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Antibody responses and resistance to challenge in volunteers vaccinated with live attenuated, detergent split and oil adjuvant A2/Hong Kong/68 (H3N2) influenza vaccines* A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines

Published online by Cambridge University Press:  19 October 2009

D. S. Freestone ,
Stephanie Hamilton-Smith ,
G. C. Schild ,
Rosemary Buckland ,
Susan Chinn  and
D. A. J. Tyrrell
D. S. Freestone
Affiliation:
Wellcome Research Laboratories, BeckenhamKent
Stephanie Hamilton-Smith
Affiliation:
Wellcome Research Laboratories, BeckenhamKent
G. C. Schild
Affiliation:
National Institute for Medical Research, London, N.W. 7
Rosemary Buckland
Affiliation:
Clinical Research Centre, Harrow, Middlesex
Susan Chinn
Affiliation:
Clinical Research Centre, Harrow, Middlesex
D. A. J. Tyrrell
Affiliation:
Clinical Research Centre, Harrow, Middlesex
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Summary

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Forty-nine subjects were vaccinated with either live attenuated, detergent split, or oil adjuvant A2/Hong Kong influenza vaccines, or a saline influenza B vaccine as control. Respiratory symptoms occurred more frequently in subjects who received the live vaccine but in total there was little difference between the symptoms in the four groups. Antibody titres hi nasal washings and serum were measured by haemagglutination inhibition, neuraminidase inhibition and virus neutralization tests. The oil adjuvant vaccine stimulated larger antibody responses than the other procedures. Six weeks after vaccination the volunteers were challenged with partially attenuated live A2/Hong Kong influenza virus administered intranasally. The live attenuated and oil adjuvant vaccines provided the best protection against challenge.

Type
Research Article
Information
Journal of Hygiene , Volume 70 , Issue 3 , September 1972 , pp. 531 - 543
Copyright
Copyright © Cambridge University Press 1972

References

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