. Sleepdeprivation and bright light as potential augmenters of antidepressant drug treatment – neurobiological and psychometric assessments of course. J Psychiat Res 1995; 28:381–99.CrossRefGoogle Scholar
6.Horowitz, MJ, Milbrath, C, Ewert, M, Sonneborn, D, Stinson, C. Cyclical patterns of States of mind in psychotherapy. Am J Psychiat 1994; 151: 1767–70.Google ScholarPubMed
7.Gordijn, MCM, Beersma, DGM, Bouhuys, AL, Korte, HJ, Van den Hoofdakker, RH. A longitudinal study of sleep deprivation response in depression; the variability is highly related to diurnal mood variability. Acta neuropsychiat 1995; 7: 58–60.CrossRefGoogle ScholarPubMed
8.Van den Hoofdakker, RH. Chronobiological theories of nonseasonal affective disorders and their implications for treatment. J biol Rhythms 1994; 9: 157–83.CrossRefGoogle ScholarPubMed
9.Hamilton, M. Mood disorders: clinical features. In: Kaplan, HI, Saddock, BJ, red. Comprehensive textbook of psychiatry. Baltimore: Williams and Wilkins, 1989:892–913.Google Scholar
10.Brown, GW, Harris, TO. Social origins of depression: a study of psychiatric disorder in women. London: Tavistock, 1978.Google Scholar
11.Kendler, KS, Kessler, RC, Neale, MC, Heath, AC, Eaves, LJ. The prediction of major depression in women: towards an integrated etiologie model. Am J Psychiat 1993; 150: 1139–48.Google Scholar
12.Kendler, KS, Kessler, RC, Walters, EE, MacLean, C, Neale, MC, Heath, AC, Eaves, LJ. Stressful life events, genetic liability, and onset of an episode of major depression in woman. Am J Psychiat 1995; 152: 833–42.Google Scholar
13.Van Willige, G, Ormel, J, Giel, R. Etiologische betekenis van ingrijpende gebeurtenissen en langdurige moeilijkheden voor het ontstaan van depressie en angststoornissen. Tijdsch Psychiat 1995; 37 (ter perse).Google Scholar
14.Davis, JM, Glassman, AH. Antidepressant drugs. In: Kaplan, HI, Saddock, BJ, red. Comprehensive textbook of psychiatry. Baltimore: Williams and Wilkins, 1989:1627–55.Google Scholar
15.Olpe, HR. Molecular view of the treatment of depression. In: Korf, J, Pepplinkhuizen, L, eds. Depression: molecular and psychologically based Therapies: an integrative View. Drachten: TGO Foundation, 1984: 21–45.Google Scholar
16.Korf, J, Sebens, JB, Postema, F. Cyclic AMP in the rat cerebral cortex after stimulation of the locus coeruleus: decrease by antidepressant drugs. Eur J Pharmacol 1979; 59: 23–30.CrossRefGoogle ScholarPubMed
17.Aghajanian, GK. Tricyclic antidepressants and single-cell responses to serotonin and noradrenaline: a review of chronic studies. In: Usdin, E, Bunney, WE, Davis, JM, eds. Neuroreceptor – basic and clinical Aspects. New York: Wiley, 1981: 217–23Google Scholar
18.Stone, EA, Piatt, JE, Herrera, AS, Kirk, KL. The effect of repeated restraint stress, desmethylimipramine or adrenocorticotropin on alpha and beta adrenergic components of the cyclic AMP response to noradrenaline in rat brain slices. J Pharmacol exp Therap 1986; 237: 702–7.Google ScholarPubMed
19.Kupfer, DJ, Frank, E, Perel, JMet al.Five year outcome for maintanance therapies in recurrent depression. Arch gen Psychiat 1992; 49: 769–73.CrossRefGoogle Scholar
20.Barden, N, Reul, JMH, Holsboer, F. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adre-nocortical system? Trends Neurosci 1995; 18: 6–11.CrossRefGoogle ScholarPubMed
21.Kelly, WF, Checkley, SA, Bender, DACushing's syndrome, tryptophan and depression. Br J Psychiat 1980; 142: 16–9.CrossRefGoogle Scholar
22.O'Dwyer, A.-M, Lightman, SL, Marks, MN, Checkley, SA. Treatment of major depression with metyrapone and hydrocortisone. J affect Disord 1995; 33: 123–8.CrossRefGoogle ScholarPubMed
23.Leibenluft, E, Wehr, T. Is sleep deprivation useful in the treatment of depression? Am J Psychiat 1992; 149: 159–69.Google ScholarPubMed
24.Gillin, JC, Ho, AP, Buchsbaum, MS, Wu, J, Abel, L, Bunney, WE Jr. Funtional brain imaging, sleep, and sleep deprivation: contributions to the overarousal hypothesis of depression. Acta neuropsy-chiat 1995; 7: 33–4.CrossRefGoogle Scholar
25.Van den Burg, W, Van den Hoofdakker, RH. Total sleep deprivation on endogenous depression. Arch gen Psychiat 1975; 32: 1121–5.CrossRefGoogle ScholarPubMed
26.Bouhuys, AL, Flentge, F, Van den Hoofdakker, RH. Effect of total sleep-deprivation on urinary Cortisol, self-rated arousel and mood in depressed patients. Psych Res 1990; 34: 149–62.CrossRefGoogle ScholarPubMed
27.Pavlides, C, Walanabe, Y, Mc Ewen, BS. Effects of glucocorticoids on hippocampal long-term potentiation. Hippocampus 1993; 3: 183–92.CrossRefGoogle ScholarPubMed
28.Krugers, HJ, Jaarsma, D, Korf, J. Rat hippocampal lactate efflux during electroconvulsive shock is differently dependent on entorhinal cortex and adrenal integrity. J Neurochem 1992; 58: 826–30.CrossRefGoogle ScholarPubMed
29.Altshuler, LL, Post, RM, Leverich, GS, Mikalauskas, K, Rosoff, A, Ackerman, L. Antidepressant-induced mania and cycle acceleration: a controversy revisited. Am J Psychiat 1995; 152: 1130–8.Google ScholarPubMed