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Frailty and associated prognosis among older emergency department patients with suspected infection: A prospective, observational cohort study

Published online by Cambridge University Press:  04 June 2020

Shannon M. Fernando Open the ORCID record for Shannon M. Fernando [Opens in a new window] ,
Kevin H. Guo ,
Matthew Lukasik ,
Bram Rochwerg ,
Deborah J. Cook ,
Kwadwo Kyeremanteng  and
Jeffrey J. Perry Open the ORCID record for Jeffrey J. Perry [Opens in a new window]
Shannon M. Fernando*
Affiliation:
Department of Emergency Medicine, University of Ottawa, Ottawa, ON Division of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON
Kevin H. Guo
Affiliation:
Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON
Matthew Lukasik
Affiliation:
Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON
Bram Rochwerg
Affiliation:
Department of Medicine, Division of Critical Care, McMaster University, Hamilton, ON Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON
Deborah J. Cook
Affiliation:
Department of Medicine, Division of Critical Care, McMaster University, Hamilton, ON Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON
Kwadwo Kyeremanteng
Affiliation:
Division of Critical Care, Department of Medicine, University of Ottawa, Ottawa, ON Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON
Jeffrey J. Perry
Affiliation:
Department of Emergency Medicine, University of Ottawa, Ottawa, ON Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON
*
Correspondence to: Dr. Shannon M. Fernando, Department of Critical Care, The Ottawa Hospital, Civic Campus, 1053 Carling Avenue, Ottawa, ONK1Y 4E9; Email: sfernando@qmed.ca

Abstract

Background

Prognosis and disposition among older emergency department (ED) patients with suspected infection remains challenging. Frailty is increasingly recognized as a predictor of poor prognosis among critically ill patients; however, its association with clinical outcomes among older ED patients with suspected infection is unknown.

Methods

We conducted a multicenter prospective cohort study at two tertiary care EDs. We included older ED patients (≥75 years) with suspected infection. Frailty at baseline (before index illness) was explicitly measured for all patients by the treating physicians using the Clinical Frailty Scale (CFS). We defined frailty as a CFS 5–8. The primary outcome was 30-day mortality. We used multivariable logistic regression to adjust for known confounders. We also compared the prognostic accuracy of frailty with the Systemic Inflammatory Response Syndrome (SIRS) and Quick Sequential Organ Failure Assessment (qSOFA) criteria.

Results

We enrolled 203 patients, of whom 117 (57.6%) were frail. Frail patients were more likely to develop septic shock (adjusted odds ratio [aOR], 1.83; 95% confidence interval [CI], 1.08–2.51) and more likely to die within 30 days of ED presentation (aOR 2.05; 95% CI, 1.02–5.24). Sensitivity for mortality was highest among the CFS (73.1%; 95% CI, 52.2–88.4), compared with SIRS ≥ 2 (65.4%; 95% CI, 44.3–82.8) or qSOFA ≥ 2 (38.4; 95% CI, 20.2–59.4).

Conclusions

Frailty is a highly prevalent prognostic factor that can be used to risk-stratify older ED patients with suspected infection. ED clinicians should consider screening for frailty to optimize disposition in this population.

Résumé

RÉSUMÉContexte

Il n'est pas facile de déterminer le pronostic et les suites à donner chez les personnes âgées souffrant d'une infection présumée, au service des urgences (SU). La fragilité est de plus en plus reconnue comme un facteur prévisionnel de pronostic sombre chez les personnes gravement malades; toutefois, on ne sait pas s'il existe une association entre les résultats cliniques observés chez les personnes âgées au SU et les infections présumées.

Méthode

Il s'agit d'une étude de cohorte, prospective et multicentrique, réalisée dans deux SU de soins tertiaires. Ont été retenus des patients âgées (≥ 75 ans) examinés au SU pour une infection présumée. Le degré de fragilité au départ (avant la maladie de référence) a été explicitement mesuré chez tous les patients par le médecin traitant à l'aide d'une échelle de fragilité clinique, la Clinical Frailty Scale (CFS). La fragilité a été définie comme une valeur variant de 5 à 8 sur la CFS. Le principal critère d’évaluation était la mortalité au bout de 30 jours. Les chercheurs ont utilisé un modèle de régression logistique plurifactorielle pour tenir compte des variables de confusion connues. L'exactitude du pronostic de fragilité selon la CFS a également été comparée avec celle de deux autres outils, soit les Systemic Inflammatory Response Syndrome (SIRS) et Quick Sequential Organ Failure Assessment (qSOFA).

Résultats

Ont participé à l’étude 203 patients, dont 117 (57,6%) étaient considérés comme fragiles. Ces derniers étaient plus susceptibles que les autres de subir un choc septique (risque relatif approché rajusté [RRAr] : 1,83; intervalle de confiance [IC] à 95% : 1,08-2,51) et de succomber à la maladie dans les 30 jours suivant la consultation au SU (RRAr : 2,05; IC à 95% : 1,02-5,24). C'est la CFS qui a révélé la plus forte sensibilité à l’égard de la mortalité (73,1%; IC à 95% : 52,2-88,4), comparativement à l’échelle SIRS ≥ 2 (65,4%; IC à 95% : 44,3-82,8) et à la qSOFA ≥ 2 (38,4; IC à 95% : 20,2-59,4).

