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Abnormal Integrity of White Matter Tracts in Acute Lacunar Stroke Patients

Published online by Cambridge University Press:  05 September 2018

Yifei Zhu ,
Yana He ,
Karen M. von Deneen Open the ORCID record for Karen M. von Deneen [Opens in a new window]  and
Ming Zhang
Yifei Zhu
Affiliation:
Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi-Province, P. R. China Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, P. R. China
Yana He
Affiliation:
Department of Medical Imaging, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, P. R. China
Karen M. von Deneen*
Affiliation:
Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an 710126, P. R. China
Ming Zhang*
Affiliation:
Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi-Province, P. R. China
*
Address for correspondence: Ming Zhang and Karen M. von Deneen, Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Xi'an 710061, Shaanxi-Province, P. R. China and Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an 710126, P. R. China E-mail: zhangming01@mail.xjtu.edu.cn and vondenk@ufl.edu.
Address for correspondence: Ming Zhang and Karen M. von Deneen, Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Xi'an 710061, Shaanxi-Province, P. R. China and Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an 710126, P. R. China E-mail: zhangming01@mail.xjtu.edu.cn and vondenk@ufl.edu.
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Abstract

Background/Study Concept: Acute lacunar stroke (Als) plays a role in death/disability worldwide. Aphasia refers to chronic difficulty with communication in >20% of patients post stroke. We describe pathophysiological features of white matter (WM) abnormalities and their relationship between WM changes and aphasia quotient (AQ) scores in Als.

Methods: Diffusion tensor imaging data were acquired in 37 Als patients and 28 healthy controls. Tract-based spatial statistics (TBSS) and correlation analyses were used.

Results: Consistent with the hypothesis, Als had decreased fractional anisotropy (FA) and increased mean diffusivity, axial diffusivity and radial diffusivity in the genu, body and splenium of the corpus callosum (CC), superior longitudinal fasciculus (SLF) and corona radiata in the bilateral hemisphere. Reduced FA of SLF was correlated with AQ scores in Als patients.

Conclusion: It is hoped that TBSS could shed new insights into aphasia mechanisms in Als to help promote aging-related disease studies.

Keywords

Acute lacunar strokediffusion tensor imagingtract-based spatial statisticsaphasiasuperior longitudinal fasciculus
Type
Articles
Information
Brain Impairment , Volume 20 , Issue 1 , March 2019 , pp. 49 - 57
Copyright
Copyright © Australasian Society for the Study of Brain Impairment 2018 

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