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Isolation of a variant strain of foot-and-mouth disease virus (type O) during passage in partly immunized cattle

Published online by Cambridge University Press:  15 May 2009

R. H. Fagg  and
N. ST G. Hyslop
R. H. Fagg
Affiliation:
The Animal Virus Research Institute, Pirbright, Woking, Surrey
N. ST G. Hyslop
Affiliation:
The Animal Virus Research Institute, Pirbright, Woking, Surrey
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Foot-and-mouth disease virus of type O (strain Israel 1/63) was passaged serially fourteen times in cattle previously vaccinated with increasing doses of formol-treated vaccine of the homologous strain. Primary and secondary lesions developed in the majority of the animals. Virus from the 14th passage, which proved to be capable of reinfecting animals only 34 and 35 days after infection with the original strain, differed from the original strain in complement-fixing properties and in sensitivity to antiserum. These changes were of a degree indicative of subtype variation.

Virus titres in the saliva, in the tongue vesicles and in the foot vesicles of partly resistant cattle were very great and would have constituted a danger to other stock under field conditions.

The experimental data confirm previous observations on the infection of partly resistant cattle and on the isolation of variant strains during passage of FMD virus in tissue cultures containing specific antiserum.

Type
Research Article
Information
Journal of Hygiene , Volume 64 , Issue 4 , December 1966 , pp. 397 - 404
Copyright
Copyright © Cambridge University Press 1966

References

REFERENCES

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