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Brain anatomy of major depression I. Focus on hippocampus

Published online by Cambridge University Press:  11 April 2011

Marcella Bellani ,
Monica Baiano  and
Paolo Brambilla
Marcella Bellani*
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, Inter-University Center for Behavioural Neurosciences (ICBN), University of Verona, Verona (Italy)
Monica Baiano
Affiliation:
Center for Weight and Eating Disorders, Portogruaro (Italy)
Paolo Brambilla
Affiliation:
DPMSC, Section of Psychiatry, Inter-University Center for Behavioural Neurosciences (ICBN) University of Udine, Udine (Italy) Scientific Institute ‘E. Medea’, Udine (Italy)
*
Address for correspondence: Dr. M. Bellani, Department of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona (Italy). Fax: +39-045-8027498 E-mail: marcella.bellani@univr.it
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Abstract

Here we briefly summarize the most consistent structural MRI studies on hippocampus in major depression and debate the effects of clinical variables on hippocampal morphology.

Keywords

major depressive disordervolumesMRI
Type
Neurobiology of Psychosis. Clinical and Psychosocial Implications
Information
Epidemiology and Psychiatric Sciences , Volume 19 , Issue 4 , December 2010 , pp. 298 - 301
Copyright
Copyright © Cambridge University Press 2010

