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A Review of Lifetime Risk Factors for Mortality

  • D. Kuh (a1), R. Hardy (a2), M. Hotopf (a3), D. A. Lawlor (a4), B. Maughan (a5), R. Westendorp (a6), R. Cooper (a7), S. Black (a8) and G. D. Mishra (a9)...

This review was undertaken for the Faculty and Institute of Actuaries as part of their programme to encourage research collaborations between health researchers and actuaries in order to understand better the factors influencing mortality and longevity. The authors presented their findings in a number of linked sessions at the Edinburgh conference (Joining Forces on Mortality and Longevity) in October 2009 and contributed to this overview. The purpose is to review evidence for the impact on adult mortality of characteristics of the individual's lifetime socioeconomic or psychosocial environment or phenotype at the behavioural; multi-system (e.g. cognitive and physical function); or body system level (e.g. vascular and metabolic traits) that may be common risk factors for a number of major causes of death. This review shows there is growing evidence from large studies and systematic reviews that these individual characteristics, measured in pre-adult as well as the adult life, are associated with later mortality risk. The relative contribution of lifetime environment, genetic factors and chance, whether these contributions change with age, and the underlying social and biological pathways are still to be clarified. This review identifies areas where further life course research is warranted.

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Allender S., Balakrishnan R., Scarborough P., Webster P. & Rayner M. (2009). The burden of smoking-related ill health in the UK. Tobacco Control, 18, 262267.
Allender S., Scarborough P., O'Flaherty M. & Capewell S. (2008). Patterns of coronary heart disease mortality over the 20th century in England and Wales: Possible plateaus in the rate of decline. BMC.Public Health, 8, 148.
Austad SN F.C. (2008). The evolutionary context of human aging and degenerative disease. In Stearns SC K.J. (ed.). Evolution in Health and Disease, Oxford University Press, 301311.
Baker J.L., Olsen L.W. & Sorensen T.I.A. (2007). Childhood body-mass index and the risk of coronary heart disease in adulthood. New England Journal of Medicine, 357, 23292337.
Baker J.L., Olsen L.W. & Sorensen T.I.A. (2008). Weight at birth and all-cause mortality in adulthood. Epidemiology, 19, 197203.
Barker D.J.P. (1998). Mothers, babies and health in later life., 2nd edn, Churchill Livingstone, Edinburgh.
Barth J., Schumacher M. & Herrmann-Lingen C. (2004). Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosomatic Medicine, 66, 802813.
Bartke A. (2008). Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings. Aging Cell, 7, 285290.
Batty G.D., Deary I.J. & Gottfredson L.S. (2007). Premorbid (early life) IQ and later mortality risk: systematic review. Annals of Epidemiology, 17, 278288.
Batty G.D., Der G., MacIntyre S. & Deary I.J. (2006). Does IQ explain socioeconomic inequalities in health? Evidence from a population based cohort study in the west of Scotland. British Medical Journal, 332, 580584.
Batty G.D., Shipley M.J., Gunnell D., Huxley R., Kivimaki M., Woodward M., Lee C.M.Y. & Davey Smith G. (2009). Height, wealth, and health: An overview with new data from three longitudinal studies. Economics and Human Biology, 7, 137152.
Ben-Shlomo Y. & Kuh D. (2002). A life course approach to chronic disease epidemiology: conceptual models, empirical challenges, and interdisciplinary perspectives. International Journal of Epidemiology, 31, 285293.
Besson H., Ekelund U., Brage S., Luben R., Bingham S., Khaw K.T. & Wareham N.J. (2008). Relationship between subdomains of total physical activity and mortality. Medicine & Science in Sports & Exercise, 40, 19091915.
Bjorge T., Engeland A., Tverdal A. & Davey Smith G. (2008). Body mass index in adolescence in relation to cause-specific mortality: a follow-up of 230,000 Norwegian adolescents. American Journal of Epidemiology, 168, 3037.
Bonafe M. & Olivieri F. (2009). Genetic polymorphism in long-lived people: cues for the presence of an insulin/IGF-pathway-dependent network affecting human longevity. Molecular and Cellular Endocrinology, 299, 118123.
Burnham J.C. (1989). American physicians and tobacco use: two surgeon generals, 1929 and 1964. Bulletin of the History of Medicine, 63, 131.
Burt V.L., Cutler J.A., Higgins M., Horan M.J., Labarthe D., Whelton P., Brown C. & Roccella E.J. (1995). Trends in the prevalence, awareness, treatment, and control of hypertension in the adult U.S. population. Data from the health examination surveys, 1960 to 1991. Hypertension, 26, 6069.
Capewell S. & O'Flaherty M. (2008). What explains declining coronary mortality? Lessons and warnings. Heart, 94, 11051108.
Carney R.M., Freedland K.E., Miller G.E. & Jaffe A.S. (2002). Depression as a risk factor for cardiac mortality and morbidity: a review of potential mechanisms. Journal of Psychosomatic Research, 53, 897902.
Carvalho J.J., Baruzzi R.G., Howard P.F., Poulter N., Alpers M.P., Franco L.J., Marcopito L.F., Spooner V.J., Dyer A.R. & Elliott P. (1989). Blood pressure in four remote populations in the INTERSALT Study. Hypertension, 14, 238246.
Castelli W.P. (1987). The Framingham Heart Study–the future. Medical Section Proceedings, 127138.
Chandola T., Deary I.J., Blane D. & Batty G.D. (2006). Childhood IQ in relation to obesity and weight gain in adult life: the National Child Development 1958 Study. International Journal of Obesity, 30, 14221432.
Chen X. & Wang Y. (2008). Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation, 117, 31713180.
Clennell S., Kuh D., Guralnik J.M., Patel K.V. & Mishra G.D. (2008). Characterisation of smoking behaviour across the life course and its impact on decline in lung function and all-cause mortality: evidence from a British birth cohort. Journal of Epidemiology and Community Health, 62, 10511056.
