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Effect of Yangxin Huoxue Jiedu recipe on inflammatory factors and oxidative stress on viral myocarditis in children

Published online by Cambridge University Press:  12 March 2024

Hengrui Hao ,
Meixia Ji ,
Kuilong Zhou ,
Yunxia Zhang ,
Gaoyin Zhang  and
Lianying Ruan Open the ORCID record for Lianying Ruan [Opens in a new window]
Hengrui Hao
Affiliation:
Department of Pediatrics, Xingtai People’s Hospital, Hebei, China
Meixia Ji
Affiliation:
Department of Ultrasound, Xingtai People’s Hospital, Hebei, China
Kuilong Zhou
Affiliation:
Department of Internal Medicine, Xingtai People’s Hospital, Hebei, China
Yunxia Zhang
Affiliation:
Department of Pediatrics, Xingtai People’s Hospital, Hebei, China
Gaoyin Zhang
Affiliation:
Department of Pediatrics, Xingtai People’s Hospital, Hebei, China
Lianying Ruan*
Affiliation:
Pediatric Intensive Care Unit, Xingtai People’s Hospital, Hebei, China
*
Corresponding author: L. Ruan; Email: ruanlianyingpicu@163.com
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Abstract

Objective:

This observation purposed to investigate the effect of the Yangxin Huoxue Jiedu formula on children with viral myocarditis and its effect on inflammatory factors and oxidative response.

Materials and methods:

A total of 121 children with viral myocarditis were randomly divided into two groups, namely the control group (N = 60) and the traditional Chinese medicine group (N = 61). The control group was mainly treated with routine therapy, while the traditional Chinese medicine group was treated with Yangxin Huoxue Jiedu recipes based on the control group. The creatine kinase, creatine kinase myocardial isoenzyme, aspartate aminotransferase, lactic dehydrogenase, hydroxybutyrate dehydrogenase, cardiac troponin I, brain natriuretic peptide, interleukin-6, interleukin-8, and tumour necrosis factor-alpha, superoxide dismutase and malondialdehyde in viral myocarditis patients were tested to estimate the myocardial function, inflammation, and oxidative situation.

Results:

After Yangxin Huoxue Jiedu treatment, 15 cases were recovered, 20 were excellent, and 21 were effective, which had a significant difference from the control group. The concentration of creatine kinase, creatine kinase myocardial isoenzyme, aspartate aminotransferase, lactic dehydrogenase, hydroxybutyrate dehydrogenase, cardiac troponin I and brain natriuretic peptide was decreased in the traditional Chinese medicine group. The levels of interleukin-6, interleukin-8, and tumour necrosis factor-alpha in the traditional Chinese medicine group were significantly lower than those in the control group. Superoxide dismutase was higher and malondialdehyde was lower than those in the control group.

Conclusion:

The use of Yangxin Huoxue Jiedu in the treatment of viral myocarditis has a definite clinical effect, which could improve myocardial function, reduce body inflammation, and promote oxidative recovery.

Keywords

Traditional Chinese medicineviral myocarditisinflammationoxidative stressefficacy
Type
Original Article
Information
Cardiology in the Young , First View , pp. 1 - 8
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Copyright
© The Author(s), 2024. Published by Cambridge University Press

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