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Emerging trends in the prenatal diagnosis of complex CHD and its influence on infant mortality in this cohort

Published online by Cambridge University Press:  26 December 2018

Sudheer R. Gorla ,
Abhishek Chakraborty ,
Ashish Garg ,
Rubee A. Gugol ,
Richard E. Kardon  and
Sethuraman Swaminathan Open the ORCID record for Sethuraman Swaminathan [Opens in a new window]
Sudheer R. Gorla
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Jackson Memorial Hospital/University of Miami Miller School of Medicine, Miami, FL, USA
Abhishek Chakraborty
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Jackson Memorial Hospital/University of Miami Miller School of Medicine, Miami, FL, USA
Ashish Garg
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Jackson Memorial Hospital/University of Miami Miller School of Medicine, Miami, FL, USA
Rubee A. Gugol
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Jackson Memorial Hospital/University of Miami Miller School of Medicine, Miami, FL, USA
Richard E. Kardon
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Jackson Memorial Hospital/University of Miami Miller School of Medicine, Miami, FL, USA
Sethuraman Swaminathan*
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Jackson Memorial Hospital/University of Miami Miller School of Medicine, Miami, FL, USA
*
Author for correspondence: Sethuraman Swaminathan, MD, 1611 NW 12th Avenue, NW Room 109 Miami, FL 33136, USA. Tel: 305-585-6683; Fax: 305-324-6012; E-mail: swami@miami.edu
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Abstract

Background

Fetal echocardiography is the main modality of prenatal diagnosis of CHD. This study was done to describe the trends and benefits associated with prenatal diagnosis of complex CHD at a tertiary care centre.

Methods

Retrospective chart review of patients with complex CHD over an 18-year period was performed. Rates of prenatal detection along with early and late infant mortality outcomes were studied.

Results

Of 381 complex CHD patients born during the study period, 68.8% were diagnosed prenatally. Prenatal detection rate increased during the study period from low-50s in the first quarter to mid-80s in the last quarter (p=0.001). Rate of detection of conotruncal anomalies increased over the study period. No infant mortality benefit was noted with prenatal detection.

Conclusions

Improved obstetrical screening indications and techniques have contributed to higher proportions of prenatal diagnosis of complex CHD. However, prenatal diagnosis did not confer survival benefits in infancy in our study.

Keywords

Prenatal diagnosiscomplex CHDinfant mortalityfetal echocardiography
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 3 , March 2019 , pp. 270 - 276
Copyright
© Cambridge University Press 2018. 

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Footnotes

Cite this article: Gorla SR, Chakraborty A, Garg A, Gugol RA, Kardon RE, Swaminathan S. (2019) Emerging trends in the prenatal diagnosis of complex CHD and its influence on infant mortality in this cohort. Cardiology in the Young29: 270–276. doi: 10.1017/S1047951118002147

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