Collishaw S., Maughan B., Goodman R. & Pickles A. (2004). Time trends in adolescent mental health. The Journal of Child Psychology and Psychiatry, 45, 13501362.
Cooper R., Kuh D., Hardy R. & The Mortality Review Group on behalf of the FALCon and HALCyon study teams (2010). Objective measures of physical capability and subsequent mortality: a systematic review and meta-analysis. British Medical Journal, 341, C4467.
Cooper R., Kuh D., Cooper C., Gale C.R., Lawlor D.A., Matthews F., Hardy R. & The FALCon and HALCyon study teams. (In press). Objective measures of physical capability and subsequent health: a systematic review' Age and Ageing.
Crozier S.R., Robinson S.M., Borland S.E. & Inskip H.M. (2006). Dietary patterns in the Southampton Women's Survey. European Journal of Clinical Nutrition, 60, 13911399.
Cuijpers P. & Smit F. (2002). Excess mortality in depression: a meta-analysis of community studies. Journal of Affective Disorders, 72, 227236.
Damon A., Damon S.T., Harpending H.C. & Kannel W.B. (1969). Predicting coronary heart disease from body measurements of Framingham males. Journal of Chronic Diseases, 21, 781802.
Danaei G., Ding E.L., Mozaffarian D., Taylor B., Rehm J., Murray C.J. & Ezzati M. (2009). The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Medicine, 6, e1000058.
Danese A., Pariante C.M., Caspi A., Taylor A. & Poulton R. (2007). Childhood maltreatment predicts adult inflammation in a life-course study. Proceedings Of The National Academy Of Sciences Of The United States Of America, 104, 13191324.
Davey Smith G. (2007). Life-course approaches to inequalities in adult chronic disease risk. Proceedings of the Nutrition Society, 66, 216236.
Davey Smith G., Gunnell D. & Ben-Shlomo Y. (2001). Life-course approaches to socio-economic differentials in cause-specific adult mortality. In Leon D. & Walt G. (eds.). Poverty, inequality and health, Oxford University Press, Oxford, 8124.
Davey Smith G., Hart C., Hole D., MacKinnon P., Gillis C., Watt G., Blane D. & Hawthorne V. (1998). Education and occupational social class: which is the more important indicator of mortality risk?. Journal of Epidemiology and Community Health, 52, 153160.
Davey Smith G. & Lynch J. (2004). Life course approaches to socioeconomic differentials in health. In Kuh D. & Ben-Shlomo Y. (eds.). A life course approach to chronic disease epidemiology, 2nd edn, Oxford University Press, Oxford.
Davidson A.R. & Reid A.R. (1927). On the calculation of rates of mortality. Transactions of the Faculty of Actuaries 11, 183232.
Deary I.J., Whiteman M.C., Starr J.M., Whalley L.J. & Fox H.C. (2004). The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947. Journal Of Personality And Social Psychology, 86, 130147.
Derrick V.P.A. (1927). Observations on (1) errors on age on the population statistics of England and Wales and (2) the changes in mortality indicated by the national records. Journal of the Institute of Actuaries, 58, 117159.
Dewey M.E. & Saz P. (2001). Dementia, cognitive impairment and mortality in persons aged 65 and over living in the community: a systematic review of the literature. International Journal of Geriatric Psychiatry, 16, 751761.
Di Castelnuovo A., Costanzo S., Bagnardi V., Donati M.B., Iacoviello L. & De Gaetano G. (2006). Alcohol dosing and total mortality in men and women: An updated meta-analysis of 34 prospective studies. Archives of Internal Medicine, 166, 24372445.
Doll R., Peto R., Boreham J. & Sutherland I. (2004). Mortality in relation to smoking: 50 years’ observations on male British doctors. British Medical Journal, 328, 1528.
dos Santos Silva I., De Stavola B. & McCormack V. (2008). Birth size and breast cancer risk: re-analysis of individual participant data from 32 studies. PLoS Medicine, 5, e193.
Draper G. (1924). Human constitution: a consideration of its relationship to disease. Saunders, Philadelphia and London.
Draper G., Dupertuis C.W. & Caughey J.L. (1944). Human constitution in clinical medicine. Paul B Hoeber Inc., New York.
Du Bray E.S. (1925). Comments on body weight in relation to health and disease. American Journal of Medical Sciences, 170, 564575.
Dublin L.I. (1930). The influence of weight on certain causes. Human Biology, II, 159183.
Dublin L.I., Lotka A.J. & Spiegelman M. (1949). Length of life. A study of the life table, The Ronald Press Company, New York.
Dublin L.I. & Marks H.H. (1937). The weight standards and mortality of very tall men. Proc A Life Ins Medicine Direct, 23, 153207.
Dublin L.I. & Marks H.H. (1938). Mortality of women according to build-experience on substandard issues. Proc A Life Ins Medicine Direct, 22, 203236.
Dumurgier J., Elbaz A., Ducimetiere P., Tavernier B., Alperovitch A. & Tzourio C. (2009). Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study. British Medical Journal, 339, b4460.