Conclusion

La fragilité est un facteur de pronostic très courant qu'on peut utiliser pour classer les patients âgés atteints d'une infection présumée, en fonction du risque, au SU. Les urgentologues devraient envisager la possibilité de mesurer le degré de fragilité dans la population concernée afin d'optimiser les suites à donner.

Keywords

Frailtygeriatricsinfectionsepsisseptic shock
Type
Original Research
Information
Canadian Journal of Emergency Medicine , Volume 22 , Issue 5 , September 2020 , pp. 687 - 691
Copyright
Copyright © Canadian Association of Emergency Physicians 2020

CLINICIAN'S CAPSULE

What is known about the topic?

Older emergency department (ED) patients with suspected infection are at risk of future deterioration, and often difficult to disposition.

What did this study ask?

What was the association between clinical frailty and 30-day mortality among older ED patients presenting with suspected infection?

What did this study find?

Patients with frailty had higher development of septic shock and increased 30-day mortality, compared with patients without frailty.

Why does this study matter to clinicians?

Frailty can be quickly and easily measured in ED patients, and can be used particularly to risk stratify older patients with suspected infection.

INTRODUCTION

Severe infection, resulting in sepsis and septic shock, remains a major cause of death.Reference Rudd, Johnson and Agesa1 In the emergency department (ED), early identification of patients with sepsis has been associated with improved outcomes,Reference Seymour, Gesten and Prescott2 while inappropriate disposition has been linked to worse outcomes and increased costs.Reference Fernando, Rochwerg and Reardon3 Older patients with suspected infection often present with nonspecific signs,Reference Fernando, McIsaac and Perry4,Reference Caterino, Kline and Leininger5 making risk-stratification in this population challenging. Frailty, a clinical state characterized by reduced physiologic reserve, has been associated with poor outcome among intensive care unit (ICU) patients.Reference Fernando, McIsaac and Perry4,Reference Fernando, McIsaac and Rochwerg6 In the ED, frailty can be easily measured and used to risk-stratify patients. We evaluated the association between frailty and outcomes of ED patients with suspected infection, and compared frailty with other prognostic tools, including the Systemic Inflammatory Response Syndrome (SIRS) criteria, and the Quick Sequential Organ Failure Assessment (qSOFA).Reference Singer, Deutschman and Seymour7

METHODS

Study approval was received from The Ottawa Health Science Network Research Ethics Board. Further methodological detail is included in the online Supplemental Table 1.

Study design, setting, and subjects

We conducted this prospective cohort study in the EDs of two university-affiliated hospitals within The Ottawa Hospital network (Ottawa, ON) from September 2018 to February 2019. We recruited a convenience sample of patients ≥75 years of age, presenting with suspected infection. We defined “suspected infection” by administration of antimicrobial therapy, and either (A) drawing of body fluid cultures (including blood, urine, and cerebrospinal fluid); or (B) chest radiography interpreted by the ED physician to represent pneumonia. We defined “septic shock” as serum lactate > 2.0 mmol/L, and persistent hypotension below a mean arterial pressure of 65 mmHg, despite fluid resuscitation. These definitions of “suspected infection” and “septic shock” largely match those used in the Third International Consensus Definitions for Sepsis and Septic Shock.Reference Singer, Deutschman and Seymour7

Identifying frailty

Treating ED physicians or residents were asked to identify the presence of frailty, before patient disposition. This was done using the Clinical Frailty Scale (CFS), a 9-point global frailty scale that evaluates baseline mobility, energy, physical activity, and function (before consultation or discharge)Reference Rockwood, Song and MacKnight8 (Supplemental Figure 1), and has been applied in the ED with good inter-rater reliability.Reference Ringer, Thompson, McLeod and Melady9 Consistent with previous research, a CFS ≥ 5 was used to identify the presence of frailty. Patients with a CFS of 9 were excluded due to the high likelihood of short-term mortality.

Data collection and outcomes measures

Following enrollment, patients were approached by a trained research assistant, who gathered data related to baseline characteristics, and calculated SIRS and qSOFA scores at the time of physician assessment. Patients were phoned by a single investigator (K.H.G.) at 30 days following enrollment. The primary outcome was 30-day mortality. Secondary outcomes included need for hospital admission, development of septic shock, and disposition to long-term care facilities.

Statistical analysis

We present data as mean values, with standard deviation (SD), or medians, with interquartile range (IQR), where appropriate. We performed the Student's t-test, Mann-Whitney test, and χReference Seymour, Gesten and Prescott2 to determine between-group differences. As recommended for observational studies (Supplemental Table 1), we determined confounders a priori, and used multivariable logistic regression modeling to adjust for important continuous (age, Canadian Triage and Acuity Score [CTAS]) and categorical (sex, treatment limitations) variables. We present adjusted odds ratios (aOR) with 95% confidence intervals (CIs). A p value of ≤ 0.05 was considered statistically significant. We calculated the sensitivity, specificity, and likelihood ratios with 95% CIs for the CFS, SIRS, and qSOFA for 30-day mortality.

