Hostname: page-component-848d4c4894-nr4z6 Total loading time: 0 Render date: 2024-05-16T02:26:17.240Z Has data issue: false hasContentIssue false
  • English
  • Français

Polyamines in sow colostrum and milk at different stages of lactation

Published online by Cambridge University Press:  09 March 2007

Z. B. Cheng ,
D. F. Li ,
C. R. Ge  and
J. J. Xing
Z. B. Cheng
Affiliation:
National Key Laboratory in Animal Nutrition, China Agricultural University, Beijing, 100094, People's Republic of China Department of Animal Science and Technology, Yunnan Agricultural University, Kunming City, Yunnan Province 650201, People's Republic of China
D. F. Li*
Affiliation:
National Key Laboratory in Animal Nutrition, China Agricultural University, Beijing, 100094, People's Republic of China
C. R. Ge
Affiliation:
Department of Animal Science and Technology, Yunnan Agricultural University, Kunming City, Yunnan Province 650201, People's Republic of China
J. J. Xing
Affiliation:
National Key Laboratory in Animal Nutrition, China Agricultural University, Beijing, 100094, People's Republic of China
*
†Email: defali@public2.bta.net.cn
Get access

Abstract

The objective of this study was to determine the effect of stage of lactation on the concentration of polyamines (spermine, spermidine, and putrescine) in sow colostrum and milk. Ten, third parity sows (Landrace×Yorkshire) were sampled throughout a 28-day lactation. Litter size for all sows was standardized at 10 sucking piglets immediately after farrowing. Colostrum collection began at the birth of the first piglet (0 h), and colostrum was subsequently collected 6, 12, 18, and 24 h after farrowing. Sow milk was sampled on days 3, 7, 10, 14, 17, 21, 24 and 28 of lactation. Spermine concentration in sow colostrum was relatively constant for the first 12 h after farrowing and then rapidly increased to 10·26 μmol/l 24 h after farrowing (linear and quadratic effect; P<0·01). In contrast, the concentrations of spermidine and putrescine showed little change during the first 24 h with spermidine concentration in colostrum ranging from 3·76 to 4·54 μmol/l, and putrescine concentration ranging from 1·15 to 1·52 μmol/l. The highest concentration of spermine in sow milk was 18·82 μmol/l, observed on day 7, with levels gradually declining to 4·28 μmol/l by day 28 of lactation (linear and quadratic effect; P<0·01). In contrast, the concentration of spermidine increased during lactation ranging from a low of 4·32 μmol/l on day 7 to a high of 9·01 μmol/l on day 28 of lactation (linear effect P<0·01; quadratic effect P=0·03). Putrescine concentration ranged from 1·53 μmol/l on day 3 to 1·84 μmol/l on day 28 (linear effect P=0·07; quadratic effect P>0·05). The results of this study show sow colostrum and milk provide polyamines for sucking piglets before weaning, which could potentially modulate intestinal maturation.