Easton D.F., Pooley K.A., Dunning A.M., Pharoah P.D., Thompson D., Ballinger D.G., Struewing J.P., Morrison J., Field H., Luben R., Wareham N., Ahmed S., Healey C.S., Bowman R., Meyer K.B., Haiman C.A., Kolonel L.K., Henderson B.E., Le Marchand L., Brennan P., Sangrajrang S., Gaborieau V., Odefrey F., Shen C.Y., Wu P.E., Wang H.C., Eccles D., Evans D.G., Peto J., Fletcher O., Johnson N., Seal S., Stratton M.R., Rahman N., Chenevix-Trench G., Bojesen S.E., Nordestgaard B.G., Axelsson C.K., Garcia-Closas M., Brinton L., Chanock S., Lissowska J., Peplonska B., Nevanlinna H., Fagerholm R., Eerola H., Kang D., Yoo K.Y., Noh D.Y., Ahn S.H., Hunter D.J., Hankinson S.E., Cox D.G., Hall P., Wedren S., Liu J., Low Y.L., Bogdanova N., Schurmann P., Dork T., Tollenaar R.A., Jacobi C.E., Devilee P., Klijn J.G., Sigurdson A.J., Doody M.M., Alexander B.H., Zhang J., Cox A., Brock I.W., MacPherson G., Reed M.W., Couch F.J., Goode E.L., Olson J.E., Meijers-Heijboer H., van den O.A., Uitterlinden A., Rivadeneira F., Milne R.L., Ribas G., Gonzalez-Neira A., Benitez J., Hopper J.L., McCredie M., Southey M., Giles G.G., Schroen C., Justenhoven C., Brauch H., Hamann U., Ko Y.D., Spurdle A.B., Beesley J., Chen X., Mannermaa A., Kosma V.M., Kataja V., Hartikainen J., Day N.E., Cox D.R. & Ponder B.A. (2007). Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447, 10871093.
Engeland A., Bjorge T., Sogaard A.J. & Tverdal A. (2003). Body mass index in adolescence in relation to total mortality: 32 year follow-up of 227,000 Norweigian boys and girls. American Journal ofEpidemiology, 157, 517523.
Engeland A., Bjorge T., Tverdal A. & Sogaard A.J. (2004). Obesity in adolescence and adulthood and the risk of adult mortality. Epidemiology, 15, 7985.
Esmaillzadeh A. & Azadbakht L. (2008). Major dietary patterns in relation to general obesity and central adiposity among Iranian women. The Journal of Nutrition, 138, 358363.
Ferreira I., Twisk J.W., van Mechelen W., Kemper H.C. & Stehouwer C.D. (2005). Development of fatness, fitness, and lifestyle from adolescence to the age of 36 years: determinants of the metabolic syndrome in young adults: the Amsterdam growth and health longitudinal study. Archives of Internal Medicine, 165, 4248.
Flatt T. & Schmidt P.S. (2009). Integrating evolutionary and molecular genetics of aging. Biochimica et Biophysica Acta, 1790, 951962.
Flegal K.M. & Graubard B.I. (2009). Estimates of excess deaths associated with body mass index and other anthropometric variables. American Journal of Clinical Nutrition, 89, 12131219.
Foresight programme of the Government Office of Science. (2007). Tackling obesities: future choices — project report. Government Office for Science.
Fujita Y., Nakamura Y., Hiraoka J., Kobayashi K., Sakata K., Nagai M. & Yanagawa H. (1995). Physical-strength tests and mortality among visitors to health-promotion centers in Japan. Journal of clinical epidemiology, 48, 13491359.
Gale C.R., Batty G.D., Cooper C. & Deary I.J. (2009). Psychomotor coordination and intelligence in childhood and health in adulthood–testing the system integrity hypothesis. Psychosomatic Medicine 71, 675681.
Gale C.R., Deary I.J., Boyle S.H., Barefoot J., Mortensen L.H. & Batty G.D. (2008). Cognitive ability in early adulthood and risk of 5 specific psychiatric disorders in middle age: the Vietnam experience study. Archives of General Psychiatry, 65, 14101418.
Gale C.R., Martyn C.N., Cooper C. & Sayer A.A. (2007). Grip strength, body composition, and mortality. International Journal of Epidemiology, 36, 228235.
Galobardes B., Lynch J.W. & Davey S.G. (2004). Childhood socioeconomic circumstances and cause-specific mortality in adulthood: systematic review and interpretation. Epidemiologic Reviews, 26, 721.
Galobardes B., Lynch J.W. & Smith G.D. (2008). Is the association between childhood socioeconomic circumstances and cause-specific mortality established? Update of a systematic review. Journal of Epidemiology & Community Health, 62, 387390.
Gilbert R., Widom C.S., Browne K., Fergusson D., Webb E. & Janson S. (2009). Burden and consequences of child maltreatment in high-income countries. The Lancet, 373, 6881.
Gillham N.W. (2001). A life of Sir Francis Galton: from African exploration to the birth of eugenics. Oxford University Press, New York.
Gluckman P., Beedle A. & Hanson M. (2009). Principles of evolutionary medicine. Oxford University Press, Oxford.
Gmel G., Gutjahr E. & Rehm J. (2003). How stable is the risk curve between alcohol and all-cause mortality and what factors influence the shape? A precision-weighted hierarchical meta-analysis. European Journal of Epidemiology, 18, 631642.
Gregg E., Cheng Y., Cadwell B., Imperatore G., Williams D., Flegal K., Narayan K. & Williamson D. (2005). Secular trends in cardiovascular disease risk factors according to body mass index in US adults. Journal of American Medical Association, 293, 18681874.
Grollman A. (1930). The action of alcohol, caffeine, and tobacco, on the cardiac output (and its related functions) of normal man. Journal of Pharmacology and Experimental Therapeutics, 39, 313327.
Gulsvik A.K., Thelle D.S., Mows M. & Wyller T.B. (2009). Increased mortality in the slim elderly: a 42 years follow-up study in a general population. European Journal of Epidemiology 24, 683690.
Gunnell D. (2001). Commentary: Early insights into height, leg length, proportionate growth and health. International Journal of Epidemiology, 30, 221222.
Gunnell D., Okasha M., Smith G.D., Oliver S.E., Sandhu J. & Holly J.M. (2001). Height, leg length, and cancer risk: a systematic review. Epidemiologic Reviews, 23, 313342.
Gunnell D.J., Davey S.G., Frankel S., Nanchahal K., Braddon F.E., Pemberton J. & Peters T.J. (1998a). Childhood leg length and adult mortality: follow up of the Carnegie (Boyd Orr) Survey of Diet and Health in Pre-war Britain. Journal of Epidemiology & Community Health, 52, 142152.
