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Type-specific action of vibriocidal antibody on Vibrio cholerae

Published online by Cambridge University Press:  15 May 2009

Angela H. Pykett  and
N. W. Preston
Angela H. Pykett
Affiliation:
Department of Bacteriology and Virology, University of Manchester, Manchester M13 9PT
N. W. Preston
Affiliation:
Department of Bacteriology and Virology, University of Manchester, Manchester M13 9PT
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Summary

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The vibriocidal activity of Inaba and Ogawa antisera, from which cross-reacting agglutinin had been absorbed, was specific for Vibrio cholerae strains of the homologous serotype. No vibriocidal action against strains of the heterologous type was detected.

The sera appeared to be equally effective in killing organisms of different biotypes (classical, intermediate, and EITor), provided that these were of the homologous serotype (Inaba or Ogawa). However, they had been raised against strains of the classical biotype only; and sera resulting from immunization with other biotypes had not been prepared.

The implications of these findings in immunity to cholera are discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 75 , Issue 3 , December 1975 , pp. 399 - 406
Copyright
Copyright © Cambridge University Press 1975

References

REFERENCES

Adibfar, P. & Preston, N. W. (1974). Some factors affecting the haemolytic activity of Vibrio cholerae. Journal of Medical Microbiology 7, 521.CrossRefGoogle ScholarPubMed
Barritt, M. M. (1936). The intensification of the Voges–Proskauer reaction by the addition of α-naphthol. Journal of Pathology and Bacteriology 42, 441.CrossRefGoogle Scholar
Benenson, A. S., Saad, A. & Mosley, W. H. (1968). Serological studies in cholera: the vibriocidal antibody response of cholera patients determined by a microtechnique. Bulletin of the World Health Organization 38, 277.Google ScholarPubMed
Finkelstein, R. A. (1962). Vibriocidal antibody inhibition analysis: a technique for the identification of the predominant vibriocidal antibodies in serum and for the detection and identification of Vibrio cholerae antigens. Journal of Immunology 89, 264.CrossRefGoogle Scholar
Gangarosa, E. J., Sanati, A., Saghari, H. & Feeley, J. C. (1967). Multiple serotypes of Vibrio cholerae isolated from a case of cholera: evidence suggesting in-vivo mutation. Lancet i, 646.CrossRefGoogle Scholar
Greig, E. D. W. (1914). The haemolytic action of Indian strains of cholera and cholera-like vibrios. Indian Journal of Medical Research 2, 623.Google Scholar
Mosley, W. H., Ahmed, S., Benenson, A. S. & Ahmed, A. (1968). The relationship of vibriocidal antibody titre to susceptibility to cholera in family contacts of cholera patients. Bulletin of the World Health Organization 38, 777.Google ScholarPubMed
Mosley, W. H., Benenson, A. S. & Barui, R. (1968). A serological survey for cholera antibodies in rural East Pakistan. Bulletin of the World Health Organization 38, 327.Google ScholarPubMed
Mosley, W. H., Woodward, W. E., Aziz, K. M. A., Rahman, A. S. M. M., Chowdhury, A. K. M. A., Ahmed, A. & Feeley, J. C. (1970). The 1968–1969 cholera-vaccine field trial in rural East Pakistan. Effectiveness of monovalent Ogawa and Inaba vaccines and a purified Inaba antigen, with comparative results of serological and animal protection tests. Journal of Infectious Diseases 121, Suppl. S1.CrossRefGoogle Scholar
Mukerjee, S. (1963). The bacteriophage-susceptibility test in differentiating Vibrio cholerae and Vibrio el tor. Bulletin of the World Health Organization 28, 333.Google ScholarPubMed
Noble, J. E. (1965). Trivalent cholera vaccine. Journal of Pathology and Bacteriology 89, 543.CrossRefGoogle ScholarPubMed
Preston, N. W. (1975). Vaccine composition in relation to antigenic variation of the microbe: is pertussis unique? Progress in Drug Research 19 (in the Press).Google Scholar