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Characterization of polymorphisms at the 11β-hydroxylase (CYP11B1) locus

Published online by Cambridge University Press:  01 March 1998

C. A. SKINNER ,
N. YOUSAF ,
J. W. HONOUR  and
G. RUMSBY
C. A. SKINNER
Affiliation:
Department of Molecular Pathology, UCL Medical School, Windeyer Building, Cleveland St, London W1P 6DB
N. YOUSAF
Affiliation:
Department of Molecular Pathology, UCL Medical School, Windeyer Building, Cleveland St, London W1P 6DB
J. W. HONOUR
Affiliation:
Department of Molecular Pathology, UCL Medical School, Windeyer Building, Cleveland St, London W1P 6DB
G. RUMSBY
Affiliation:
Department of Molecular Pathology, UCL Medical School, Windeyer Building, Cleveland St, London W1P 6DB
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Abstract

Four sequence variants in the 11β-hydroxylase (CYP11B1) gene are reported. One of the sequence changes occurs in exon 1 and is in linkage disequilibrium with a second variant in intron 3. The other two changes occur at adjacent nucleotides in intron 1. The finding of easily demonstrable, intragenic variants will be beneficial to the study of the role of the CYP11B1 and the adjacent aldosterone synthase (CYP11B2) gene in hypertensive disease.

Type
SHORT COMMUNICATION
Information
Annals of Human Genetics , Volume 62 , Issue 2 , March 1998 , pp. 181 - 183
Copyright
© University College London 1998

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