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Oral Antipsychotic Update: A Brief Review of New and Investigational Agents for the Treatment of Schizophrenia

Published online by Cambridge University Press:  10 December 2012

Leslie Citrome
Leslie Citrome*
Affiliation:
Clinical Professor of Psychiatry & Behavioral Sciences, New York Medical College, Valhalla, NY
*
Address correspondence to: Leslie Citrome, 11 Medical Park Drive, Suite 106, Pomona, NY 10970, USA. (Email nntman@gmail.com)
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Abstract

This narrative review provides an overview of the three new oral second-generation antipsychotics that have become available in the US: iloperidone, asenapine and lurasidone. Although they are associated with less weight gain and fewer metabolic abnormalities than some of the older second-generation antipsychotics, iloperidone, asenapine and lurasidone have differences that make them unique from each other. Examples of these differences include dosing frequency, specific instructions on dosing with food, titration requirements, and potential association with sedation, extrapyramidal side effects, akathisia, and prolongation of the ECG QT interval. Additional information is provided regarding agents in late stage clinical development for the treatment of schizophrenia: cariprazine and brexpiprazole (both are dopamine D2 receptor partial agonists) and bitopertin (a glycine transport inhibitor that may have antipsychotic effects).

Keywords

antipsychoticasenapinebitopertinbrexpiprazolecariprazineiloperidonelurasidoneschizophrenia
Type
CME Article
Information
CNS Spectrums , Volume 17 , Issue s1: CME SUPPLEMENT: Optimizing Care for Patients with Schizophrenia , November 2012 , pp. 1 - 9
Copyright
Copyright © Cambridge University Press 2012

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