Gunnell D.J., Frankel S.J., Nanchahal K., Peters T.J. & Davey S.G. (1998b). Childhood obesity and adult cardiovascular mortality: a 57-y follow-up study based on the Boyd Orr cohort. American Journal of Clinical Nutrition, 67, 11111118.
Guralnik J.M., Branch L.G., Cummings S.R. & Curb J.D. (1989). Physical performance measures in aging research. Journal of Gerontology: Medical Sciences, 44, M141–M146.
Guralnik J.M., Simonsick E.M., Ferrucci L., Glynn R.J., Berkman L.F., Blazer D.G., Scherr P.A. & Wallace R.B. (1994). A Short Physical Performance Battery Assessing Lower-Extremity Function — Association with Self-Reported Disability and Prediction of Mortality and Nursing-Home Admission. Journals of Gerontology, 49, M85–M94.
Hacking I. (1990). The taming of chance. Cambridge University Press.
Hamer M. & Chida Y. (2008). Walking and primary prevention: A meta-analysis of prospective cohort studies. British Journal of Sports Medicine. 42, 238243.
Harris E.C. & Barraclough B. (1998). Excess mortality of mental disorder. The British Journal of Psychiatry, 173, 1153.
Hart C.L., Taylor M.D., Smith G.D., Whalley L.J., Starr J.M., Hole D.J., Wilson V. & Deary I.J. (2005). Childhood IQ and all-cause mortality before and after age 65: prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies. British Journal of Health Psychology, 10, 153165.
Helgadottir A., Thorleifsson G., Manolescu A., Gretarsdottir S., Blondal T., Jonasdottir A., Jonasdottir A., Slgurdsson A., Baker A., Palsson A., Masson G., Gudbjartsson D.F., Magnusson K.P., Andersen K., Levey A.I., Backman V.M., Matthiasdottir S., Jonsdottir T., Palsson S., Einarsdottir H., Gunnarsdottir S., Gylfason A., Vaccarino V., Hooper W.C., Reilly M.P., Granger C.B., Austin H., Rader D.J., Shah S.H., Quyyumi A.A., Gulcher J.R., Thorgeirsson G., Thorsteinsdottir U., Kong A. & Stefansson K. (2007). A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science, 316, 14911493.
Hemmingsson T., Essen J., Melin B., Allebeck P. & Lundberg I. (2007). The association between cognitive ability measured at ages 18–20 and coronary heart disease in middle age among men: a prospective study using the Swedish 1969 conscription cohort. Social Science & Medicine, 65, 14101419.
Hemmingsson T., Melin B., Allebeck P. & Lundberg I. (2009). Cognitive ability in adolescence and mortality in middle age: a prospective life course study. Journal of Epidemiology & Community Health, 63, 697702.
Henderson L, Irving K, Gregory J, Bates CJ, Prentice A, Perks J, Swan G & Farron M. (2003). The National Diet and Nutrition Survey: adults aged 19 to 64 years. Vol 3: Vitamin and mineral intake and urinary analyses, the Stationery Office, London.
Henderson M., Hotopf M., Hayes R., Shah I. & Kuh D. (under review). Psychiatric disorder in early adulthood and risk of premature mortality in the 1946 British Birth Cohort.
Herskind A.M., McGue M., Holm N.V., Sorensen T.I., Harvald B. & Vaupel J.W. (1996). The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870–1900. Human Genetics, 97, 319323.
Hiroeh U., Appleby L., Mortensen P.B. & Dunn G. (2001). Death by homicide, suicide, and other unnatural causes in people with mental illness: a population-based study. The Lancet, 358, 21102112.
Hjelmborg J., Iachine I., Skytthe A., Vaupel J.W., McGue M., Koskenvuo M., Kaprio J., Pedersen N.L. & Christensen K. (2006). Genetic influence on human lifespan and longevity. Human Genetics, 119, 312321.
Hoffmans M.D., Kromhout D. & de Lezenne C.C. (1988). The impact of body mass index of 78,612 18-year old Dutch men on 32-year mortality from all causes. Journal of Clinical Epidemiology, 41, 749756.
Hu F.B., Rimm E., Smith-Warner S.A., Feskanich D., Stampfer M.J., Ascherio A., Sampson L. & Willett W.C. (1999). Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. American Journal of Clinical Nutrition, 69, 243249.
Hueper F. (1945). Arteriosclerosis. Archives of Pathology, 38, 162181.
Huxley R., Mendis S., Zheleznyakov E., Reddy S. & Chan J. (2010). Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk-a review of the literature. European Journal of Clinical Nutrition, 64, 1622.
Huxley R., Owen C.G., Whincup P.H., Cook D.G., Rich-Edwards J., Smith G.D. & Collins R. (2007). Is birth weight a risk factor for ischemic heart disease in later life?. American Journal of Clinical Nutrition, 85, 12441250.
Jokela M., Ferrie J. & Kivimaki M. (2009). Childhood problem behaviors and death by midlife: the British National Child Development Study. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 1924.
Joukamaa M., Heliovaara M., Knekt P., Aromaa A., Raitasalo R. & Lehtinen V. (2001). Mental disorders and cause-specific mortality. British Journal of Psychiatry, 179, 498502.
Katzmarzyk P.T., Perusse L., Malina R.M., Bergeron J., Despres J.P. & Bouchard C. (2001). Stability of indicators of the metabolic syndrome from childhood and adolescence to young adulthood: the Quebec Family Study. Journal of Clinical Epidemiology, 54, 190195.
Kermack W.O., McKendrick A.G. & McKinlay P.L. (1934). Death rates in Great Britain and Sweden: Some general regularities and their significance. The Lancet, 226, 698703.
Kesse-Guyot E., Bertrais S., Peneau S., Estaquio C., Dauchet L., Vergnaud A.C., Czernichow S., Galan P., Hercberg S. & Bellisle F. (2009). Dietary patterns and their sociodemographic and behavioural correlates in French middle-aged adults from the SU.VI.MAX cohort. European Journal of Clinical Nutrition, 63, 521528.
