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Bovine respiratory syncytial virus infection: immunopathogenic mechanisms

Published online by Cambridge University Press:  24 January 2008

Laurel J. Gershwin
Laurel J. Gershwin*
Affiliation:
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
*
*Corresponding author. E-mail: ljgershwin@ucdavis.edu
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Abstract

Bovine respiratory syncytial virus (BRSV) causes severe respiratory disease in young cattle. Much like the human respiratory syncytial virus, BRSV induces immunomodulation in the infected host, favoring a Th2 response. Several groups have demonstrated IgE responses to BRSV proteins during infection and particularly in response to vaccination with formalin-inactivated vaccine in the field and experimentally. Newer vaccine modalities that favor a shift to Th1 cytokine production have provided promising results. Infection with BRSV is a major contributor to the multi-pathogen disease, bovine respiratory disease complex. This review stresses the unique immunomodulatory aspects of BRSV infection, vaccination and its interaction with the host's immune system.

Keywords

bovine respiratory syncytial virusIgEvaccineimmunomodulation
Type
Review Article
Information
Animal Health Research Reviews , Volume 8 , Issue 2 , December 2007 , pp. 207 - 213
Copyright
Copyright © Cambridge University Press 2008

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