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Probabilities of Concordance of Twins With Respect to Genetic Markers. A General Formulation

Published online by Cambridge University Press:  01 August 2014

Seppo Sarna
Seppo Sarna*
Affiliation:
Department of Public Health Science, University of Helsinki
*
Department of Public Health Science, Haartmaninkatu 3, SF-00290 Helsinki 29, Finland

Abstract

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The formulas needed in the determination of monozygosity in twin pairs using genetic markers are derived and presented. A general formula for the calculation of concordance probabilities independent of gene frequencies and allele number is derived, enabling either manual computation or computer programming for any Mendelian markers usable in twin zygosity diagnosis.

Keywords

Twin zygosity diagnosisGenetic markersConcordance probabilitiesComputer programming
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 28 , Issue 2 , April 1979 , pp. 125 - 132
Copyright
Copyright © The International Society for Twin Studies 1979

References

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