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Effects of combined treatment with clorgyline and selegiline on extracellular noradrenaline and serotonin levels

Published online by Cambridge University Press:  24 June 2014

Yuji Kitaichi ,
Takeshi Inoue ,
Shin Nakagawa ,
Shuken Boku  and
Tsukasa Koyama
Yuji Kitaichi*
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Takeshi Inoue
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Shin Nakagawa
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Shuken Boku
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Tsukasa Koyama
Affiliation:
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
*
Yuji Kitaichi, Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan. Tel: +81-11-706-5160; Fax: +81-11-706-5081; E-mail: muenchen-yuji@huhp.hokudai.ac.jp
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Extract

Kitaichi Y, Inoue T, Nakagawa S, Boku S, Koyama T. Effects of combined treatment with clorgyline and selegiline on extracellular noradrenaline and serotonin levels.

Objective Combined treatment with clorgyline, an irreversible monoamine oxidase (MAO)-A inhibitor, and selegiline, an irreversible MAO-B inhibitor, reportedly increases extracellular serotonin levels in the raphe nuclei more than clorgyline does alone. However, the effects of combination of these MAO inhibitors on extracellular noradrenaline have not been reported.

Methods Using in vivo microdialysis, we measured extracellular noradrenaline and serotonin levels after administration of clorgyline and/or selegiline in the medial prefrontal cortex of rats.

Results Administration of clorgyline (10 mg/kg) significantly increased both extracellular serotonin and noradrenaline levels. Combined treatment using clorgyline (10 mg/kg) and selegiline (3 mg/kg) increased extracellular serotonin and noradrenaline levels more than each drug alone did.

Conclusions These findings of this study suggest the augmented antidepressant action of the combination of MAO-A inhibition and MAO-B inhibition. The addition of a MAO-A inhibitor to selegiline or increasing dose of selegiline to achieve full MAO-A inhibition might be the promising strategy for the antidepressant treatment in partial responders or non-responders to selegiline.

Keywords

clorgylinein vivo microdialysisnoradrenalineselegilineserotonin
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 6 , December 2012 , pp. 369 - 373
Copyright
Copyright © Cambridge University Press 2012

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