Public and regulatory agency scrutiny of large-scale infrastructure projects has grown in recent years. There is national attention on the issues of urban expansion and the preservation of open space and fragile ecosystems. This has made the substantive assessment of indirect impacts and cumulative effects an increasingly important component of environmental studies conducted under the auspices of the National Environmental Policy Act (NEPA). This article describes the NEPA assessment of indirect impacts and cumulative effects as conducted for the proposed Ohio River Bridges Project in the Louisville, Kentucky, metropolitan area. The project's size and complexity required the detailed study of many NEPA environmental issues. These issues included the range of alternatives to meet varied transportation needs, land use and community impacts, environmental justice concerns, aesthetics, potential effects on National Register historic properties and districts, water quality, wetlands, and threatened and endangered species, among others. The project captured the interest of local and regional residents, business and property owners, civic leaders, local interest groups, and national environmental organizations. In this article, three objectives are accomplished. First, the article presents an overview of indirect and cumulative effects analysis and the mandate to do them. Second, the article presents a seven-step assessment process for indirect impacts and cumulative effects. This method is adapted from Council on Environmental Quality (CEQ) guidance that identifies resources affected, other major actions, geographic limits and time frames for analysis, and the methods, tools, and techniques used to analyze each resource. And third, the article presents some of the results or specific outputs of the indirect and cumulative effects analysis (ICEA) for this important project and briefly discusses potential mitigation options that have been considered.