Hostname: page-component-848d4c4894-p2v8j Total loading time: 0.001 Render date: 2024-05-17T19:25:35.725Z Has data issue: false hasContentIssue false
  • English
  • Français

Selenium and diabetes

Published online by Cambridge University Press:  11 September 2013

Get access

In a nutshell

Selenium is involved in diabetes through its anti-oxidant and insulin-like functions. Diabetes depletes selenium status.

However, there is little evidence that giving selenium supplements prevents diabetes, and some evidence that it may increase the risk. RCTs on use of selenium to treat diabetics are lacking. However, any established deficiency should be corrected.

Type
Brief Report
Information
Arbor Clinical Nutrition Updates , Volume 304 , March 2009 , pp. 1 - 3
Copyright
Copyright © Cambridge University Press 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Köhrle, J. et al. Selenium, the thyroid, and the endocrine system. Endocr Rev. 2005 Dec;26(7):944–84.CrossRefGoogle ScholarPubMed
2. Beckett, GJ. et al. Selenium and endocrine systems. J Endocrinol. 2005 Mar;184(3):455–65.Google Scholar
3. Wu, J. et al. Plasma selenium content, platelet glutathione peroxidase and superoxide dismutase activity of residents in Kashin-Beck disease affected area in China. J Trace Elem Electrolytes Health Dis. 1987 Sep;1(1):39–43.Google ScholarPubMed
4. Ezaki, O. The insulin-like effects of selenate in rat adipocytes. J Biol Chem. 1990 Jan 15;265(2):1124–8.Google Scholar
5. Mechanick, JI. et al. Nutritional Strategies for the Diabetic & Prediabetic Patient. CRC Press, 2006, ISBN 0824725875, 9780824725877.Google Scholar
6. Helman, A. Zinc and diabetes. Arb Clin Nutr Upd. 2009 Mar;303:1–3.Google Scholar
7. Mueller, AS. et al. Compendium of the antidiabetic effects of supranutritional selenate doses. In vivo and in vitro investigations with type II diabetic db/db mice. J Nutr Biochem. 2006 Aug;17(8):548–60.Google Scholar
8. Kowluru, RA. et al. Diabetes-induced metabolic abnormalities in myocardium: effect of antioxidant therapy. Free Radic Res. 2000 Jan;32(1):67–74.Google Scholar
9. Becker, DJ. et al. Oral selenate improves glucose homeostasis and partly reverses abnormal expression of liver glycolytic and gluconeogenic enzymes in diabetic rats. Diabetologia. 1996 Jan;39(1):3–11.Google Scholar
10. Rajpathak, S. et al. Toenail selenium and cardiovascular disease in men with diabetes. J Am Coll Nutr. 2005 Aug;24(4):250–6.Google Scholar
11. Quilliot, D. et al. Diabetes mellitus worsens antioxidant status in patients with chronic pancreatitis. Am J Clin Nutr. 2005 May;81(5):1117–25.Google Scholar
12. Bo, S. et al. Gestational hyperglycemia, zinc, selenium, and antioxidant vitamins. Nutrition. 2005 Feb;21(2):186–91.Google Scholar
13. Hawkes, WC. et al. Plasma selenium decrease during pregnancy is associated with glucose intolerance. Biol Trace Elem Res. 2004 Jul;100(1):19–29.CrossRefGoogle ScholarPubMed
14. Al-Saleh, E. et al. Maternal-fetal status of copper, iron, molybdenum, selenium and zinc in patients with gestational diabetes. J Matern Fetal Neonatal Med. 2004 Jul;16(1):15–21.Google Scholar
15. Tan, M. et al. Changes of serum selenium in pregnant women with gestational diabetes mellitus. Biol Trace Elem Res. 2001 Dec;83(3):231–7.Google Scholar
16. Kljai, K. et al. Selenium and glycogen levels in diabetic patients. Biol Trace Elem Res. 2001 Dec;83(3):223–9.Google Scholar
17. Ekmekcioglu, C. et al. Concentrations of seven trace elements in different hematological matrices in patients with type 2 diabetes as compared to healthy controls. Biol Trace Elem Res. 2001 Mar;79(3):205–19.Google Scholar