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References

REFERENCES

Ballmaier, M., Narr, K.L., Toga, A.W., Elderkin-Thompson, V., Thompson, P.M., Hamilton, L., Haroon, E., Pham, D., Heinz, A. & Kumar, A. (2008). Hippocampal morphology and distinguishing lateonset from early-onset elderly depression. American Journal of Psychiatry 165, 229–237.CrossRefGoogle ScholarPubMed
Bearden, C.E., Thompson, P.M., Avedissian, C., Klunder, A.D., Nicoletti, M., Dierschke, N., Brambilla, P. & Soares, J.C. (2009). Altered hippocampal morphology in unmedicated patients with major depressive illness. ASN Neuro10, 265–273.Google ScholarPubMed
Bell-McGinty, S., Butters, M.A., Meltzer, C.C., Greer, P.J., Reynolds, C.F., 3rd & Becker, J.T. (2002). Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration. American Journal of Psychiatry 159, 1424–1427.CrossRefGoogle Scholar
Bremner, J.D., Narayan, M., Anderson, E.R., Staib, L.H., Miller, H.L. & Charney, D.S. (2000). Hippocampal volume reduction in major depression. American Journal of Psychiatry 157, 115–118.CrossRefGoogle ScholarPubMed
Caetano, S.C., Hatch, J.P., Brambilla, P., Sassi, R.B., Nicoletti, M., Mallinger, A.G., Frank, E., Kupfer, D.J., Keshavan, M.S. & Soares, J.C. (2004). Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression. Psychiatry Research 132, 141–147.CrossRefGoogle ScholarPubMed
Caetano, S.C., Fonseca, M., Hatch, J.P., Olvera, R.L., Mark Nicoletti, M., Hunter, K., Lafer, B., Steven, R., Pliszka, S.R. & Soares, J.C. (2007). Medial temporal lobe abnormalities in pediatric unipolar depression. Neuroscience Letters 427, 142–147.CrossRefGoogle ScholarPubMed
Campbell, S., Marriott, M., Nahmias, C. & MacQueen, G.M. (2004). Lower hippocampal volume in patients suffering from depression: a meta-analysis. American Journal of Psychiatry 161, 598–607.CrossRefGoogle ScholarPubMed
Chen, M.C., Hamilton, P. & Gotlib, I.H. (2010). Decreased hippocampus volume in healthy girls at risk for depression. Archives of General Psychiatry 67, 270–276.CrossRefGoogle Scholar
Colla, M., Kronenberg, G., Deuschle, M., Meichel, K., Hagen, T., Bohrer, M. & Heuser, I. (2007). Hippocampal volume reduction and HPA-system activity in major depression. Journal of Psychiatry Research 41, 553–560.CrossRefGoogle ScholarPubMed
Danese, A. (2008). Genetic opportunities for psychiatric epidemiology: on life stress and depression. Epidemiologia e Psichiatria Sociale 17, 201–210.CrossRefGoogle ScholarPubMed
Drevets, W.C., Price, J.L. & Furey, M.L. (2008). Brain structural and functional abnormalities in mood disorders: implications for neurocir-cuitry models of depression. Brain Structure and Function 213, 93–118.CrossRefGoogle ScholarPubMed
Frodl, T., Schaub, A., Banac, S., Charypar, M., Jäger, M., Kümmler, P., Bottlender, R., Zetzsche, T., Born, C., Leinsinger, G., Reiser, M., Möller, H.J. & Meisenzahl, E.M. (2006). Reduced hippocampal volume correlates with executive dysfunctioning in major depression. Journal of Psychiatry and Neuroscience 31, 316–325.Google ScholarPubMed
Frodl, T., Zill, P., Baghai, T., Schüle, C., Rupprecht, R., Zetzsche, T., Bondy, B., Reiser, M., Möller, H.J. & Meisenzahl, E.M. (2008a). Reduced hip-pocampal volumes associated with the long variant of the tri- and di-allelic serotonin transporter polymorphism in major depression. American Journal of Medical Genetics Part B: Neuropsychiatry Genetics 147, 1003–1007.CrossRefGoogle Scholar
Frodl, T., Jäger, M., Smajstrlova, I., Born, C., Bottlender, R., Palladino, T., Reiser, M., Möller, H.J. & Meisentzhal, E. (2008b). Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3 year prospective magnetic resonance imaging study. Journal of Psychiatry and Neuroscience 33, 423–430.Google ScholarPubMed
Frodl, T.S., Koutsouleris, N., Bottlender, R., Born, C., Jäger, M., Scupin, I., Reiser, M., Möller, H.J., & Meisenzahl, M.E. (2008c). Depression-related variation in brain morphology over 3 years. Effects of Stress? Archives of General Psychiatry 65, 1156–1165.CrossRefGoogle ScholarPubMed
Kronmuller, K.T., Pantel, J., Götz, B., Köhler, S., Victor, D., Mundt, C., Magnotta, V., Giesel, F., Essig, M. & Schröder, J. (2008). Life events and hippocampal volume in first-episode major depression. Journal of Affective Disorders 110, 241–247.CrossRefGoogle ScholarPubMed
MacMaster, F.P., Mirza, Y., Szeszko, P.R., Kmiecik, L.E., Easter, P., Taormina, S.P., Lynch, M., Rose, M., Moore, G.J. & Rosenberg, D.R. (2008). Amygdala and hippocampal volumes in familial early onset major depressive disorder. Biological Psychiatry 63, 385–390.CrossRefGoogle ScholarPubMed
MacQueen, G.M., Campbell, S., McEwen, B.S., MacDonald, K., Amano, S., Joffe, R.T., Nahmias, C. & Young, L.T. (2003). Course of illness, hippocampal function, and hippocampal volume in major depression. Proceedings of National Academy of Science U.S. A. 3, 1387–1392.Google Scholar
McKinnon, M.C., Yucel, K., Nazarov, A. & MacQueen, G.M. (2009). A meta-analysis examining clinical predictors of hippocampal volume in patients. Journal of Psychiatry and Neuroscience 34, 41–54.Google ScholarPubMed
Montag, C., Weber, B., Fliessbach, K., Elger, C. & Reuter, M. (2009). The BDNF Val 66 Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression. Psychological Medicine 39, 1831–1839.CrossRefGoogle Scholar
Neumeister, A., Wood, S., Bonne, O., Nugent, A.C., Luckenbaugh, D.A., Young, T., Bain, E.E., Charney, D.S. & Drevets, W. (2005). Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects. Biological Psychiatry 57, 935–937.CrossRefGoogle ScholarPubMed
Paizanis, E., Hamon, M. & Lanfumey, L. (2007). Hippocampal neuroge-nesis, depressive disorders and antidepressant therapy. Neural Plasticity 2007, 1–7.CrossRefGoogle ScholarPubMed
Rao, U., Chen, L.A., Bidesi, A.S., Shad, M.U., Thomas, M.A. & Hammen, C.L. (2010). Hippocampal changes associated with earlylife adversity and vulnerability to depression. Biological Psychiatry 67, 357–364.CrossRefGoogle ScholarPubMed
Sala, M., Perez, J., Soloff, P., Ucelli, di Nemi S., Caverzasi, E., Soares, J.C. & Brambilla, P. (2004). Stress and hippocampal abnormalities in psychiatric disorders. European Neuropsychopharmacology 14, 393–405.CrossRefGoogle ScholarPubMed
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., Belzung, C. & Hen, R. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805–809.CrossRefGoogle ScholarPubMed
Shah, P.J., Glabus, M.F., Goodwin, G.M. & Ebmeier, K.P. (2002). Chronic, treatment resistant depression and right fronto-striatal atrophy. British Journal of Psychiatry 180, 434–440.CrossRefGoogle ScholarPubMed
Sheline, Y.I., Gado, M.H. & Kraemer, H.C. (2003). Untreated depression and hippocampal volume loss. American Journal of Psychiatry 160, 1516–1518.CrossRefGoogle ScholarPubMed
Tosato, S. & Lasalvia, A. (2009). The contribution of epidemiology to defining the most appropriate approach to genetic research on schizophrenia. Epidemiologia e Psichiatria Sociale 18, 81–90.CrossRefGoogle ScholarPubMed
Videbech, P. & Ravnkilde, B. (2004). Hippocampal volume and depression: a meta-analysis of MRI studies. American Journal of Psychiatry 161, 1957–1966.CrossRefGoogle ScholarPubMed
Vythilingam, M.H., Newport, J., Miller, A.H., Anderson, E., Bronen, R., Brumner, M., Staib, L., Vermetten, E., Charney, D.S., Nemeroff, C.B. & Bremner, J.D. (2002). Childhhod trauma associated with smaller hippocampal volume in women with major depression. American Journal of Psychiatry 159, 2072–2080.CrossRefGoogle Scholar
Vythilingam, M., Vermetten, E., Anderson, G.M., Luckenbaugh, D., Anderson, E.R., Snow, J., Staib, L.H., Charney, D.S. & Bremner, J.D. (2004). Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry 56, 101–12.CrossRefGoogle ScholarPubMed
Zou, K., Deng, W., Li, T., Zhang, B., Jiang, L., Huang, C., Sun, X. & Sun, X. (2010). Changes of brain morphometry in first-episode, drug-naïve, non-late-life adult patients with major depression: optimized voxel-based morphometry study. Biological Psychiatry 67, 186–188.CrossRefGoogle ScholarPubMed