Khaw K.T., Wareham N., Bingham S., Welch A., Luben R. & Day N. (2008). Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study. PLoS Medicine, 5, e12.
Kim-Cohen J., Caspi A., Moffitt T.E., Harrington H., Milne B.J. & Poulton R. (2003). Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohort. Archives of General Psychiatry, 60, 709717.
Kirkwood T., Bond J., May C., McKeith I. & Teh M. (2008). Foresight Mental Capital and Wellbeing Project. Mental capital through life: Future challenges. The Government Office for Science, London.
Kirkwood T.B. (1977). Evolution of ageing. Nature, 270, 301304.
Kivimaki M., Lawlor D.A., Singh-Manoux A., Batty G.D., Ferrie J.E., Shipley M.J., Nabi H., Sabia S., Marmot M.G. & Jokela M. (2009). Common mental disorder and obesity: insight from four repeat measures over 19 years: prospective Whitehall II cohort study. British Medical Journal 339, b3765.
Klatsky A.L. & Udaltsova N. (2007). Alcohol Drinking and Total Mortality Risk. Annals of Epidemiology, 17 S63S67.
Kodama S., Saito K., Tanaka S., Maki M., Yachi Y., Asumi M., Sugawara A., Totsuka K., Shimano H., Ohashi Y., Yamada N. & Sone H. (2009). Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: A meta-analysis. Journal of the American Medical Association, 301, 20242035.
Kuh D. & Ben-Shlomo Y. (2004). A life course approach to chronic disease epidemiology Oxford University Press, 2nd Edition.
Kuh D., Ben Shlomo Y., Lynch J., Hallqvist J. & Power C. (2003). Life course epidemiology. Journal of Epidemiology and Community Health, 57, 778783.
Kuh D., Butterworth S., Kok H., Richards M., Hardy R., Wadsworth M.E. & Leon D.A. (2005). Childhood cognitive ability and age at menopause: evidence from two cohort studies. Menopause., 12, 475482.
Kuh D., Cooper R., Hardy R., Guralnik J. & Richards M. (2009a). Lifetime cognitive performance is associated with midlife physical performance in a prospective national birth cohort study. Psychosomatic Medicine, 71, 3848.
Kuh D. & Davey Smith G. (2004). The life course and adult chronic disease: an historical perspective with particular reference to coronary heart disease. In Kuh D. & Ben-Shlomo Y. (eds.). A life course approach to chronic disease epidemiology, Oxford University Press, 1537.
Kuh D., Hardy R., Langenberg C., Richards M. & Wadsworth M.E. (2002). Mortality in adults aged 26–54 years related to socioeconomic conditions in childhood and adulthood: post war birth cohort study. British Medical Journal, 325, 10761080.
Kuh D., Shah I., Richards M., Mishra G., Wadsworth M. & Hardy R. (2009b). Do childhood cognitive ability or smoking behaviour explain the influence of lifetime socio-economic conditions on premature adult mortality in a British post war birth cohort?. Social Science & Medicine, 68, 15651573.
Kuningas M., van Bodegom D., May L., Meij J.J., Slagboom P.E. & Westendorp R.G. (In press). Common CFTR gene variants influence body composition and survival in rural Ghana. Human Genetics.
Laub J.H. & Vaillant G.E. (2000). Delinquency and mortality: A 50-year follow-up study of 1,000 delinquent and nondelinquent boys. The American Journal of Psychiatry, 157, no. 1, 96102.
Lawlor D.A., Ebrahim S. & Davey S.G. (2001). Sex matters: secular and geographical trends in sex differences in coronary heart disease mortality. British Medical Journal, 323, 541545.
Lawlor D.A. & Smith G.D. (2005). Early life determinants of adult blood pressure. Current Opinion In Nephrology And Hypertension, 14, 259264.
Lawlor D.A., Sterne J.A., Tynelius P., Davey S.G. & Rasmussen F. (2006). Association of childhood socioeconomic position with cause-specific mortality in a prospective record linkage study of 1,839,384 individuals. American Journal of Epidemiology, 164, 907915.
Lee W.E., Wadsworth M.E. & Hotopf M. (2006). The protective role of trait anxiety: a longitudinal cohort study. Psychological Medicine, 36, no. 3, 345351.
Lee C.M.Y., Barzi F., Woodward M., Batty G.D., Giles G.G., Wong J.W., Jamrozik K., Lam T.L., Ueshima H., Kim H.C., Gu D.F., Schooling M., Huxley R.R. & for the Asia Pacific Cohort studies Collaboration (2009). Adult height and the risks of cardiovascular disease and major causes of death in the Asia-Pacific region: 21 000 deaths in 510 000 men and women. International Journal of Epidemiology, 38, 10601071.
Levine S.A. & Brown C.L. (1929). Coronary thrombosis: its various clinical features. Medicine, 8, 245418.
Lorenz M.W., Markus H.S., Bots M.L., Rosvall M. & Sitzer M. (2007). Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation, 115, 459467.
Magnussen C.G., Raitakari O.T., Thomson R., Juonala M., Patel D.A., Viikari J.S., Marniemi J., Srinivasan S.R., Berenson G.S., Dwyer T. & Venn A. (2008). Utility of currently recommended pediatric dyslipidemia classifications in predicting dyslipidemia in adulthood: evidence from the Childhood Determinants of Adult Health (CDAH) study, Cardiovascular Risk in Young Finns Study, and Bogalusa Heart Study. Circulation, 117, 3242.
Marmot M.G., Bosma H., Hemingway H., Brunner E. & Stansfeld S. (1997). Contribution of job control and other risk factors to social variations in coronary heart disease incidence. The Lancet, 350, 235239.
