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Iodine and the brain

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

Iodine is required for thyroid hormone production, which is crucial to brain development. Iodine deficiency is widespread throughout the world, and mild deficiency is surprisingly common in developed countries.

There is some good evidence that even milder deficiencies are associated with cognitive deficit. Public health policy is important (e.g. iodine fortification of salt), but also clinicians should be aware of individual iodine status, especially in pregnant women and children.

Type
Brief Report
Information
Arbor Clinical Nutrition Updates , Volume 325 , November 2010 , pp. 1 - 4
Copyright
Copyright © Cambridge University Press 2010

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References

References:

1. Melse-Boonstra, A. et al. Iodine deficiency in pr egnancy, infancy and childhood and its consequences for brain development. Best Pract Res Clin Endocrinol Metab. 2010 Feb;24(1):29–38.CrossRefGoogle Scholar
2. DeLange, F. et al. The iodine deficiency disorders. Ch.20 Supportingdocumentation for medical course, University of Fiji, 2001, on web at: http://application.fnu.ac.fj/classshare/Medical_Science_Resources/MBBS/MBBS1-3/PBL/Endocrine/Thyroid/Chapter%2020-Iodine%20Deficiency%20Disorders.pdf Google Scholar
3. Gallego, G. et al. Iodine deficiency in Australia: is iodine supplementation for pregnant and lactating women warranted? Med J Aust. 2010 Apr 19;192(8):461–3.CrossRefGoogle ScholarPubMed
4. Lazarus, J. Iodine and brain function. Ch 15 In: Kanarek, RB, Lieberman, H, Prasad, C. (eds). Nutritional Neuroscience. CRC Press, Boca Raton, FL, 2005.Google Scholar
5. Bernal, J. Thyroid hormones and brain development. Vitam Horm. 2005;71:95–122.CrossRefGoogle ScholarPubMed
6. Bleichrodt, N. et al. Measuring intelligence and learning potential in iodine-deficient and non-iodine deficient populations. In: Stanbury, JB, ed. The damaged brain of iodine deficiency. New York: Cognizant Communication, 1994:37–42.Google Scholar
7. Qian, M. et al. The effects of iodine on intelligence in children: a meta-analysis of studies conducted in China. Asia Pac J Clin Nutr. 2005;14(1):32–42.Google ScholarPubMed
8. Kooistra, L. et al. Neonatal effects of maternal hypothyroxinemia during early pregnancy. Pediatrics. 2006 Jan;117(1):161–7.CrossRefGoogle ScholarPubMed
9. Zimmermann, MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr. 2009 Feb;89(2):668S–72S.CrossRefGoogle ScholarPubMed
10. Choudhury, N. et al. Subclinical prenatal iodine deficiency negatively affects infant development in Northern China. J Nutr. 2003 Oct;133(10):3162–5.CrossRefGoogle ScholarPubMed
11. Haddow, JE. et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999 Aug 19;341(8):549–55.CrossRefGoogle ScholarPubMed
12. Pop, VJ. et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol (Oxf). 1999 Feb;50(2):149–55.CrossRefGoogle ScholarPubMed
13. Zimmermann, MB. Symposium on ‘Geographical and geological influences on nutrition’: Iodine deficiency in industrialised countries. Proc Nutr Soc. 2010 Feb;69(1):133–43.CrossRefGoogle ScholarPubMed
14. Cunnane, SC. Origins and evolution of the Western diet: implications of iodine and seafood intakes for the human brain. Am J Clin Nutr. 2005 Aug;82(2):483.CrossRefGoogle ScholarPubMed
15. Hetzel, BS. Iodine and neuropsychological development. J Nutr. 2000 Feb;130(2S Suppl):493S–495S.CrossRefGoogle ScholarPubMed
