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Enteroaggregative Escherichia coli associated with an outbreak of diarrhoea in a neonatal nursery ward

  • M. Čobeljić (a1), B. Miljković-Selimović (a2), D. Paunović-Todosijević (a2), Z. Veličković (a2), Z. Lepšanović (a1), N. Zec (a1), D. Savić (a3), R. Ilić (a3), S. Konstantinović (a3), B. Jovanović (a3) and V. Kostić (a3)...

Over a 9-day period in February 1995, 16 newborn babies (age range 2–11 days) and 3 infants (24, 47 and 180 days of age) in a neonatal nursery ward developed diarrhoea accompanied by pyrexia and weight loss. Known enteropathogens were not detected in their stools but Escherichia coli displaying aggregative adherence to HEp-2 cells (enteroaggregative E. coli) were found in 12 (63%) ill infants and in none of 5 well neonates (P = 0·02). The illness lasted 3–9 days (mean 5·2) in 16 babies, whereas in 3 neonates it showed a protracted course of 18–20 days. The source of infection and the mode of transmission remained unclear. The outbreak isolates manifested properties common in this new group of diarrhoeagenic E. coli: mannose-resistant haemagglutination, haemolysis on blood agar, and clump formation in liquid culture medium. They belonged to the O4 E. coli serogroup and expressed multiple antibiotic resistance.

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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
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