College students often experience mental anxiety due to academic pressure, employment pressure, and environmental pressure. Conventional drug therapy can easily develop resistance under sustained action. Therefore, research has combined cognitive behavioral therapy with university student management strategies to treat college students’ mental anxiety through a combination approach.

A total of 120 students with mental anxiety disorder in their third and fourth years of a certain major in a certain university were selected as the research subjects. According to different treatment methods, the two groups of student patients were divided into Group E and Group F. Group E used traditional treatment methods, while Group F used a combination of cognitive behavioral therapy and university student management strategies. After treatment, Hamilton’s anxiety of 200 hours was used to quantify the mental state of students, and SPSS 21.0 statistical software was used for data analysis.

The overall effective rate of treatment in Group F was as high as 96.15%, higher than 76.92% in Group E; After treatment, the Hamilton score of Group F was 13.21 ± 2.07, which was lower than the 27.18 ± 4.62 score before treatment, and also significantly lower than the 19.28 ± 3.49 score of Group E. Meanwhile, the incidence of adverse reactions in Group F after treatment was 1.15%, lower than Group E’s 6.58%.

The combination of cognitive behavioral therapy and university student management strategies is effective in treating students’ mental anxiety disorder.