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Pappworth's Guinea Pigs

Published online by Cambridge University Press:  01 June 2008

Carl Elliott
Carl Elliott
Affiliation:
Center for Bioethics, University of Minnesota, N504 Boynton, 410 Church St SE, Minneapolis MN 55455-0346USA E-mail: ellio0232@umn.edu
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Abstract

M.H. Pappworth's 1967 book, Human guinea pigs, was a major catalyst for change in the ethics and regulation of human research in the 1970s. Many of Pappworth's ethical concerns about the threats posed to human subjects are still valid today, yet the source of those threats has shifted from universities to industry sponsors.

Keywords

Healthy VolunteersHistory of MedicineHuman Subjects ResearchMedical EthicsPhase I Clinical TrialsResearch Ethics
Type
Articles
Information
BioSocieties , Volume 3 , Issue 2 , June 2008 , pp. 147 - 149
Copyright
Copyright © London School of Economics and Political Science 2008

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References

Abadie, R. (in press). A guinea pig's wage: Risk, body commodification, and the ethics of pharmaceutical research in America. Durham, NC: Duke UP.Google Scholar
Beecher, H.K. (1966). Ethics and clinical research. New England Journal of Medicine, 274, 1354–60.CrossRefGoogle ScholarPubMed
Bodenheimer, T. (2000). Uneasy alliance: clinical investigators and the pharmaceutical industry. New England Journal of Medicine, 342,1539–1544.CrossRefGoogle ScholarPubMed
Booth, C. (1994). Obituaries (Maurice Henry Pappworth). British Medical Journal, 309, 1577–1578.Google Scholar
Elliott, C. (2008). Guinea-pigging. New Yorker, 7 January, 36–41.Google ScholarPubMed
Evans, D., Smith, M., & Willen, L. (2005). Big pharma's shameful secret. Bloomberg Markets, 14, 36–62.Google Scholar
Helms, B. (Ed.) (2002). Guinea pig zero: An anthology of the journal of human research subjects. New Orleans: Garrett County Press.Google Scholar
Ingelfinger, F.J. (1975). The unethical in medical ethics. Annals of Internal Medicine, 83, 254–269.Google Scholar
Lemmens, T., & Freedman, B. (2000). Ethics review for sale? Conflict of interest and commercial research ethics review boards. Milbank Quarterly, 78, 547–584.Google Scholar
Pappworth, M.H. (1967). Human guinea pigs: Experimentation on man. Boston, MA: Beacon Press.Google Scholar
Steinbrook, R (2005). Gag clauses in clinical trial agreements. New England Journal of Medicine, 352, 2160.Google Scholar
Steinbrook, R. (2006). Compensation for injured research subjects. New England Journal of Medicine, 354, 1871–1873.CrossRefGoogle ScholarPubMed