Marmot M.G., Smith G.D., Stansfeld S., Patel C., North F., Head J., White I., Brunner E. & Feeney A. (1991). Health inequalities among British civil servants: the Whitehall II study. The Lancet, 337, 13871393.
McCarron P., Okasha M., McEwen J. & Davey S.G. (2002). Blood pressure in early life and cardiovascular disease mortality. Archives Of Internal Medicine, 162, 610611.
McCarron P., Smith G.D., Okasha M. & McEwen J. (2000). Blood pressure in young adulthood and mortality from cardiovascular disease. The Lancet, 355, 14301431.
McGill H.C. Jr, McMahan C.A., Herderick E.E., Malcom G.T., Tracy R.E. & Strong J.P. (2000). Origin of atherosclerosis in childhood and adolescence. American Journal of Clinical Nutrition, 72, 1307S-1315S.
Metter E.J., Talbot L.A., Schrager M. & Conwit R. (2002). Skeletal muscle strength as a predictor of all-cause mortality in healthy men. Journals of gerontology, The Series A, Biological Sciences and Medical Sciences, 57, B359B365.
Mezuk B., Eaton W.W., Albrecht S. & Golden S.H. (2008). Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care, 31, 23832390.
Milne J.S. & Maule M.M. (1984). A longitudinal study of handgrip and dementia in older people. Age and ageing, 13, 4248.
Mishra G., Ball K., Arbuckle J. & Crawford D. (2002). Dietary patterns of Australian adults and their association with socioeconomic status: results from the 1995 National Nutrition Survey. European Journal of Clinical Nutrition, 56, 687693.
Mitchell A.J. & Shiri-Feshki M. (2008). Temporal trends in the long term risk of progression of mild cognitive impairment: a pooled analysis. Journal Of Neurology, Neurosurgery And Psychiatry, 79, 13861391.
Mitchell B.D., Hsueh W.C., King T.M., Pollin T.I., Sorkin J., Agarwala R., Schaffer A.A. & Shuldiner A.R. (2001). Heritability of life span in the Old Order Amish. American Journal Of Medical Genetics, 102, 346352.
Miura K., Daviglus M.L., Dyer A.R., Liu K., Garside D.B., Stamler J. & Greenland P. (2001). Relationship of blood pressure to 25-year mortality due to coronary heart disease, cardiovascular diseases, and all causes in young adult men: the Chicago Heart Association Detection Project in Industry. Archives Of Internal Medicine, 161, 15011508.
Morris J.N., Heady J.A., Raffle P.A., Roberts C.G. & Parks J.W. (1953a). Coronary heart-disease and physical activity of work. The Lancet, 265, 10531057.
Morris J.N., Heady J.A., Raffle P.A., Roberts C.G. & Parks J.W. (1953b). Coronary heart-disease and physical activity of work. The Lancet, 265, 11111120.
Mossberg H.O. (1989). 40-year follow-up of overweight children. The Lancet, 2, 491493.
Must A., Jacques P.F., Dallal G.E., Bajema C.J. & Dietz W.H. (1992). Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. New England Journal Of Medicine, 327, 13501355.
Mustard C.A. & Etches J. (2003). Gender differences in socioeconomic inequality in mortality. Journal of Epidemiology and Community Health, 57, 974980.
Mykletun A., Bjerkeset O., Dewey M., Prince M., Overland S. & Stewart R. (2007). Anxiety, depression, and cause-specific mortality: the HUNT study. Psychosomatic Medicine, 69, 323331.
Naess O., Strand B.H. & Smith G.D. (2007). Childhood and adulthood socioeconomic position across 20 causes of death: a prospective cohort study of 800,000 Norwegian men and women. Journal of Epidemiology and Community Health, 61, 10041009.
Newman A.B., Walter S., Lunetta K.L., Garcia M.E., Slagboom P.E. & Christensen K.E.A. (2010). A Meta-analysis of Four Genome-wide Association Studies of Survival to Age 90 years or Older: The Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) Consortium. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 65, 478487.
Nielsen N.R., Kristensen T.S., Schnohr P. & Gronbaek M. (2008). Perceived stress and cause-specific mortality among men and women: results from a prospective cohort study. American Journal of Epidemiology, 168, 481491.
Nieto F.J., Szklo M. & Comstock G.W. (1992). Childhood weight and growth rate as predictors of adult mortality. American Journal of Epidemiology, 136, 201213.
O'Flaherty M., Bishop J., Redpath A., McLaughlin T., Murphy D., Chalmers J. & Capewell S. (2009). Coronary heart disease mortality among young adults in Scotland in relation to social inequalities: time trend study. British Medical Journal, 339, b2613.
Oeppen J. & Vaupel J.W. (2002). Demography. Broken limits to life expectancy. Science, 296, 10291031.
Office for National Statistics. Alcohol deaths rates stabilise in the UK. Office for National Statistics. (2009). Ref Type: Electronic Citation.
Oguma Y., Sesso H.D., Paffenbarger J. & Lee I.-M. (2002). Physical activity and all cause mortality in women: A review of the evidence. British Journal of Sports Medicine, 36, 162172.
Osler M., Andersen A.M., Due P., Lund R., Damsgaard M.T. & Holstein B.E. (2003). Socioeconomic position in early life, birth weight, childhood cognitive function, and adult mortality. A longitudinal study of Danish men born in 1953. Journal of Epidemiology and Community Health, 57, 681686.
Owen C.G., Whincup P.H., Orfei L., Chou Q.-A., Rudnicka A.R., Wathern A.K., Kaye S.J., Eriksson J.G., Osmond C. & Cook D.G. (2009). Is body mass index before middle age related to coronary heart disease risk in later life? Evidence from observational studies. International Journal of Obesity, 33, 866877.
Paffenbarger R.S. Jr, & Wing A.L. (1967). Characteristics in youth predisposing to fatal stroke in later years. The Lancet, 1, 753754.
