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QT dispersion and cardiac involvement in children with Familial Mediterranean fever

Published online by Cambridge University Press:  09 November 2011

Bülent Koca ,
Özgür Kasapçopur ,
Süleyman Bakari ,
Emine Sönmez ,
Funda Öztunç ,
Ayşe Güler Eroğlu ,
Levent Saltik  and
Özden Calay
Bülent Koca*
Affiliation:
Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Özgür Kasapçopur
Affiliation:
Department of Pediatric Rheumatology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Süleyman Bakari
Affiliation:
Department of Pediatric Cardiology, Vivo Medical Center, Istanbul, Turkey
Emine Sönmez
Affiliation:
Department of Pediatrics, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Funda Öztunç
Affiliation:
Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Ayşe Güler Eroğlu
Affiliation:
Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Levent Saltik
Affiliation:
Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Özden Calay
Affiliation:
Department of Biostatistics, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
*
Correspondence to: Dr B. Koca, MD, Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Tel: +90 212 4143000; Fax: +90 212 632 86 33; E-mail: bkoca78@yahoo.com
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Abstract

Familial Mediterranean fever is a hereditary disease characterised by recurrent and self-terminated attacks of fever and polyserositis. An earlier study found that adult patients of Familial Mediterranean fever had an abnormally longer QT dispersion and corrected QT dispersion, markers for ventricular arrhythmogenicity. QT dispersion is a simple non-invasive arrhythmogenic marker that can be used to assess homogeneity of cardiac repolarisation; however, it has not been studied in children with Familial Mediterranean fever before. The aim of this study was to assess QT dispersion and corrected QT dispersion, and their relationship with systolic and diastolic function of the left ventricle in a group of children with Familial Mediterranean fever. We performed electrocardiography and Doppler echocardiography on patients and controls. Maximum QT, minimum QT, QT dispersion, corrected QT, maximum corrected QT, minimum corrected QT, and corrected QT dispersion intervals were measured from standard 12-lead electrocardiography. No statistically significant differences were found between the groups in QT dispersion, corrected QT dispersion, and systolic–diastolic function of the left ventricle parameters. During the 12 months of follow-up, no ventricular arrhythmias were documented in either group.

Keywords

Familial Mediterranean feverQT dispersionelectrocardiographyarrhythmiaechocardiographydiastolic dysfunction
Type
Original Article
Information
Cardiology in the Young , Volume 22 , Issue 4 , August 2012 , pp. 404 - 409
Copyright
Copyright © Cambridge University Press 2012

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