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Diversity and composition of dengue virus type 2 in Venezuela

  • E. HUHTAMO (a1), G. COMACH (a2), G. SIERRA (a2), D. E. CAMACHO (a2), T. SIRONEN (a1), O. VAPALAHTI (a1) (a3) (a4) and N. Y. UZCÁTEGUI (a1)...

Summary

Dengue is a mosquito-borne disease caused by four closely related dengue virus (genus Flavivirus) serotypes (DENV-1–4). The clinical outcomes vary from mild febrile illness to life-threatening haemorrhagic manifestations. DENVs are endemic in the tropics and subtropics globally and currently no specific treatment or vaccines are available. In Venezuela, the American-Asian genotype of DENV-2 is the most prevalent and has been associated with severe disease outcomes. We aimed to follow-up the molecular epidemiology of DENV-2 in Venezuela to investigate if the evolution of the virus has remained the same throughout time or if the same dynamics documented in Brazil (hyperendemic co-circulation) also occurred. The results show that whereas the epidemiology of DENV in several endemic areas is characterized by serotype replacements through time, in Venezuela the American-Asian genotype DENV-2 has evolved into several genetic lineages and has remained in hyperendemic co-circulation with the other serotypes.

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Copyright

Corresponding author

*Address for correspondence: Dr N. Y. Uzcategui, Department of Clinical Microbiology, Entrance 78, Malmö University Hospital, Lund University, SE-20502 Malmö, Sweden. (Email: nuzcateg@hotmail.com)

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Epidemiology & Infection
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