Paffenbarger R.S. Jr, & Wing A.L. (1969). Chronic disease in former college students.X. The effects of single and multiple characteristics on risk of fatal coronary heart disease. American Journal of Epidemiology, 90, 527535.
Palatini P. (2006). Moderate or vigorous exercise? Which best helps prolong life?. Journal of Cardiovascular Medicine, 7, 721725.
Pearl R. (1924). Studies in human biology. Williams and Wilkins, Baltimore.
Pearl R. (1926). Alcohol and longevity. Knopf, New York.
Pearl R. (1938). Tobacco smoking and longevity. Science, 87, 216217.
Pearl R. & Ciocco A. (1934). Studies in constitution II. Somatological differences associated with disease of the heart in white males. Human Biology, 6, 650713.
Perkovic V., Huxley R., Wu Y., Prabhakaran D. & MacMahon S. (2007). The burden of blood pressure-related disease: a neglected priority for global health. Hypertension, 50, 991997.
Perls T.T., Wilmoth J., Levenson R., Drinkwater M., Cohen M., Bogan H., Joyce E., Brewster S., Kunkel L. & Puca A. (2002). Life-long sustained mortality advantage of siblings of centenarians. Proceedings Of The National Academy Of Sciences Of The United States Of America, 99, 84428447.
Pollitt R.A., Rose K.M. & Kaufman J.S. (2005). Evaluating the evidence for models of life course socioeconomic factors and cardiovascular outcomes: a systematic review. BMC. Public Health, 5, 7.
Porkka K.V. & Viikari J.S. (1995). Tracking of serum lipids in children; association with the absolute lipid level–the cardiovascular risk in young Finns study. Journal of Clinical Epidemiology, 48, 221228.
Postel-Vinay N. (1996). History of hypertension and of vascular risk: at the origins of change of contemporary medicine, Histoire des sciences medicales, 30, 235241.
Power C., Hypponen E. & Smith G.D. (2005). Socioeconomic position in childhood and early adult life and risk of mortality: a prospective study of the mothers of the 1958 British birth cohort. American Journal of Public Health, 95, 13961402.
Prospective Studies Collaboration (2009). Body-mass index and cause-specific mortality in 900 000 adults: colaborative analysis of 57 prospective studies. The Lancet, 373, 10831096.
Raitakari O.T., Juonala M., Kahonen M., Taittonen L., Laitinen T., Maki-Torkko N., Jarvisalo M.J., Uhari M., Jokinen E., Ronnemaa T., Akerblom H.K. & Viikari J.S. (2003). Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. Journal of the American Medical Association, 290, 22772283.
Rankinen T. & Bouchard C. (2007). Invited commentary: Physical activity, mortality, and genetics. American Journal of Epidemiology, 166, 260262.
Rantanen T. (2003). Muscle strength, disability and mortality. Scandinavian journal of medicine and science in sports, 13, 38.
Richards M., Shipley B., Fuhrer R. & Wadsworth M.E. (2004). Cognitive ability in childhood and cognitive decline in mid-life: longitudinal birth cohort study. British Medical Journal, 328, 552.
Robins L.N. (1966). Deviant children grown up, Williams & Wilkins, Baltimore.
Rosengren A. (2009). Declining cardiovascular mortality and increasing obesity: a paradox. Canadian Medical Association Journal, 181, 127128.
Sacks F.M., Pfeffer M.A., Moye L.A., Rouleau J.L., Rutherford J.D., Cole T.G., Brown L., Warnica J.W., Arnold J.M., Wun C.C., Davis B.R. & Braunwald E. (1996). The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. New England Journal Of Medicine, 335, 10011009.
Samaras T.T. (2009). Should we be concerned over increasing body height and weight?. Experimental Gerontology, 44, 8392.
Samaras T.T., Elrick H. & Storms L.H. (2003). Is height related to longevity?. Life Sciences, 72, 17811802.
Samaras T.T., Elrick H. & Storms L.H. (2004). Is short height really a risk factor for coronary heart disease and stroke mortality? A review. Medical Science Monitor, 10, RA63–RA76.
Sasaki H., Kasagi F., Yamada M. & Fujita S. (2007). Grip strength predicts cause-specific mortality in middle-aged and elderly persons. American Journal of Medicine, 120, 337342.
Scandinavian Simvastatin Survival Study Group (1994). Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). The Lancet, 344, 13831389.
Schoenmaker M., de Craen A.J., de Meijer P.H., Beekman M., Blauw G.J., Slagboom P.E. & Westendorp R.G. (2006). Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. European Journal Of Human Genetics, 14, 7984.
Seidell J.C. (In press). Waist circumference and waist/hip ratio in relation to all-cause mortality, cancer and sleep apnea. European Journal Of Clinical Nutrition.
Shaper A.G., Wannamethee G. & Walker M. (1988). Alcohol and mortality in British men: Explaining the U-shaped curve. Lancet. 2, 12671273.
Shepherd J., Cobbe S.M., Ford I., Isles C.G., Lorimer A.R., MacFarlane P.W., McKillop J.H. & Packard C.J. (1995). Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. New England Journal of Medicine, 333, 13011307.
Shonkoff J.P., Boyce W.T. & McEwen B.S. (2009). Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention. Journal of the American Medical Association, 301, 22522259.
Silventoinen K., Magnusson P.K., Tynelius P., Batty G.D. & Rasmussen F. (2009). Association of body size and muscle strength with incidence of coronary heart disease and cerebrovascular diseases: a population-based cohort study of one million Swedish men. International Journal of Epidemiology, 38, 110118.
Smith C.P., Archibald H.R., Thomas J.M., Tarn A.C., Williams A.J., Gale E.A. & Savage M.O. (1988). Basal and stimulated insulin levels rise with advancing puberty. Clinical Endocrinology, 28, 714.
Sofi F., Cesari F., Abbate R., Gensini G.F. & Casini A. (2008). Adherence to Mediterranean diet and health status: meta-analysis. British Medical Journal, 337, a1344.
