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Genetic predisposition to tuberculosis (A study of 447 pairs of affected brothers)

Published online by Cambridge University Press:  01 August 2014

L. Gedda ,
S. Volta ,
R. Bresadola  and
G. Brenci
L. Gedda
Affiliation:
Istituto di Genetica Medica e Gemellologia, «Gregorio Mendel», Roma (Italia) Clinica Tisiologica dell'Universita, Roma (Italia), Centro Studi «C. Forlanini» dell' I.N.P.S.
S. Volta
Affiliation:
Istituto di Genetica Medica e Gemellologia, «Gregorio Mendel», Roma (Italia) Clinica Tisiologica dell'Universita, Roma (Italia), Centro Studi «C. Forlanini» dell' I.N.P.S.
R. Bresadola
Affiliation:
Istituto di Genetica Medica e Gemellologia, «Gregorio Mendel», Roma (Italia) Clinica Tisiologica dell'Universita, Roma (Italia), Centro Studi «C. Forlanini» dell' I.N.P.S.
G. Brenci
Affiliation:
Istituto di Genetica Medica e Gemellologia, «Gregorio Mendel», Roma (Italia) Clinica Tisiologica dell'Universita, Roma (Italia), Centro Studi «C. Forlanini» dell' I.N.P.S.

Summary

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The study of the clinical material concerning the patients hospitalized at the Rome Forlanini Sanatorium during 25 years has indicated 894 patients of postprimary pulmonary tuberculosis, constituting 447 pairs of single-born brothers (♂♂ or ♂♀ or ♀♀).

The above pairs have been studied from the standpoint of their concordance with respect to the following three clinical parameters: (i) age of onset of postprimary tuberculosis; (ii) clinical form of the reinfection; (iii) pulmonary localization of the tubercular process. Such parameters were studied in the case of the brothers living together, as well as in the opposite case.

On the basis of the statistical analysis of the results, the AA. conclude for the existence of a tubercular predisposition in terms of a hereditary trait significantly influencing the course of postprimary tuberculosis with respect to both onset and localization, and especially to the clinical form. The clinical parameters appear to be more concordant, though in a statistically nonsignificant way, when the two affected brothers lived together.

The family and individual variability of the predisposition to pulmonary tuberculosis appears to be demonstrated. According to the AA., such predisposition would be inherited through a multifactorial mechanism.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 15 , Issue 1 , January 1966 , pp. 1 - 33
Copyright
Copyright © The International Society for Twin Studies 1966

References

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