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Anomalies of the aortic arch and arterial duct induced by small doses of bis-diamine in fetal rats

Published online by Cambridge University Press:  19 August 2008

Kazuo Momma  and
Masahiko Ando
Kazuo Momma*
Affiliation:
Department of Pediatric Cardiology, The Heart Institute of Japan,Tokyo Women's Medical College,Tokyo,Japan
Masahiko Ando
Affiliation:
Department of Pediatric Cardiology, The Heart Institute of Japan,Tokyo Women's Medical College,Tokyo,Japan
*
Kazuo Momma, M D, The Heart Institute of Japan,Tokyo Women's Medical College, Kawadacho,Shinjuku-ku,Tokyo 162,Japan Tel, 03-3353-8111, Fax, 03-3356-0441
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Abstract

Deletion of chromosome 22 and DiGeorge syndrome are associated with inappropriate development of the neural crest and abnormalities of the ventricular outflow tracts. Bis-diamine induces comparable cardiac anomalies by inhibiting the normal development of the neural crest. In order to clarify the effect of damage on the development of the neural crest and its relation to the cardiac anomalies, the effects of giving a small dose of bis-diamine were compared with the results of a large dose of bis-diamine. A small dose of bis-diamine (20 mg), therefore, was administered to 40 pregnant rats on the 10th day of pregnancy, and 330 fetal hearts were studied on the 21st day with the rapid whole-body freezing method. Intracardiac anomalies were rare, being found in only 55 fetuses. The anomalies discovered were: aberrant origin of the subclavian artery in 88 fetuses, right aortic arch in 26 fetuses, interruption of the aortic arch in 23 fetuses, and high location of the aortic arch in 8 fetuses. Anomalies of the arterial duct were also common; with a vascular ring formed by the aortic arch and contra-lateral duct being seen in 21 fetuses, isolation of the right subclavian artery associated with either bilateral ducts (9 fetuses) or a right duct and absent left duct (9 fetuses), absent duct with tetralogy of Fallot in 7 fetuses, and with common arterial trunk in one fetus. In conclusion, a small dose of bis-diamine induced extra cardiac anomalies of the aortic arch and arterial duct, indicating a greater susceptibility of the aortic arch and the duct to inappropriate formation of the neural crest cells in the early developing embryo. Clinically, these anomalies of the aortic arch and the duct should be searched for in all patients suspected of having deletion of their 22nd chromosome.

Keywords

DiGeorge syndromeDel 22q 11bis-diaminecongenital anomalyaortic archarterial duct
Type
Original Articles
Information
Cardiology in the Young , Volume 8 , Issue 2 , April 1998 , pp. 172 - 179
Copyright
Copyright © Cambridge University Press 1998