Statistics on obesity, physical activity and diet: England (2009). The Health and Social Care Information Centre, London.
Stearns S.C., Nesse M.N. & Haig D. (2008). Introducing evolutionary thinking for medicine. In Stearns S.C. & Koella J.C. (eds.). Evolution in health and disease, Oxford University Press, 301311.
Stockard C.R. (1927). Constitution and type in relation to disease. De Lamar lectures 1925–26 The Williams and Wilkins Company, Baltimore.
Stockard C.R. (1927). Hormones and structural development. The Beaumont Foundation Lecture. Series number six. Wayne County Medical Society, Detroit, Michigan.
Suh Y., Atzmon G., Cho M.O., Hwang D., Liu B., Leahy D.J., Barzilai N. & Cohen P. (2008). Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proceedings Of The National Academy Of Sciences Of The United States Of America, 105, 34383442.
Swan G. (2004). Findings from the latest National Diet and Nutrition Survey. Proceedings Of The Nutrition Society, 63, 505512.
Takata Y., Ansai T., Akifusa S., Soh I., Yoshitake Y., Kimura Y., Sonoki K., Fujisawa K., Awano S., Kagiyama S., Hamasaki T., Nakamichi I., Yoshida A. & Takehara T. (2007). Physical fitness and 4-year mortality in an 80-year-old population. Journals of gerontology, Series A, Biological Sciences and Medical Sciences, 62, 851858.
Thomas K. & Gunnell D. (In press). Suicide in England and Wales 1861–2007: a time trends analysis. International Journal of Epidemiology.
Turnbull F. (2003). Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet, 362, 1527–35.
U.S. Department of Health and Human Services (1990). The health benefits of smoking cessation. A report of the surgeon general, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Rockville (MD).
Unal B., Critchley J.A. & Capewell S. (2005). Modelling the decline in coronary heart disease deaths in England and Wales, 1981–2000: comparing contributions from primary prevention and secondary prevention. British Medical Journal, 331, 614.
van Dam R.M., Li T., Spiegelman D., Franco O.H. & Hu F.B. (2008). Combined impact of lifestyle factors on mortality: prospective cohort study in US women. British Medical Journal, 337, a 1440.
van Heemst D., Beekman M., Mooijaart S.P., Heijmans B.T., Brandt B.W., Zwaan B.J., Slagboom P.E. & Westendorp R.G. (2005). Reduced insulin/IGF-1 signalling and human longevity. Aging Cell, 4, 7985.
Walston J., Hadley E.C., Ferrucci L., Guralnik J.M., Newman A.B., Studenski S.A., Ershler W.B., Harris T. & Fried L.P. (2006). Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. Journal Of The American Geriatrics Society, 54, 9911001.
Webber L.S., Srinivasan S.R., Wattigney W.A. & Berenson G.S. (1991). Tracking of serum lipids and lipoproteins from childhood to adulthood. The Bogalusa Heart Study. American Journal Of Epidemiology, 133, 884899.
Weeks C.C. (1938). Alcohol and human life. Lewis & Co, London.
Westendorp R.G. & Kirkwood T.B. (1998). Human longevity at the cost of reproductive success. Nature, 396, 743746.
Westendorp R.G., van Heemst D., Rozing M.P., Frolich M., Mooijaart S.P., Blauw G.J., Beekman M., Heijmans B.T., de Craen A.J. & Slagboom P.E. (2009). Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. Journal Of The American Geriatrics Society, 57, 16341637.
Whincup P.H., Kaye S.J., Owen C.G., Huxley R., Cook D.G., Anazawa S., Barrett-Connor E., Bhargava S.K., Birgisdottir B.E., Carlsson S., de Rooij S.R., Dyck R.F., Eriksson J.G., Falkner B., Fall C., Forsen T., Grill V., Gudnason V., Hulman S., Hypponen E., Jeffreys M., Lawlor D.A., Leon D.A., Minami J., Mishra G., Osmond C., Power C., Rich-Edwards J.W., Roseboom T.J., Sachdev H.S., Syddall H., Thorsdottir I., Vanhala M., Wadsworth M. & Yarbrough D.E. (2008). Birth weight and risk of type 2 diabetes: a systematic review. Journal of the American Medical Association, 300, 28862897.
White I.R., Altmann D.R., Nanchahal K. (2002). Alcohol consumption and mortality: modelling risks for men and women at different ages. British Medical Journal, 325, 191197.
White P.D. (1931). Heart disease. Macmillan Co., New York.
Whitely E., Martin R.M., Davey Smith G., Holly J.M.P. & Gunnell D. (2009). Childhood stature and adult cancer risk: the Boyd Orr cohort. Cancer Causes Control, 20, 243251.
WHO (2002). The world health report 2002 — reducing risks, promoting healthy life, WHO, Geneva.
Willett W.C. (2000). Nutritional epidemiology issues in chronic disease at the turn of the century. Epidemiologic Reviews, 22, 8286.
Williams G.C. (1957). Pleiotropy, Natural Selection, and the Evolution of Senescence. Evolution, 11, 398411.
Wulsin L.R., Vaillant G.E. & Wells V.E. (1999). A systematic review of the mortality of depression. Psychosomatic Medicine, 61, 617.
Yarnell J.W., Patterson C.C., Thomas H.F. & Sweetnam P.M. (2000). Comparison of weight in middle age, weight at 18 years, and weight change between, in predicting subsequent 14 year mortality and coronary events: Caerphilly Prospective Study Journal of Epidemiology and Community Health, 54, 344348.
Yusuf S., Hawken S., Ounpuu S., Bautista L., Franzosi M.G., Commerford P., Lang C.C., Rumboldt Z., Onen C.L., Lisheng L., Tanomsup S., Wangai P. Jr, Razak F., Sharma A.M. & Anand S.S. (2005). Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. The Lancet, 366, 16401649.
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British Actuarial Journal
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