16. Li, M. et al. Re-emergence of iodine deficiency in Australia. Asia Pac J Clin Nutr. 2001;10(3):200–3.CrossRefGoogle ScholarPubMed
17. Pearce, EN. What do we know about iodine supplementation in pregnancy? J Clin Endocrinol Metab. 2009 Sep;94(9):3188–90.CrossRefGoogle ScholarPubMed
18. Li, M. et al. Are Australian children iodine deficient? Results of the Australian National Iodine Nutrition Study. Med J Aust. 2006 Feb 20;184(4):165–9.Google ScholarPubMed
19. Connolly, KJ. et al. Foetal iodine deficiency and motor performance during childhood. Lancet. 1979 Dec 1;2(8153):1149–51.CrossRefGoogle ScholarPubMed
20. Pharoah, PO. et al. Effects of maternal iodine supplementation during pregnancy. Arch Dis Child. 1991 Jan;66(1):145–7.CrossRefGoogle ScholarPubMed
21. Hess, SY. et al. Treatment of iron deficiency in goitrous children improves the efficacy of iodized salt in Côte d'Ivoire. Am J Clin Nutr. 2002 Apr;75(4):743–8.CrossRefGoogle ScholarPubMed
22. van Stuijvenberg, ME. et al. Effect of iron-, iodine-, and beta-carotene-fortified biscuits on the micronutrient status of primary school children: a randomized controlled trial. Am J Clin Nutr. 1999 Mar;69(3):497–503.CrossRefGoogle ScholarPubMed
23. Huda, SN. et al. Cognitive and motor functions of iodine-deficient but euthyroid children in Bangladesh do not benefit from iodized poppy seed oil (Lipiodol). J Nutr. 2001 Jan;131(1):72–7.CrossRefGoogle Scholar
24. Zimmermann, MB. et al. Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. Am J Clin Nutr. 2006 Jan;83(1):108–14.CrossRefGoogle ScholarPubMed
25. Manger, MS. et al. A micronutrient-fortified seasoning powder reduces morbidity and improves short-term cognitive function, but has no effect on anthropometric measures in primary school children in northeast Thailand: a randomized controlled trial. Am J Clin Nutr. 2008 Jun;87(6):1715–22.CrossRefGoogle ScholarPubMed
26. Bautista, A. et al. The effects of oral iodized oil on intelligence, thyroid status, and somatic growth in school-age children from an area of endemic goiter. Am J Clin Nutr. 1982 Jan;35(1):127–34.CrossRefGoogle ScholarPubMed
27. Wang, YY. et al. Improvement in hearing among otherwise normal schoolchildren in iodine-deficient areas of Guizhou, China, following use of iodized salt. Lancet. 1985 Sep 7;2(8454):518–20.Google ScholarPubMed
28. Shrestha, RM. The effect of iodine and iron supplementation on physical, psychomotor and mental development in primary school children in Malawi. PhD thesis. Division of Human Nutrition, Wageningen University: the Netherlands; 1994.Google Scholar
29. Isa, ZM. et al. Effect of iodized oil supplementation on thyroid hormone levels and mental performance among Orang asli schoolchildren and pregnant mothers in an endemic goitre area of peninsular Malaysia. Asia Pac J Clin Nutr. 2000; 9(4): 274–281.CrossRefGoogle Scholar
30. van den Briel, T. et al. Improved iodine status is associated with improved mental performance of schoolchildren in Benin. Am J Clin Nutr. 2000 Nov;72(5):1179–85.CrossRefGoogle ScholarPubMed
31. Pharoah, PO. et al. A controlled trial of iodinated oil for the prevention of endemic cretinism: a long-term follow-up. Int J Epidemiol. 1987 Mar;16(1):68–73.CrossRefGoogle ScholarPubMed
32. Zimmermann, MB. Iodine deficiency. Endocr Rev. 2009 Jun;30(4):376–408.CrossRefGoogle ScholarPubMed
33. Berbel, P. et al. Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation. Thyroid. 2009 May;19(5):511–9.CrossRefGoogle ScholarPubMed