18. Kruse-Jarres, JD. et al. Trace elements in diabetes mellitus. Peculiarities and clinical validity of determinations in blood cells. J Trace Elem Med Biol. 2000 Apr;14(1):21–7.Google Scholar
19. Osterode, W. et al. Nutritional antioxidants, red cell membrane fluidity and blood viscosity in type 1 (insulin dependent) diabetes mellitus. Diabet Med. 1996 Dec;13(12):1044–50.Google Scholar
20. Schlienger, JL. et al. [Disorders of plasma trace elements in diabetes. Relation to blood glucose equilibrium] Presse Med. 1988 May 28;17(21):1076–9.Google Scholar
21. Ruíz, C. et al. Selenium, zinc and copper in plasma of patients with type 1 diabetes mellitus in different metabolic control states. J Trace Elem Med Biol. 1998 Jul;12(2):91–5.Google Scholar
22. Whiting, PH. et al. The relationship between chronic glycaemic control and oxidative stress in type 2 diabetes mellitus. Br J Biomed Sci. 2008;65(2):71–4.CrossRefGoogle ScholarPubMed
23. Cser, A. et al. Selenium status and lipoproteins in healthy and diabetic children. J Trace Elem Electrolytes Health Dis. 1993 Dec;7(4):205–10.Google Scholar
24. Gebre-Medhin, M. et al. Dietary intake, trace elements and serum protein status in young diabetics. Acta Paediatr Scand Suppl. 1985;320:38–43.CrossRefGoogle ScholarPubMed
25. Gebre-Medhin, M. et al. Elevated serum selenium in diabetic children. Acta Paediatr Scand. 1984 Jan;73(1):109–14.Google Scholar
26. Nève, J. Human selenium supplementation as assessed by changes in blood selenium concentration and glutathione peroxidase activity. J Trace Elem Med Biol. 1995 Jul;9(2):65–73.Google Scholar
27. Neve, J. New indices for the assment of trace element status and requirement. Ch. In Trace elements in man and animals 10. Roussel, A, Anderson, RA, Favier, A. (eds.) Springer, 2000, ISBN 0306463784, 9780306463785Google Scholar
28. Burke, RF. et al. Selenium. Ch. In Modern nutrition in health and disease, 10th ed. Shils, M. et al (eds). Lippincott Williams & Wilkins, 2005, ISBN 0781741335, 9780781741330Google Scholar
29. Skripchenko, ND. et al. [Effect of selenium enriched diet on lipid peroxidation in patients with diabetes mellitus type 2] Vopr Pitan. 2003;72(1):14–7.Google Scholar
30. Faure, P. et al. Selenium supplementation decreases nuclear factor-kappa B activity in peripheral blood mononuclear cells from type 2 diabetic patients. Eur J Clin Invest. 2004 Jul;34(7):475–81.Google Scholar
31. Ravn-Haren, G. et al. A short-term intervention trial with selenate, selenium-enriched yeast and selenium-enriched milk: effects on oxidative defence regulation. Br J Nutr. 2008 Apr;99(4):883–92.Google Scholar
32. Elango, N. et al. Enzymatic and non-enzymatic antioxidant status in stage (III) human oral squamous cell carcinoma and treated with radical radio therapy: influence of selenium supplementation. Clin Chim Acta. 2006 Nov;373(1–2):92–8.Google Scholar
33. Czernichow, S. et al. Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations. Am J Clin Nutr. 2006 Aug;84(2):395–9.Google Scholar
34. Kähler, W. et al. [Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation] Z Gesamte Inn Med. 1993 May;48(5):223–32.Google ScholarPubMed
35. Lippman, SM. et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2009 Jan 7;301(1):39–51.Google Scholar
36. Combs, GF Jr. Selenium in global food systems. Br J Nutr. 2001 May;85(5):517–47.Google Scholar
37. Oldfield, JE. The two faces of selenium. J Nutr. 1987 Dec;117(12):2002–8.Google Scholar