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Sacubitril/Valsartan: potential treatment for paediatric heart failure

Published online by Cambridge University Press:  06 July 2018

Bibhuti B. Das Open the ORCID record for Bibhuti B. Das [Opens in a new window] ,
Frank Scholl ,
Breanna Vandale  and
Maryanne Chrisant
Bibhuti B. Das*
Affiliation:
Joe DiMaggio Children’s Hospital Heart Institute, Memorial Health Care, Hollywood, FL, USA
Frank Scholl
Affiliation:
Joe DiMaggio Children’s Hospital Heart Institute, Memorial Health Care, Hollywood, FL, USA
Breanna Vandale
Affiliation:
Joe DiMaggio Children’s Hospital Heart Institute, Memorial Health Care, Hollywood, FL, USA
Maryanne Chrisant
Affiliation:
Joe DiMaggio Children’s Hospital Heart Institute, Memorial Health Care, Hollywood, FL, USA
*
Author for correspondence: B. B. Das, MD, FAAP, FACC, Joe DiMaggio Children’s Hospital Heart Institute, Memorial Health Care, 1150 North 35 Avenue, Hollywood, FL 33021, USA. E-mail: bdas@mhs.net
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Abstract

The Prospective comparison of angiotensin receptor antagonist Valsartan and neprilysin inhibitor Sacubitril with angiotensin-converting enzyme inhibitor (enalapril) to determine impact on Global Mortality and Morbidity in Heart Failure trial has demonstrated that Sacubitril/Valsartan is superior to Enalapril in reducing the risks of both sudden cardiac death and death from worsening heart failure. This novel combination, Sacubitril/Valsartan, is also shown to reduce the risk of hospitalisation and progression of heart failure in adults. However, the benefit of Sacubitril/Valsartan in paediatric heart failure patients is unknown. In this review, we discuss the similarities and differences in pathophysiology of heart failure in children versus adults, and the potential role of Sacubitril/Valsartan in paediatric heart failure patients.

Keywords

Paediatric heart failureangiotensin receptor blockerneprilysin inhibitor
Type
Review Article
Information
Cardiology in the Young , Volume 28 , Issue 9 , September 2018 , pp. 1077 - 1081
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Copyright
© Cambridge University Press 2018 

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Footnotes

Cite this article: Das BB, Scholl F, Vandale B, Chrisant M. (2018) Sacubitril/Valsartan: potential treatment for paediatric heart failure. Cardiology in the Young28: 1077–1081. doi: 10.1017/S104795111800080X

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