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Lactoferrin

Published online by Cambridge University Press:  11 September 2013

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In a nutshell

Lactoferrin is found in milk - human and animal. It has therapeutic potential as an iron supplement, against infection, inflammation and cancer.

The evidence is so far mainly laboratory and animal data, with a small number of human trials beginning to be published, to this point with mixed results. An example is its use as treatment for Helicobacter pylori infection.

Type
Brief Report
Information
Arbor Clinical Nutrition Updates , Volume 263 , October 2006 , pp. 1 - 3
Copyright
Copyright © Cambridge University Press 2006

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References

1. Ling, JM. et al. Perspectives on interactions between lactoferrin and bacteria. Biochem Cell Biol. 2006 Jun;84(3):275–81.Google Scholar
2. Marshall, K. Therapeutic applications of whey protein. Altern Med Rev. 2004 Jun;9(2):136–56.Google Scholar
3. Andersen, JH. Technology evaluation: rh lactoferrin, Agennix. Curr Opin Mol Ther. 2004 Jun;6(3):344–9.Google Scholar
4. Ward, PP. et al. Multifunctional roles of lactoferrin: a critical overview. Cell Mol Life Sci. 2005 Nov;62(22):2540–8.Google Scholar
5. Clare, DA. et al. Biodefense properties of milk: the role of antimicrobial proteins and peptides. Curr Pharm Des. 2003;9(16):1239–55.Google Scholar
6. D'Inca, R. et al. Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease. Int J Colorectal Dis. 2006 Jul 13; [Epub ahead of print]Google Scholar
7. Yakuwa, K. et al. Recombinant human lactoferrin has a potential to suppresses uterine cervical ripening in preterm delivery in animal model. Arch Gynecol Obstet. 2006 Oct 10; [Epub ahead of print]Google Scholar
8. Bethell, DR. et al. Recombinant human lactoferrin treatment for global health issues: iron deficiency and acute diarrhea. Biometals. 2004 Jun;17(3):337–42.Google Scholar
9. Lonnerdal, B. et al. Absorption of iron from recombinant human lactoferrin in young US women. Am J Clin Nutr. 2006 Feb;83(2):305–9.Google Scholar
10. Hernell, O. et al. Iron status of infants fed low-iron formula: no effect of added bovine lactoferrin or nucleotides. Am J Clin Nutr. 2002 Oct;76(4):858–64.Google Scholar
11. Yamauchi, K. et al. Bovine lactoferrin: benefits and mechanism of action against infections. Biochem Cell Biol. 2006 Jun;84(3):291–6.Google Scholar
12. Berkhout, B. et al. The antiviral activity of the milk protein lactoferrin against the human immunodeficiency virus type 1. Biometals. 2004 Jun;17(3):291–4.Google Scholar
13. Kim, WS. et al. Growth-promoting effects of lactoferrin on L. acidophilus and Bifidobacterium spp. Biometals. 2004 Jun;17(3):279–83.CrossRefGoogle Scholar
14. Conneely, OM. Antiinflammatory activities of lactoferrin. J Am Coll Nutr. 2001 Oct;20(5 Suppl):389S–395S.Google Scholar
15. Okuda, M. et al. Bovine lactoferrin is effective to suppress Helicobacter pylori colonization in the human stomach: a randomized, double-blind, placebo-controlled study. J Infect Chemother. 2005 Dec;11(6):265–9.Google Scholar
16. Zullo, A. et al. Quadruple therapy with lactoferrin for Helicobacter pylori eradication: a randomised, multicentre study. Dig Liver Dis. 2005 Jul;37(7):496–500.Google Scholar
17. Okada, S. et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C. Jpn J Cancer Res. 2002 Sep;93(9):1063–9.Google Scholar
18. Tanaka, K. et al. Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: a pilot study. Jpn J Cancer Res. 1999 Apr;90(4):367–71.Google Scholar
19. Yamauchi, K. et al. Oral administration of bovine lactoferrin for treatment of tinea pedis. A placebo-controlled, double-blind study. Mycoses. 2000;43(5):197–202.Google Scholar
20. Trumpler, U. et al. Antibacterial prophylaxis with lactoferrin in neutropenic patients. Eur J Clin Microbiol Infect Dis. 1989 Apr;8(4):310–3.Google Scholar
21. Cornish, J. et al. Lactoferrin and bone; structure-activity relationships. Biochem Cell Biol. 2006 Jun;84(3):297–302.Google Scholar
22. Lindmark-Mansson, H. et al. Antioxidative factors in milk. Br J Nutr. 2000 Nov;84 Suppl 1:S103–10.Google Scholar
23. Tsuda, H. et al. Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies. Biochem Cell Biol. 2002;80(1):131–6.Google Scholar
24. Hayes, TG. et al. Phase I trial of oral talactoferrin alfa in refractory solid tumors. Invest New Drugs. 2006 May;24(3):233–40.Google Scholar