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Effect of training and recovery on airway inflammation in an animal model of ‘ski asthma’

Published online by Cambridge University Press:  09 March 2007

MS Davis ,
EC McKenzie ,
CM Royer ,
KK Williamson ,
M Payton  and
SL Nelson
MS Davis*
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater OK 74078, USA
EC McKenzie
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater OK 74078, USA
CM Royer
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater OK 74078, USA
KK Williamson
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater OK 74078, USA
M Payton
Affiliation:
Department of Statistics, College of Arts and Sciences, Oklahoma State University, Stillwater OK 74078, USA
SL Nelson
Affiliation:
Iditarod Trail Committee, Wasilla AK 99786, USA
*
*msdavis@okstate.edu
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Abstract

Repeated strenuous exercise while breathing cold air is believed to induce chronic airway inflammation and hyperreactivity, a condition referred to in humans as ‘ski asthma’. However, the time course of development and resolution of ski asthma is unknown. We have previously shown that multi-day aerobic exercise induces airway inflammation and hyperreactivity in racing sled dogs. In the present study, a similar group of subjects was examined at multiple times during training to test the hypothesis that ski asthma spontaneously resolves during seasonal detraining, but is re-induced during training in the cold weather. At the beginning of training, bronchoalveolar lavage fluid (BALF) from detrained elite sled dogs (n = 16) had higher concentrations of lymphocytes (median 53.63 vs. 8.30 cells μl−1) and neutrophils (median 23.03 vs. 1.10 cells μl−1) compared with normal laboratory dogs (n = 5). However, there was no significant effect of training on BALF nucleated cell concentrations from exercised sled dogs (n = 11) compared with sedentary sled dogs (n = 8). In contrast to our hypothesis, our data support the contention that cold weather exercise-induced airway inflammation can persist through seasonal detraining, but that routine training does not cause significant worsening of the condition.

Keywords

Exercisebronchitissled dog
Type
Research Article
Information
Equine and Comparative Exercise Physiology , Volume 2 , Issue 2 , May 2005 , pp. 133 - 138
Copyright
Copyright © Cambridge University Press 2005

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