RESULTS

We recruited 205 older ED patients presenting with suspected infection. Two (1.0%) were lost to follow-up at 30-days, leaving 203 patients available for analysis (Supplemental Figure 2). Of these, 117 (57.6%) were identified as being frail. Baseline characteristics are shown in Supplemental Table 2. Frail patients were older (mean age 86.5 v. 83.0 years; p < 0.001), and were more likely to have bladder and bowel incontinence, cognitive impairment, and require assistance with mobility and activities of daily living. Frail patients were less likely to be from home, and more likely to have limitations with regard to critical care interventions. No differences were seen in initial CTAS score, suspected source of infection, or initial ED vital signs. Outcomes are displayed in Supplemental Table 3. In this cohort, 26 patients (12.8%) died before day 30. Frailty was associated with development of septic shock (aOR, 1.83 [95% CI, 1.08–2.51]) and increased 30-day mortality (aOR, 2.05 [95% CI, 1.02–5.24]; Supplemental Table 4).

Prognostic accuracy of the CFS, SIRS, and qSOFA criteria for 30-day mortality are shown in Table 1. CFS ≥ 5 had a sensitivity of 73.1% (95% CI, 52.2–88.4) and specificity of 44.6% (95% CI, 37.2–55.3). SIRS ≥ 2 had a sensitivity of 65.4% (95% CI, 44.3–82.8) and specificity of 57.1% (95% CI, 49.4–64.5). Finally, qSOFA ≥ 2 had a sensitivity of 38.4% (95% CI, 20.2–59.4%) and a specificity of 91.5% (95% CI, 86.4–95.2). A qSOFA ≥ 2 was only seen in 12.8% of patients. Presence of frailty combined with a qSOFA ≥ 2 had an odds ratio of 7.83 (95% CI, 2.99–19.5) for 30-day mortality.

Table 1. Prognostic accuracy of Clinical Frailty Scale, Systemic Inflammatory Response Syndrome, and Quick Sequential Organ Failure Assessment for 30-day mortality among older patients with suspected infection (n = 203)

CI = confidence interval.

DISCUSSION

Risk-stratification of older ED patients with suspected infection is difficult. The SIRS criteria are commonly used to screen for initiation of therapyReference Seymour, Gesten and Prescott2; however, these criteria are less reliable in older patients, who may not mount the same compensatory response seen from systemic inflammation.Reference Caterino, Kline and Leininger5 We found that a CFS 5–8 had superior sensitivity to the SIRS criteria ≥ 2, making it potentially more valuable in the ED setting. In keeping with existing research, qSOFA ≥ 2 was found to have particularly poor sensitivity for mortality,Reference Fernando, Tran and Taljaard10 and only a minority of patients met this criteria. Regardless, the high odds ratio of qSOFA suggests that it may be valuable in identifying very high-risk patients, and synergistic combination with the CFS identified patients with the highest odds of dying. Interestingly, our results show that frail patients are at increased risk of deterioration to septic shock, suggesting a potential underlying relationship between the poor physiologic reserve associated with frailty, immunosenesence, and specific features such as an overwhelming systemic host response to infection. Whether this population may benefit from earlier and more aggressive interventions could be an important avenue of future research.

Our study has important limitations. First, we enrolled a convenience sample of patients on the basis of research assistant availability, leaving open the possibility for selection bias. We do not know what proportion of patients with “suspected infection” were missed. Second, the majority of patients had pulmonary or urinary infections, and how our findings extend to other infection sources is unclear. Third, we included initial goals-of-care in our regression models, but do not have data related to how goals-of-care may have changed throughout hospital admission, as clinicians may be more likely to engage with frail patients and their families in conversations about prognosis. Finally, our study was conducted at two hospitals within the same city and is potentially susceptible to bias from regional practice.

CONCLUSION

Pre-admission frailty was associated with increased odds of development of septic shock and 30-day mortality in older ED patients with suspected infection. The CFS had higher sensitivity than SIRS or qSOFA for prognosis of 30-day mortality. ED clinicians should consider use of the CFS for quick screening, prognostication, and disposition.

Supplemental material

The supplemental material for this article can be found at https://doi.org/10.1017/cem.2020.377.

Competing interests

Dr. Bram Rochwerg is supported by a Hamilton Health Sciences New Investigator Grant. Dr. Deborah J. Cook is supported by a Canada Research Chair in Critical Care Knowledge Translation. Dr. Jeffrey J. Perry is supported by a Heart and Stroke Foundation of Canada Mid-Career Award. None of the other authors report any conflict of interest.

Author Contributions

S.M.F. and J.J.P. designed the study. S.M.F. and K.H.G. gathered the data. All authors analyzed and interpreted the data. All authors wrote the manuscript.

Financial support

Canadian Association of Emergency Physicians Emergency Medicine Advancement Fund.

References

REFERENCES

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Figure 0

Table 1. Prognostic accuracy of Clinical Frailty Scale, Systemic Inflammatory Response Syndrome, and Quick Sequential Organ Failure Assessment for 30-day mortality among older patients with suspected infection (n = 203)

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