Abdel-Moein, Khaled A. and Hamza, Dalia A. 2016. Occurrence of human pathogenicClostridium botulinumamong healthy dairy animals: an emerging public health hazard. Pathogens and Global Health, Vol. 110, Issue. 1, p. 25.
Babrak, Lmar Lin, Alice Stanker, Larry McGarvey, Jeffery and Hnasko, Robert 2016. Rapid Microfluidic Assay for the Detection of Botulinum Neurotoxin in Animal Sera. Toxins, Vol. 8, Issue. 1, p. 13.
Benditt, Joshua O. and McCool, F. Dennis 2016. Murray and Nadel's Textbook of Respiratory Medicine.
Harris, A. 2016. Encyclopedia of Food and Health.
Hyun, Sang Hwa Park, Dae Keun Kang, Aeyeon Kim, Soohyun Kim, Daehee Shin, Yu Mi Song, Ji-Joon and Yun, Wan Soo 2016. Label-free electrochemical detection of botulinum neurotoxin type E based on its enzymatic activity using interdigitated electrodes. Applied Physics Letters, Vol. 108, Issue. 9, p. 093101.
Kuhn, Philipp Fühner, Viola Unkauf, Tobias Moreira, Gustavo Marcal Schmidt Garcia Frenzel, André Miethe, Sebastian and Hust, Michael 2016. Recombinant antibodies for diagnostics and therapy against pathogens and toxins generated by phage display. PROTEOMICS - Clinical Applications, Vol. 10, Issue. 9-10, p. 922.
Proverbio, Maria Renata Lamba, Marta Rossi, Alessandro and Siani, Paolo 2016. Early diagnosis and treatment in a child with foodborne botulism. Anaerobe, Vol. 39, p. 189.
Sandrock, Christian 2016. Murray and Nadel's Textbook of Respiratory Medicine.
Wan, M.L.Y. Shah, N.P. and El-Nezami, H.I. 2016. Microbial Toxins in Dairy Products.
Diamant, Eran Torgeman, Amram Ozeri, Eyal and Zichel, Ran 2015. Monoclonal Antibody Combinations that Present Synergistic Neutralizing Activity: A Platform for Next-Generation Anti-Toxin Drugs. Toxins, Vol. 7, Issue. 6, p. 1854.
El-Masry, Eman M. and Abou-Donia, Mohamed B. 2015. Mammalian Toxicology.
Feng, Ling Chen, Xueping Liu, Shujie Zhou, Zengrong and Yang, Rong 2015. Two-family outbreak of botulism associated with the consumption of smoked ribs in Sichuan Province, China. International Journal of Infectious Diseases, Vol. 30, p. 74.
Hammer, Tóra Hedinsdottir Jespersen, Sanne Kanstrup, Jakob Ballegaard, Vibe Cecilie Kjerulf, Anne and Gelvan, Allan 2015. Fatal outbreak of botulism in Greenland. Infectious Diseases, Vol. 47, Issue. 3, p. 190.
Liu, Bo Shi, DanYang Chang, ShaoHong Gong, Xin Yu, YunZhou Sun, ZhiWei and Wu, Jun 2015. Characterization and immunological activity of different forms of recombinant secreted Hc of botulinum neurotoxin serotype B products expressed in yeast. Scientific Reports, Vol. 5, p. 7678.
Rosen, Osnat Feldberg, Liron Gura, Sigalit Brosh-Nissimov, Tal Guri, Alex Zimhony, Oren Shapiro, Eli Beth-Din, Adi Stein, Dana Ozeri, Eyal Barnea, Ada Turgeman, Amram Ben David, Alon Schwartz, Arieh Elhanany, Eytan Diamant, Eran Yitzhaki, Shmuel and Zichel, Ran 2015. Early, Real-Time Medical Diagnosis of Botulism by Endopeptidase-Mass Spectrometry. Clinical Infectious Diseases, Vol. 61, Issue. 12, p. e58.
Wang, Yong Montana, Vedrana Grubišić, Vladimir Stout, Randy F. Parpura, Vladimir and Gu, Li-Qun 2015. Nanopore Sensing of Botulinum Toxin Type B by Discriminating an Enzymatically Cleaved Peptide from a Synaptic Protein Synaptobrevin 2 Derivative. ACS Applied Materials & Interfaces, Vol. 7, Issue. 1, p. 184.
Yu, YunZhou Shi, DanYang Liu, Si Gong, Zheng-Wei Wang, Shuang and Sun, ZhiWei 2015. Production and evaluation of a recombinant subunit vaccine against botulinum neurotoxin serotype B using a 293E expression system. Human Vaccines & Immunotherapeutics, Vol. 11, Issue. 2, p. 468.
2015. Practical Medical Microbiology for Clinicians.
Anniballi, Fabrizio Lonati, Davide Fiore, Alfonsina Auricchio, Bruna De Medici, Dario and Locatelli, Carlo Alessandro 2014. New targets in the search for preventive and therapeutic agents for botulism. Expert Review of Anti-infective Therapy, Vol. 12, Issue. 9, p. 1075.
Baskaran, Padmamalini and Thyagarajan, Baskaran 2014. Acute and chronic effects of botulinum neurotoxin a on the mammalian neuromuscular junction. Muscle & Nerve, Vol. 50, Issue. 2, p. 206.
Botulism is a neuroparalytic disease caused by neurotoxins produced by the bacteria Clostridium botulinum. Botulinum neurotoxins (BoNTs) are among the most potent naturally occurring toxins and are a category A biological threat agent. The 7 toxin serotypes of BoNTs (serotypes A–G) have different toxicities, act through 3 different intracellular protein targets, and exhibit different durations of effect. Botulism may follow ingestion of food contaminated with BoNT, from toxin production of C botulinum present in the intestine or wounds, or from inhalation of aerosolized toxin. Intoxication classically presents as an acute, symmetrical, descending flaccid paralysis. Early diagnosis is important because antitoxin therapy is most effective when administered early. Confirmatory testing of botulism with BoNT assays or C botulinum cultures is time-consuming, and may be insensitive in the diagnosis of inhalational botulism and in as many as 32% of food-borne botulism cases. Therefore, the decision to initiate botulinum antitoxin therapy is primarily based on symptoms and physical examination findings that are consistent with botulism, with support of epidemiological history and electrophysiological testing. Modern clinical practice and antitoxin treatment has reduced botulism mortality rates from ∼60% to ≤10%. The pentavalent botulinum toxoid is an investigational product and has been used for more than 45 years in at-risk laboratory workers to protect against toxin serotypes A to E. Due to declining immunogenicity and potency of the pentavalent botulinum toxoid, novel vaccine candidates are being developed. (Disaster Med Public Health Preparedness. 2007;1:122–134)
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