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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Gilsdorf, Janet R. 2015. What the pediatrician should know about non-typeable Haemophilus influenzae. Journal of Infection, Vol. 71, p. S10.


    Van Eldere, Johan Slack, Mary P E Ladhani, Shamez and Cripps, Allan W 2014. Non-typeable Haemophilus influenzae, an under-recognised pathogen. The Lancet Infectious Diseases, Vol. 14, Issue. 12, p. 1281.


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High prevalence of nasal carriage of β-lactamase-negative ampicillin-resistant Haemophilus influenzae in healthy children in Korea

  • S. M. BAE (a1), J. H. LEE (a1), S. K. LEE (a1), J. Y. YU (a1), S. H. LEE (a2) and Y. H. KANG (a1)
  • DOI: http://dx.doi.org/10.1017/S0950268812001082
  • Published online: 30 May 2012
Abstract
SUMMARY

This study investigated the carriage of antimicrobial resistant Haemophilus influenzae in 582 healthy children attending kindergarten or elementary school at four intervals over a 9-month period in Seoul, Korea. Diverse colonization patterns and a lower level of long-term persistent carriage by H. influenzae status were evident in this study. Colonizing H. influenzae isolates showed a high rate of resistance to β-lactams including ampicillin (51·9%), cefaclor (52·1%), and amoxicillin/clavulanate (16·3%). Based on the ampicillin resistance mechanism, H. influenzae isolates were categorized as β-lactamase-negative, ampicillin-susceptible (BLNAS) (48·1%), β-lactamase-positive, ampicillin-resistant (BLPAR) (22·6%), β-lactamase-negative, ampicillin-resistant (BLNAR) (22·8%), and β-lactamase-positive, amoxicillin/clavulanate-resistant (BLPACR) strains (6·5%). This study provides the first evidence of a high prevalence (22·8%) of BLNAR strains of H. influenzae nasal carriage in healthy children attending kindergarten or the first 2 years of elementary school in Korea. The high carriage of these resistant strains in overcrowded urban settings may create reservoirs for development of H. influenzae-resistant strains.

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Corresponding author
*Author for correspondence: Y. H. Kang, Director, Division of Bacterial Respiratory Infections, Center for Infectious Diseases, National Institute of Health, Korea Centers for Disease Control and Prevention, Osong Health Technology Administration Complex, 643, Yeonje-ri, Gangoe-myeon, Cheongwon-gun, Chungcheongbuk-do, 363-951, Korea. (Email: slowpc@hanmail.net)
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Epidemiology & Infection
  • ISSN: 0950-2688
  • EISSN: 1469-4409
  • URL: /core/journals/epidemiology-and-infection
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