Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 3
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Nelson, Timothy and Cantero Peral, Susana 2016. Stem Cell Therapy and Congenital Heart Disease. Journal of Cardiovascular Development and Disease, Vol. 3, Issue. 3, p. 24.

    Nesteruk, Julia Duckers, Hendrikus J. Strauer, Bodo E. and Steinhoff, Gustav 2016. Regenerative Medicine - from Protocol to Patient.

    Selem, Sarah M. Kaushal, Sunjay and Hare, Joshua M. 2013. Stem Cell Therapy for Pediatric Dilated Cardiomyopathy. Current Cardiology Reports, Vol. 15, Issue. 6,


Intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill child with dilated cardiomyopathy

  • Aris Lacis (a1) and Andrejs Erglis (a2)
  • DOI:
  • Published online: 27 October 2010

Almost half of the children with symptomatic dilated cardiomyopathy receive a transplant or die within 2 years; however, cardiac stem cell transplantation has become a promising therapeutic option. The present case demonstrates for the first time, to our knowledge, the intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill 4-month-old child with severe dilated cardiomyopathy. Left ventricular ejection fraction increased from 20% before stem cell transplantation to 41% at 4 months of follow-up.

Corresponding author
Correspondence to: Prof. A. Erglis, MD, PhD, Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Pilsonu 13, LV-1002, Riga, Latvia. Tel: +371 67069379; Fax: +371 67069548; E-mail:
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1.MM Boucek , LB Edwards , BM Keck , The registry of the international society for heart and lung transplantation: fifth official pediatric report, 2001 to 2002. J Heart Lung Transplant 2002; 21: 827840.

2.A Matitiau , A Perez-Atayde , SP Sanders , Infantile dilated cardiomyopathy: relation to outcome to left ventricular mechanics, hemodynamics, and histology at the time of presentation. Circulation 1994; 90: 13101318.

3.CP Taliercio , JB Seward , DJ Driscoll , LD Fischer , BJ Gersh , AJ Tajik . Idiopathic dilated cardiomyopathy in the young: clinical profile and natural history. J Am Coll Cradiol 1985; 6: 11261131.

4.B Assmus , J Honold , V Schachinger , Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006; 335: 12221232.

5.V Schachinger , S Erbs , A Elsasserv , Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med 2006; 355: 12101221.

6.S Rupp , J Bauer , T Tonn , Intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with dilated cardiomyopathy. Pediatr Transplant 2009; 13: 620623.

7.EC Perin , HF Dohmann , R Borojevic , Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003; 107: 22942302.

8.R Lange , M Vogt , J Horer , Long-term results of repair of anomalous origin of the left coronary artery from the pulmonary artery. Ann Thorac Surg 2007; 83: 14631471.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Cardiology in the Young
  • ISSN: 1047-9511
  • EISSN: 1467-1107
  • URL: /core/journals/cardiology-in-the-young
Please enter your name
Please enter a valid email address
Who would you like to send this to? *