Keywords

milkputrescinesowsspermidinespermine
Type
Research Article
Information
Animal Science , Volume 82 , Issue 1 , February 2006 , pp. 95 - 99
Copyright
Copyright © British Society of Animal Science 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Association of Official Analytical Chemists. 2000. Official methods of analysis, 17th edition. Association of Official Analytical Chemists, Washington, DC.Google Scholar
Bardocz, S. 1995. Polyamines in food and their consequences for food quality and human health. Trends in Food Science and Technology 6: 341–346.CrossRefGoogle Scholar
Bowland, J. P., Grummer, R. H., Phillips, P. H. and Bohstedt, G. 1949. The effect of plane of nutrition on the composition of sows’ colostrum and milk. Journal of Animal Science 8: 199–206.CrossRefGoogle Scholar
Buts, J. P., Keyser, N., de Kolanowski, J., Sokal, E., Hoof, F. van. 1993. Maturation of villus and crypt cell functions in rat small intestine: role of dietary polyamines. Digestive Diseases and Science 38: 1091–1098.CrossRefGoogle ScholarPubMed
Cranwell, P. D. 1995. Development of the neonatal gut and enzyme systems. In The neonatal pig: development and survival (ed. Varley, M. A.), pp. 99–154, CAB International, Wallingford, UK.Google Scholar
Dufour, C., Dandrifosse, G., Forget, P., Vermesse, F., Romain, N. and Lepoint, P. 1988. Spermine and spermidine induce intestinal maturation in the rat. Gastroenterology 95: 112–116.CrossRefGoogle ScholarPubMed
Kalac, P., Krausová, P. 2005. A review of dietary polyamines: formation, implications for growth and health and occurrence in foods. Food Chemistry 90: 219–230.CrossRefGoogle Scholar
Kelly, D., King, T. P., Brown, D. S. and McFadyen, M. 1991. Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling. Reproduction, Nutrition, Development 31: 73–80.CrossRefGoogle ScholarPubMed
Klobasa, F., Werhahn, E. and Butler, J. E. 1987. Composition of sow milk during lactation. Journal of Animal Science 64: 1458–1466.CrossRefGoogle ScholarPubMed
Lopez-Pedrosa, J. M., Torres, M. I., Fernandez, M. I., Rios, A. and Gil, A. 1998. Severe malnutrition alters lipid composition and fatty acid profile of small intestine in newborn piglets. Journal of Nutrition 128: 224–233.CrossRefGoogle ScholarPubMed
Loret, S., Brolet, P., Pierzymowski, S., Gouders, I., Klimek, M., Danielson, V., Rosted, A., Lesniewska, V. and Dandrifosse, G. 2000. Pancreatic exocrine secretions as a source of luminal polyamines in pigs. Experimental Physiology 85: 301–308.CrossRefGoogle ScholarPubMed
Mateo, C. D., Peters, D. N. and Stein, H. H. 2004. Nucleotides in sow colostrum and milk at different stages of lactation. Journal of Animal Science 82: 1339–1342.CrossRefGoogle ScholarPubMed
Motyl, T., Poszaj, T., Wojtasik, A., Kukulska, W. and Podgurniak, M. 1995. Polyamines in cow's and sow's milk. Comparative Biochemistry and Physiology B 111: 427–433.CrossRefGoogle ScholarPubMed
National Research Council. 1998. Nutrient requirements of swine, 10th edition. National Academic Press, Washington, DC.Google Scholar
Osman, N. E., Westrom, B., Wang, Q., Persson, L. and Karlsson, B. 1998. Spermine affects intestinal in vitro permeability to different-sized molecules in rats. Comparative Biochemistry and Physiology C 120: 211–216.Google ScholarPubMed
Pegg, A. E. and McCann, P. P. 1982. Polyamine metabolism and function American Journal of Physiology 243: C212–C221CrossRefGoogle ScholarPubMed
Ploszaj, T., Ryniewicz, Z. and Motyl, T. 1997. Polyamines in goat's colostrum and milk. Comparative Biochemistry and Physiology B 118: 45–52.CrossRefGoogle ScholarPubMed
Pluske, J. R., Hampson, D. J. and Williams, I. H. 1997. Factors influencing the structure and function of the small intestine in the weaned pig: a review. Livestock Production Science 51: 215–236.CrossRefGoogle Scholar
Pollack, P. F., Koldousky, O. and Nishioka, F. 1992. Polyamines in human and rat milk and in infant formulas. American Journal of Clinical Nutrition 56: 371–375.CrossRefGoogle ScholarPubMed
Seiler, H. and Knodgen, B. 1980. High performance liquid chromatographic procedure for the simultaneous determination of the natural polyamines and their monoacetyl derivatives. Journal of Chromatography 221: 227–235.CrossRefGoogle ScholarPubMed
Statistical Analysis Systems Institute. 1989. SAS/STAT user's guide, version 6. SAS Institute Inc., Cary, NC.Google Scholar
Ter Steege, J. C., Buurman, W. A. and Forget, P. P. 1997. Spermine induces maturation of the immature intestinal immune system in neonatal mice. Journal of Pediatric Gastroenterology and Nutrition 25: 332–340.Google ScholarPubMed
United States Department of Human Health and Services. 1996. Guide for the care and use of laboratory animals. National Institute of Health, publication number ISBN 0-3-9-05377-3, Washington, DC.Google Scholar
Wang, J. Y., Johnson, L. R., Tsai, Y. H. and Castro, G. A. 1991. Mucosal ornithine decarboxylase, polyamines and hyperplasia in infected intestine American Journal of Physiology 260: G45–G51Google ScholarPubMed
Wu, G., Flynn, N. E. and Knabe, D. A. 2000a. Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets American Journal of Physiology, Endocrinology and Metabolism 279: E395–E402CrossRefGoogle ScholarPubMed
Wu, G., Flynn, N. E., Knabe, D. A. and Jaeger, L. A. 2000b. A cortisol surge mediates the enhanced polyamine synthesis in porcine enterocytes during weaning American Journal of Physiology and Regulatory Integrative Comparative Physiology 279: R554–R559CrossRefGoogle ScholarPubMed
Zhang, H., Malo, C. and Buddington, R. K. 1997b. Suckling induces rapid intestinal growth and changes in brush border functions of newborn pigs. Journal of Nutrition 127: 418–426.CrossRefGoogle ScholarPubMed