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Brain energy metabolism is increased by chronic administration of bupropion

Published online by Cambridge University Press:  24 June 2014

Gabriela K. Ferreira ,
Gislaine T. Rezin ,
Mariane R. Cardoso ,
Cinara L. Gonçalves ,
Lislaine S. Borges ,
Júlia S. Vieira ,
Lara M. Gomes ,
Alexandra I. Zugno ,
João Quevedo  and
Emilio L. Streck
Gabriela K. Ferreira
Affiliation:
Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil
Gislaine T. Rezin
Affiliation:
Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil
Mariane R. Cardoso
Affiliation:
Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil
Cinara L. Gonçalves
Affiliation:
Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil
Lislaine S. Borges
Affiliation:
Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil
Júlia S. Vieira
Affiliation:
Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil
Lara M. Gomes
Affiliation:
Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil
Alexandra I. Zugno
Affiliation:
Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil Laboratório de Neurociências, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil
João Quevedo
Affiliation:
Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil Laboratório de Neurociências, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil
Emilio L. Streck*
Affiliation:
Laboratório de Bioenergética, Programa de Pós-graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil Instituto Nacional de Ciência e Tecnologia em Medicina Translacional, do Extremo Sul Catarinense, Criciúma, SC, Brazil
*
Prof. Emilio L. Streck, PharmD, PhD, Laboratório de Bioenergética, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil. Tel: +55 48 3431 2539; Fax: +55 48 3431 2750; E-mail: emiliostreck@gmail.com
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Extract

Objectives: Based on the hypothesis that energy impairment may be involved in the pathophysiology of depression, we evaluated the activities of citrate synthase, malate dehydrogenase, succinate dehydrogenase (SDH), mitochondrial respiratory chain complexes I, II, II-III, IV and creatine kinase (CK) in the brain of rats submitted to chronic administration of bupropion.

Methods: Animals received daily administration of bupropion dissolved in saline (10 mg/kg, intraperitoneal) at 1.0 ml/kg body weight. The rats received injections once a day for 14 days; control rats received an equivalent volume of saline. Twelve hours after the last administration, the rats were killed by decapitation and brain was rapidly removed and kept on an ice plate. The activities of the enzymes were measured in different brain areas.

Results: We observed that the activities of citrate synthase and malate dehydrogenase, mithocondrial respiratory chain complexes I, II-III and IV and CK were not altered after chronic administration of bupropion. However, SDH activity was increased in the prefrontal cortex and cerebellum. In the hippocampus, cerebellum and striatum the activity of complex II was increased after chronic administration of bupropion.

Conclusions: Our results demonstrated that bupropion increased some enzymes of brain energy metabolism. These findings are in accordance with other studies which showed that some antidepressants may improve energy metabolism. The present results reinforce the hypothesis that antidepressants modulate brain energy metabolism.

Keywords

brainbupropioncreatine kinaseKrebs cyclemitochondrial respiratory chain
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 2 , April 2012 , pp. 115 - 121
Copyright
Copyright © Cambridge University Press 2011

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