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Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2)

Published online by Cambridge University Press:  15 May 2009

H. E. Larson ,
D. A. J. Tyrrell ,
C. H. Bowker ,
C. W. potter  and
G. C. Schild
H. E. Larson
Affiliation:
Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
D. A. J. Tyrrell
Affiliation:
Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
C. H. Bowker
Affiliation:
Wellcome foundation Ltd, Ravens Lane, Brekhamsted, Herts HP4 2DY
C. W. potter
Affiliation:
Department of Virology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX
G. C. Schild
Affiliation:
National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB
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Volunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong/8/73. Preliminary experiments showed that the 30c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the ‘current’ 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but the vaccine prepared from the current strain gave more.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 2 , April 1978 , pp. 243 - 248
Copyright
Copyright © Cambridge University Press 1978

References

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