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Congenital heart defects in La Réunion Island: a 6-year survey within a EUROCAT-affiliated congenital anomalies registry

Published online by Cambridge University Press:  13 February 2012

Hélène Bourdial ,
Karim Jamal-Bey ,
Abdelhafid Edmar ,
Dominique Caillet ,
Françoise Wuillai ,
Claire Bernede-Bauduin ,
Brahim Boumahni ,
Pierre-Yves Robillard ,
Edouard Kauffmann  and
Annick Laffitte
...Show all authors
Hélène Bourdial
Affiliation:
Neonatal and Paediatric Intensive Care Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Karim Jamal-Bey
Affiliation:
Neonatal and Paediatric Intensive Care Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France Naitre Aujourd'hui Association, Saint-Denis, La Réunion, France Competence Center of Rare Complex Congenital Cardiac Malformations, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Abdelhafid Edmar
Affiliation:
Competence Center of Rare Complex Congenital Cardiac Malformations, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France Department of Pediatrics, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Dominique Caillet
Affiliation:
Competence Center of Rare Complex Congenital Cardiac Malformations, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France Cardiology Unit, Pôle des Spécialités Médicales, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Françoise Wuillai
Affiliation:
Naitre Aujourd'hui Association, Saint-Denis, La Réunion, France
Claire Bernede-Bauduin
Affiliation:
Observatoire Régional de la Santé, Saint-Denis, La Réunion, France
Brahim Boumahni
Affiliation:
Neonatal and Paediatric Intensive Care Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Pierre-Yves Robillard
Affiliation:
Neonatal and Paediatric Intensive Care Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Edouard Kauffmann
Affiliation:
Medical Genetics Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France Department of Obstetrics and Gynecology, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Annick Laffitte
Affiliation:
Medical Genetics Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France Department of Obstetrics and Gynecology, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Yasmina Touret
Affiliation:
Medical Genetics Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France Department of Obstetrics and Gynecology, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Fabrice Cuillier
Affiliation:
Department of Obstetrics and Gynecology, Pôle Femme, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Alain Fourmaintraux
Affiliation:
Neonatal and Paediatric Intensive Care Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France Naitre Aujourd'hui Association, Saint-Denis, La Réunion, France Medical Genetics Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Jean-Luc Alessandri
Affiliation:
Naitre Aujourd'hui Association, Saint-Denis, La Réunion, France Paediatric and Neonatal Intensive Care Unit, Pôle Enfant, Centre Hospitalier Régional, Saint-Denis, La Réunion, France Competence Center of Embryonic Development Abnormalities of Genetic Origin, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Patrick Gérardin*
Affiliation:
Neonatal and Paediatric Intensive Care Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France Naitre Aujourd'hui Association, Saint-Denis, La Réunion, France Centre for Clinical Investigation-Clinical Epidemiology, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
Hanitra Randrianaivo
Affiliation:
Naitre Aujourd'hui Association, Saint-Denis, La Réunion, France Medical Genetics Unit, Pôle Femme-Mère-Enfant, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France Competence Center of Embryonic Development Abnormalities of Genetic Origin, Centre Hospitalier Régional, Saint-Pierre, La Réunion, France
*
Correspondence to: Dr P. Gérardin, Centre Hospitalier Régional Sud, Saint-Pierre 97448, La Réunion, France. Tel: (+262) 2.35.58.21; Fax: 02.62.35.97.11; E-mail: patrick.gerardin@chr-reunion.fr
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Abstract

Objectives

This study compares the prevalence and perinatal mortality of congenital heart defects on La Réunion with European (EUROCAT) standards.

Methods and results

Data were extracted from a EUROCAT-affiliated congenital malformations registry, covering 88,025 births during the period 2002–2007, on the whole island territory. A total of 512 congenital heart defects were registered, including 424 live births, 18 foetal deaths from 16 weeks of gestation, and 70 terminations of pregnancy. The total prevalence of congenital heart defects was 5.8 per 1000 births and live birth prevalence was 4.8 per 1000. The total prevalence of non-chromosomal congenital heart defects was 5.1 per 1000 births, of which 3% were perinatal deaths, 33.3% prenatally diagnosed, and 11.6% termination of pregnancy. Severe non-chromosomal congenital heart defects – excluding ventricular septal defects, atrial septal defects, and pulmonary valve stenosis – occurred in 2.1 per 1000 births, of which 10.3% were perinatal deaths, 59.1% prenatally diagnosed, and 24.3% termination of pregnancy. Of the severe congenital heart defects, the rates of single ventricle (0.20‰), Ebstein anomaly (0.11‰), common arterial trunk (0.25‰), and atrioventricular septal defect (0.62‰) exceeded averages found in Europe, although coarctation of the aorta was infrequent. Conversely, rates of ventricular septal defects, atrial septal defects, and pulmonary valve stenosis were inferior to European standards. Slightly less than half of the congenital heart defects of chromosomal origin were associated with Down syndrome.

Conclusion

In La Réunion, the total prevalence of congenital heart defects is far inferior to that found in Europe. The difference can be attributable to lower prevalences of mild congenital heart defects.

Keywords

Congenital heart diseasemalformationepidemiologyprevalenceneonate
Type
Original Article
Information
Cardiology in the Young , Volume 22 , Issue 5 , 13 September 2012 , pp. 547 - 557
Copyright
Copyright © Cambridge University Press 2012

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Footnotes

*

Contributed equally.

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