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Influence of Placentation on High Density Lipoproteins in Adult Males: The NHLBI Twin Study

Published online by Cambridge University Press:  01 August 2014

T. Reed ,
J.C. Christian ,
P.D. Wood  and
E.J. Schaefer
T. Reed*
Affiliation:
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA
J.C. Christian
Affiliation:
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA
P.D. Wood
Affiliation:
Stanford Center for Research in Disease Prevention, Stanford, California
E.J. Schaefer
Affiliation:
Lipid Metabolism Laboratory, U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
*
Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB 130, Indianapolis, IN 46202-5251, USA.

Abstract

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Dizygotic (DZ) World War II veteran twins who participated in the National Heart Lung and Blood Institute (NHLBI) Twin Study have been reported to have greater variance than monozygotic (MZ) twins for plasma high-density lipoprotein cholesterol (HDL-C), cholesterol in the low-density fraction of HDL (HDL2-C) and apolipoprotein A-I, a major protein component of HDL. It was hypothesized that a possible source of this difference in zygosity variance could be prenatal environmental influences related to placental type. Dermatoglyphics were used to provide a retrospective index of placental type in a subset of the NHLBI MZ twins aged 59-70. The MZ twins classified as dichorionic were found to have significantly greater within-pair variability than the monochorionic MZ twins for HDL-C, HDL2-C and Apo A-I. These findings indicate that intrauterine environmental influences on HDL are manifest later in life.

Keywords

CholesterolDermatoglyphicsHigh-density lipoproteinTwin placentation
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 40 , Issue 3-4 , October 1991 , pp. 353 - 359
Copyright
Copyright © The International Society for Twin Studies 1991

References

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