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References

1.Driscoll, D A, Budarf, M L, Emanuel, B S.A genetic etiology for DiGeorge syndrome: Consistent deletions and microdeletions of 22q11. Am J Hum Genet 1992; 50: 924–933.Google Scholar
2.Wilson, D I,Burn, J,Scambler, P, Goodship, J.DiGeorge syndrome: Part of CATCH 22. J Med Genet 1993; 30: 852–856.Google Scholar
3.Driscoll, D A, Spinner, N, Budarf, M L, McDonald-McGinn, D M, Zackai, E H, Goldberg, R B, Shprintzen, R J, Saal, H M, Zonana, J, Jones, M C, Mascarello, J T, Emanuel, B S.Deletions and microdeletions of 22q11.2 in velo-cardio-facial syndrome. Am J Med Genet 1992; 44: 261–268.CrossRefGoogle ScholarPubMed
4.Burn, J,Takao, A,Wilson, D,Cross, I, Momma, K,Wadley, R, Scambler, P, Goodship, J.Conotruncal anomaly face syndrome is associated with a deletion within chromosome 22q11. J Med Genet 1993;30: 822–824.CrossRefGoogle ScholarPubMed
5.Van Microp, L H S, Kutsche, L M.Cardiovascular anomalies in DiGeorge syndrome and importance of neural crest as a possible pathogenetic factor. Am J Cardiol 1986; 58: 133–137.Google Scholar
6.Shprintzen, R J, Goldberg, R B, Young, D, Wolford, L.The velo-cardio-facial syndrome: a clinical and genetic analysis Pediatrics 1981; 67: 167–172.Google Scholar
7.Matsuoka, R,Takao, A, Kimura, M, Imamura, S, Kondo, C, Joho, K, Ikeda, K, Nishibatake, M, Ando, M, Momma, K.Confirmation that the conotruncal anomaly face syndrome is associated with a deletion within 22q11.2. Am J Med Genet 1994; 53: 285–289.CrossRefGoogle ScholarPubMed
8.Taleporos, P, Salgo, M P, Oste, G.Teratogenic action of a bis(dichloroacetyl) diamine on rats:Patterns of malformations produced in high incidence at time-limited period of development. Teratology 1978; 18: 5–16.CrossRefGoogle ScholarPubMed
9.Ikeda, T, Matsuo, T, Kawamoto, K Bis-diamine induced defects of the branchial apparatus in rats, in Nora, J J, Takao, A (eds.): Congenital Heart Disease: Causes and Processes. Futura Publishing Co., Inc, Mt.Kisco, NY. 1984; pp 222–235.Google Scholar
10.Jackson, M, Connell, MG,Smith, A, Drury, J.Anderson, RH.Common arterial trunk and pulmonary atresia:close developmental cousins? Results from a teratogen induced animal model. Cardiovasc Res 1995; 30: 992–1000.CrossRefGoogle ScholarPubMed
11.Momma, K, Ando, M, Takao, A.Fetal cardiac morphology of tetralogy of Fallot with absent pulmonary valve in the rat. Circulation 1990; 82: 1343–1351.Google Scholar
12.Momma, K, Ando, M, Takao, A, Wu, F-F.Fetal cardiovascular cross-sectional morphology of tetralogy of Fallot in rats. Fetal Diag Ther 1990; 5: 196–204CrossRefGoogle ScholarPubMed
13.Momma, K, Ando, M, Takao, A, Miyagawa-Tomita, S.Fetal cardiovascular morphology of truncus arteriosus with or without truncal valve insufficiency in the rat. Circulation 1991; 83: 2094–2100.Google Scholar
14.Momma, K, Ando, M.Fetal cardiovascular morphology of interrupted aortic arch type B in rats. Fetal Diag Ther 1994; 9: 44–52.CrossRefGoogle ScholarPubMed
15.Nishibatake, M, Kirby, M L, Van Mierop, L HS.Pathogenesis of persistent truncus arteriosus and dextroposed aorta in the chick embryo after neural crest ablation. Circulation 1986; 75: 255–264.Google Scholar
16.Wilson, D I, Goodship, J A, Burn, J, Cross, I E, Scambler, P J.Deletions within chromosome 22q11 in familial congenital heart disease. Lancet 1992; 340: 537–539.CrossRefGoogle ScholarPubMed
17.Momma, K, Takao, A, Ito, R.In situ morphology of the heart and great vessels in fetal and neonatal rats. Pediat Res 1987; 22: 573–580.CrossRefGoogle Scholar
18.Momma, K.Ando, M.Fetal in situ cardiovascular and pulmonary morphology of vascular ring due to left aortic arch and right ductus arteriosus in rats. Fetal Diag Ther 1995; 10: 41–47.CrossRefGoogle ScholarPubMed
19.McDonald-McGinn, D M, Driscoll, D A,Bason, L,Christensen, K,Lynch, D, Sullivan, D,Canning, D, Zavod, BJ, Emanuel, B S, Zackai, E H.Autosomal dominant Opitz GBBB syndrome due to a 22q11.2 deletion. Am J Med Genet 1995; 59: 103–113Google Scholar
20.Momma, K,Kondo, C,Matsuoka, R, Takao, A.Cardiac anomalies associated with a chromosome 22q11.2 deletion in patients with conotruncal anomaly face syndrome. Am J Cardiol 1996; 78: 591–594CrossRefGoogle Scholar
21.Momma, K, Kondo, C, Ando, M, Matsuoka, R, Takao, A.Tetralogy of Fallot associated with chromosome 22q11 deletion. Am J Cardiol 1995; 76: 618–621CrossRefGoogle ScholarPubMed
22.Momma, K,Kondo, C, Matsuoka, R.Tetralogy of Fallot with pulmonary atresia associated with chromosome 22q11 deletion. J Am Coll Cardiol 1996; 27: 198–202Google Scholar
22.Kirby, M L, Waldo, K L.Role of neural crest in congenital heart disease. Circulation 1990; 82: 332–340.CrossRefGoogle ScholarPubMed
23.Bockman, D E,Redmond, M E, Kirby, M L.Alteration of early vascular development after ablation of cranial neural crest. Anat Record 1989; 225: 209–217.Google Scholar
24.Choy, M, Oltijen, S, Armstrong, M T, Armstrong, P B.Are atrioventricular septal defects or truncus arteriosus the result of reduced cell proliferation in the cushion tissues ? Circulation 1994; 90:1–246(abstract).Google Scholar
25.Kuratani, S, Bockman, D F.Impaired development of the thymic primordium after neural crest ablation. Anat Record 1990; 228: 185–190CrossRefGoogle ScholarPubMed