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Strain specificity of serum antibody to the haemagglutinin of influenza A (H3N2) viruses in children following immunization or natural infection

Published online by Cambridge University Press:  25 March 2010

J. S. Oxford ,
L. R. Haaheim ,
A. Slepushkin ,
J. Werner ,
E. Kuwert  and
G. C. Schild
J. S. Oxford
Affiliation:
Division of Virology, National Institute for Biological Standards and Control, Holly Hill, London NW3 6RB
L. R. Haaheim
Affiliation:
National Institute of Public Health, Oslo, Norway
A. Slepushkin
Affiliation:
Ivanovsky Institute of Virology, U. Gamalei 16, Moscow 123098, U.S.S.R.
J. Werner
Affiliation:
Institute of Medical Virology and Immunology, University of Essen, Essen 1, Germany
E. Kuwert
Affiliation:
Institute of Medical Virology and Immunology, University of Essen, Essen 1, Germany
G. C. Schild
Affiliation:
Division of Virology, National Institute for Biological Standards and Control, Holly Hill, London NW3 6RB
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The specificity of serum anti-HA antibody from children immunized or infected with A/Victoria/75 (H3N2) or A/Texas/77 (H3N2) virus was examined using the single radial haemolysis test together with adsorption of antibody with three antigenic variants A/Hong Kong/68 (H3N2), A/Port Chalmers/73 (H3N2) and A/Victoria/75 (H3N2). The majority of young children reacted to vaccination or infection by producing strain-specific (SS) antibody to the homologous virus. A small proportion of children's sera contained cross-reacting (CR) antibodies capable of reacting with the haemagglutinins of all antigenic variants of the subtype including A/HK/1/68. In contrast, most adults reacted immunologically to either vaccination or infection by producing CR antibody, reacting with all variants of the antigenic subtype including the prototype virus A/HK/1/68 (H3N2).

Type
Research Article
Information
Journal of Hygiene , Volume 86 , Issue 1 , February 1981 , pp. 17 - 26
Copyright
Copyright © Cambridge University Press 1981

References

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